Doxycycline hyclate and Fever - a phase IV clinical study of FDA data

Created by: eHealthMe | Source of data: FDA | Published on: Dec, 28, 2023

Summary:

We study 14,862 people who have side effects when taking Doxycycline hyclate. Fever is found, especially among people who are female, 60+ old, have been taking the drug for < 1 month, also take Acetaminophen and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people take Doxycycline hyclate and have Fever. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

On Dec, 28, 2023

14,862 people reported to have side effects when taking Doxycycline hyclate.
Among them, 404 people (2.72%) have Fever.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is used in acne. Currently, eHealthMe is studying from 16,219 Doxycycline hyclate users.

What is Fever?

Fever is found to be associated with 4,478 drugs and 6,059 conditions by eHealthMe. Currently, we are studying 472,347 people who have Fever.

Number of Doxycycline hyclate and Fever reports submitted per year:

Time on Doxycycline hyclate when people have Fever *:

Gender of people who have Fever when taking Doxycycline hyclate *:

female: 74.39 %
male: 25.61 %

Age of people who have Fever when taking Doxycycline hyclate *:

Common drugs people take besides Doxycycline hyclate *:

Common side effects people have besides Fever *:

Fatigue (feeling of tiredness): 154 people, 38.12%
Nausea (feeling of having an urge to vomit): 150 people, 37.13%
Rashes (redness): 138 people, 34.16%
Pain: 132 people, 32.67%
Headache (pain in head): 105 people, 25.99%
High Blood Pressure: 104 people, 25.74%
Malaise (a feeling of general discomfort or uneasiness): 100 people, 24.75%
Sinusitis (inflammation of sinus): 90 people, 22.28%
Joint Pain: 85 people, 21.04%
Breathing Difficulty: 81 people, 20.05%

Common conditions people have *:

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 67 people, 16.58%
Immunodeficiency Common Variable: 43 people, 10.64%
Pain: 41 people, 10.15%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 39 people, 9.65%
Multiple Myeloma (cancer of the plasma cells): 31 people, 7.67%
Headache (pain in head): 23 people, 5.69%
Psoriasis (immune-mediated disease that affects the skin): 22 people, 5.45%
High Blood Pressure: 19 people, 4.70%
Fibromyalgia (a long-term condition which causes pain all over the body): 18 people, 4.46%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 17 people, 4.21%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline hyclate and have Fever?

Check whether Fever is associated with a drug or a condition

What are phase IV trials?

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world, as opposed to phase I-III trials that are used in drug approval. With real-world big data and AI/ML algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public.

Why use real-world data?

New drugs have to go through a series (phase I-III) of clinical trials before they are approved by the FDA. These clinical trials have guidelines about who can participate. The guidelines ensure that only a selected set of people are chosen due to time and costs. When the drugs are approved and released in the market to a much bigger and ever-changing public, it is not uncommon for drugs to behave differently in the real world than in (phase I-III) clinical trials.

During the past 30 years, special regulatory programs are available to the FDA including Fast Track (1988, in statute 1997), Priority Review (1992), Accelerated Approval (1992), and Breakthrough Therapy designation (2012). These programs potentially contribute to the variability of the quantity and quality of evidence supporting recent drug approvals.

All these suggest an ongoing need for continued evaluation of therapeutic safety and efficacy after drug approvals. The 21st Century Cures Act, passed in 2016, places additional focus on the use of real-world data to support regulatory decision making. The FDA has started to use real-world data to monitor postmarket safety and adverse events, and payers to support value-based payment program.

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Schiller D, Maieron A, Sch?fl R, Donnerer J, "Drug fever due to a single dose of pantoprazole", Pharmacology, 2015 Jan .

Related studies

Doxycycline hyclate side effects by duration, gender and age:

Doxycycline hyclate side effects (16,219 reports)

Fever treatments and more:

Fever (472,347 reports)

Common drugs associated with Fever:

Prednisone and Fever: 30,484 reports
Methotrexate and Fever: 23,406 reports
Humira and Fever: 20,147 reports
Enbrel and Fever: 14,311 reports
Aspirin and Fever: 14,157 reports
Omeprazole and Fever: 12,909 reports
Pantoprazole and Fever: 12,397 reports
Prednisolone and Fever: 11,832 reports
Tylenol and Fever: 11,340 reports
Cyclophosphamide and Fever: 10,914 reports

All the drugs that are associated with Fever:

Fever (4,478 drugs)

Common conditions associated with Fever:

Rheumatoid arthritis and Fever: 25,712 reports
Multiple sclerosis and Fever: 19,094 reports
High blood pressure and Fever: 15,712 reports
Crohn's disease and Fever: 12,822 reports
Multiple myeloma and Fever: 11,515 reports
Pain and Fever: 11,416 reports
Asthma and Fever: 9,063 reports

All the conditions that are associated with Fever:

Fever (6,059 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline hyclate) and Doxycycline hyclate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With real-world medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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