Books

Contents:
G protein-coupled receptors : research and methods in the post-genomic era / Craig W. Stevens
Examining the dynamic evolution of G protein-coupled receptors / Claudia Stäubert, Diana Le Duc, and Torsten Schöneberg
Functional properties of virus-encoded and virus-regulated G protein-coupled receptors / Katja Spiess and Mette M. Rosenkilde
Discovery and function of the very large G protein-coupled receptor / Perrin C. White and D. Randy McMillan
Functional evolution of opioid family G protein-coupled receptors / Eyal Vardy, Craig W. Stevens, and Bryan L. Roth
Investigation of G protein-coupled receptor function and regulation using antisense / Jonathon Willets and Craig Nash
Signalosome profiling reveals allosteric interactions between G protein-coupled receptors / Katrin Altosaar ... [et al.]
Use of optogenetic approaches to control intracellular signaling of G protein-coupled receptors / Olivia A. Masseck, Melanie D. Mark, and Stefan Herlitze
Viral infection for G protein-coupled receptor expression in eukaryotic cells / Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi
Using in vitro mutagenesis to characterize structure- function relationships in G protein-coupled receptors / Gregory W. Sawyer and Frederick J. Ehlert
CRE Luc Mouse model for bioimaging ligand activation of G protein-coupled receptors / H. Gregory Polites and Kyriakos D. Economides
Inducing conformational changes in G protein-coupled receptors by domain coupling / Hamiyet Unal and Sadashiva S. Karnik
Rescue of defective G protein-coupled receptor function by intermolecular cooperation / Ashutosh Trehan ... [et al.]
Design of super-arrestins for gene therapy of diseases associated with excessive signaling of G protein-coupled receptors / Vsevolod V. Gurevich and Eugenia V. Gurevich
Importance of G protein-coupled receptor genetics in clinical medicine / Ramakrishna Devaki
Pharmacogenomics of G protein-coupled receptor signaling and other pathways in essential hypertension / Pedro A. Jose ... [et al.]
Exon sequencing of G protein-coupled receptor genes and perspectives for disease treatment / Angeliki Karamitri and Ralf Jockers
Gene therapy using G protein-coupled receptors for the treatment of cardiovascular disease / Dario Leosco ... [et al.]
Novel mechanisms of G protein-coupled receptor oligomer and ion channel Iiteractions in nociception / Ajay S. Yekkirala
Discovery and characterization of leucine-rich repeat-containing G protein-coupled receptors / Marie-Isabelle Garcia, Valeria Fernandez-Vallone, and Gilbert Vassart
Role of G protein-coupled receptors in adult neurogenesis / Katie M. Collette, Van A. Doze, and Dianne M. Perez.

Contents:
G protein-coupled receptors : an overview of signaling mechanisms and screening assays / Duarte Miguel F. Prazeres and Sofia Aires M. Martins
Time-resolved FRET strategy to screen GPCR ligand library / Nadia Oueslati [and others]
Homogeneous fluorescence anisotropy-based assay for characterization of ligand binding dynamics to GPCRs in budded baculoviruses : the case of Cy3B-NDP-α-MSH binding to MC4 receptors / Santa Veiksina . . [and others]
Construction of recombinant HEK293 cell lines for the expression of the neurotensin receptor NTSR1 / Su Xiao, Joseph Shiloach, and Reinhard Grisshammer
cAMP assay for GPCR ligand characterization : application of BacMam expression system / Olga Mazina [and others]
Ca2+ mobilization assays in GPCR drug discovery / Grzegorz Woszczek and Elisabeth Fuerst
Using constitutive activity to define appropriate high- throughput screening assays for orphan G protein-coupled receptors / Tony Ngo, James L.J. Coleman, and Nicola J. Smith
Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV / Michael C. Wehr, Sabrina Galinski, and Moritz J. Rossner
Quantifying GPCR iternalization : a focus on the kisspeptin receptor / Macarena Pampillo and Andy V. Babwah
GPCR oligomerization analysis by means of BRET and dFRAP / Francisco Ciruela and Víctor Fernández-Dueñas
Use of imageJ to recover information from individual cells in a G protein-coupled receptor assay / João R.C. Trabuco, Sofia Aires M. Martins, and Duarte Miguel F. Prazeres
Methods to immobilize GPCR on the surface of SPR sensors / Laura Martínez-Muñoz [and others]
Olfactory receptor screening assay using nanovesicle- immobilized carbon nanotube transistor / Jong Hyun Lim [and others]
Label-free biosensor assays in GPCR screening / Manuel Grundmann and Evi Kostenis
Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay / Ning Ke [and others]
Label-free functional selectivity assays / Ann M. Ferrie [and others]
Measurement of surface-mediated Ca2+ transients on the single-cell level in a microfluidic lab-on-a-chip environment / Michael Kirschbaum, Magnus S. Jaeger, and Claus Duschl
Cell-based assays and animal models for GPCR drug screening / Hideo Takakura [and others]
Computer-aided design of GPCR ligands / Hugo Gutiérrez-de-Terán [and others].

