- Hugh Jackman
- Gabriel Van Helsing
- Kate Beckinsale
- Anna Valerious
- Richard Roxburgh
- Count Vladislaus Dracula
- David Wenham
- Carl
- Shuler Hensley
- Frankenstein's Monster
- Elena Anaya
- Aleera
- Will Kemp
- Velkan
- Kevin J. O'Connor
- Igor
- Alun Armstrong
- Cardinal Jinette
- Silvia Colloca
- Verona
- Josie Maran
- Marishka
- Tom Fisher
- Top Hat
- Samuel West
- Dr. Victor Frankenstein
- Robbie Coltrane
- Mr. Hyde
- Stephen Sommers
- Director, Producer, Writer
- Alan Silvestri
- Original Music
- Allen Daviau
- Cinematographer
- Bob Ducsay
- Film Editing, Producer
- Steve Arnold
- Art Director
- Cindy Carr
- Set Decoration, Set Director
- Gabriella Pescucci
- Costume Design
- Sam Mercer
- Executive Producer
- Allan Cameron
- Production Design
- Kelly Matsumoto
- Film Editing
- Carlo Poggioli
- Costume Design
- R.A. Rondell
- Stunt Coordinator
- Anna Pinnock
- Set Director
- Joanna Colbert
- Casting
- Priscilla John
- Casting
- Ellen Lewis
- Casting
