Gentamicin

Identification

Summary

Gentamicin is an aminoglycoside used to treat a wide variety of aerobic infections in the body.

Brand Names

Gentak, Pred-G, Valisone-G

Generic Name

Gentamicin

DrugBank Accession Number

DB00798

Background

Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963.⁷ It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.^5,8 Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by Pseudomonas aeruginosa.^6,10,11 There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams.¹¹ This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.^10,11

Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.¹²

Type

Small Molecule

Groups

Approved, Vet approved

Structure

Similar Structures

Weight: Average: 1390.728
Monoisotopic: 1389.901796041
Chemical Formula: C₆₀H₁₂₃N₁₅O₂₁

Synonyms

Gentamicin
Gentamicina

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Pharmacology

Indication

Not Available

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Dose Form
Used in combination to treat	Bacterial conjunctivitis	Combination Product in combination with: Dexamethasone (DB01234)	••••••••••••	•••••••• • •••••
Treatment of	Bacterial infections		••••••••••••
Treatment of	Bacterial meningitis		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Treatment of	Bacterial corneal ulcer		••••••••••••	••••••••••
Treatment of	Bacterial dacryocystitis		••••••••••••	••••••••••
Treatment of	Blepharitis		••••••••••••	••••••••••
Treatment of	Blepharoconjunctivitis		••••••••••••	••••••••••
Treatment of	Central nervous system infection		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Used in combination to treat	Conjunctivitis allergic	Combination Product in combination with: Dexamethasone (DB01234)	••••••••••••	•••••••• • •••••
Treatment of	Conjunctivitis bacterial		••••••••••••	••••••••••
Used in combination to treat	Corneal infection	Combination Product in combination with: Dexamethasone (DB01234)	••••••••••••	•••••••• • •••••
Treatment of	Dermatitis infected		••••••••••••
Treatment of	Ecthyma		••••••••••••
Treatment of	Eczematous dermatitis infected		••••••••••••
Used in combination to treat	Eye inflammation	Combination Product in combination with: Dexamethasone (DB01234)	••••••••••••	••••••••
Used in combination to treat	Eye inflammation	Combination Product in combination with: Dexamethasone (DB01234)	••••••••••••	•••••••• • •••••
Treatment of	Folliculitis		••••••••••••
Treatment of	Furunculosis		••••••••••••
Treatment of	Gram-negative enteric bacilli neonatal sepsis		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Treatment of	Impetigo contagious		••••••••••••
Used in combination to treat	Inflammatory reaction	Combination Product in combination with: Tolnaftate (DB00525), Clioquinol (DB04815), Betamethasone (DB00443)	••••••••••••	•••••
Treatment of	Keratitis bacterial		••••••••••••	••••••••••
Treatment of	Keratoconjunctivitis		••••••••••••	••••••••••
Treatment of	Meibomianitis		••••••••••••	••••••••••
Treatment of	Peritonitis bacterial		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Treatment of	Pustular psoriasis		••••••••••••
Treatment of	Pustular acne		••••••••••••
Treatment of	Pyoderma gangrenosum		••••••••••••
Treatment of	Seborrheic dermatitis		••••••••••••
Treatment of	Septicemia gram-negative		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Used in combination to treat	Skin infections	Combination Product in combination with: Clotrimazole (DB00257), Betamethasone (DB00443)	••• •••	•••••
Treatment of	Skin and subcutaneous tissue bacterial infections		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Treatment of	Skin bacterial infection		••••••••••••
Treatment of	Sycosis barbae		••••••••••••
Used in combination to treat	Bacterial dermatoses	Combination Product in combination with: Betamethasone (DB00443), Clioquinol (DB04815)	••••••••••••	•••••
Treatment of	Complicated respiratory tract infection bacterial		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Treatment of	Complicated urinary tract infection bacterial		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Used in combination to treat	Corticosteroid-responsive dermatosis	Combination Product in combination with: Betamethasone (DB00443)	••••••••••••	••••••••
Used in combination to treat	Ocular bacterial infections	Combination Product in combination with: Dexamethasone (DB01234)	••••••••••••	•••••••• • •••••
Used in combination to treat	Severe endocarditis enterococcal	Regimen in combination with: Benzylpenicillin (DB01053)	••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Used in combination to treat	Severe infection pseudomonas aeruginosa	Regimen in combination with: Carbenicillin (DB00578)	••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••
Treatment of	Severe staphylococcal infection		••••••••••••	•••••••••• ••••••••• •••••••••• ••••••••• •••••••••••

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

There are 3 key phases of aminoglycoside entry into cells.⁹ The first “ionic binding phase” occurs when polycationic aminoglycosides bind electrostatically to negatively charged components of bacterial cell membranes including with lipopolysaccharides and phospholipids within the outer membrane of Gram-negative bacteria and to teichoic acids and phospholipids within the cell membrane of Gram-positive bacteria. This binding results in displacement of divalent cations and increased membrane permeability, allowing for aminoglycoside entry.^9,13,14,15 The second “energy-dependent phase I” of aminoglycoside entry into the cytoplasm relies on the proton-motive force and allows a limited amount of aminoglycoside access to its primary intracellular target - the bacterial 30S ribosome.^9,15 This ultimately results in the mistranslation of proteins and disruption of the cytoplasmic membrane.¹⁶ Finally, in the “energy-dependent phase II” stage, concentration-dependent bacterial killing is observed. Aminoglycoside rapidly accumulates in the cell due to the damaged cytoplasmic membrane, and protein mistranslation and synthesis inhibition is amplified.^9,15 The necessity of oxygen-dependent active transport explains why aminoglycosides are ineffective against anaerobic bacteria.¹ Hence, aminoglycosides have both immediate bactericidal effects through membrane disruption and delayed bactericidal effects through impaired protein synthesis; observed experimental data and mathematical modeling support this two-mechanism model.⁹ Inhibition of protein synthesis is a key component of aminoglycoside efficacy. Structural and cell biological studies suggest that aminoglycosides bind to the 16S rRNA in helix 44 (h44), near the A site of the 30S ribosomal subunit, altering interactions between h44 and h45. This binding also displaces two important residues, A1492 and A1493, from h44, mimicking normal conformational changes that occur with successful codon-anticodon pairing in the A site.¹⁷ Overall, aminoglycoside binding has several negative effects including inhibition of translation, initiation, elongation, and ribosome recycling.^9,18,19 Recent evidence suggests that the latter effect is due to a cryptic second binding site situated in h69 of the 23S rRNA of the 50S ribosomal subunit.^17,19 Also, by stabilizing a conformation that mimics correct codon-anticodon pairing, aminoglycosides promote error-prone translation.²⁰ Mistranslated proteins can incorporate into the cell membrane, inducing the damage discussed above.⁹

Target	Actions	Organism
A30S ribosomal protein S12	binder	Escherichia coli (strain K12)
A16S ribosomal RNA	binder	Enteric bacteria and other eubacteria
A23S ribosomal RNA	inhibitor	Enteric bacteria and other eubacteria
ABacterial outer membrane	incorporation into and destabilization	Bacteria
ACytoplasmic membrane	incorporation into and destabilization	Bacteria
UNH(3)-dependent NAD(+) synthetase	inhibitor	Bacillus subtilis (strain 168)
UDihydrofolate reductase	Not Available	Humans

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Studies have determined that plasma protein binding of gentamicin is between 0-30% depending on the method of testing.²¹

Metabolism

Gentamicin undergoes little to no metabolism.²⁴

Route of elimination

Gentamicin is excreted primarily by the kidneys. In patients with normal renal function, 70% or more of an initial gentamicin dose can be recovered in the urine within 24 hours. Excretion of gentamicin is significantly reduced in patients with renal impairment.²⁴

Half-life

One study assessing the pharmacokinetics of gentamicin in children and adults reported a mean half-life of 75 minutes after intravenous administration.² The mean half-life associated with intramuscular administration was about 29 minutes longer.² Fever and anemia may result in a shorter half-life although dose adjustments are not usually necessary.^2,24 Severe burns are also associated with a shorter half-life and may result in lower gentamicin serum concentrations.²⁴

Clearance

The renal clearance of gentamicin is comparable to individual creatinine clearance.^3,24

Adverse Effects

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Toxicity

As with other aminoglycosides, nephrotoxicity and ototoxicity are associated with gentamicin.⁹ Signs of nephrotoxicity include an increase in plasma creatinine and urea, while signs of ototoxicity include issues with balance, nausea, tinnitus, and hearing loss.⁵ It is important to note that aminoglycoside-induced nephrotoxicity is typically reversible, while ototoxicity is more likely to be permanent.⁹ The risk of both toxicities increases with long-term gentamicin therapy.¹ Gentamicin is considered to be more vestibulotoxic than cochleotoxic compared to other aminoglycosides.^9,4 Unfortunately, gentamicin-related ototoxicity does not correlate with cumulative dosing, peak and trough levels, or dosing schedule.⁵ The unpredictability of ototoxicity supports close monitoring of the patient throughout treatment.⁵ In cases of toxicity or overdose, the medication should be discontinued immediately; hemodialysis may be initiated to lower gentamicin serum concentrations.²⁴

