The management of patients at risk for a low-frequency but serious illness poses many challenges for health professionals. Neonatal early-onset sepsis (EOS) in late-preterm and term neonates is a classic example of such a low-frequency serious condition. Faced with the possibility that such an infant, even if well appearing, can develop EOS, clinicians have traditionally erred on the side of treating with antibiotics until the EOS is ruled out by some combination of a continued normal clinical examination, negative blood cultures, and negative rapid diagnostic test results. A liberal antibiotic treatment strategy resulted in a large number (as high as several hundreds) of infants being needlessly treated with antibiotics for every neonate with true EOS. This strategy has been relatively easy for clinicians to follow because the burden of administering a short course of antibiotics is relatively low, and the adverse effects of antibiotics (eg, emergence of antibiotic resistance, altered...
Skip Nav Destination
Article navigation
April 2019
Commentaries|
April 01 2019
Management of Late-Preterm and Term Neonates at Risk for Early-Onset Sepsis
Gautham Suresh, MD, DM, MS, FAAP;
Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, Texas
Address correspondence to Gautham Suresh, MD, DM, MS, FAAP, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, 6621 Fannin St, Suite W6104, Houston, TX 77030. E-mail: gksuresh@texaschildrens.org
Search for other works by this author on:
Mohan Pammi, MD, PhD
Mohan Pammi, MD, PhD
Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, Texas
Search for other works by this author on:
Address correspondence to Gautham Suresh, MD, DM, MS, FAAP, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, 6621 Fannin St, Suite W6104, Houston, TX 77030. E-mail: gksuresh@texaschildrens.org
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
Hosp Pediatr (2019) 9 (4): 311–313.
Citation
Gautham Suresh, Mohan Pammi; Management of Late-Preterm and Term Neonates at Risk for Early-Onset Sepsis. Hosp Pediatr April 2019; 9 (4): 311–313. https://doi.org/10.1542/hpeds.2019-0005
Download citation file:
Comments