Summary: G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.--Back cover.

Contents:
Pt. I. Progress in structural modeling of GPCRs
The GPCR crystallography boom: providing an invaluable source of structural information and expanding the scope of homology modeling
Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes
Pt. II. GPCRs in motion: insights from simulations
Structure and dynamics of G-protein coupled receptors
How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment
Coarse-grained molecular dynamics provides insights into the interactions of lipids and cholesterol with rhodopsin
Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods
Pt. III. GPCR-focused design and mathematical modeling
From three-dimensional GPCR structure to rational ligand discovery
Mathematical modeling of G protein-coupled receptor function: what can we learn from empirical and mechanistic models?
Pt. IV. Bioinformatics tools and resources for GPCRs
GPCR & company: databases and servers for GPCRs and interacting partners
Bioinformatics tools for predicting GPCR gene functions.

Contents:
Purification of stabilized GPCRs for structural and biophysical analyses / James C. Errey ... [et al.]
Purification and crystallization of a thermostabilized agonist-bound conformation of the human adenosine A2A receptor / Christopher G. Tate and Guillaume Lebon
2D projection analysis of GPCR complexes by negative stain electron microscopy / Alys Peisley and Georgios Skiniotis
Nuts and bolts of CF3 and CH3 NMR towards the understanding of conformational exchange of GPCRs / R. Scott Prosser and Tae Hun Kim
Single-molecule fluorescence microscopy for the analysis of fast receptor dynamics / Julia Wagner ... [et al.]
Quantitative multi-color detection strategies for bioorthogonally labeled GPCRs / Minyoung Park ... [et al.]
Approaches to characterize and quantify oligomerization of GPCRs / Sara Marsango, María José Varela, and Graeme Milligan
Monitoring G protein activation in cells with BRET / Ikuo Masuho, Kirill A. Martemyanov, and Nevin A. Lambert
Use of fluorescence indicators in receptor ligands / Kaleeckal G. Harikumar and Laurence J. Miller
Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging / Michelle L. Halls ... [et al.]
Measurement of receptor signaling bias / Terry Kenakin
Approaches to assess functional selectivity in GPCRs : evaluating G protein signaling in an endogenous environment / Laura M. Bohn, Lei Zhou, and Jo-Hao Ho
Bioluminescence resonance energy transfer approaches to discover bias in GPCR signaling / Elizabeth K. M. Johnstone and Kevin D. G. Pfleger
Virus-mediated expression of DREADDs for in vivo metabolic studies / Mario Rossi ... [et al.]
High-throughput screening for allosteric modulators of GPCRs / Robert L. Bertekap Jr. ... [et al.]
Radioligand binding assay for an exon 11-associated mu opioid receptor target / Gina F. Marrone, Susruta Majumdar, and Gavril W. Pasternak
Docking and virtual screening strategies for GPCR drug discovery / Thijs Beuming ... [et al.]
Dynamic process of drug-GPCR binding at either orthosteric or allosteric sites evaluated by metadynamics / Sebastian Schneider, Davide Provasi, and Marta Filizola
Experiment-guided molecular modeling of protein-protein complexes involving GPCRs / Irina Kufareva, Tracy M. Handel, and Ruben Abagyan
Interaction fingerprints and their applications to identify hot spots / Andrés F. Marmolejo ... [et al.].

Summary: "The second edition of Gabbard's Textbook of Psychotherapeutic Treatments provides up-to-date information on psychotherapies, including psychodynamic therapies, mentalization-based treatment, transference-focused therapy, cognitive-behavioral therapy, supportive psychotherapy, and interpersonal psychotherapy. The textbook also reflects social changes that have had profound impacts on how therapists practice, including the advancement of LGBTQ rights, calls for racial and social justice, and the COVID-19 pandemic"-- Provided by publisher.