Pathways

Pathway	Category
Gentamicin Action Pathway	Drug action

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Abacavir	Abacavir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Aceclofenac	Aceclofenac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Acenocoumarol	The risk or severity of bleeding can be increased when Gentamicin is combined with Acenocoumarol.
Acetaminophen	Acetaminophen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Acetylcholine	The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Gentamicin.
Acetyldigitoxin	The risk or severity of adverse effects can be increased when Gentamicin is combined with Acetyldigitoxin.
Acetylsalicylic acid	Acetylsalicylic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Aclidinium	Aclidinium may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Acrivastine	Acrivastine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Acyclovir	Acyclovir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Agalsidase alfa	The therapeutic efficacy of Agalsidase alfa can be decreased when used in combination with Gentamicin.
Agalsidase beta	The therapeutic efficacy of Agalsidase beta can be decreased when used in combination with Gentamicin.
Albuterol	Salbutamol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Albutrepenonacog alfa	Albutrepenonacog alfa may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Alclofenac	Alclofenac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Aldesleukin	Aldesleukin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Alendronic acid	The risk or severity of nephrotoxicity and hypocalcemia can be increased when Gentamicin is combined with Alendronic acid.
Allopurinol	Allopurinol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Almasilate	Almasilate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Almotriptan	Almotriptan may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Alogliptin	Alogliptin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Alprazolam	Alprazolam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Amantadine	The serum concentration of Gentamicin can be increased when it is combined with Amantadine.
Ambroxol	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Ambroxol.
Amikacin	Amikacin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Amiloride	The serum concentration of Gentamicin can be increased when it is combined with Amiloride.
Aminohippuric acid	The serum concentration of Gentamicin can be increased when it is combined with Aminohippuric acid.
Aminophenazone	Aminophenazone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Amiodarone	The serum concentration of Gentamicin can be increased when it is combined with Amiodarone.
Amitriptyline	Amitriptyline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ammonium chloride	Ammonium chloride may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Amoxicillin	Amoxicillin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Amphetamine	Amphetamine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Amphotericin B	Amphotericin B may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ampicillin	Ampicillin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Amrinone	Amrinone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ancestim	Ancestim may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Antihemophilic factor (recombinant), PEGylated	Antihemophilic factor (recombinant), PEGylated may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Antipyrine	Antipyrine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Antithrombin III human	Antithrombin III human may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Antrafenine	Antrafenine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Apalutamide	The serum concentration of Gentamicin can be increased when it is combined with Apalutamide.
Apremilast	Apremilast may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ardeparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Ardeparin.
Arformoterol	Arformoterol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Arsenic trioxide	Arsenic trioxide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Articaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Articaine.
Atazanavir	Atazanavir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Atomoxetine	Atomoxetine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Atracurium	The therapeutic efficacy of Atracurium can be increased when used in combination with Gentamicin.
Atracurium besylate	The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Gentamicin.
Auranofin	Auranofin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Aurothioglucose	Aurothioglucose may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Azacitidine	Azacitidine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Azathioprine	Azathioprine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Azelaic acid	Azelaic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Azlocillin	The serum concentration of Gentamicin can be decreased when it is combined with Azlocillin.
Aztreonam	Aztreonam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bacampicillin	The serum concentration of Gentamicin can be decreased when it is combined with Bacampicillin.
Bacitracin	Bacitracin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Baclofen	Gentamicin may decrease the excretion rate of Baclofen which could result in a higher serum level.
Balsalazide	Balsalazide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Baricitinib	Baricitinib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
BCG vaccine	The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Gentamicin.
Bemiparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Bemiparin.
Benorilate	Benorilate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Benoxaprofen	Benoxaprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Benserazide	Benserazide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Benzatropine	Benzatropine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Benznidazole	Benznidazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Benzocaine.
Benzydamine	Benzydamine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Benzyl alcohol.
Benzylpenicillin	The serum concentration of Gentamicin can be decreased when it is combined with Benzylpenicillin.
Benzylpenicilloyl polylysine	The serum concentration of Gentamicin can be decreased when it is combined with Benzylpenicilloyl polylysine.
Bepotastine	Bepotastine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bethanechol	The therapeutic efficacy of Bethanechol can be decreased when used in combination with Gentamicin.
Bicisate	Bicisate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bismuth subgallate	Bismuth subgallate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bisoprolol	Bisoprolol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bisoxatin	Bisoxatin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bleomycin	Bleomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Botulinum toxin type A	The therapeutic efficacy of Botulinum toxin type A can be increased when used in combination with Gentamicin.
Botulinum toxin type B	The risk or severity of adverse effects can be increased when Gentamicin is combined with Botulinum toxin type B.
Brivaracetam	Brivaracetam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bromazepam	Bromazepam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Budesonide	Budesonide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bumadizone	Bumadizone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Bumetanide	The serum concentration of Gentamicin can be increased when it is combined with Bumetanide.
Bupivacaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Bupivacaine.
Bupropion	The excretion of Gentamicin can be decreased when combined with Bupropion.
Buspirone	Buspirone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Butabarbital	Butabarbital may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Butacaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Butacaine.
Butamben	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Butamben.
Canagliflozin	Canagliflozin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Capecitabine	Capecitabine may increase the nephrotoxic activities of Gentamicin.
Capivasertib	The serum concentration of Gentamicin can be increased when it is combined with Capivasertib.
Capreomycin	Capreomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Capsaicin.
Captopril	The excretion of Captopril can be decreased when combined with Gentamicin.
Carbamazepine	Gentamicin may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Carbamoylcholine	The therapeutic efficacy of Carbamoylcholine can be decreased when used in combination with Gentamicin.
Carbenicillin	The serum concentration of Gentamicin can be decreased when it is combined with Carbenicillin.
Carbidopa	Carbidopa may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Carboplatin	The risk or severity of ototoxicity and nephrotoxicity can be increased when Gentamicin is combined with Carboplatin.
Carindacillin	The serum concentration of Gentamicin can be decreased when it is combined with Carindacillin.
Carmustine	Carmustine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Carprofen	Carprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefaclor	Cefaclor may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefadroxil	Cefadroxil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefalotin	Cefalotin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefamandole	Cefamandole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefapirin	Cefapirin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefazolin	Cefazolin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefdinir	Cefdinir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefditoren	Cefditoren may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefepime	The risk or severity of ototoxicity and nephrotoxicity can be increased when Cefepime is combined with Gentamicin.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefonicid	Cefonicid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefoperazone	Cefoperazone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceforanide	Ceforanide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefotaxime	Cefotaxime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefotetan	Cefotetan may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefoxitin	Cefoxitin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefpirome	Cefpirome may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefpodoxime	Cefpodoxime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefprozil	Cefprozil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefradine	Cefradine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceftaroline fosamil	Ceftaroline fosamil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceftazidime	Ceftazidime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceftibuten	Ceftibuten may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceftizoxime	Ceftizoxime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceftobiprole	Ceftobiprole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceftolozane	Ceftolozane may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ceftriaxone	Ceftriaxone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cefuroxime	Cefuroxime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Celecoxib	Celecoxib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cephalexin	Cephalexin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cephaloglycin	Cephaloglycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Certolizumab pegol	Certolizumab pegol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cetirizine	Cetirizine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cevimeline	Cevimeline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chloral hydrate	Chloral hydrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Chloroprocaine.
Chloroquine	Chloroquine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chlorpheniramine	The serum concentration of Gentamicin can be increased when it is combined with Chlorpheniramine.
Chlorpromazine	Chlorpromazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chlorpropamide	Chlorpropamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chlorzoxazone	Chlorzoxazone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Choline	The serum concentration of Gentamicin can be increased when it is combined with Choline.
Choline C 11	Choline C 11 may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Choline magnesium trisalicylate	Choline magnesium trisalicylate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Choline salicylate	The serum concentration of Gentamicin can be increased when it is combined with Choline salicylate.
Chondroitin sulfate	Chondroitin sulfate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chromic chloride	Chromic chloride may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chromic nitrate	Chromic nitrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chromium	Chromium may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chromium gluconate	Chromium gluconate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chromium nicotinate	Chromium nicotinate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Chromous sulfate	Chromous sulfate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cidofovir	Cidofovir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cilostazol	Cilostazol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cimetidine	The serum concentration of Gentamicin can be increased when it is combined with Cimetidine.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Cinchocaine.
Ciprofloxacin	Ciprofloxacin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cisatracurium	Gentamicin may increase the neuromuscular blocking activities of Cisatracurium.
Cisplatin	The serum concentration of Gentamicin can be increased when it is combined with Cisplatin.
Clevidipine	Clevidipine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Clindamycin	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Clindamycin.
Clobazam	Clobazam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Clodronic acid	The risk or severity of nephrotoxicity and hypocalcemia can be increased when Gentamicin is combined with Clodronic acid.
Clofarabine	Clofarabine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Clomipramine	Clomipramine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Clonazepam	Clonazepam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Clopidogrel	The serum concentration of Gentamicin can be increased when it is combined with Clopidogrel.
Clorazepic acid	Clorazepic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Clove oil	Clove oil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cloxacillin	The serum concentration of Gentamicin can be decreased when it is combined with Cloxacillin.
Clozapine	Clozapine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Cocaine.
Colchicine	Colchicine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Colistimethate	Colistimethate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Colistin	Gentamicin may decrease the excretion rate of Colistin which could result in a higher serum level.
Conjugated estrogens	Conjugated estrogens may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Corifollitropin alfa	Corifollitropin alfa may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Crizotinib	The serum concentration of Gentamicin can be increased when it is combined with Crizotinib.
Cyanocobalamin	Cyanocobalamin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Cyclacillin	The serum concentration of Gentamicin can be decreased when it is combined with Cyclacillin.
Cyclosporine	Cyclosporine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dabigatran etexilate	Dabigatran etexilate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dabrafenib	The serum concentration of Gentamicin can be increased when it is combined with Dabrafenib.
Dacarbazine	Dacarbazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dalfampridine	Dalfampridine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dalteparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Dalteparin.
Danaparoid	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Danaparoid.
Dantrolene	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Dantrolene.
Daptomycin	Daptomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
DaxibotulinumtoxinA	Gentamicin may increase the neuromuscular blocking activities of DaxibotulinumtoxinA.
Decamethonium	The therapeutic efficacy of Decamethonium can be increased when used in combination with Gentamicin.
Deferiprone	Deferiprone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Delafloxacin	Delafloxacin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Demeclocycline	The risk or severity of neuromuscular blockade can be increased when Demeclocycline is combined with Gentamicin.
Desipramine	The serum concentration of Gentamicin can be increased when it is combined with Desipramine.
Deslanoside	The risk or severity of adverse effects can be increased when Gentamicin is combined with Deslanoside.
Desmopressin	Desmopressin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Desvenlafaxine	Desvenlafaxine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Deutetrabenazine	Deutetrabenazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dexchlorpheniramine maleate	The serum concentration of Gentamicin can be increased when it is combined with Dexchlorpheniramine maleate.
Dexibuprofen	Dexibuprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dexketoprofen	Dexketoprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dexmedetomidine	Dexmedetomidine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dexpanthenol	Dexpanthenol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dexrazoxane	Dexrazoxane may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dextran	Dextran may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Diatrizoate	Diatrizoate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Diazepam	Diazepam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dichlorobenzyl alcohol	Dichlorobenzyl alcohol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Diclofenac	Diclofenac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dicloxacillin	The serum concentration of Gentamicin can be decreased when it is combined with Dicloxacillin.
Dicoumarol	The risk or severity of bleeding can be increased when Gentamicin is combined with Dicoumarol.
Dicyclomine	Dicyclomine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Didanosine	Didanosine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dienogest	Dienogest may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Diflunisal	Diflunisal may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Difluocortolone	Difluocortolone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Digitoxin	The risk or severity of adverse effects can be increased when Gentamicin is combined with Digitoxin.
Digoxin	The serum concentration of Digoxin can be increased when it is combined with Gentamicin.
Dihydrostreptomycin	Dihydrostreptomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dimercaprol	Dimercaprol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dimethyl sulfoxide	Dimethyl sulfoxide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dinoprostone	The serum concentration of Gentamicin can be increased when it is combined with Dinoprostone.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Diphenhydramine.
Disopyramide	The serum concentration of Gentamicin can be increased when it is combined with Disopyramide.
DL-Methylephedrine	DL-Methylephedrine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dobutamine	Dobutamine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dolutegravir	The serum concentration of Gentamicin can be increased when it is combined with Dolutegravir.
Dopamine	The serum concentration of Gentamicin can be increased when it is combined with Dopamine.
Doripenem	Doripenem may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Doxacurium	The therapeutic efficacy of Doxacurium can be increased when used in combination with Gentamicin.
Doxepin	Doxepin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Doxycycline	Doxycycline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dronedarone	The serum concentration of Gentamicin can be increased when it is combined with Dronedarone.
Droxidopa	Droxidopa may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Duloxetine	Duloxetine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Dyclonine.
Dyphylline	Dyphylline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Edoxaban	Edoxaban may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Edrophonium	Edrophonium may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Enalaprilat	Enalaprilat may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Enasidenib	The serum concentration of Gentamicin can be increased when it is combined with Enasidenib.
Encorafenib	The serum concentration of Gentamicin can be increased when it is combined with Encorafenib.
Enoxaparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Enoxaparin.
Enzalutamide	Enzalutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Epinephrine	The serum concentration of Gentamicin can be increased when it is combined with Epinephrine.
Epoprostenol	Epoprostenol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Erdafitinib	The serum concentration of Gentamicin can be increased when it is combined with Erdafitinib.
Ertapenem	Ertapenem may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Estazolam	Estazolam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Estetrol	The therapeutic efficacy of Estetrol can be decreased when used in combination with Gentamicin.
Estradiol	The serum concentration of Gentamicin can be increased when it is combined with Estradiol.
Estradiol acetate	The serum concentration of Gentamicin can be increased when it is combined with Estradiol acetate.
Estradiol benzoate	The serum concentration of Gentamicin can be increased when it is combined with Estradiol benzoate.
Estradiol cypionate	The serum concentration of Gentamicin can be increased when it is combined with Estradiol cypionate.
Estradiol dienanthate	The serum concentration of Gentamicin can be increased when it is combined with Estradiol dienanthate.
Estradiol valerate	The serum concentration of Gentamicin can be increased when it is combined with Estradiol valerate.
Estrone sulfate	Estrone sulfate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Eszopiclone	Eszopiclone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Etacrynic acid	The serum concentration of Gentamicin can be increased when it is combined with Etacrynic acid.
Etafedrine	Etafedrine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ethambutol	Ethambutol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Ethyl chloride.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Etidocaine.
Etidronic acid	The risk or severity of nephrotoxicity and hypocalcemia can be increased when Gentamicin is combined with Etidronic acid.
Etodolac	Etodolac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Etomidate	Etomidate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Etonogestrel	Etonogestrel may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Etoricoxib	Etoricoxib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Eucalyptus oil	Eucalyptus oil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ezogabine	Ezogabine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Famotidine	The serum concentration of Gentamicin can be increased when it is combined with Famotidine.
Fecal microbiota	The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Gentamicin.
Fedratinib	Fedratinib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fenbufen	Fenbufen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fenofibrate	Fenofibrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fenofibric acid	Fenofibric acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fenoldopam	Fenoldopam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fenoprofen	Fenoprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fentanyl	Fentanyl may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fesoterodine	Fesoterodine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fexinidazole	The serum concentration of Gentamicin can be increased when it is combined with Fexinidazole.
Flavoxate	Flavoxate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Floctafenine	Floctafenine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Florbetaben F-18	Florbetaben (18F) may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Florbetapir (18F)	Florbetapir (18F) may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Floxuridine	Floxuridine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Flucloxacillin	The serum concentration of Gentamicin can be decreased when it is combined with Flucloxacillin.
Fluconazole	Fluconazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Flucytosine	Flucytosine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fludeoxyglucose (18F)	Fludeoxyglucose (18F) may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fluindione	The risk or severity of bleeding can be increased when Gentamicin is combined with Fluindione.
Flumazenil	Flumazenil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fluocinolone acetonide	Fluocinolone acetonide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fluorescein	The excretion of Fluorescein can be decreased when combined with Gentamicin.
Flurazepam	The serum concentration of Gentamicin can be increased when it is combined with Flurazepam.
Flurbiprofen	Flurbiprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Flutamide	Flutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fluvoxamine	Fluvoxamine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Folic acid	Folic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fomepizole	Fomepizole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fondaparinux	Fondaparinux may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Formestane	Formestane may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Foscarnet	The risk or severity of nephrotoxicity can be increased when Gentamicin is combined with Foscarnet.
Fosfomycin	Fosfomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Fosinopril	Fosinopril may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Framycetin	Framycetin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Furosemide	Furosemide may increase the ototoxic activities of Gentamicin.
Gabapentin enacarbil	Gabapentin enacarbil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gadobenic acid	Gadobenic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gadodiamide	Gadodiamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gadofosveset trisodium	Gadofosveset trisodium may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gadopentetic acid	Gadopentetic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gadoteric acid	Gadoteric acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gadoteridol	Gadoteridol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gallamine triethiodide	The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Gentamicin.
Ganciclovir	Ganciclovir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gemcitabine	Gemcitabine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gemfibrozil	Gemfibrozil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gimeracil	Gimeracil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Givinostat	The serum concentration of Gentamicin can be increased when it is combined with Givinostat.
Givosiran	Givosiran may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Glipizide	Glipizide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Glycerol phenylbutyrate	Glycerol phenylbutyrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Glycol salicylate	The risk or severity of nephrotoxicity can be increased when Glycol salicylate is combined with Gentamicin.
Golodirsen	Golodirsen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Goserelin	Goserelin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Grepafloxacin	The serum concentration of Gentamicin can be increased when it is combined with Grepafloxacin.
Guanethidine	Guanethidine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Guanfacine	Guanfacine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Guanidine	The serum concentration of Gentamicin can be increased when it is combined with Guanidine.
Haloperidol	Haloperidol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Heparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Heparin.
Hetacillin	The serum concentration of Gentamicin can be decreased when it is combined with Hetacillin.
Histamine	The serum concentration of Gentamicin can be increased when it is combined with Histamine.
Hydralazine	Hydralazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Hydrochlorothiazide	Hydrochlorothiazide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Hydromorphone	Hydromorphone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Hydroxocobalamin	Hydroxocobalamin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Hydroxyethyl Starch	Hydroxyethyl Starch may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ibandronate	The risk or severity of nephrotoxicity and hypocalcemia can be increased when Gentamicin is combined with Ibandronate.
Ibuprofen	Ibuprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ibutilide	Ibutilide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Icatibant	Icatibant may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Icosapent	Icosapent may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Idarucizumab	Idarucizumab may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Idebenone	Idebenone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ifosfamide	Ifosfamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Imatinib	The serum concentration of Gentamicin can be increased when it is combined with Imatinib.
Imipramine	The serum concentration of Gentamicin can be increased when it is combined with Imipramine.
Indapamide	Indapamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Indigotindisulfonic acid	Indigotindisulfonic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Indomethacin	Indomethacin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Inosine pranobex	Inosine pranobex may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Inositol	Inositol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Inotersen	The risk or severity of nephrotoxicity can be increased when Inotersen is combined with Gentamicin.
Iobenguane sulfate I-123	Iobenguane sulfate I-123 may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Iodixanol	Iodixanol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ioflupane I-123	Ioflupane I-123 may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Iopromide	Iopromide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Iothalamic acid	Iothalamic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ioversol	Ioversol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ioxilan	Ioxilan may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ipecac	Ipecac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ipilimumab	Ipilimumab may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Isavuconazole	The serum concentration of Gentamicin can be increased when it is combined with Isavuconazole.
Isavuconazonium	The serum concentration of Gentamicin can be increased when it is combined with Isavuconazonium.
Isoniazid	Isoniazid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Isosorbide mononitrate	Isosorbide mononitrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Isosulfan blue	Isosulfan blue may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Isotretinoin	Isotretinoin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Isoxicam	Isoxicam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Isradipine	Isradipine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ixazomib	Ixazomib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Kanamycin	Gentamicin may decrease the excretion rate of Kanamycin which could result in a higher serum level.
