Yellow Fever Commission

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Walter Reed authored these informed consent documents in 1900 for his research on yellow fever

The Yellow Fever Commission was a research team of the United States Army which researched treatment for yellow fever.

The research process itself became a focus of study for later generations.[1]

A United States nurse named Clara Maass and two Spanish immigrants were among those who died as a result of their research participation.[2]

Researchers mark the research of the Yellow Fever Commission as the origin of the model of modern consent in medical research.[3]

The 1934 play Yellow Jack told the story of Walter Reed in the Yellow Fever Commission. That play was the basis of Yellow Jack, a 1938 movie presenting the same narrative.


  1. ^ Clements, Alan N.; Harbach, Ralph E. (December 2017). "History of the discovery of the mode of transmission of yellow fever virus". Journal of Vector Ecology. 42 (2): 208–222. doi:10.1111/jvec.12261. hdl:10141/622451. PMID 29125246.
  2. ^ Chaves-Carballo, Enrique (May 2013). "Clara Maass, Yellow Fever and Human Experimentation". Military Medicine. 178 (5): 557–562. doi:10.7205/MILMED-D-12-00430. PMID 23756016.
  3. ^ Güereña-Burgueño, F (2002). "The centennial of the Yellow Fever Commission and the use of informed consent in medical research". Salud Publica de Mexico. 44 (2): 140–4. doi:10.1590/s0036-36342002000200009. PMID 12053781.

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