Abstract
Various 1-arylcyclohexylamines were synthesized for evaluation as central nervous system depressants. The compounds were prepared by several procedures. 1-(1-Phenylcyclohexyl)piperidine, the first compound of this type synthesized, was prepared from 1-piperidinocyclohexanecarbonitrile by replacement of the cyano group by phenyl using phenylmagnesium bromide. These compounds were tested for cataleptoid activity and antitonic extensor properties.
Original language | English |
---|---|
Pages (from-to) | 230-235 |
Number of pages | 6 |
Journal | Journal of Medicinal Chemistry |
Volume | 8 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1965 |