Ketamine	Ketamine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ketazolam	Ketazolam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ketoprofen	Ketoprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ketorolac	Ketorolac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Labetalol	Labetalol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lamivudine	Lamivudine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lamotrigine	The serum concentration of Gentamicin can be increased when it is combined with Lamotrigine.
Latamoxef	Latamoxef may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ledipasvir	Ledipasvir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lenalidomide	Lenalidomide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lenvatinib	The serum concentration of Gentamicin can be increased when it is combined with Lenvatinib.
Lesinurad	Lesinurad may decrease the excretion rate of Gentamicin which could result in a higher serum level.
LetibotulinumtoxinA	The therapeutic efficacy of Letibotulinumtoxina can be increased when used in combination with Gentamicin.
Leuprolide	Leuprolide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Levobupivacaine.
Levocarnitine	Levocarnitine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Levocetirizine	Levocetirizine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Levofloxacin	Levofloxacin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Levoketoconazole	The serum concentration of Gentamicin can be increased when it is combined with Levoketoconazole.
Levomilnacipran	Levomilnacipran may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Levosalbutamol	Levosalbutamol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lidocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Lidocaine.
Linagliptin	The serum concentration of Gentamicin can be increased when it is combined with Linagliptin.
Lincomycin	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Lincomycin.
Liothyronine	Liothyronine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lisinopril	Lisinopril may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lithium carbonate	Gentamicin may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium citrate	Lithium citrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lixisenatide	Lixisenatide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lofexidine	Lofexidine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lopinavir	Lopinavir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Loracarbef	Loracarbef may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lorazepam	Lorazepam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lorcaserin	Lorcaserin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lornoxicam	Lornoxicam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lorpiprazole	Lorpiprazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Loxoprofen	Loxoprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lubiprostone	Lubiprostone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lumiracoxib	Lumiracoxib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Lymecycline	The risk or severity of neuromuscular blockade can be increased when Lymecycline is combined with Gentamicin.
Macitentan	Macitentan may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Magnesium	The serum concentration of Magnesium can be decreased when it is combined with Gentamicin.
Magnesium acetate	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium acetate.
Magnesium acetate tetrahydrate	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium acetate tetrahydrate.
Magnesium Aluminum Silicate	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium Aluminum Silicate.
Magnesium carbonate	Magnesium carbonate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Magnesium cation	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium cation.
Magnesium chloride	Magnesium chloride may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Magnesium citrate	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium citrate.
Magnesium gluconate	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium gluconate.
Magnesium glycinate	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium glycinate.
Magnesium hydroxide	Magnesium hydroxide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Magnesium oxide	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium oxide.
Magnesium silicate	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Magnesium silicate.
Magnesium sulfate	The risk or severity of neuromuscular blockade can be increased when Magnesium sulfate is combined with Gentamicin.
Magnesium trisilicate	Magnesium trisilicate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mangafodipir	Mangafodipir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mannitol	The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Gentamicin.
Maprotiline	Maprotiline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mecamylamine	Mecamylamine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Meclofenamic acid	Meclofenamic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Medroxyprogesterone acetate	Medroxyprogesterone acetate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mefenamic acid	Mefenamic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Megestrol acetate	Megestrol acetate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Meloxicam	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Meloxicam.
Memantine	Memantine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Menthyl salicylate	The risk or severity of nephrotoxicity can be increased when Menthyl salicylate is combined with Gentamicin.
Meperidine	Meperidine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Mepivacaine.
Meropenem	Meropenem may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mesalazine	The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Gentamicin.
Metacycline	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Metacycline.
Metamfetamine	Metamfetamine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Metamizole	Metamizole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Metaxalone	Metaxalone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Metformin	Metformin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Methacholine	The therapeutic efficacy of Methacholine can be decreased when used in combination with Gentamicin.
Methadone	Methadone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Methimazole	Methimazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Methotrexate	Methotrexate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Methoxsalen	Methoxsalen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Methyldopa	Methyldopa may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Methylene blue	The serum concentration of Gentamicin can be increased when it is combined with Methylene blue.
Methylnaltrexone	Methylnaltrexone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Methyltestosterone	Methyltestosterone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Meticillin	The serum concentration of Gentamicin can be decreased when it is combined with Meticillin.
Metoclopramide	Metoclopramide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Metocurine	The therapeutic efficacy of Metocurine can be increased when used in combination with Gentamicin.
Metocurine iodide	The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Gentamicin.
Metolazone	Metolazone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Metoprolol	The serum concentration of Gentamicin can be increased when it is combined with Metoprolol.
Metyrapone	Metyrapone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mezlocillin	The serum concentration of Gentamicin can be decreased when it is combined with Mezlocillin.
Midazolam	Midazolam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Migalastat	Migalastat may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Milnacipran	Milnacipran may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Milrinone	Milrinone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Minocycline	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Minocycline.
Mirabegron	Mirabegron may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mivacurium	The therapeutic efficacy of Mivacurium can be increased when used in combination with Gentamicin.
Moxisylyte	Moxisylyte may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mycophenolate mofetil	Mycophenolate mofetil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Mycophenolic acid	Mycophenolic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
N-acetyltyrosine	N-acetyltyrosine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nabumetone	Nabumetone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nadolol	Nadolol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nadroparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Nadroparin.
Nafcillin	The serum concentration of Gentamicin can be decreased when it is combined with Nafcillin.
Naldemedine	Naldemedine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nalmefene	Nalmefene may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Naloxone	Naloxone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Naproxen	Naproxen may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nateglinide	Nateglinide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nedaplatin	Gentamicin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Nedocromil	Nedocromil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nefazodone	Nefazodone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Neomycin	The risk or severity of nephrotoxicity can be increased when Gentamicin is combined with Neomycin.
Netilmicin	Gentamicin may decrease the excretion rate of Netilmicin which could result in a higher serum level.
Nicorandil	Nicorandil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nicotine	The serum concentration of Gentamicin can be increased when it is combined with Nicotine.
Nifedipine	Nifedipine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nilutamide	Nilutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nimesulide	Nimesulide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nisoldipine	Nisoldipine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nitric Oxide	Nitric Oxide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nitrofurantoin	Nitrofurantoin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Nitroprusside	Nitroprusside may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Norepinephrine	The serum concentration of Gentamicin can be increased when it is combined with Norepinephrine.
Octinoxate	Octinoxate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Olsalazine	The risk or severity of nephrotoxicity can be increased when Gentamicin is combined with Olsalazine.
Opium	Opium may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Oseltamivir	Oseltamivir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ouabain	The risk or severity of adverse effects can be increased when Gentamicin is combined with Ouabain.
Oxacillin	Oxacillin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Oxaliplatin	The risk or severity of nephrotoxicity can be increased when Oxaliplatin is combined with Gentamicin.
Oxaprozin	Oxaprozin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Oxazepam	Oxazepam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Oxetacaine.
Oxprenolol	The serum concentration of Gentamicin can be increased when it is combined with Oxprenolol.
Oxybenzone	Oxybenzone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Oxybuprocaine.
Oxyphenbutazone	Oxyphenbutazone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Oxyquinoline	Oxyquinoline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Oxytetracycline	The risk or severity of neuromuscular blockade can be increased when Oxytetracycline is combined with Gentamicin.
Paliperidone	Paliperidone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Palonosetron	Palonosetron may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pancuronium	The therapeutic efficacy of Pancuronium can be increased when used in combination with Gentamicin.
Pantoprazole	Pantoprazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Parecoxib	Parecoxib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Parnaparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Parnaparin.
Paromomycin	Paromomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Patent Blue	Patent Blue may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pegaptanib	Pegaptanib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Peginesatide	Peginesatide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pemetrexed	Gentamicin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Penbutolol	Penbutolol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pentaerythritol tetranitrate	Pentaerythritol tetranitrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pentamidine	Pentamidine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pentastarch	Pentastarch may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pentetic acid	Pentetic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pentobarbital	Pentobarbital may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pentolinium	The risk or severity of adverse effects can be increased when Gentamicin is combined with Pentolinium.
Pentostatin	Gentamicin may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Pentoxifylline	Pentoxifylline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Perindopril	Perindopril may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Permethrin	Permethrin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Phenazopyridine	Phenazopyridine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Phenelzine	Phenelzine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pheneticillin	The serum concentration of Gentamicin can be decreased when it is combined with Pheneticillin.
Phenformin	The serum concentration of Gentamicin can be increased when it is combined with Phenformin.
Phenindione	The risk or severity of bleeding can be increased when Gentamicin is combined with Phenindione.
Phenol	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Phenol.
Phenoxybenzamine	The serum concentration of Gentamicin can be increased when it is combined with Phenoxybenzamine.
Phenoxymethylpenicillin	The serum concentration of Gentamicin can be decreased when it is combined with Phenoxymethylpenicillin.
Phenprocoumon	The risk or severity of bleeding can be increased when Gentamicin is combined with Phenprocoumon.
Phenylbutazone	Phenylbutazone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pholcodine	Pholcodine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Phosphoric acid	Phosphoric acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Phylloquinone	Phylloquinone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Picosulfuric acid	Picosulfuric acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pilocarpine	The therapeutic efficacy of Pilocarpine can be decreased when used in combination with Gentamicin.
Pindolol	Pindolol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pipecuronium	The therapeutic efficacy of Pipecuronium can be increased when used in combination with Gentamicin.
Piperacillin	Piperacillin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Piracetam	Piracetam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Piretanide	The serum concentration of Gentamicin can be increased when it is combined with Piretanide.
Piroxicam	Piroxicam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pitolisant	Pitolisant may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pivampicillin	The serum concentration of Gentamicin can be decreased when it is combined with Pivampicillin.
Pivmecillinam	The serum concentration of Gentamicin can be decreased when it is combined with Pivmecillinam.
Plazomicin	Gentamicin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Plerixafor	Plerixafor may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Polymyxin B	The risk or severity of adverse effects can be increased when Gentamicin is combined with Polymyxin B.
Pomalidomide	Pomalidomide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Potassium acetate	Potassium acetate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Potassium bicarbonate	Potassium bicarbonate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Potassium cation	Potassium cation may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Potassium chloride	Potassium chloride may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Potassium nitrate	Potassium nitrate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Potassium perchlorate	Potassium perchlorate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Potassium sulfate	Potassium sulfate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pralatrexate	Pralatrexate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pralidoxime	Pralidoxime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pramipexole	Pramipexole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Pramocaine.
Prasugrel	Prasugrel may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Prednisone	Prednisone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pregabalin	Pregabalin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Prilocaine.
Probenecid	The serum concentration of Gentamicin can be increased when it is combined with Probenecid.
Procainamide	The serum concentration of Gentamicin can be increased when it is combined with Procainamide.
Procaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Procaine.
Procaine benzylpenicillin	Procaine benzylpenicillin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Progesterone	The serum concentration of Gentamicin can be increased when it is combined with Progesterone.
Promethazine	Promethazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Propantheline	Propantheline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Proparacaine.
Propiverine	Propiverine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Propoxycaine.
Propranolol	The serum concentration of Gentamicin can be increased when it is combined with Propranolol.
Prucalopride	Prucalopride may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pyrantel	The therapeutic efficacy of Pyrantel can be increased when used in combination with Gentamicin.
Pyrazinamide	Pyrazinamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Pyridoxine	Pyridoxine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Quetiapine	Quetiapine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Quinidine	The serum concentration of Gentamicin can be increased when it is combined with Quinidine.
Quinine	The serum concentration of Gentamicin can be increased when it is combined with Quinine.
Rabeprazole	Rabeprazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ramelteon	Ramelteon may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ranitidine	The serum concentration of Gentamicin can be increased when it is combined with Ranitidine.
Ranolazine	The serum concentration of Gentamicin can be increased when it is combined with Ranolazine.
Rapacuronium	The therapeutic efficacy of Rapacuronium can be increased when used in combination with Gentamicin.
Rasagiline	Rasagiline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Reserpine	Reserpine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Resorcinol	Resorcinol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Reviparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Reviparin.
Ribavirin	Ribavirin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ribostamycin	Gentamicin may decrease the excretion rate of Ribostamycin which could result in a higher serum level.
Risedronic acid	The risk or severity of nephrotoxicity and hypocalcemia can be increased when Gentamicin is combined with Risedronic acid.
Rivaroxaban	Rivaroxaban may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Rizatriptan	Rizatriptan may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Rocuronium	The therapeutic efficacy of Rocuronium can be increased when used in combination with Gentamicin.
Rofecoxib	Rofecoxib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Roflumilast	Roflumilast may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Rolitetracycline	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Rolitetracycline.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Ropivacaine.
Rosiglitazone	Rosiglitazone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ruxolitinib	Ruxolitinib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sacubitril	Sacubitril may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Salicylamide	Salicylamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Salicylic acid	Salicylic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Salmeterol	The serum concentration of Gentamicin can be increased when it is combined with Salmeterol.
Salmon calcitonin	Salmon calcitonin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Salsalate	Salsalate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Saxagliptin	Saxagliptin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Secobarbital	Secobarbital may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Selenious acid	Selenious acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Selenium	Selenium may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sibutramine	Sibutramine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sitagliptin	Sitagliptin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sodium acetate	Sodium acetate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sodium aurothiomalate	Sodium aurothiomalate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sodium fluoride	Sodium fluoride may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sodium sulfate	Sodium sulfate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sofosbuvir	Sofosbuvir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Solriamfetol	Solriamfetol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sorafenib	Sorafenib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sorbitol	Sorbitol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Stavudine	The excretion of Stavudine can be decreased when combined with Gentamicin.
Stiripentol	Stiripentol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Streptomycin	Gentamicin may decrease the excretion rate of Streptomycin which could result in a higher serum level.
Strontium chloride	Strontium chloride may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Succinylcholine	The therapeutic efficacy of Succinylcholine can be increased when used in combination with Gentamicin.
Sucralfate	Sucralfate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sulbactam	Sulbactam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sulfadiazine	Sulfadiazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sulfamethoxazole	Sulfamethoxazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sulfasalazine	Sulfasalazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sulindac	Sulindac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Sulodexide	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Sulodexide.
Sultamicillin	The serum concentration of Gentamicin can be decreased when it is combined with Sultamicillin.
Sumatriptan	Sumatriptan may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Synthetic Conjugated Estrogens, A	Synthetic Conjugated Estrogens, A may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Synthetic Conjugated Estrogens, B	Synthetic Conjugated Estrogens, B may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tacrolimus	Tacrolimus may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tadalafil	Tadalafil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tafenoquine	The serum concentration of Gentamicin can be increased when it is combined with Tafenoquine.
Tamsulosin	Tamsulosin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tasimelteon	Tasimelteon may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Taurocholic acid	The excretion of Taurocholic acid can be decreased when combined with Gentamicin.
Tazobactam	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Tazobactam.
Technetium Tc-99m exametazime	Technetium Tc-99m exametazime may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Technetium Tc-99m mebrofenin	Technetium Tc-99m mebrofenin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Technetium Tc-99m oxidronate	Technetium Tc-99m oxidronate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Technetium Tc-99m pyrophosphate	Technetium Tc-99m pyrophosphate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Teduglutide	Teduglutide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tegafur	Tegafur may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Telavancin	Telavancin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Temazepam	Temazepam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Temocillin	The serum concentration of Gentamicin can be decreased when it is combined with Temocillin.
Temozolomide	Temozolomide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tenofovir alafenamide	Gentamicin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil	Gentamicin may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenoxicam	Tenoxicam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Terbutaline	Terbutaline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Testolactone	Testolactone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Testosterone	Testosterone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Testosterone cypionate	Testosterone cypionate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Testosterone enanthate	Testosterone enanthate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Testosterone propionate	Testosterone propionate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Testosterone undecanoate	Testosterone undecanoate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tetracaine	The risk or severity of methemoglobinemia can be increased when Gentamicin is combined with Tetracaine.
Tetracycline	Tetracycline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tetradecyl hydrogen sulfate (ester)	Tetradecyl hydrogen sulfate (ester) may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Thiabendazole	Thiabendazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Thiamine	The serum concentration of Gentamicin can be increased when it is combined with Thiamine.
Thiethylperazine	Thiethylperazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tiaprofenic acid	Tiaprofenic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Ticarcillin	The serum concentration of Gentamicin can be decreased when it is combined with Ticarcillin.
Ticlopidine	Ticlopidine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tigecycline	The risk or severity of neuromuscular blockade can be increased when Tigecycline is combined with Gentamicin.
Tiludronic acid	Tiludronic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Timolol	Timolol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tinidazole	Tinidazole may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tinzaparin	The therapeutic efficacy of Gentamicin can be decreased when used in combination with Tinzaparin.
Tiopronin	Tiopronin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tiotropium	Tiotropium may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tirofiban	Tirofiban may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tixocortol	Tixocortol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tobramycin	Tobramycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tocopherol	Tocopherol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tolazamide	Tolazamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tolbutamide	Tolbutamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tolcapone	Tolcapone may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tolfenamic acid	Tolfenamic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tolmetin	Tolmetin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tolterodine	Tolterodine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Topiramate	Topiramate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Topotecan	Topotecan may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Torasemide	The serum concentration of Gentamicin can be increased when it is combined with Torasemide.
Tositumomab	Tositumomab may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tramadol	Tramadol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Trametinib	Trametinib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Triamterene	Triamterene may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Triazolam	Triazolam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Triethylenetetramine	Triethylenetetramine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Trifluridine	Trifluridine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Trilaciclib	The serum concentration of Gentamicin can be increased when it is combined with Trilaciclib.
Trimebutine	Trimebutine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Trimethaphan	The risk or severity of adverse effects can be increased when Gentamicin is combined with Trimethaphan.
Trimethoprim	The serum concentration of Gentamicin can be increased when it is combined with Trimethoprim.
Trimetrexate	Trimetrexate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tropisetron	Tropisetron may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Tubocurarine	The therapeutic efficacy of Tubocurarine can be increased when used in combination with Gentamicin.
Tucatinib	The serum concentration of Gentamicin can be increased when it is combined with Tucatinib.
Typhoid vaccine	The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Gentamicin.
Vaborbactam	Vaborbactam may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Vadadustat	The serum concentration of Vadadustat can be increased when it is combined with Gentamicin.
Valaciclovir	Valaciclovir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Valbenazine	Valbenazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Valdecoxib	Valdecoxib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Valganciclovir	Valganciclovir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Vancomycin	Vancomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Vandetanib	The serum concentration of Gentamicin can be increased when it is combined with Vandetanib.
Varenicline	The serum concentration of Gentamicin can be increased when it is combined with Varenicline.
Vecuronium	The therapeutic efficacy of Vecuronium can be increased when used in combination with Gentamicin.
Venlafaxine	Venlafaxine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Verapamil	Verapamil may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Vibrio cholerae CVD 103-HgR strain live antigen	The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Gentamicin.
Vilanterol	Vilanterol may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Viloxazine	Viloxazine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Viomycin	The risk or severity of neuromuscular blockade can be increased when Gentamicin is combined with Viomycin.
Vortioxetine	Vortioxetine may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin	Gentamicin may decrease the excretion rate of Warfarin which could result in a higher serum level.
Zalcitabine	The excretion of Zalcitabine can be decreased when combined with Gentamicin.
Zaleplon	Zaleplon may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Zanamivir	Zanamivir may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Zidovudine	The excretion of Zidovudine can be decreased when combined with Gentamicin.
Zoledronic acid	The risk or severity of nephrotoxicity and hypocalcemia can be increased when Gentamicin is combined with Zoledronic acid.
Zonisamide	Zonisamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.

