- Keanu Reeves
- Thomas A. Anderson/Neo
- Laurence Fishburne
- Morpheus
- Carrie-Anne Moss
- Trinity
- Hugo Weaving
- Agent Smith
- Jada Pinkett Smith
- Niobe
- Gloria Foster
- Oracle
- Harold Perrineau
- Link
- Monica Bellucci
- Persephone
- Harry Lennix
- Commander Lock
- Lambert Wilson
- Merovingian
- Randall Duk Kim
- Keymaker
- Anthony Zerbe
- Councillor Hamann
- Helmut Bakaitis
- The Architect
- Neil Rayment
- Twin
- Adrian Rayment
- Twin
- Lilly Wachowski
- Director, Executive Producer, Writer
- Lana Wachowski
- Director, Executive Producer, Writer
- Grant Hill
- Executive Producer
- Bruce Berman
- Executive Producer
- Andrew Mason
- Executive Producer
- Joel Silver
- Producer
- Bill Pope
- Cinematographer
- Owen Paterson
- Production Design
- Zach Staenberg
- Film Editing
- Don Davis
- Conductor, Original Music
- Kym Barrett
- Costume Design
- John Gaeta
- Visual Effects Supervisor
- Woo-Ping Yuen
- Fight Choreographer
- Dane A. Davis
- Sound Designer, Supervising Sound Editor
- Jules Cook
- Art Director
- Nanci Noblett
- Art Director
- Mali Finn
- Casting
- Shauna Wolifson
- Casting
