- Melissa McCarthy
- Tammy, Producer, Screenwriter
- Susan Sarandon
- Pearl
- Kathy Bates
- Lenore
- Allison Janney
- Deb
- Dan Aykroyd
- Don
- Mark Duplass
- Bobby
- Gary Cole
- Earl
- Toni Collette
- Missi
- Nat Faxon
- Greg
- Sandra Oh
- Susanne
- Ben Falcone
- Keith Morgan, Screenwriter, Director, Executive Producer
- Sarah Baker
- Becky
- Rich Williams
- Larry
- Steve Little
- Jet Ski Rental Guy
- Dakota Lee
- Kathleen
- Mark L. Young
- Jesse
- Mia Rose Frampton
- Karen
- Ben Falcone
- Keith Morgan, Screenwriter, Director, Executive Producer
- Melissa McCarthy
- Tammy, Producer, Screenwriter
- Will Ferrell
- Producer
- Adam McKay
- Producer
- Rob Cowan
- Executive Producer
- Chris Henchy
- Executive Producer
- Kevin J. Messick
- Executive Producer
- Toby Emmerich
- Executive Producer
- Richard Brener
- Executive Producer
- Michael Disco
- Executive Producer
- Russ T. Alsobrook
- Cinematographer
- Jefferson Sage
- Production Design
- Michael L. Sale
- Film Editing
- Michael Andrews
- Original Music
- Wendy Chuck
- Costume Design
- Allison Jones
- Casting
- Richard Fojo
- Art Director
- Marthe Pineau
- Set Decoration