Food Interactions

No interactions found.

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Gentamicin sulfate	8X7386QRLV	1405-41-0	RDEIXVOBVLKYNT-VQBXQJRRSA-N

International/Other Brands

Alcomicin / Bristagen / G-Mycin / Genoptic (Allergan) / Gentacidin / Gentafair / Gentamar / Jenamicin / Ocu-Mycin / Spectro-Genta / U-gencin (U-Liang)

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Alcomicin Oph Sol 3mg/ml	Liquid	3 mg / mL	Ophthalmic	Alcon, Inc.	1983-12-31	2009-04-24
Cidomycin Inj 10mg/ml	Liquid	10 mg / mL	Intramuscular; Intravenous	Hoechst Roussel Canada Inc.	1995-12-31	2000-07-28
Cidomycin Inj 40mg/ml	Liquid	40 mg / mL	Intramuscular; Intravenous	Roussel Canada Inc.	1979-12-31	1997-08-05
Cidomycin Inj 40mg/ml	Liquid	40 mg / mL	Intramuscular; Intravenous	Hoechst Roussel Canada Inc.	1995-12-31	1999-08-20
Cidomycin Inj Pediatric 10mg	Liquid	10 mg / mL	Intramuscular; Intravenous	Roussel Canada Inc.	1972-12-31	1997-08-05
Garamycin Cream 0.1%	Cream	.1 %	Topical	Schering Plough	1966-12-31	2007-08-03
Garamycin Inj 10mg/ml Pediatric	Solution	10 mg / mL	Intramuscular; Intravenous	Schering Plough	1970-12-31	2004-07-21
Garamycin Inj 40mg/ml	Solution	40 mg / mL	Intramuscular; Intravenous	Schering Plough	1966-12-31	2004-07-21
Garamycin Ont 0.1%	Ointment	1 mg / g	Topical	Schering Plough	1966-12-31	2007-08-03
Garamycin Ophthalmic Drops 0.3%	Solution / drops	3 mg / mL	Ophthalmic	Merck Ltd.	1981-12-31	2014-09-02
Garamycin Ophthalmic Ointment 0.3%	Ointment	0.3 %	Ophthalmic	Merck Ltd.	1969-12-31	2013-07-15
Garamycin Otic Drops 0.3%	Solution / drops	3 mg / mL	Auricular (otic)	Merck Ltd.	1981-12-31	2014-03-03
Garatec Ophthalmic Dps 5mg/ml	Solution / drops	5 mg / mL	Ophthalmic	Technilab Pharma Inc.	1992-12-31	2004-08-03
Garatec Otic Dps 5mg/ml	Solution / drops	5 mg / mL	Auricular (otic)	Technilab Pharma Inc.	1992-12-31	2004-08-03
Gentacidin Oph Soln 3mg/ml	Solution / drops	3 mg / mL	Ophthalmic	Iolab Pharmaceuticals	1991-12-31	1996-09-09
Gentacidin Ophthalmic Solution 3mg/ml	Solution / drops	3 mg / mL	Ophthalmic	Ciba Vision	1996-12-31	2000-06-30
Gentamicin	Ointment	0.3 %	Ophthalmic	Pharma Stulln Inc.	1994-12-31	2019-11-23
Gentamicin	Solution	0.3 %	Ophthalmic	Pharma Stulln Inc.	1994-12-31	2019-11-23
Gentamicin	Solution	.3 %	Ophthalmic	Ivax Pharmaceuticals Incorporated	1996-09-10	2015-10-26
Gentamicin Injection USP	Solution	10 mg / mL	Intramuscular; Intravenous	Sandoz Canada Incorporated	2005-08-29	Not applicable
Gentamicin Injection USP	Solution	40 mg / mL	Intramuscular; Intravenous	Sandoz Canada Incorporated	2000-12-20	Not applicable
Gentamicin Injection USP	Solution	10 mg / mL	Intramuscular; Intravenous	Hikma Canada Limited	2019-05-14	Not applicable
Gentamicin Injection USP	Solution	40 mg / mL	Intramuscular; Intravenous	Hikma Canada Limited	2017-01-05	Not applicable
Gentamicin Sulfate	Injection, solution	60 mg/100mL	Intravenous	Baxter Healthcare Corporation	2007-03-31	2007-03-31
Gentamicin Sulfate	Injection, solution	40 mg/100mL	Intravenous	Baxter Healthcare Corporation	2007-03-31	2007-03-31
Gentamicin Sulfate	Injection, solution	120 mg/50mL	Intravenous	Baxter Healthcare Corporation	2007-03-31	2007-03-31
Gentamicin Sulphate 0.3% - Liq Oph	Liquid	3 mg / mL	Ophthalmic	Rivex Ophthalmics Inc.	1997-05-07	2003-07-28
Gentamicin Sulphate Injection USP-10mg/ml	Solution	10 mg / mL	Intramuscular; Intravenous	Novopharm Limited	1995-12-31	2005-08-10
Gentamicin Sulphate Injection USP-40mg/ml	Solution	40 mg / mL	Intramuscular; Intravenous	Novopharm Limited	1995-12-31	2005-08-10
Gentamicin(e)	Solution	1 mg / mL	Intravenous	Baxter Laboratories	1995-12-31	Not applicable
Gentamicin(e)	Solution	1.6 mg / mL	Intravenous	Baxter Laboratories	1995-12-31	Not applicable
Gentamicin(e) 120mg Liq IV 1.2mg/ml	Solution	1.2 mg / mL	Intravenous	Baxter Laboratories	1995-12-31	2016-07-15
Gentrasul Liq 3mg/ml	Solution / drops	3 mg / mL	Ophthalmic	Bausch & Lomb Inc	1988-12-31	1996-09-09
Gentrasul Oph Ointment 3mg/gm	Ointment	3 mg / g	Ophthalmic	Bausch & Lomb Inc	1988-12-31	1996-09-09
Minims Gentamicin Sulfate 0.3%	Solution / drops	0.3 % w/v	Ophthalmic; Topical	Chauvin Pharmaceuticals Limited	1995-12-31	2009-02-04
Ocugram Liq 3mg/ml	Liquid	3 mg / mL	Ophthalmic; Topical	Herdt Et Charton Inc.	1994-12-31	1999-01-16
Ocugram Ont 3mg/gm	Ointment	3 mg / g	Ophthalmic; Topical	Herdt Et Charton Inc.	1994-12-31	1999-01-16
R.O.-gentycin	Liquid	3 mg / mL	Ophthalmic	Richmond Pharmaceuticals Inc.	1992-12-31	1997-08-11
Septopal	Implant	4.5 mg	Parenteral	Biomet Orthopedics, Inc.	1987-10-19	2014-07-24
Truemed Group LLC	Solution / drops	3 mg/5mL	Ophthalmic	Truemed Group LLC	2022-09-17	Not applicable

Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Garamycin	Ointment	3 mg/1g	Ophthalmic	Fera Pharmaceuticals	2010-10-08	2013-06-14
Garamycin	Solution / drops	3 mg/1mL	Ophthalmic	Fera Pharmaceuticals	2011-05-15	2013-06-14
Garamycin Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	Paddock Laboratories, Inc.	2014-06-05	2016-04-01
Gentak	Ointment	3 mg/1g	Ophthalmic	REMEDYREPACK INC.	2017-07-24	2020-04-07
Gentak	Ointment	3 mg/1g	Ophthalmic	Nucare Pharmaceuticals,inc.	2006-05-08	Not applicable
Gentak	Ointment	3 mg/1g	Ophthalmic	Proficient Rx LP	2006-05-08	Not applicable
Gentak	Ointment	3 mg/1g	Ophthalmic	Akorn	2006-05-08	Not applicable
Gentak	Ointment	3 mg/1g	Ophthalmic	Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC	2012-03-27	2019-10-11
Gentak	Ointment	3 mg/1g	Ophthalmic	Preferred Pharmaceuticals, Inc.	2012-10-23	Not applicable
Gentak	Ointment	3 mg/1g	Ophthalmic	A-S Medication Solutions	2006-05-08	Not applicable
Gentak	Ointment	3 mg/1g	Ophthalmic	Remedy Repack	2012-11-21	2017-02-15
Gentak	Ointment	3 mg/1g	Ophthalmic	A-S Medication Solutions	2006-05-08	Not applicable
Gentak	Ointment	3 mg/1g	Ophthalmic	A S Medication Solutions	2006-05-08	Not applicable
Gentak	Ointment	3 mg/1g	Ophthalmic	Akorn	2013-03-11	Not applicable
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Henry Schein, Inc	2022-01-10	Not applicable
Gentamicin	Injection, solution	10 mg/1mL	Intramuscular; Intravenous	Cardinal Health	1982-03-04	2011-12-31
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Eugia US LLC	2024-01-08	Not applicable
Gentamicin	Injection, solution	10 mg/1mL	Intramuscular; Intravenous	Cardinal Health	2004-11-29	2014-11-30
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Fresenius Kabi USA, LLC	2000-08-10	Not applicable
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	REMEDYREPACK INC.	2023-01-30	Not applicable
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	General Injectables & Vaccines, Inc	2010-09-01	2023-02-28
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Eugia US LLC	2024-01-08	Not applicable
Gentamicin	Injection, solution	10 mg/1mL	Intramuscular; Intravenous	Fresenius Kabi USA, LLC	1982-03-04	2018-08-17
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Medical Purchasing Solutions, Llc	2000-08-10	Not applicable
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Hikma Pharmaceuticals USA Inc.	2022-02-15	Not applicable
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Cardinal Health	2000-08-10	2016-07-31
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2021-05-10	Not applicable
Gentamicin	Injection, solution	10 mg/1mL	Intramuscular; Intravenous	Eugia US LLC	2024-01-08	Not applicable
Gentamicin	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Hikma Pharmaceuticals USA Inc.	2022-02-15	Not applicable
Gentamicin	Injection, solution	10 mg/1mL	Intramuscular; Intravenous	Fresenius Kabi USA, LLC	2004-11-29	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Aidarex Pharmaceuticals LLC	2006-12-13	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Preferred Pharmaceuticals, Inc.	2014-03-25	2019-10-01
Gentamicin Sulfate	Ointment	1 mg/1g	Topical	Proficient Rx LP	2014-11-28	Not applicable
Gentamicin Sulfate	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	General Injectables & Vaccines, Inc	2010-08-01	Not applicable
Gentamicin Sulfate	Ointment	3 mg/1g	Ophthalmic	Fera Pharmaceuticals	2011-01-03	2013-06-14
Gentamicin Sulfate	Cream	1 mg/1g	Topical	Stat Rx USA	2009-08-11	Not applicable
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	Proficient Rx LP	1996-04-05	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Aidarex Pharmaceuticals LLC	1998-01-05	Not applicable
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	REMEDYREPACK INC.	2018-07-26	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Direct Rx	2014-01-01	Not applicable
Gentamicin Sulfate	Injection, solution, concentrate	10 mg/1mL	Intravenous	Hospira, Inc.	2006-01-13	2011-03-01
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Pacific Pharma, Inc.	1998-01-05	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Preferred Pharmaceuticals, Inc.	2013-03-14	2020-06-04
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Physicians Total Care, Inc.	1993-09-17	Not applicable
Gentamicin sulfate	Ointment	1 mg/1g	Topical	A S Medication Solutions	2010-03-17	Not applicable
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	Sandoz Inc	1996-04-05	Not applicable
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	A-S Medication Solutions	1996-04-05	2017-12-31
Gentamicin Sulfate	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Cardinal Health 107, LLC	1983-08-15	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Lake Erie Medical &Surgical Supply Dba Quality Care Products Llc	2012-03-12	2017-06-01
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Rpk Pharmaceuticals, Inc.	1994-05-11	Not applicable
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	Preferred Pharmaceuticals Inc.	2019-03-12	Not applicable
Gentamicin Sulfate	Solution	3.0 mg/1mL	Ophthalmic	Rebel Distributors	1984-10-10	Not applicable
Gentamicin Sulfate	Ointment	3 mg/1g	Ophthalmic	Mwi	2015-03-23	Not applicable
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	Rpk Pharmaceuticals, Inc.	1996-04-05	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Proficient Rx LP	2006-12-13	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Bausch & Lomb Incorporated	1994-05-11	Not applicable
Gentamicin Sulfate	Ointment	3 mg/1g	Ophthalmic	Paddock Laboratories, Inc.	2013-12-12	2017-02-01
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	medsource pharmaceuticals	1994-05-11	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Preferred Pharmaceuticals Inc.	2024-02-22	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	A-S Medication Solutions	1994-05-11	2017-09-30
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Rpk Pharmaceuticals, Inc.	1998-01-05	Not applicable
Gentamicin Sulfate	Cream	1 mg/1g	Topical	Dispensing Solutions, Inc.	1984-07-05	Not applicable
Gentamicin Sulfate	Cream	1 mg/1g	Topical	Teligent Pharma, Inc.	2019-10-18	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Akorn	2013-03-11	Not applicable
Gentamicin Sulfate	Ointment	3 mg/1g	Ophthalmic	A-S Medication Solutions	2013-12-12	2017-02-28
Gentamicin Sulfate	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Henry Schein, Inc.	2022-01-10	Not applicable
Gentamicin Sulfate	Cream	1 mg/1g	Topical	Cosette Pharmaceuticals, Inc.	2016-11-11	Not applicable
Gentamicin Sulfate	Cream	1 mg/1g	Topical	Physicians Total Care, Inc.	1995-05-12	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Unit Dose Services	1994-05-11	Not applicable
Gentamicin Sulfate	Injection, solution, concentrate	10 mg/1mL	Intravenous	Hospira, Inc.	2006-04-12	2010-12-01
Gentamicin Sulfate	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2022-10-01	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	2004-01-30	2004-01-30
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Nucare Pharmaceuticals,inc.	1998-01-05	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	A S Medication Solutions	1994-05-11	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	REMEDYREPACK INC.	2016-11-10	2018-05-17
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	A-S Medication Solutions	2006-12-13	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Unit Dose Services	1994-05-11	2017-12-31
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	Asclemed Usa, Inc.	1996-04-05	Not applicable
Gentamicin Sulfate	Ointment	1 mg/1g	Topical	Padagis Israel Pharmaceuticals Ltd	2006-07-10	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Akorn	2006-12-13	Not applicable
Gentamicin Sulfate	Ointment	3 mg/1g	Ophthalmic	Physicians Total Care, Inc.	1994-09-21	Not applicable
Gentamicin Sulfate	Cream	1 mg/1g	Topical	E. Fougera & Co. a division of Fougera Pharmaceuticals Inc.	1984-07-05	2013-11-29
Gentamicin Sulfate	Ointment	3 mg/1g	Ophthalmic	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	2004-07-30	2009-07-31
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	H.J. Harkins Company, Inc	2014-08-24	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Nucare Pharmaceuticals, Inc.	2006-12-13	Not applicable
Gentamicin Sulfate	Ointment	1 mg/1g	Topical	Teligent Pharma, Inc.	2018-12-31	Not applicable
Gentamicin Sulfate	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Medical Purchasing Solutions, Llc	2015-12-09	Not applicable
Gentamicin Sulfate	Injection, solution, concentrate	10 mg/1mL	Intravenous	Hospira, Inc.	2006-06-05	2011-03-01
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	REMEDYREPACK INC.	2014-11-19	2016-03-18
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Clinical Solutions Wholsesale	1994-05-11	2017-06-22
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Direct Rx	2019-03-19	2023-12-31
Gentamicin Sulfate	Ointment	1 mg/1g	Topical	Cosette Pharmaceuticals, Inc.	2014-11-28	Not applicable
Gentamicin Sulfate	Solution	3 mg/1mL	Ophthalmic	Nucare Pharmaceuticals,inc.	1996-04-05	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	A-S Medication Solutions	1994-05-11	Not applicable
Gentamicin Sulfate	Injection, solution, concentrate	40 mg/1mL	Intramuscular; Intravenous	Physicians Total Care, Inc.	2003-02-12	2011-06-30
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Proficient Rx LP	1994-05-11	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Lake Erie Medical & Surgical Suppy DBA Quality Care Products LLC	1998-01-05	2019-06-30
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Rpk Pharmaceuticals, Inc.	2006-12-13	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Proficient Rx LP	1998-01-05	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Nucare Pharmaceuticals,inc.	1994-05-11	Not applicable
Gentamicin Sulfate	Cream	1 mg/1g	Topical	Padagis Israel Pharmaceuticals Ltd	2006-08-23	Not applicable
Gentamicin Sulfate	Ointment	1 mg/1g	Topical	Physicians Total Care, Inc.	2010-06-02	Not applicable
Gentamicin Sulfate	Injection, solution	40 mg/1mL	Intramuscular; Intravenous	Hospira, Inc.	2015-12-09	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	REMEDYREPACK INC.	2023-07-11	Not applicable
Gentamicin sulfate	Ointment	1 mg/1g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	2010-03-17	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	A-S Medication Solutions	1998-01-05	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Asclemed Usa, Inc.	1994-05-11	Not applicable
Gentamicin Sulfate	Solution / drops	3 mg/1mL	Ophthalmic	Preferred Pharamcaeuticals Inc.	2016-10-13	Not applicable
Gentamicin Sulfate Cream 0.1%	Cream	1 mg/1g	Topical	Sola Pharmaceuticals	2020-04-07	Not applicable
Gentamicin Sulfate Cream USP, 0.1%	Cream	1 mg/1g	Topical	McKesson Corporation	2019-10-18	Not applicable
Gentamicin Sulfate In Sodium Chloride	Injection, solution	0.6 mg/1mL	Intravenous	B. Braun Medical Inc.	2010-09-08	2013-05-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	100 mg/50mL	Intravenous	Baxter Healthcare Corporation	1982-09-07	Not applicable
Gentamicin Sulfate in Sodium Chloride	Injection, solution	60 mg/50mL	Intravenous	Baxter Healthcare Corporation	1982-09-07	Not applicable
Gentamicin Sulfate In Sodium Chloride	Injection, solution	1 mg/1mL	Intravenous	B. Braun Medical Inc.	2010-09-08	2013-05-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	0.8 mg/1mL	Intravenous	Hospira, Inc.	2005-07-12	2015-05-01
Gentamicin Sulfate In Sodium Chloride	Injection, solution	1.2 mg/1mL	Intravenous	B. Braun Medical Inc.	2010-09-08	2013-05-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	1.2 mg/1mL	Intravenous	Hospira, Inc.	2006-04-11	2015-08-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	1 mg/1mL	Intravenous	Hospira, Inc.	2005-09-20	2015-07-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	1.6 mg/1mL	Intravenous	Hospira, Inc.	2006-01-24	2015-06-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	80 mg/100mL	Intravenous	Baxter Healthcare Corporation	1982-09-07	Not applicable
Gentamicin Sulfate In Sodium Chloride	Injection, solution	0.8 mg/1mL	Intravenous	B. Braun Medical Inc.	2010-09-08	2013-05-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	100 mg/100mL	Intravenous	Baxter Healthcare Corporation	1982-09-07	Not applicable
Gentamicin Sulfate in Sodium Chloride	Injection, solution	80 mg/50mL	Intravenous	Baxter Healthcare Corporation	1982-09-07	Not applicable
Gentamicin Sulfate in Sodium Chloride	Injection, solution	0.9 mg/1mL	Intravenous	Hospira, Inc.	2006-01-31	2010-07-01
Gentamicin Sulfate In Sodium Chloride	Injection, solution	1.6 mg/1mL	Intravenous	B. Braun Medical Inc.	2010-09-08	2013-05-01
Gentamicin Sulfate in Sodium Chloride	Injection, solution	1.4 mg/1mL	Intravenous	Hospira, Inc.	2006-01-30	2010-08-01
Gentamicin Sulfate Opth Solution	Solution / drops	3 mg/1mL	Ophthalmic	Direct_Rx	2022-06-17	Not applicable
Odan-gentamicin	Solution	5 mg / mL	Ophthalmic	Odan Laboratories Ltd	1991-12-31	Not applicable
Odan-gentamicin	Ointment	5 mg / g	Ophthalmic	Odan Laboratories Ltd	1994-12-31	Not applicable
PMS-gentamicin Cream 1mg/gm	Cream	1 mg / g	Topical	Pharmascience Inc	1990-12-31	2018-01-31
PMS-gentamicin Ointment 1mg/gm	Ointment	1 mg / g	Topical	Pharmascience Inc	1990-12-31	2018-01-31
PMS-gentamicin Otic Drops 0.3%	Solution / drops	3 mg / mL	Auricular (otic)	Pharmascience Inc	1997-07-18	2017-09-30
PMS-gentamicin Sulfate Oph Dps 0.3%	Solution / drops	3 mg / mL	Ophthalmic	Pharmascience Inc	1989-12-31	2018-01-31
Ratio-gentamicin	Cream	0.1 %	Topical	Ratiopharm Inc Division Of Teva Canada Limited	1990-12-31	2016-07-06
Ratio-gentamicin	Ointment	.1 %	Topical	Ratiopharm Inc Division Of Teva Canada Limited	1990-12-31	2016-07-06
Sandoz Gentamicin	Solution	3 mg / mL	Auricular (otic)	Sandoz Canada Incorporated	1996-11-26	2019-08-01
Sandoz Gentamicin	Ointment	3 mg / g	Ophthalmic	Sandoz Canada Incorporated	1997-11-25	2017-08-01
Sandoz Gentamicin	Liquid	3 mg / mL	Ophthalmic	Sandoz Canada Incorporated	1997-05-06	2017-08-01

