Assay of Ibuprofen: Medicinal Chemistry Practical

Aim

To carry out the assay of Ibuprofen tablet

REFERENCE:

1. Indian Pharmacopoeia 2018 page no:2261-65.

REQUIREMENTS:

Ibuprofen,0.1N sodium hydroxide solution, phenolphthalein indicator, 0.1N oxalic acid solution, conical flask, burette, beaker etc.

PRINCIPLE:

Ibuprofen is determined by neutralization titration in which free carboxylic group is titrated with sodium hydroxide solution using phenolphthalein indicator. The amount of sodium hydroxide consumed in the reaction indicates the amount of ibuprofen present in the sample.

PROCEDURE:

PREPARATION AND STANDARDIZATION OF STANDARD SOLUTIONS

SODIUM HYDROXIDE,XM

Solutions of any molarity xM may be prepared by dissolving 40x g of Sodium hydroxide in sufficient water to produce 1000ml.

STANDARDIZATION OF 0.1M SODIUM HYDROXIDE SOLUTION

Weighed accurately about 5g of potassium hydrogen phthalate previously dried at 1200C for two hours dissolve in 75ml of carbon dioxide free water.

Added 0.1ml of phenolphthalein solution and titrate with the sodium hydroxide until a permanent pink color is produced.

Each ml of 0.1M NaOH equivalent to 0.02042g of potassium hydrogen phthalate.

Phenolphthalein solution

A 1.0%w/v solution of phenolphthalein in ethanol(95%).

PROCEDURE:

Weighed and powdered 20 tablets.

Weighed a quantity of powder containing about 0.4g of ibuprofen, dissolve in 100ml of ethanol (95%) and titrated with 0.1M sodium hydroxide using 0.2ml of phenolphthalein solution as indicator. Perform a blank determination and make necessary correction.

Each ml of 0.1 M sodium hydroxide is equivalent to 0.02063 g of C13 H18 O2

REPORT

The given sample contains …………………. mg of Ibuprofen.

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Assay of Ibuprofen: Medicinal Chemistry Practical