Contents:
Intellectual disability (intellectual developmental disorder)
Communication disorders
Autism spectrum disorder
Attention-deficit/hyperactivity disorder
Specific learning disorder
Tic disorders
Elimination disorders
Early-stage schizophrenia
Toward a dimensional understanding of psychosis and its treatment
Psychosocial treatments for chronic psychosis
Pharmacological treatment of psychosis
Psychotherapy of mood disorders
Acute and maintenance treatment of bipolar and related disorders
Pharmacological and somatic treatments for major depressive disorder
Brain stimulation treatments for mood disorders
Panic disorder
Separation anxiety disorder
Social anxiety disorder (social phobia)
Generalized anxiety disorder
Specific phobia
Obsessive-compulsive disorder
Body dysmorphic disorder
Hoarding disorder, trichotillomania (hair-pulling disorder), and excoriation (skin-picking) disorder
Dissociative identity disorder
Depersonalization/derealization disorder
Dissociative amnesia
Posttraumatic stress disorder
Acute stress disorder
Adjustment disorders
Evidence-based psychological treatments for eating disorders
Pharmacological treatment of eating disorders
Intensive treatment for eating disorders
Primary care and consultation-liaison interventions for somatic symptom and related disorders
Pharmacological interventions for psychosomatic disorders
Intensive interventions for somatic symptom disorders
Sleep-wake disorders
Sexual dysfunctions
Paraphilias and paraphilic disorders
Gender dysphoria
Oppositional defiant disorder
Intermittent explosive disorder
Conduct disorder
With limited prosocial emotions specifier for conduct disorder
Pyromania
Kleptomania
Alcohol-related disorders
Sedative-, hypnotic-, or anxiolytic-related disorders
Opioid-related disorders: opioid detoxification
Opioid-related disorders: antagonist treatment
Opioid-related disorders: agonist maintenance treatment
Hallucinogen-related disorders
Cannabis-related disorders
Club drug addiciton
Stimulant-related disorders
Nicotine-related disorders
Individual therapy for substance use disorders
Cognitive, behavioral, and motivational therapies for substance use disorders
Group therapy for substance use disorders
Family therapy in substance abuse treatment
Network therapy for substance use disorders
Pain and addiction
Gambling disorder
Delirium
Neurocognitive disorder due to Alzheimer's disease
Frontotemporal neurocognitive disorder
Vascular neurocognitive disorder
Neurocognitive disorder due to Parkinson's disease
Paranoid, schizotypal, and schizoid personality disorders
Antisocial personality disorder
Borderline personality disorder
Histrionic personality disorder
Narcissistic personality disorder
Cluster C personality disorders: avoidant, dependent, and obsessive-compulsive.

Summary: "This book focuses solely on obstetrics with only the most important, clinically relevant points included, making it a quick and reliable way to find answers, confirm clinical decisions, or guide initial assessments. Includes key points at the beginning of each chapter, specially selected figures and tables, and a glossary of terms for efficient study and fast reference. Features clinically important information throughout." -- Publisher.

Contents:
Part I: Physiology
Part II: Prenatal care
Part III: Intrapartum care
Part IV: Postpartum care
Part V: Complicated pregnancy
Part VI: Pregnancy and coexisting disease
Part VII: Legal and ethical issues in perinatology

Summary: This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.

Contents:
GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis
GADD45 in Development and Cancer
GADD45 in Normal Hematopoiesis and Leukemia
GADD45 in DNA Methylation and DNA Repair
GADD45 Proteins in Immunity
GADD45 in Liver Function and Cancer
GADD45 in Pre-Eclampsia
GADD45 in Senescence
GADD45 in Neuronal Development, Function, and Injury
Index.