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
ELTACIN 0.1%	Ointment	0.1 %w/w	Topical	บริษัท โอลิค (ประเทศไทย) จำกัด	2008-04-01	Not applicable
GENTAL EYE DROPS	Liquid	3 mg/1ml	Ophthalmic	บริษัท เยนเนอร์ราลดรั๊กส์เฮ้าส์ จำกัด	1985-07-18	Not applicable
MIRAMYCIN EYE/EAR DROP	Liquid	3 mg/1ml	Ophthalmic	บริษัท โรงงานเภสัชกรรมแอตแลนติค จำกัด	1986-06-06	2020-06-11
ยาหยอดตา มาโนเจนต้า	Solution	40 mg/1ml		บริษัท โรงงานเภสัชกรรมแหลมทองการแพทย์ จำกัด จำกัด	2009-12-18	Not applicable
สกินเฟ็กต์ ครีม	Cream	0.1 %w/w	Topical	บริษัท บางกอกแล็ป แอนด์ คอสเมติค จำกัด จำกัด	2000-07-12	Not applicable
เจนซิดาล ครีม	Cream	0.1 %w/w	Topical	บริษัท ไทยนครพัฒนา จำกัด	1998-11-05	Not applicable
เย็นตั้ล ครีม	Cream	0.1 %w/w	Topical	บริษัท เยนเนอร์ราลดรั๊กส์เฮ้าส์ จำกัด	1984-04-25	Not applicable
เยนต้า ครีม	Cream	0.1 %w/w	Topical	บริษัท เอเชี่ยนยูเนี่ยนแล็บบอราตอรี่ จำกัด จำกัด	1987-03-27	Not applicable
เย็นต้า-อ๊อฟ ยาหยอดตา	Liquid	3 mg/1ml	Ophthalmic	บริษัท แสงไทยกำปะนี จำกัด	1986-07-07	Not applicable
เยนตาเดอร์ม ครีม	Cream	0.1 %w/w	Topical	บริษัท ที.โอ.เคมีคอลส์ (1979) จำกัด	1990-06-26	Not applicable
เย็นต้าเดอร์ม ครีม	Cream	0.1 %w/w	Topical	บริษัท อังกฤษตรางู (แอล.พี.) จำกัด	1985-11-07	Not applicable
เย็นเตร๊กซ์ ครีม	Cream	0.1 %w/w	Topical	บริษัท แสงไทยกำปะนี จำกัด	1986-01-24	Not applicable
แกรมมิกซ์ซิน ครีม	Cream	0.1 %w/w	Topical	บริษัท สยามเภสัช จำกัด	1985-07-31	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Amolg A	Gentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)	Cream	Topical	OASIS TRADING	2018-11-15	Not applicable
ANTASONE CREAM	Gentamicin (1 mg) + Betamethasone (1 mg/g)	Cream	Topical	ZYFAS PHARMA PTE LTD	1988-06-25	Not applicable
B-MYCIN CREAM	Gentamicin (1 mg/g) + Betamethasone (0.5 mg/g)	Cream	Topical	YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD	2013-07-25	Not applicable
B-TASONE-G CREAM	Gentamicin (0.3 % w/w) + Betamethasone (0.1 % w/w)	Cream	Topical	BEACONS PHARMACEUTICALS PTE. LTD.	1990-02-26	Not applicable
BELOGENT %0,05+%0,1 KREM, 15 G	Gentamicin sulfate (0.1 %) + Betamethasone dipropionate (0.05 %)	Cream	Topical	FARMA-TEK İLAÇ SAN. VE TİC. A.Ş.	2015-09-29	Not applicable
BELOGENT %0,05+%0,1 KREM, 30 G	Gentamicin sulfate (0.1 %) + Betamethasone dipropionate (0.05 %)	Cream	Topical	FARMA-TEK İLAÇ SAN. VE TİC. A.Ş.	2013-01-29	Not applicable
BELOGENT %0,05+%0,1 MERHEM, 15 G	Gentamicin sulfate (0.1 %) + Betamethasone dipropionate (0.05 %)	Ointment	Topical	FARMA-TEK İLAÇ SAN. VE TİC. A.Ş.	2015-09-29	Not applicable
BELOGENT %0,05+%0,1 MERHEM, 30 G	Gentamicin sulfate (0.1 %) + Betamethasone dipropionate (0.05 %)	Ointment	Topical	FARMA-TEK İLAÇ SAN. VE TİC. A.Ş.	2013-01-29	Not applicable
BEPROGENT CREAM	Gentamicin sulfate (0.1 % w/w) + Betamethasone dipropionate (0.05 % w/w)	Cream	Topical	ZUELLIG PHARMA PTE. LTD.	1996-11-28	Not applicable
BEPROGENT OINTMENT	Gentamicin sulfate (0.17 % w/w) + Betamethasone dipropionate (0.064 % w/w)	Ointment	Cutaneous	HOE PHARMACEUTICALS SDN. BHD.	2020-09-08	Not applicable
BETACREAM	Gentamicin (0.1 %) + Betamethasone (0.1 %)	Cream	Topical	Laboratorio Chimico Deca Dr.Capuani S.R.L.	2014-07-08	Not applicable
BETAGEN CREMA TOPICA	Gentamicin sulfate (0.1 g) + Betamethasone valerate (0.05 g) + Clioquinol (3 g)	Cream	Topical	COASPHARMA S.A.S.	2007-02-26	2009-08-26
Betamycin Ophthalmic/otic Solution	Gentamicin sulfate (3 mg / mL) + Betamethasone sodium phosphate (1 mg / mL)	Solution	Auricular (otic); Ophthalmic	Sterimax Inc	Not applicable	Not applicable
BIODERM® CREMA	Gentamicin sulfate (0.1 g) + Dexamethasone (0.04 g) + Ketoconazole (2 g)	Cream	Topical	LABORATORIOS SIEGFRIED S.A.S.	2006-11-10	Not applicable
Celestone-G	Gentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)	Ointment	Topical	OASIS TRADING	2018-11-15	Not applicable
Celestone-G	Gentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)	Ointment	Topical	OASIS TRADING	2018-11-15	Not applicable
COMBIDERM CREAM	Gentamicin sulfate (0.1 %) + Betamethasone dipropionate (0.05 %) + Clotrimazole (1 %)	Cream	Topical	APOTHECA MARKETING PTE LTD	1990-08-10	Not applicable
Decoderm compositum - Creme	Gentamicin (1 mg) + Fluprednidene acetate (1 mg)	Cream	Topical	Almirall Hermal Gmb H	1969-03-11	Not applicable
DERMA - 3CREMA	Gentamicin sulfate (0.1 g) + Betamethasone valerate (0.05 g) + Clioquinol (3 g)	Cream	Topical	LABORATORIOS COASPHARMA-SOCIEDAD COASPHARMA (PLANTA RICAURTE)	2007-02-26	Not applicable
DERMAKRON®	Gentamicin sulfate (0.1 g) + Betamethasone valerate (0.05 g) + Clotrimazole (1 g)	Cream	Topical	FABRIFARMA S.A.	2008-11-14	Not applicable
DERMATREX® CREMA	Gentamicin sulfate (0.1 g) + Dexamethasone (0.04 g) + Ketoconazole (2 g)	Cream	Topical	COASPHARMA S.A.S. (PLANTA PALOQUEMAO)	2006-11-10	Not applicable
DEXA-GENTAMICIN EYE DROPS	Gentamicin sulfate (5 mg/ml) + Dexamethasone sodium phosphate (1 mg/ml)	Solution	Ophthalmic	PHARMAFORTE SINGAPORE PTE LTD	1998-04-24	Not applicable
DEXA-GENTAMICIN EYE OINTMENT	Gentamicin sulfate (3 mg/g) + Dexamethasone (0.3 mg/g)	Ointment	Ophthalmic	PHARMAFORTE SINGAPORE PTE LTD	1998-05-14	Not applicable
Dexagenta - POS - Augensalbe	Gentamicin (3 mg) + Dexamethasone (0.3 mg)	Ointment	Ophthalmic	Ursapharm Gmb H	1996-11-18	Not applicable
Dexagenta - POS - Augentropfen	Gentamicin (3 mg) + Dexamethasone sodium phosphate (1 mg)	Solution / drops	Ophthalmic	Ursapharm Gmb H	1996-11-29	Not applicable
DIFAZIN MAX ®.	Gentamicin sulfate (0.1 g) + Betamethasone valerate (0.05 g) + Clotrimazole (1 g)	Cream	Topical	FABRIFARMA S.A.	2019-03-11	2019-10-24
Diprogen Cream	Gentamicin sulfate (0.1 %) + Betamethasone dipropionate (0.05 %)	Cream	Topical	Merck Ltd.	1980-12-31	2017-03-13
Diprogen Ointment	Gentamicin sulfate (0.1 %) + Betamethasone dipropionate (0.05 %)	Ointment	Topical	Merck Ltd.	1980-12-31	2017-03-13
Diprogenta - Creme	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.5 mg/g)	Cream	Topical	Organon Healthcare Gmb H	1976-08-27	Not applicable
Diprogenta - Salbe	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.5 mg/g)	Ointment	Topical	Organon Healthcare Gmb H	1976-08-27	Not applicable
DIPROGENTA CREAM	Gentamicin sulfate (1 mg) + Betamethasone dipropionate (0.5 mg)	Cream	Topical	ORGANON MALAYSIA SDN. BHD.	2020-09-08	Not applicable
DIPROGENTA CREAM	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.5 mg/g)	Cream	Topical	ORGANON SINGAPORE PTE. LTD.	1988-05-27	Not applicable
DIPROSTA	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.5 mg/g)	Cream		Konimex	2017-12-29	2027-03-04
Dom-gentamicin-betamethasone	Gentamicin sulfate (3 mg / mL) + Betamethasone sodium phosphate (1 mg / mL)	Liquid	Auricular (otic); Ophthalmic	Dominion Pharmacal	Not applicable	Not applicable
Garasone Ophthalmic and Otic Solution	Gentamicin sulfate (3 mg / mL) + Betamethasone sodium phosphate (1 mg / mL)	Solution	Auricular (otic); Ophthalmic	Merck Ltd.	1987-12-31	2014-04-01
Garasone Ophthalmic Ointment	Gentamicin sulfate (3 mg / g) + Betamethasone sodium phosphate (1 mg / g)	Ointment	Ophthalmic	Merck Ltd.	1983-12-31	2013-07-15
GEBEXONE	Gentamicin (0.1 %) + Betamethasone (0.1 %)	Cream	Topical	Esapharma s.p.a.	2014-07-08	Not applicable
GENTA-DEX EYE DROPS	Gentamicin sulfate (3 mg) + Dexamethasone sodium phosphate (1 mg)	Solution / drops	Ophthalmic	DUOPHARMA (M) SDN. BHD.	2020-09-08	Not applicable
GENTALYN BETA	Gentamicin (0.1 %) + Betamethasone (0.1 %)	Cream	Topical	Organon Italia S.R.L.	2014-07-08	Not applicable
GENTALYN BETA	Gentamicin (0.1 %) + Betamethasone (0.05 %)	Cream	Topical	Organon Italia S.R.L.	2014-07-08	Not applicable
GENTAMICIN POS	Gentamicin sulfate (5 mg) + Gentamicin sulfate (5 mg)	Kit			2006-04-01	Not applicable
GENTAMICIN POS	Gentamicin sulfate (5 mg) + Gentamicin sulfate (5 mg)	Kit			2006-04-01	Not applicable
Gentamicin Sulfate In 0.9% Sodium Chloride Injection	Gentamicin sulfate (0.8 mg / mL) + Sodium chloride (9 mg / mL)	Solution	Intravenous	Hospira Healthcare Ulc	1991-12-31	2018-11-22
Gentamicin Sulfate In Nacl 0.9% Inj	Gentamicin sulfate (1.2 mg / mL) + Sodium chloride (9 mg / mL)	Solution	Intravenous	Hospira Healthcare Ulc	1991-12-31	2011-08-05
Gentamicin Sulfate In Nacl 0.9% Inj	Gentamicin sulfate (1 mg / mL) + Sodium chloride (9 mg / mL)	Solution	Intravenous	Hospira Healthcare Ulc	1994-12-31	2011-08-05
Gentamicin Sulfate In Nacl O.9% Inj	Gentamicin sulfate (0.8 mg / mL) + Sodium chloride (9 mg / mL)	Solution	Intravenous	Hospira Healthcare Ulc	1991-12-31	2014-08-01
GENTAMICINA E BETAMETASONE PENSA	Gentamicin (0.1 %) + Betamethasone (0.1 %)	Cream	Topical	Towa Pharmaceutical S.P.A.	2014-07-08	Not applicable
GENTASON B	Gentamicin sulfate (3 mg/ml) + Betamethasone sodium phosphate (1 mg/ml)	Solution / drops	Ophthalmic	Cendo	2016-12-27	2026-12-27
GENTRIDERM CREAM	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.64 mg/g) + Clotrimazole (10 mg/g)	Cream	Topical	PHARMAFORTE SINGAPORE PTE LTD	1999-09-02	Not applicable
GENTRISONE CREAM	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.64 mg/g) + Clotrimazole (10 mg/g)	Cream	Topical	ZYFAS PHARMA PTE LTD	1990-03-08	Not applicable
INDOBIOTIC GOZ DAMLASI, 5 ML	Gentamicin sulfate (15000 IU) + Indomethacin (5 mg)	Solution / drops	Ophthalmic	BAUSCH & LOMB SAĞLIK VE OPTİK ÜRÜNLERİ TİC. A.Ş.	2011-01-19	2018-02-01
KAMELYN	Gentamicin sulfate (0.1 %) + Betamethasone (0.1 %)	Cream	Topical	Neopharmed Gentili S.P.A.	2014-07-08	2022-08-05
NEODERM CREAM	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.5 mg/g) + Clotrimazole (10 mg/g)	Cream	Topical	POLYMEDIC TRADING ENTERPRISE PTE LTD	1998-11-23	Not applicable
PERMUT®	Gentamicin sulfate (0.1 g) + Betamethasone valerate (0.05 g) + Clioquinol (1 g) + Tolnaftate (1 g)	Cream	Topical	EUROFARMA COLOMBIA S.A.S.	2019-10-15	Not applicable
PHILVOLTE	Gentamicin (100 mg/100g) + Betamethasone dipropionate (64 mg/100g) + Clotrimazole (1 g/100g)	Cream	Topical	บริษัท ฟาร์มาแลนด์ (1982) จำกัด	2013-04-06	Not applicable
PMS-gentamicin-betamethasone	Gentamicin sulfate (3 mg / mL) + Betamethasone sodium phosphate (1 mg / mL)	Liquid	Auricular (otic); Ophthalmic	Pharmascience Inc	Not applicable	Not applicable
Pred-G	Gentamicin (3 mg/1mL) + Prednisolone acetate (10 mg/1mL)	Suspension / drops	Ophthalmic	Allergan, Inc.	1990-02-19	2022-11-30
Pred-G	Gentamicin (3 mg/1mL) + Prednisolone acetate (10 mg/1mL)	Suspension / drops	Ophthalmic	Physicians Total Care, Inc.	1990-02-19	2012-06-30
Pred-G	Gentamicin sulfate (3 mg/1g) + Prednisolone acetate (6 mg/1g)	Ointment	Ophthalmic	Allergan, Inc.	1990-01-01	Not applicable
SAEROGENTA-A CREAM	Gentamicin sulfate (1 mg/g) + Betamethasone dipropionate (0.64 mg/g) + Clotrimazole (10 mg/g)	Cream	Topical	SINGAPORE PHARMACEUTICAL PRIVATE LIMITED	1996-06-20	Not applicable
SALGEN PLUS	Gentamicin sulfate (1 mg/g) + Betamethasone valerate (1 mg/g)	Cream		Erlimpex	2017-09-06	2026-06-14
Sandoz Pentasone	Gentamicin sulfate (3 mg / mL) + Betamethasone sodium phosphate (1 mg / mL)	Solution	Auricular (otic); Ophthalmic	Sandoz Canada Incorporated	2001-12-04	2017-08-01
SEPTOPAL	Gentamicin sulfate (7.5 mg) + Zirconium dioxide (20 MG/1BEAD)	Bead		บริษัท ซิมเมอร์ ไบโอเมท (ประเทศไทย) จำกัด จำกัด	2016-05-17	2020-09-29
Sulmycin Implant - Schwamm	Gentamicin sulfate (1.3 mg/cm2) + Equine collagen (2.8 mg/cm2)	Implant; Sponge	Intralesional	Serb Sa	1993-09-14	Not applicable
TRI-MICON CREAM	Gentamicin (0.1 % w/w) + Betamethasone valerate (0.1 % w/w) + Miconazole nitrate (2 % w/w)	Cream	Topical	BEACONS PHARMACEUTICALS PTE. LTD.	1999-01-26	Not applicable
TROK G® CREMA	Gentamicin sulfate (0.1 mg) + Betamethasone dipropionate (0.05 mg)	Cream	Topical	EUROFARMA COLOMBIA S.A.S.	2019-10-11	Not applicable
Valisone-G	Gentamicin sulfate (0.1 % w/w) + Betamethasone valerate (0.1 % w/w)	Ointment	Topical	Bausch Health, Canada Inc.	1972-12-31	Not applicable
Valisone-G	Gentamicin sulfate (0.1 % w/w) + Betamethasone valerate (0.1 % w/w)	Cream	Topical	Bausch Health, Canada Inc.	1970-12-31	Not applicable
ควอดริเดิร์ม ครีม	Gentamicin (0.1 G/100G) + Betamethasone (0.05 G/100G) + Clioquinol (1 G/100G) + Tolnaftate (1 G/100G)	Cream	Topical	บริษัท เอ็มเอสดี (ประเทศไทย) จำกัด	2007-11-14	Not applicable
ซีโต้-เดิร์ม	Gentamicin (100 mg/100g) + Betamethasone (50 mg/100g) + Clioquinol (1 g/100g) + Tolnaftate (1 g/100g)	Cream	Topical	บริษัท ปัจจุบันโอสถ จำกัด จำกัด	2008-02-18	Not applicable
บีต้าแกรมครีม	Gentamicin (1 MG/1G) + Betamethasone (1 MG/1G)	Cream		บริษัท โรงงานผลิตเวชภัณฑ์ชินต้าเทรดดิ้ง (1971) จำกัด จำกัด	1984-09-09	Not applicable
พีบัส ครีม	Gentamicin (100 mg/100g) + Betamethasone (50 mg/100g) + Clioquinol (1 g/100g) + Tolnaftate (1 g/100g)	Cream	Topical	บริษัท ฟาร์สเป็ค จำกัด จำกัด	1998-11-16	Not applicable
สกินเฟ็กต์ - บี ครีม	Gentamicin (1 MG/1G) + Betamethasone (1 MG/1G)	Cream		บริษัท บางกอกแล็ป แอนด์ คอสเมติค จำกัด จำกัด	2005-05-03	Not applicable
เดอมาฮิว	Gentamicin (100 mg/100g) + Betamethasone (50 mg/100g) + Clioquinol (1 g/100g) + Tolnaftate (1 g/100g)	Cream	Topical	บริษัท ไทยนครพัฒนา จำกัด	1999-10-28	Not applicable
เดอมิกซ์-4	Gentamicin (0.1 G/100G) + Betamethasone (0.05 G/100G) + Clioquinol (1 G/100G) + Tolnaftate (1 G/100G)	Cream	Topical	บริษัท ที. แมน ฟาร์มา จำกัด	2015-04-02	Not applicable
เดอร์เทค	Gentamicin (100 mg/100g) + Betamethasone (50 mg/100g) + Clioquinol (1 g/100g) + Tolnaftate (1 g/100g)	Cream	Topical	บริษัท มิลลิเมด จำกัด จำกัด	2007-06-01	Not applicable
เบต้าเดอร์ม-คว้อด ครีม	Gentamicin (100 mg/100g) + Betamethasone (50 mg/100g) + Clioquinol (1 g/100g) + Tolnaftate (1 g/100g)	Cream	Topical	บริษัท อังกฤษตรางู (แอล.พี.) จำกัด	1990-03-01	Not applicable
เบต้าเดอร์ม-จี ครีม	Gentamicin (1 MG/1G) + Betamethasone (1 MG/1G)	Cream		บริษัท อังกฤษตรางู (แอล.พี.) จำกัด	1986-02-11	Not applicable
เบทาเจน	Gentamicin (1 MG/1G) + Betamethasone (0.5 MG/1G)	Cream		บริษัท ไทยนครพัฒนา จำกัด	2002-02-07	Not applicable
เบโทรคอท	Gentamicin (1 MG/1G) + Betamethasone (1 MG/1G)	Cream		บริษัท ฟาร์สเป็ค จำกัด จำกัด	2005-03-12	Not applicable
เพรดอ๊อฟ ยาหยอดตาหู	Gentamicin (3 MG/1ML) + Prednisolone (5 MG/1ML)	Liquid	Auricular (otic); Ophthalmic	บริษัท แสงไทยกำปะนี จำกัด	1986-09-08	Not applicable
เยนตั้ล-เอฟ ครีม	Gentamicin (0.25 MG/1G) + Fluocinolone acetonide (1 MG/1G)	Cream		บริษัท เยนเนอร์ราลดรั๊กส์เฮ้าส์ จำกัด	1987-04-16	Not applicable
เย็นต้า-บีตาโซน ครีม	Gentamicin (1 MG/1G) + Betamethasone (1 MG/1G)	Cream		บริษัท แสงไทยกำปะนี จำกัด	1986-01-28	Not applicable
แบคโตะแซน-วีจี	Gentamicin (1 MG/1G) + Betamethasone (1 MG/1G)	Ointment		บริษัท โอลิค (ประเทศไทย) จำกัด	2017-11-09	2020-09-29
ไมเดิร์ม ควอท	Gentamicin (100 mg/100g) + Betamethasone (50 mg/100g) + Clioquinol (1 g/100g) + Tolnaftate (1 g/100g)	Cream	Topical	บริษัท ที. แมน ฟาร์มา จำกัด	2014-06-26	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Amolg A	Gentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)	Cream	Topical	OASIS TRADING	2018-11-15	Not applicable
Celestone-G	Gentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)	Ointment	Topical	OASIS TRADING	2018-11-15	Not applicable
Celestone-G	Gentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)	Ointment	Topical	OASIS TRADING	2018-11-15	Not applicable
GENSIF 20 MG/2 ML AMPUL	Gentamicin (20 mg/2ml)	Injection	Intramuscular; Intravenous	AVİCENNA FARMA DIŞ TİC. VE PAZ. A.Ş.	2019-04-30	Not applicable
GENSIF 40 MG/2 ML AMPUL	Gentamicin (40 mg/2ml)	Injection	Intramuscular; Intravenous	AVİCENNA FARMA DIŞ TİC. VE PAZ. A.Ş.	2019-04-30	Not applicable
GENSIF 80 MG/2 ML AMPUL	Gentamicin (80 mg/2ml)	Injection	Intramuscular; Intravenous	AVİCENNA FARMA DIŞ TİC. VE PAZ. A.Ş.	2019-04-30	Not applicable

