Filmography
| Year | Title | Role |
| 2024 | Bad Boys: Ride or Die (2024) | Mike Lowrey |
| 2022 | Emancipation (2022) | Peter |
| 2021 | King Richard (2021) | Richard Williams |
| 2020 | Bad Boys for Life | Mike |
| 2019 | Gemini Man | Henry Brogan/Junior |
| 2019 | Spies in Disguise | Lance |
| 2019 | Aladdin (2019) | Genie/Mariner |
| 2017 | Bright (2017) | Daryl Ward |
| 2016 | Suicide Squad (2016) | Deadshot |
| 2016 | Collateral Beauty | Howard |
| 2015 | Focus (2015) | Nicky |
| 2015 | Concussion | Dr. Bennet Omalu |
| 2014 | Annie (2014) | Producer |
| 2013 | After Earth | Cypher Raige |
| 2012 | Men in Black III | Agent J |
| 2012 | This Means War | Producer |
| 2012 | Free Angela and All Political Prisoners | Executive Producer |
| 2010 | The Karate Kid (2010) | Producer |
| 2008 | Seven Pounds | Tim Thomas |
| 2008 | Lakeview Terrace | Producer |
| 2008 | Hancock | John Hancock |
| 2008 | The Secret Life of Bees | Producer |
| 2007 | I Am Legend | Robert Neville |
| 2006 | The Pursuit of Happyness | Chris Gardner |
| 2006 | ATL | Producer |
| 2005 | Hitch | Alex "Hitch" Hitchens |
| 2004 | Jersey Girl | Self |
| 2004 | I, Robot | Detective Del Spooner |
| 2004 | Shark Tale | Oscar |
| 2003 | Bad Boys II | Mike Lowrey |
| 2003 | A Closer Walk | Narrator |
| 2002 | Showtime | Executive Producer |
| 2002 | Men in Black II | Agent Jay |
| 2001 | Ali | Cassius Clay/Muhammad Ali |
| 2000 | The Legend of Bagger Vance | Bagger Vance |
| 1999 | Wild Wild West | Capt. James West |
| 1998 | Enemy of the State | Robert Clayton Dean |
| 1997 | Men in Black | Officer James Darrel Edwards III/MiB Agent J (Jay) |
| 1996 | Independence Day (1996) | Captain Steven 'Eagle' Hiller |
| 1995 | Bad Boys | Detective Mike Lowrey |
| 1993 | Six Degrees of Separation | Paul |
| 1993 | Made in America (1993) | Tea Cake Walters |
| 1992 | Where the Day Takes You | Manny |
