Each team is limited to their in-game powers and movesets (no cutscenes/tie-in material) from the Injustice and Marvel Vs. Capcom games.
Takes place in the Watchtower stage from Injustice.
Justice League:
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Aquaman
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Batman
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Flash
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Green Arrow
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Green Lantern
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Martian Manhunter
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Shazaam
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Scorpion
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Superman
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Wonder Woman
Avengers:
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Captain America
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Doctor Strange
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Ghost Rider
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Hawkeye
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Hulk
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Iron Man
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Nemesis
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Spider-Man
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Thor
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Wolverine
Bonus Round: Regime Superman Vs. Galactus