Chemical Identifiers

UNII: T6Z9V48IKG
CAS number: 1403-66-3
InChI Key: NPEFREDMMVQEPL-RWPARATISA-N
InChI: InChI=1S/C21H43N5O7.C20H41N5O7.C19H39N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3/t9?,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8?,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-/m110/s1
IUPAC Name: (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol
SMILES: [H][C@@]1(CN)CC[C@@H](N)[C@@H](O[C@]2([H])[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1.[H][C@]1(CC[C@@H](N)[C@@H](O[C@]2([H])[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1)C(C)N.[H][C@]1(CC[C@@H](N)[C@@H](O[C@]2([H])[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1)C(C)NC

References

Synthesis Reference

George H. Scherr, "Preparation of gentamicin sensitized particles for agglutination tests." U.S. Patent US4100268, issued August, 1975.

US4100268

General References

Chaves BJ, Tadi P: Gentamicin . [Article]
Siber GR, Echeverria P, Smith AL, Paisley JW, Smith DH: Pharmacokinetics of gentamicin in children and adults. J Infect Dis. 1975 Dec;132(6):637-51. doi: 10.1093/infdis/132.6.637. [Article]
Jones TE, Peter JV, Field J: Aminoglycoside clearance is a good estimate of creatinine clearance in intensive care unit patients. Anaesth Intensive Care. 2009 Nov;37(6):944-52. doi: 10.1177/0310057X0903700611. [Article]
Ahmed RM, Hannigan IP, MacDougall HG, Chan RC, Halmagyi GM: Gentamicin ototoxicity: a 23-year selected case series of 103 patients. Med J Aust. 2012 Jun 18;196(11):701-4. doi: 10.5694/mja11.10850. [Article]
Black FO, Pesznecker S, Stallings V: Permanent gentamicin vestibulotoxicity. Otol Neurotol. 2004 Jul;25(4):559-69. doi: 10.1097/00129492-200407000-00025. [Article]
Authors unspecified: Aminoglycosides . [Article]
Authors unspecified: Gentamicin. Br Med J. 1967 Jan 21;1(5533):158-9. [Article]
Kushner B, Allen PD, Crane BT: Frequency and Demographics of Gentamicin Use. Otol Neurotol. 2016 Feb;37(2):190-5. doi: 10.1097/MAO.0000000000000937. [Article]
Serio AW, Keepers T, Andrews L, Krause KM: Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018. [Article]
Chen C, Chen Y, Wu P, Chen B: Update on new medicinal applications of gentamicin: evidence-based review. J Formos Med Assoc. 2014 Feb;113(2):72-82. doi: 10.1016/j.jfma.2013.10.002. Epub 2013 Nov 9. [Article]
Krause KM, Serio AW, Kane TR, Connolly LE: Aminoglycosides: An Overview. Cold Spring Harb Perspect Med. 2016 Jun 1;6(6). pii: 6/6/a027029. doi: 10.1101/cshperspect.a027029. [Article]
Hayward RS, Harding J, Molloy R, Land L, Longcroft-Neal K, Moore D, Ross JDC: Adverse effects of a single dose of gentamicin in adults: a systematic review. Br J Clin Pharmacol. 2018 Feb;84(2):223-238. doi: 10.1111/bcp.13439. Epub 2017 Nov 3. [Article]
Moore RA, Bates NC, Hancock RE: Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxin. Antimicrob Agents Chemother. 1986 Mar;29(3):496-500. doi: 10.1128/aac.29.3.496. [Article]
Hancock RE, Raffle VJ, Nicas TI: Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1981 May;19(5):777-85. doi: 10.1128/aac.19.5.777. [Article]
Taber HW, Mueller JP, Miller PF, Arrow AS: Bacterial uptake of aminoglycoside antibiotics. Microbiol Rev. 1987 Dec;51(4):439-57. [Article]
Waters M, Tadi P: Streptomycin . [Article]
Ying L, Zhu H, Shoji S, Fredrick K: Roles of specific aminoglycoside-ribosome interactions in the inhibition of translation. RNA. 2019 Feb;25(2):247-254. doi: 10.1261/rna.068460.118. Epub 2018 Nov 9. [Article]
Wallace BJ, Tai PC, Herzog EL, Davis BD: Partial inhibition of polysomal ribosomes of Escherichia coli by streptomycin. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1234-7. doi: 10.1073/pnas.70.4.1234. [Article]
Borovinskaya MA, Pai RD, Zhang W, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH: Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol. 2007 Aug;14(8):727-32. doi: 10.1038/nsmb1271. Epub 2007 Jul 29. [Article]
Tai PC, Wallace BJ, Davis BD: Streptomycin causes misreading of natural messenger by interacting with ribosomes after initiation. Proc Natl Acad Sci U S A. 1978 Jan;75(1):275-9. doi: 10.1073/pnas.75.1.275. [Article]
FDA Approved Drug Products: Gentamicin solution for injection [Link]
FDA Approved Drug Products: PRED-G (gentamicin and prednisolone acetate) ophthalmic suspension [Link]
FDA Approved Drug Products: PRED-G (gentamicin and prednisolone acetate) ophthalmic ointment [Link]
DailyMed Drug Label Information: Gentamicin sulfate injection [Link]
DailyMed Drug Label Information: Gentamicin ophthalmic solution [Link]
DailyMed Drug Label Information: Gentamicin topical cream [Link]
DPD Approved Drug Products: Gentamicin solution for injection [Link]

External Links

Human Metabolome Database: HMDB0014936
KEGG Compound: C00505
PubChem Compound: 3467
PubChem Substance: 46506523
ChemSpider: 8074297
BindingDB: 50476074
RxNav: 1596450
ChEBI: 17833
ChEMBL: CHEMBL3039597
Therapeutic Targets Database: DAP000116
PharmGKB: PA449753
Guide to Pharmacology: GtP Drug Page
RxList: RxList Drug Page
Drugs.com: Drugs.com Drug Page
PDRhealth: PDRhealth Drug Page
Wikipedia: Gentamicin

