New Horizons in the Diagnosis of Neonatal Sepsis: A Closer Look at IL-6

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Assumma M, Signore F, Pacifico L, et al. Serum procalcitonin concentrations in term delivering mothers and their healthy offspring: a longitudinal study. Clin Chem. 2000;46:1583-1587.
Brown JVE, Meader N, Wright K, et al. Assessment of C-reactive protein diagnostic test accuracy for late-onset infection in newborn infants a systematic review and meta-analysis. JAMA Pediatrics. 2020;174:260-268.
Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013;60:367-389.
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Ebenebe C, Hesse F, Blohm ME, et al. Diagnostic accuracy of interleukin-6 for early-onset sepsis in preterm neonates. J Matern Fetal Neonatal Med. 2021;34:253-258.
Ebenebe CU, Boiger A, Perez A, et al. Interleukin-6 elevation in healthy neonates. J Perinatol. 2020;40:294-298.
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Hornik CP, Benjamin DK, Becker KC, et al. Use of the complete blood cell count in early-onset neonatal sepsis. Pediatr Infect Dis. 2012;31:799-802.
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Faculty

Lee A. Polikoff, MD

Assistant Professor of Pediatrics
Division of Pediatric Critical Care Medicine
The Warren Alpert School of Medicine
Brown University
Providence, Rhode Island, United States

Disclosures

Disclosure: Lee A. Polikoff, MD, has disclosed no relevant financial relationships.

Irwin Reiss, MD, PhD

Professor of Medicine and Pediatrics
Department of Neonatology
Erasmus MC -- Sophia Children's Hospital
Rotterdam, the Netherlands

Disclosures

Disclosure: Irwin Reiss, MD, PhD, has disclosed no relevant financial relationships.

Chinedu Ulrich Ebenebe, MD, MBA

Senior Researcher
Division of Neonatology and Pediatric Intensive Care
University Medical Center Hamburg-Eppendorf
Hamburg, Germany

Disclosures

Disclosure: Chinedu Ulrich Ebenebe, MD, MBA, has disclosed no relevant financial relationships.

Editors

Roderick Smith, MS

Senior Medical Education Director
Medscape, LLC

Disclosures

Disclosure: Roderick Smith, MS, has disclosed no relevant financial relationships

Ryan Blanchard, BS

Scientific Content Manager
Medscape, LLC

Disclosures

Disclosure: Ryan Blanchard, BS, has disclosed no relevant financial relationships

CME Reviewer

Robert Morris, PharmD

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Disclosure: Robert Morris, PharmD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: ViiV Healthcare
Owns stock, stock options, or bonds from: GlaxoSmithKline

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

CME

New Horizons in the Diagnosis of Neonatal Sepsis: A Closer Look at IL-6

Authors: Lee A. Polikoff, MD; Irwin Reiss, MD, PhD; Chinedu Ulrich Ebenebe, MD, MBA
CME Released: 2/8/2021
THIS ACTIVITY HAS EXPIRED FOR CREDIT
Valid for credit through: 2/8/2022, 11:59 PM EST

Start Activity

Target Audience and Goal Statement

This activity is intended for OB/GYNs, critical care specialists, and pediatricians.

The goal of this activity is to advance clinicians' knowledge regarding the pathophysiology of interleukin (IL)-6 in early-onset sepsis in neonates and to improve their competence related to the use of biomarkers, including IL-6, to allow for earlier diagnosis and treatment of neonatal sepsis.

Upon completion of this activity, participants will:

Have increased knowledge regarding the
- Role of IL-6 as a biomarker in early-onset sepsis among neonates
- Key data evaluating the use of different biomarkers for neonatal sepsis
Have greater competence related to
- Incorporating biomarkers into the diagnosis of neonatal sepsis

Disclosures

Faculty

Lee A. Polikoff, MD

Assistant Professor of Pediatrics
Division of Pediatric Critical Care Medicine
The Warren Alpert School of Medicine
Brown University
Providence, Rhode Island, United States

Disclosures

Disclosure: Lee A. Polikoff, MD, has disclosed no relevant financial relationships.

Irwin Reiss, MD, PhD

Professor of Medicine and Pediatrics
Department of Neonatology
Erasmus MC -- Sophia Children's Hospital
Rotterdam, the Netherlands

Disclosures

Disclosure: Irwin Reiss, MD, PhD, has disclosed no relevant financial relationships.

Chinedu Ulrich Ebenebe, MD, MBA

Senior Researcher
Division of Neonatology and Pediatric Intensive Care
University Medical Center Hamburg-Eppendorf
Hamburg, Germany

Disclosures

Disclosure: Chinedu Ulrich Ebenebe, MD, MBA, has disclosed no relevant financial relationships.

Editors

Roderick Smith, MS

Senior Medical Education Director
Medscape, LLC

Disclosures

Disclosure: Roderick Smith, MS, has disclosed no relevant financial relationships

Ryan Blanchard, BS

Scientific Content Manager
Medscape, LLC

Disclosures

Disclosure: Ryan Blanchard, BS, has disclosed no relevant financial relationships

CME Reviewer

Robert Morris, PharmD

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Disclosure: Robert Morris, PharmD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: ViiV Healthcare
Owns stock, stock options, or bonds from: GlaxoSmithKline

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

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From Medscape Education Pediatrics

CME

New Horizons in the Diagnosis of Neonatal Sepsis: A Closer Look at IL-6

Authors: Lee A. Polikoff, MD; Irwin Reiss, MD, PhD; Chinedu Ulrich Ebenebe, MD, MBAFaculty and Disclosures

THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME Released: 2/8/2021

Valid for credit through: 2/8/2022, 11:59 PM EST

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Educational Impact Challenge

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The educational activity presented above may involve simulated, case-based scenarios. The patients depicted in these scenarios are fictitious and no association with any actual patient, whether living or deceased, is intended or should be inferred. The material presented here does not necessarily reflect the views of Medscape, LLC, or any individuals or commercial entities that support companies that support educational programming on medscape.org. These materials may include discussion of therapeutic products that have not been approved by the US Food and Drug Administration, off-label uses of approved products, or data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal. Readers should verify all information and data before treating patients or employing any therapies described in this or any educational activity. A qualified healthcare professional should be consulted before using any therapeutic product discussed herein.

References

Faculty and Disclosures

Faculty

Lee A. Polikoff, MD

Irwin Reiss, MD, PhD

Chinedu Ulrich Ebenebe, MD, MBA

Editors

Roderick Smith, MS

Ryan Blanchard, BS

CME Reviewer

Robert Morris, PharmD

CME

New Horizons in the Diagnosis of Neonatal Sepsis: A Closer Look at IL-6

Target Audience and Goal Statement

Disclosures

Faculty

Lee A. Polikoff, MD

Irwin Reiss, MD, PhD

Chinedu Ulrich Ebenebe, MD, MBA

Editors

Roderick Smith, MS

Ryan Blanchard, BS

CME Reviewer

Robert Morris, PharmD

Accreditation Statements

For Physicians

Instructions for Participation and Credit

New Horizons in the Diagnosis of Neonatal Sepsis: A Closer Look at IL-6

Educational Impact Challenge

Expert Commentary