MSDS

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Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Treatment	Appendicitis	1
4	Completed	Not Available	Staphylococcus Aureus	1
4	Completed	Prevention	Benign Prostatic Hyperplasia (BPH)	1
4	Completed	Prevention	Inguinal Hernias	1
4	Completed	Prevention	Kidney Stones / Urinary Tract Infection	1
4	Completed	Treatment	Bacteremia	1
4	Completed	Treatment	Bronchiectasis	1
4	Completed	Treatment	Complicated Appendicitis	1
4	Completed	Treatment	Diabetic Foot Ulcers (DFUs)	1
4	Completed	Treatment	Gonorrhea	1
4	Completed	Treatment	Infant Bacterial Meningitis	1
4	Completed	Treatment	Infection	2
4	Completed	Treatment	Kidney Failure / Peritonitis	1
4	Completed	Treatment	Sepsis	1
4	Enrolling by Invitation	Prevention	Kidney Stones	1
4	Not Yet Recruiting	Prevention	Urinary Tract Infections, Recurrent	1
4	Not Yet Recruiting	Treatment	Bronchiectasis With Acute Exacerbation	1
4	Recruiting	Prevention	Catheter Related Infections	1
4	Recruiting	Prevention	Open Tibia Fracture	1
4	Recruiting	Prevention	Open Tibia Fracture / Osteomyelitis Tibia / Tibial Fractures	1
4	Recruiting	Treatment	Carbapenem Resistant Klebsiella Pneumoniae	1
4	Recruiting	Treatment	Complicated Urinary Tract Infection / Infection / Pediatric Infectious Diseases	1
4	Terminated	Other	Renal Failure Chronic Requiring Hemodialysis	1
4	Terminated	Prevention	Fractures, Open / Post-Op Wound Infection	1
4	Terminated	Treatment	Atopic Dermatitis / Skin Diseases, Eczematous	1
4	Terminated	Treatment	Infective Endocarditis (IE)	1
4	Unknown Status	Prevention	Infection	1
4	Unknown Status	Prevention	Rate of Atypical Mycobacterial Infection / Rate of Exit Site Infection / Rate of Peritoneal Dialysis	1
4	Unknown Status	Prevention	Urinary Tract Infection	1
4	Unknown Status	Treatment	Rhino Sinusitis	1
4	Withdrawn	Prevention	Vestibular Schwannomas	2
4	Withdrawn	Treatment	Chronic Sinusitis	1
4	Withdrawn	Treatment	Urinary Tract Infection	1
3	Completed	Other	Kidney Stones	1
3	Completed	Prevention	Axillary Drainage Volume After Lymph Node Dissection	1
3	Completed	Prevention	Breast Cancer	1
3	Completed	Prevention	Pain	1
3	Completed	Prevention	Postoperative Wound Infection / Surgery, Colorectal	1
3	Completed	Prevention	Sternal Wound Infection / Surgery, Cardiac	1
3	Completed	Treatment	Atopic Dermatitis	1
3	Completed	Treatment	Cutaneous Leishmaniasis	1
3	Completed	Treatment	Diabetic Foot Ulcers (DFUs) / Infection	2
3	Completed	Treatment	Gonorrhea	1
3	Completed	Treatment	Infection / Sepsis / Sepsis, Neonatal	1
3	Completed	Treatment	Keratitis; Infectious Disease (Manifestation)	1
3	Completed	Treatment	Sepsis	1
3	Completed	Treatment	Total Knee Arthoplasty	1
3	Not Yet Recruiting	Other	Open tíbia Fracture / Osteomyelitis Tibia / Tibial Fractures	1
3	Not Yet Recruiting	Treatment	Acute Mesenteric Ischemia	1
3	Not Yet Recruiting	Treatment	Antibiotics / Neurodevelopment / Premature Births	1
3	Recruiting	Prevention	Antibiotic Side Effect / Complications Implants / Implant Capsular Contracture / Implant Expulsion / Implant Infection / Implant site infection / Implant Site Pocket Infection	1
3	Recruiting	Prevention	Fracture of Neck of Femur (Hip) / Prosthetic Infections	1
3	Recruiting	Treatment	Bullous Pemphigoid (BP) / Pemphigus Vulgaris (PV)	1
3	Recruiting	Treatment	Cat scratch disease	1
3	Recruiting	Treatment	Plague, Bubonic / Pneumonic Plague	1
3	Recruiting	Treatment	Pneumonia	1
3	Terminated	Treatment	Infection	1
3	Unknown Status	Treatment	Antibiotic Resistance, Bacterial / Antibiotic Toxicity / Severe Malnutrition	1
3	Unknown Status	Treatment	Bacterial Infections / Newborn, Infant / Sepsis	1
3	Withdrawn	Treatment	Chronic Sinusitis	1
2	Active Not Recruiting	Prevention	Neurogenic Bladder / Spinal Cord Injuries	1
2	Completed	Prevention	Pelvic Organ Prolapse (POP) / Post-operative Urinary Tract Infections / Stress Urinary Incontinence (SUI)	1
2	Completed	Treatment	Bacteremia / Chronic Lung Disease of Prematurity / Ileal perforation / Intraventricular Hemorrhage (IVH) / Lung Disorder / Necrotizing Enterocolitis (NEC) / Periventricular Leukomalacia	1
2	Completed	Treatment	Cutaneous Leishmaniasis	2
2	Completed	Treatment	Diabetic Foot Ulcers (DFUs)	2
2	Completed	Treatment	Respiratory Infections / Tracheobronchitis / Ventilator Associated Bacterial Pneumonia (VABP)	1
2	Not Yet Recruiting	Prevention	Sepsis / Urinary Tract Infection	1
2	Not Yet Recruiting	Treatment	Ichthyosis	1
2	Recruiting	Basic Science	Healthy Volunteers (HV)	1
2	Recruiting	Basic Science	Nasal and Pharyngeal Microbiome	1
2	Recruiting	Treatment	Urinary Tract Infection	1
2	Terminated	Prevention	Diabetic Foot Ulcers (DFUs)	1
2	Terminated	Treatment	Bacterial Pneumonia	1
2	Terminated	Treatment	Cutaneous Leishmaniasis	3
2	Terminated	Treatment	Cystic Fibrosis (CF)	1
2	Unknown Status	Treatment	Abdominal Abscess	1
2	Unknown Status	Treatment	Hereditary Hypotrichosis Simplex	1
2	Unknown Status	Treatment	Nasopharyngeal Neoplasms / Stomatitis	1
2	Unknown Status	Treatment	Stomatitis	1
2, 3	Active Not Recruiting	Prevention	Neurogenic Bladder / Spinal Cord Diseases / Spinal Cord Injuries / Urinary Tract Infection	1
2, 3	Completed	Prevention	Chorioamnionitis / Neonatal Early Onset Sepsis / Neonatal Meningitis / Pneumonia Neonatal / Puerperal Endometritis	1
2, 3	Completed	Treatment	Chorioamnionitis	1
2, 3	Completed	Treatment	Complicated Intra-Abdominal Infections (cIAIs)	1
2, 3	Completed	Treatment	Menière's Disease	1
2, 3	Completed	Treatment	Plague	1
2, 3	Completed	Treatment	Ventilator Associated Bacterial Pneumonia (VABP)	1
2, 3	Recruiting	Treatment	Children - Malnutrition / Human Immunodeficiency Virus Type 1 (HIV-1) Infection	1
2, 3	Suspended	Treatment	Folliculitis	1
2, 3	Terminated	Treatment	Cancer	1
2, 3	Terminated	Treatment	Pharyngeal Gonococcal Infection	1
2, 3	Unknown Status	Prevention	Bypass Complications / Peripheral Vascular Disease Patient / Surgical Site Infections / Vascular Diseases	1
1	Completed	Health Services Research	Breast Implant Infection / Breast Reconstruction	1
1	Completed	Prevention	Hemodialysis Catheter Infection	1
1	Completed	Treatment	Atopic Dermatitis	1
1	Completed	Treatment	Becker's Muscular Dystrophy (BMD) / Duchenne Muscular Dystrophy (DMD)	1
1	Completed	Treatment	Duchenne Muscular Dystrophy (DMD)	1
1	Completed	Treatment	Ventilator Associated Bacterial Pneumonia (VABP)	1
1, 2	Completed	Treatment	Epidermolysis Bullosa (EB)	1
1, 2	Completed	Treatment	Recessive Dystrophic Epidermolysis Bullosa	2
1, 2	Recruiting	Treatment	Epidermolysis Bullosa, Junctional	2
1, 2	Recruiting	Treatment	Recessive Dystrophic Epidermolysis Bullosa	1
1, 2	Terminated	Treatment	Diabetic Foot Ulcers (DFUs)	1
0	Completed	Basic Science	Diabetes / Inflammation / Obesity / Osteoporosis	1
0	Completed	Treatment	Antibiotic Resistance, Bacterial / Respiratory Failure / Respiratory Infections	1
0	Terminated	Treatment	Osteomyelitis	1
Not Available	Completed	Not Available	Antibiotic Resistant Infection / Bacterial Infections / Surgical Site Infections	1
Not Available	Completed	Not Available	Bacterial Keratitis / Fungal infections of the cornea / Microbial Keratitis / Mixed Bacterial and Fungal Keratitis	1
Not Available	Completed	Not Available	Drug Metabolism During Pregnancy	1
Not Available	Completed	Not Available	End Stage Renal Disease (ESRD) / Infection	1
Not Available	Completed	Not Available	Perforated Appendicitis	1
Not Available	Completed	Not Available	Pneumonia	1
Not Available	Completed	Not Available	Pregnancy	1
Not Available	Completed	Not Available	Urinary Tract Infection / Urinary Tract Infections, Recurrent	1
Not Available	Completed	Other	Colic / Gastrointestinal Diseases	1
Not Available	Completed	Prevention	Antibiotic Resistance, Bacterial / Postoperative Wound Infection	1
Not Available	Completed	Prevention	Cholangitis	1
Not Available	Completed	Supportive Care	Vestibular Schwannomas	1
Not Available	Completed	Treatment	Breast Cancer	1
Not Available	Completed	Treatment	Chorioamnionitis	1
Not Available	Completed	Treatment	Exacerbation of Ulcerative Colitis / Granulomatous Colitis / Ulcerative Colitis, Active Severe	1
Not Available	Completed	Treatment	Klebsiella Pneumoniae Carbapenemase Resistant Associated Bacteremia or Pneumonia	1
Not Available	Completed	Treatment	Open Tibia Fracture	1
Not Available	Completed	Treatment	Peritonitis	1
Not Available	Completed	Treatment	Sepsis	1
Not Available	Not Yet Recruiting	Prevention	Premature Rupture of Membranes Prolonged / Preterm Labor With Preterm Delivery	1
Not Available	Recruiting	Prevention	Kidney Stones / Sepsis / Urinary Tract Infection	1
Not Available	Recruiting	Prevention	Peritoneal Dialysis Catheter Exit Site Infection	1
Not Available	Recruiting	Prevention	Peritoneal Dialysis-related Infection	1
Not Available	Recruiting	Treatment	Cholangitis	1
Not Available	Recruiting	Treatment	Post-TURP Infectious Complications	1
Not Available	Recruiting	Treatment	Vestibular Disorder Preservation	1
Not Available	Unknown Status	Not Available	Asymptomatic Infections / Bacteriuria / Transplantation Infection / Urinary Tract Infection	1
Not Available	Unknown Status	Prevention	Infection	1
Not Available	Unknown Status	Treatment	Chorioamnionitis	1

Pharmacoeconomics

Manufacturers

Schering corp sub schering plough corp
Pharmafair inc
Alpharma us pharmaceuticals division
Bausch and lomb pharmaceuticals inc
E fougera div altana inc
Perrigo new york inc
Pharmaderm div altana inc
Taro pharmaceuticals usa inc
King pharmaceuticals inc
Bristol laboratories inc div bristol myers co
International medication systems ltd
Abbott laboratories pharmaceutical products div
App pharmaceuticals llc
Baxter healthcare corp anesthesia and critical care
Hospira inc
Kalapharm inc
Pharmaceutical specialist assoc
Solopak laboratories inc
Teva parenteral medicines inc
Watson laboratories inc
Wyeth ayerst laboratories
B braun medical inc
Baxter healthcare corp
Pharmacia and upjohn co
Novartis pharmaceuticals corp
Akorn inc
Altana inc
Allergan
Alcon universal ltd
Falcon pharmaceuticals ltd
Paco research corp

Packagers

Accutome Inc.
Advanced Pharmaceutical Services Inc.
Akorn Inc.
Alcon Laboratories
APP Pharmaceuticals
A-S Medication Solutions LLC
B. Braun Melsungen AG
Bausch & Lomb Inc.
Baxter International Inc.
Cardinal Health
Carlisle Laboratories Inc.
Darby Dental Supply Co. Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
E. Fougera and Co.
Falcon Pharmaceuticals Ltd.
General Injectables and Vaccines Inc.
H.J. Harkins Co. Inc.
Hospira Inc.
Innoviant Pharmacy Inc.
Keltman Pharmaceuticals Inc.
Major Pharmaceuticals
Martin Surgical Supply
Medisca Inc.
MWI Veterinary Supply Co.
Novartis AG
Nycomed Inc.
Ocusoft
OMJ Pharmaceuticals
Pacific Pharma Lp
Palmetto Pharmaceuticals Inc.
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Pharmedix
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Qualitest
Rebel Distributors Corp.
Redpharm Drug
Rx Veterinary Products
Stat Rx Usa
Stat Scripts LLC
Taro Pharmaceuticals USA
Taylor Pharmaceuticals
Vedco Inc.
Wa Butler Co.

Dosage Forms

Form	Route	Strength
Cream	Topical
Cream	Topical	0.1 %
Solution / drops	Auricular (otic); Ophthalmic
Cream	Topical	0.1 % w/w
Solution / drops	Ophthalmic	0.3 %W/V
Solution / drops	Auricular (otic); Ophthalmic	0.3 %W/V
Cream	Topical	0.05 % w/w
Ointment	Cutaneous
Solution / drops	Ophthalmic
Solution	Parenteral	40 mg
Ointment	Topical
Solution	Intramuscular	80 mg
Solution	Intramuscular	160 mg
Solution	Intravenous	20 mg
Liquid	Intramuscular; Intravenous	40 mg / mL
Liquid	Intramuscular; Intravenous	10 mg / mL
Gel
Ointment	Topical
Ointment	Ophthalmic	0.3 g
Cream
Cream	Topical	0.1 % w/w
Solution	Ophthalmic	1 mg/ml
Ointment	Ophthalmic	0.3 mg/g
Suspension	Auricular (otic)
Ointment	Topical	0.1 %w/w
Cream
Injection	Intramuscular; Intravenous
Implant	Topical	130 mg
Ointment	Conjunctival; Ophthalmic	300 mg
Solution	Parenteral	160 mg
Solution	Parenteral	80 mg
Solution	Parenteral	20.00 mg
Cream	Topical	.1 %
Solution	Ophthalmic	3 mg/1mL
Solution	Intramuscular; Intravenous	10 mg / mL
Solution	Intramuscular; Intravenous	40 mg / mL
Ointment	Topical	1 mg / g
Ointment	Ophthalmic	0.3 %
Solution / drops	Auricular (otic)	3 mg / mL
Injection	Intramuscular; Intravenous	80 mg/2ml
Solution	Auricular (otic); Ophthalmic
Solution / drops	Ophthalmic	5 mg / mL
Solution / drops	Auricular (otic)	5 mg / mL
Solution / drops	Ophthalmic
Cream	Topical
Solution	Parenteral	80.0 mg
Gel	Topical
Injection, solution	Intramuscular; Intravenous	160 mg/2ml
Injection, solution	Intramuscular; Intravenous	40 mg
Injection, solution	Intramuscular; Intravenous	80 mg
Ointment
Ointment	Ophthalmic
Solution	Parenteral	160.000 mg
Solution	Parenteral	40.000 mg
Solution	Parenteral	20.000 mg
Injection	Intramuscular; Intravenous	40 mg/1ml
Injection	Intramuscular; Intravenous	40 mg/2ml
Solution / drops; suspension / drops	Ophthalmic	5 mg
Ointment	Ophthalmic	5 mg
Solution	Intramuscular; Intravenous	160 g
Injection	Intramuscular; Intravenous	120 mg
Injection	Intramuscular; Intravenous	160 mg
Injection	Intramuscular; Intravenous	20 mg
Injection	Intramuscular; Intravenous	40 mg
Injection	Intramuscular; Intravenous	80 mg
Solution / drops	Auricular (otic)	5 ml
Solution / drops	Ophthalmic	3 mg / mL
Solution	Parenteral	8 g
Solution / drops	Auricular (otic); Ophthalmic	0.3 %
Cream	Topical	15 g
Cream	Topical	30 g
Ointment	Topical	15 g
Ointment	Topical	30 g
Ointment	Ophthalmic	5 g
Liquid	Ophthalmic	3 mg/1ml
Injection, solution		10 MG/1ML
Injection, solution		120 MG/1.5ML
Injection, solution		160 MG/2ML
Injection, solution		20 MG/2ML
Ointment	Topical	0.1 %
Solution	Parenteral	280 mg
Solution / drops	Auricular (otic); Ophthalmic	5 ml
Injection, solution	Intramuscular
Injection, solution
Injection, solution	Intramuscular; Intravenous	10 mg/1mL
Injection, solution	Intramuscular; Intravenous	40 mg/1mL
Solution	Ophthalmic	.3 %
Solution	Ophthalmic	0.3 %
Solution	Parenteral	1 MG/ML
Solution	Parenteral	3 MG/ML
Cream	Topical	0.3 % w/w
Injection, solution		40 mg/1ml
Kit
Injection, solution	Parenteral	40 MG/ML
Injection, solution	Parenteral	160 MG
Injection, solution	Parenteral	80 MG
Solution	Intramuscular; Intravenous	80 mg/2ml
Cream	Topical	1 mg/1g
Injection, solution	Intravenous	120 mg/50mL
Injection, solution	Intravenous	40 mg/100mL
Injection, solution	Intravenous	60 mg/100mL
Injection, solution, concentrate	Intramuscular; Intravenous	40 mg/1mL
Injection, solution, concentrate	Intravenous	10 mg/1mL
Ointment	Ophthalmic	3 mg/1g
Ointment	Topical	1 mg/1g
Powder	Not applicable	1 kg/1kg
Powder	Not applicable	1 g/1g
Solution	Ophthalmic	3.0 mg/1mL
Solution / drops	Ophthalmic	3 mg/1mL
Solution	Intravenous
Injection, solution	Intravenous	0.6 mg/1mL
Injection, solution	Intravenous	0.8 mg/1mL
Injection, solution	Intravenous	0.9 mg/1mL
Injection, solution	Intravenous	1 mg/1mL
Injection, solution	Intravenous	1.2 mg/1mL
Injection, solution	Intravenous	1.4 mg/1mL
Injection, solution	Intravenous	1.6 mg/1mL
Injection, solution	Intravenous	100 mg/100mL
Injection, solution	Intravenous	100 mg/50mL
Injection, solution	Intravenous	60 mg/50mL
Injection, solution	Intravenous	80 mg/100mL
Injection, solution	Intravenous	80 mg/50mL
Solution	Ophthalmic	3 mg/ml
Solution	Intravenous	1 mg / mL
Solution	Intravenous	1.6 mg / mL
Solution	Intravenous	1.2 mg / mL
Cream	Topical	0.1 g
Solution	Conjunctival; Ophthalmic	300000 mg
Solution	Conjunctival; Ophthalmic	0.003 g
Solution	Conjunctival; Ophthalmic	3 mg
Solution	Parenteral	126 mg
Solution	Intramuscular; Intravenous	120 mg
Solution	Parenteral	120 mg
Solution	Intramuscular	120 mg
Solution	Intramuscular; Intravenous	0.16 g
Solution	Intramuscular; Intravenous	160 mg
Solution	Intramuscular; Intravenous; Parenteral	20 mg
Solution	Intramuscular; Intravenous	20 mg
Solution	Intramuscular; Intravenous	40 mg
Solution	Intramuscular; Intravenous; Parenteral	40 mg
Solution	Intramuscular; Intravenous	80 mg
Injection	Parenteral	80 mg
Solution	Intramuscular; Intravenous; Parenteral	80 mg
Solution	Parenteral	20 mg
Solution	Intramuscular; Intravenous	16000000 mg
Solution	Parenteral	60 mg
Injection, solution		80 MG/2ML
Injection, solution	Parenteral	40 MG/2ML
Injection, solution	Parenteral	80 MG/2ML
Solution	Intravenous	3 mg
Solution	Intravenous	80 mg
Solution	Ophthalmic	3.000 mg
Solution / drops	Ophthalmic	5 ml
Solution / drops	Ophthalmic	3 mg/ml
Ointment	Ophthalmic	5 mg/g
Injection	Intramuscular; Intravenous	160 mg/2ml
Injection	Intramuscular; Intravenous	40 mg/ml
Solution / drops	Ophthalmic	3 %
Solution	Parenteral	80.000 mg
Injection, solution	Intramuscular; Intravenous
Ointment	Ophthalmic	3 mg / g
Injection, solution	Intramuscular; Intravenous	120 mg/2ml
Injection, solution	Intramuscular; Intravenous	80 mg/2ml
Solution		20 mg/2ml
Injection	Intramuscular; Intravenous	120 mg/2ml
Solution / drops	Auricular (otic); Ophthalmic	15 mg/5ml
Injection	Intramuscular; Intravenous	20 mg/2ml
Ointment	Topical	5 gr
Solution	Conjunctival; Ophthalmic	214.8 mg
Ointment	Conjunctival; Ophthalmic	0.537 g
Cream	Cutaneous
Cream	Topical	1 mg/g
Cream	Cutaneous	0.1 %
Suspension	Conjunctival; Ophthalmic
Solution / drops; suspension / drops	Ophthalmic	3 mg
Cream	Topical	1 mg
Ointment		1 mg
Solution	Parenteral	1.6 mg
Ointment		20 g
Ointment		70 g
Solution / drops	Ophthalmic; Topical	0.3 % w/v
Ointment	Conjunctival; Ophthalmic	0.3 g
Solution		140 mg/1ml
Cream	Topical	0.3 %w/w
Injection	Intramuscular	280 mg/2ml
Injection	Parenteral
Cream	Topical	0.5 mg/g
Liquid	Ophthalmic; Topical	3 mg / mL
Ointment	Ophthalmic; Topical	3 mg / g
Ointment	Ophthalmic	5 mg / g
Solution	Ophthalmic	5 mg / mL
Solution	Ophthalmic	3 mg
Ointment	Ophthalmic	3 mg
Solution	Ophthalmic	0.3 % w/v
Solution / drops	Ophthalmic	0.3 % W/V
Solution / drops	Auricular (otic)	5 mg
Cream	Cutaneous
Cream	Topical	1 mg / g
Ointment	Ophthalmic
Suspension / drops	Ophthalmic
Liquid	Ophthalmic	3 mg / mL
Ointment	Topical	.1 %
Injection, solution	Parenteral	10 mg
Solution	Intramuscular; Intravenous; Subconjunctival	10 mg/2ml
Injection, solution	Parenteral	120 mg
Solution	Intramuscular; Intravenous; Subconjunctival	120 mg/2ml
Injection, solution	Parenteral	40 mg
Solution	Intramuscular; Intravenous; Subconjunctival	40 mg/ml
Solution	Intramuscular; Intravenous; Subconjunctival	80 mg/2ml
Injection, powder, for solution	Parenteral	1.25 g
Cream	Topical	0.64 mg/g
Solution / drops	Auricular (otic); Ophthalmic
Solution	Auricular (otic)	3 mg / mL
Bead
Implant	Parenteral	4.5 mg
Drug delivery system	Topical	1.7 mg
Implant; sponge	Intralesional
Solution	Intramuscular	160.000 mg
Solution / drops	Ophthalmic	3 mg/5mL
Injection, solution	Intramuscular; Intravenous	20 mg/2ml
Injection, solution	Intramuscular; Intravenous	40 mg/ml
Ointment	Ophthalmic; Topical	0.3 g
Solution		10 mg/1ml
Liquid	Auricular (otic); Ophthalmic
Cream	Topical	0.1 %w/w
Solution		40 mg/1ml
Ointment

Prices

Unit description	Cost	Unit
Gentak 0.3% Ointment 3.5 gm Tube	19.99USD	tube
Gentamicin Sulfate 0.1% Cream 15 gm Tube	12.99USD	tube
Gentamicin Sulfate 0.1% Ointment 15 gm Tube	11.99USD	tube
Gentamicin Sulfate 0.3% Solution 5ml Bottle	11.99USD	bottle
Gentamicin sulfate powder	5.05USD	g
Gentamicin Sulfate 10 mg/ml Solution 2ml Vial	5.0USD	vial
Gentamicin 40 mg/ml	2.82USD	ml
Gentamicin ped 10 mg/ml vial	2.4USD	ml
Gentak 3 mg/ml eye drops	1.91USD	ml
Gentamicin 3 mg/ml eye drops	1.89USD	ml
Gentamicin 10 mg/ml vial	1.29USD	ml
Garamycin 0.3 % Ointment	1.2USD	g
Sandoz Gentamicin Sulfate 0.3 % Ointment	1.2USD	g
Garamycin 0.3 % Solution	0.75USD	ml
Sandoz Gentamicin Sulfate 0.3 % Solution	0.75USD	ml
Gentamicin 40 mg/ml vial	0.45USD	ml
Ratio-Gentamicin Sulfate 0.1 % Cream	0.43USD	g
Ratio-Gentamicin Sulfate 0.1 % Ointment	0.37USD	g
Gentamicin 0.1% cream	0.16USD	g
Iso gentamicin 120 mg/100 ml	0.09USD	ml
Gentamicin 90 mg/ns 100 ml pb	0.05USD	ml
Isoton gentamicin 40 mg/100 ml	0.05USD	ml
Gentamicin 60 mg/ns 100 ml pb	0.04USD	ml
Gentamicin 100 mg/ns 100 ml	0.03USD	ml
Gentamicin 80 mg/ns 100 ml pb	0.03USD	ml

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	105 °C	PhysProp
logP	-3.1	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	12.6 mg/mL	ALOGPS
logP	-1.6	ALOGPS
logP	-3.1	Chemaxon
logS	-1.6	ALOGPS
pKa (Strongest Acidic)	12.55	Chemaxon
pKa (Strongest Basic)	10.12	Chemaxon
Physiological Charge	5	Chemaxon
Hydrogen Acceptor Count	12	Chemaxon
Hydrogen Donor Count	8	Chemaxon
Polar Surface Area	199.73 Å²	Chemaxon
Rotatable Bond Count	19	Chemaxon
Refractivity	118.02 m³·mol^-1	Chemaxon
Polarizability	51.52 Å³	Chemaxon
Number of Rings	9	Chemaxon
Bioavailability	0	Chemaxon
Rule of Five	No	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	Yes	Chemaxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	-	0.944
Blood Brain Barrier	-	0.9826
Caco-2 permeable	-	0.6987
P-glycoprotein substrate	Substrate	0.6882
P-glycoprotein inhibitor I	Non-inhibitor	0.6808
P-glycoprotein inhibitor II	Non-inhibitor	0.9586
Renal organic cation transporter	Non-inhibitor	0.8738
CYP450 2C9 substrate	Non-substrate	0.8001
CYP450 2D6 substrate	Non-substrate	0.8314
CYP450 3A4 substrate	Substrate	0.5917
CYP450 1A2 substrate	Non-inhibitor	0.9034
CYP450 2C9 inhibitor	Non-inhibitor	0.891
CYP450 2D6 inhibitor	Non-inhibitor	0.9331
CYP450 2C19 inhibitor	Non-inhibitor	0.9043
CYP450 3A4 inhibitor	Non-inhibitor	0.9517
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9294
Ames test	Non AMES toxic	0.7338
Carcinogenicity	Non-carcinogens	0.9696
Biodegradation	Not ready biodegradable	0.9588
Rat acute toxicity	2.0383 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9954
hERG inhibition (predictor II)	Non-inhibitor	0.8784

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available
Chromatographic Properties: Collision Cross Sections (CCS)
Not Available

Targets

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insights and accelerate drug research.

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Details1. 30S ribosomal protein S12

Kind: Protein
Organism: Escherichia coli (strain K12)
Pharmacological action: Yes
Actions: Binder

General Function: Trna binding
Specific Function: With S4 and S5 plays an important role in translational accuracy.Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Lo...
Gene Name: rpsL
Uniprot ID: P0A7S3
Uniprot Name: 30S ribosomal protein S12
Molecular Weight: 13736.995 Da

References

Gill AE, Amyes SG: The contribution of a novel ribosomal S12 mutation to aminoglycoside resistance of Escherichia coli mutants. J Chemother. 2004 Aug;16(4):347-9. [Article]
Tamehiro N, Hosaka T, Xu J, Hu H, Otake N, Ochi K: Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl Environ Microbiol. 2003 Nov;69(11):6412-7. [Article]
Hu H, Ochi K: Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations. Appl Environ Microbiol. 2001 Apr;67(4):1885-92. [Article]
Schroeder R, Waldsich C, Wank H: Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 2000 Jan 4;19(1):1-9. [Article]

Details2. 16S ribosomal RNA

Kind

Nucleotide

Organism

Enteric bacteria and other eubacteria

Pharmacological action

Yes

Actions

Binder

In prokaryotes, the 16S rRNA is essential for recognizing the 5' end of mRNA and hence positioning it correctly on the ribosome. The 16S rRNA has a characteristic secondary structure in which half of the nucleotides are base-paired. The 16S rRNA sequence has been highly conserved and is often used for evolutionary and species comparative analysis.

References

Doi Y, de Oliveira Garcia D, Adams J, Paterson DL: Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil. Antimicrob Agents Chemother. 2007 Mar;51(3):852-6. Epub 2006 Dec 11. [Article]
Bogaerts P, Galimand M, Bauraing C, Deplano A, Vanhoof R, De Mendonca R, Rodriguez-Villalobos H, Struelens M, Glupczynski Y: Emergence of ArmA and RmtB aminoglycoside resistance 16S rRNA methylases in Belgium. J Antimicrob Chemother. 2007 Mar;59(3):459-64. Epub 2007 Jan 15. [Article]
Aslangul E, Massias L, Meulemans A, Chau F, Andremont A, Courvalin P, Fantin B, Ruimy R: Acquired gentamicin resistance by permeability impairment in Enterococcus faecalis. Antimicrob Agents Chemother. 2006 Nov;50(11):3615-21. [Article]
Schroeder R, Waldsich C, Wank H: Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 2000 Jan 4;19(1):1-9. [Article]

Details3. 23S ribosomal RNA

Kind

Nucleotide

Organism

Enteric bacteria and other eubacteria

Pharmacological action

Yes

Actions

Inhibitor

In prokaryotes, the 23S rRNA is part of the large subunit (the 50S) that joins with the 30S small subunit to create the functional 70S ribosome. The ribosome is comprised of 3 RNAs: the 23S, the 16S and the 5S ribosomal RNAs. The 23S and the 5S associate with their respective proteins to make up the large subunit of the ribosome, while the 16S RNA associates with its proteins to make up the small subunit.

References

Ying L, Zhu H, Shoji S, Fredrick K: Roles of specific aminoglycoside-ribosome interactions in the inhibition of translation. RNA. 2019 Feb;25(2):247-254. doi: 10.1261/rna.068460.118. Epub 2018 Nov 9. [Article]
Borovinskaya MA, Pai RD, Zhang W, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH: Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol. 2007 Aug;14(8):727-32. doi: 10.1038/nsmb1271. Epub 2007 Jul 29. [Article]

4. Bacterial outer membrane

Kind

Group

Organism

Bacteria

Pharmacological action

Yes

Actions

Incorporation into and destabilization

References

Serio AW, Keepers T, Andrews L, Krause KM: Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018. [Article]
Moore RA, Bates NC, Hancock RE: Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxin. Antimicrob Agents Chemother. 1986 Mar;29(3):496-500. doi: 10.1128/aac.29.3.496. [Article]
Hancock RE, Raffle VJ, Nicas TI: Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1981 May;19(5):777-85. doi: 10.1128/aac.19.5.777. [Article]
Taber HW, Mueller JP, Miller PF, Arrow AS: Bacterial uptake of aminoglycoside antibiotics. Microbiol Rev. 1987 Dec;51(4):439-57. [Article]

5. Cytoplasmic membrane

Kind

Group

Organism

Bacteria

Pharmacological action

Yes

Actions

Incorporation into and destabilization

References

Serio AW, Keepers T, Andrews L, Krause KM: Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018. [Article]
Taber HW, Mueller JP, Miller PF, Arrow AS: Bacterial uptake of aminoglycoside antibiotics. Microbiol Rev. 1987 Dec;51(4):439-57. [Article]
Davis BD, Chen LL, Tai PC: Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proc Natl Acad Sci U S A. 1986 Aug;83(16):6164-8. doi: 10.1073/pnas.83.16.6164. [Article]

Details6. NH(3)-dependent NAD(+) synthetase

Kind: Protein
Organism: Bacillus subtilis (strain 168)
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Nad+ synthase activity
Specific Function: Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction.
Gene Name: nadE
Uniprot ID: P08164
Uniprot Name: NH(3)-dependent NAD(+) synthetase
Molecular Weight: 30394.995 Da

References

Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ: Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem. 2003 Jul 17;46(15):3371-81. [Article]

Details7. Dihydrofolate reductase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Nadph binding
Specific Function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA pre...
Gene Name: DHFR
Uniprot ID: P00374
Uniprot Name: Dihydrofolate reductase
Molecular Weight: 21452.61 Da

References

Al-Omary FA, Abou-Zeid LA, Nagi MN, Habib el-SE, Abdel-Aziz AA, El-Azab AS, Abdel-Hamide SG, Al-Omar MA, Al-Obaid AM, El-Subbagh HI: Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem. 2010 Apr 15;18(8):2849-63. doi: 10.1016/j.bmc.2010.03.019. Epub 2010 Mar 12. [Article]

Transporters

Details1. Solute carrier family 22 member 2

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Quaternary ammonium group transmembrane transporter activity
Specific Function: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creat...
Gene Name: SLC22A2
Uniprot ID: O15244
Uniprot Name: Solute carrier family 22 member 2
Molecular Weight: 62579.99 Da

References

Gai Z, Visentin M, Hiller C, Krajnc E, Li T, Zhen J, Kullak-Ublick GA: Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5573-80. doi: 10.1128/AAC.00907-16. Print 2016 Sep. [Article]

Details2. Low-density lipoprotein receptor-related protein 2

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Calcium ion binding
Specific Function: Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
Gene Name: LRP2
Uniprot ID: P98164
Uniprot Name: Low-density lipoprotein receptor-related protein 2
Molecular Weight: 521952.77 Da

References

Watanabe A, Nagai J, Adachi Y, Katsube T, Kitahara Y, Murakami T, Takano M: Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists. J Control Release. 2004 Mar 24;95(3):423-33. [Article]
Takamoto K, Kawada M, Ikeda D, Yoshida M: Apolipoprotein E3 (apoE3) safeguards pig proximal tubular LLC-PK1 cells against reduction in SGLT1 activity induced by gentamicin C. Biochim Biophys Acta. 2005 Apr 15;1722(3):247-53. [Article]
Nagai J, Saito M, Adachi Y, Yumoto R, Takano M: Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides. J Control Release. 2006 May 1;112(1):43-50. Epub 2006 Feb 20. [Article]
Elsakka EGE, Elsisi AM, Mansour OAA, Elsadek BEM, Abd Elaziz AI, Salama SA, Allam S: Androgen/androgen receptor affects gentamicin-induced nephrotoxicity through regulation of megalin expression. Life Sci. 2020 Jun 15;251:117628. doi: 10.1016/j.lfs.2020.117628. Epub 2020 Apr 2. [Article]
Dagil R, O'Shea C, Nykjaer A, Bonvin AM, Kragelund BB: Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin. J Biol Chem. 2013 Feb 8;288(6):4424-35. doi: 10.1074/jbc.M112.434159. Epub 2012 Dec 27. [Article]

Details3. Canalicular multispecific organic anion transporter 1

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Organic anion transmembrane transporter activity
Specific Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name: ABCC2
Uniprot ID: Q92887
Uniprot Name: Canalicular multispecific organic anion transporter 1
Molecular Weight: 174205.64 Da

References

Notenboom S, Wouterse AC, Peters B, Kuik LH, Heemskerk S, Russel FG, Masereeuw R: Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. J Pharmacol Exp Ther. 2006 Sep;318(3):1194-202. doi: 10.1124/jpet.106.104547. Epub 2006 Jun 6. [Article]

Drug created at June 13, 2005 13:24 / Updated at May 03, 2024 10:05

Gentamicin

Identification

Structure for Gentamicin (DB00798)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

References

References

References

References

References

References

References

Transporters

References

References

References