Contents:
Evolving mechanistic insights into galectin functions / Connie M. Arthur [and three others]
Cloning, expression, and purification of galectins for in vitro studies / Paul A. Poland, Carol L. Kinlough, and Rebecca P. Hughey
Alkylation of galectin-1 with iodoacetamide and mass spectrometric mapping of the sites of incorporation / Sean R. Stowell [and three others]
Evaluation of galectin binding by frontal affinity chromatography (FAC) / Jun Iwaki and Jun Hirabayashi
Probing lectin-mucin interactions by isothermal titration microcalorimetry / Tarun K. Dam and C. Fred Brewer
Examination of whole cell galectin binding by solid phase and flow cytometric analysis / Anne Leppänen, Connie M. Arthur, Sean R. Stowell, and Richard D. Cummings
Evaluation of galectin binding by surface plasmon resonance / Padmaja Mehta-D'souza
Examining galectin binding specificity using glycan microarrays / Connie M. Arthur [and seven others]
Methods for assessing the effects of galectins on leukocyte trafficking / Beatrice R. Gittens, Rachael D. Wright, and Dianne Cooper
Examination of the role of galectins in plasma cell differentiation / Chih-Ming Tsai and Kuo-I Lin
Examination of galectin-induced lattice formation on early B-cell development / Stéphane J.C. Mancini [and five others]
Detection of phosphatidylserine exposure on leukocytes following treatment with human galectins / Connie M. Arthur [and five others]
Examination of galectins in phagocytosis / Huan-Yuan Chen [and four others]
Assessing the roles of galectins in regulating dendritic cell migration through extracellular matrix and across lymphatic endothelial cells / Sandra Thiemann, Jeanette H. Man, and Linda G. Baum
Examination of the role of galectins in intestinal inflammation / Atsushi Nishida, Cindy W. Lau, and Atsushi Mizoguchi
Study of galectins in tumor immunity : strategies and methods / Juan P. Cerliani [and seven others]
Galectins in the regulation of platelet biology / Maria A. Romaniuk, Gabriel A. Rabinovich, and Mirta Schattner
Examination of the role of galectins and galectin inhibitors in endothelial cell biology / Iris A. E. Schulkens [and four others]
Regulation of galectins by hypoxia and their relevance in angiogenesis : strategies and methods / Mariana Salatino [and ten others]
Examination of the role of galectins during in vivo angiogenesis using the chick chorioallantoic membrane assay / Esther A. Kleibeuker [and four others]
Examination of the role of galectins in cell migration and re-epithelialization of wounds / Zhiyi Cao [and three others]
Manipulating galectin expression in Zebrafish (Danio rerio) / Chiguang Feng [and seven others]
Examination of galectin localization using confocal microscopy / Daniel Giuliano Cerri [and six others]
Examination of the regulation of galectin-3 expression in cancer / Hafiz Ahmed and Gargi Bandyopadhyaya
Evaluation of the role of galectins in parasite immunity / Sarah Preston [and four others]
Effect of galectins on viral transmission / Michel Ouellet [and three others]
Evaluation of the bactericidal activity of galectins / Connie M. Arthur, Richard D. Cummings, and Sean R. Stowell
Examination of the role of galectins in pre-mRNA splicing / Ronald J. Patterson [and three others]
Analysis of the intracellular role of galectins in cell growth and apoptosis / Daniel K. Hsu [and three others]
Nucleocytoplasmic shuttling of galectin-3 / Eric J. Arnoys, Cheri M. Ackerman, and John L. Wang.

Summary: The book discusses the recent progress in understanding the therapeutic targets for gallbladder cancer to provide opportunities for research and for developing innovative strategies that may enhance the benefit of conventional chemotherapy. The book focuses on identifying candidate molecules and the overall status of the targeted therapies available for gallbladder cancer, as there is an urgent need to discover new molecular targets that can guide the emergence of new treatment strategies to improve patient outcomes and act as biomarkers for the early detection of diseases. Recently, new treatment therapeutics targets for gallbladder cancer patients have been identified and the field is evolving rapidly. The book is relevant for the clinical researcher, surgeon, scientist and academician.

Contents:
Gallbladder Cancer: Current treatment options and therapeutics
Surgical Management of Gallbladder Cancer Patients
Conventional therapy in Gallbladder Cancer
Adjuvant Therapy following Surgical Treatment of Gallbladder Cancer
Incidental gallbladder cancer: the role of routine versus selective histopathological examination of gallbladder specimens after cholecystectomy
Minimally Invasive Surgery for Management of Gallbladder Cancer
Thickwalled Gallbladder: Differential diagnosis and surgical approach to a thickened gallbladder
Management of incidentally detected gallbladder cancer after cholecystectomy
Adjuvant treatment in radically resected gallbladder cancer
A look at emerging therapeutic targets for gallbladder cancer: a multi-omics approach
MicroRNA and their role in Carcinoma Gallbladder
Gallbladder cancer: Epigenetic landscape, Targeted therapy and Prospect of Epitherapy
Targeted treatment of Gallbladder cancer
Molecular pathways in Gallbladder cancer as potential therapeutic target
Targeted Therapy: Molecular Pathology and Targets of Gallbladder Cancer
Targeted Therapies in Gallbladder Cancer: Current Status and Future Perspectives
Integrative omics - the roadmap for gallbladder biomarkers identification
Anti-EGFR Therapy in Gall Bladder Cancer.

Summary: "Seventeen years since the first edition and eight years since DSM-5 reclassified "pathological gambling," Gambling Disorder: A Clinical Guide to Treatment is here to provide clinicians with the latest thinking about gambling disorder. It is an exciting moment in the history of gambling research, with scholarly inquiry into the epidemiology, etiology, neurobiology, and treatment of this disorder growing by leaps and bounds. However, many clinicians remain unaware of the disorder's symptoms, though common, and are uninformed about available treatments, many developed quite recently. Acting on this knowledge, the editors set out to compile a guide that would equip clinicians to recognize patients exhibiting signs of the disorder, competently assess them, and work to identify effective treatment options. In addition, the book explores different ways the disorder may manifest across genders and among older and younger patients, forensic issues, and the relatively new area of study, online gambling and gambling-gaming convergence. Not so much a revision as a reconceptualization, Gambling Disorder: A Clinical Guide to Treatment brings a new cast of contributors, a totally restructured text, and the research and clinical wisdom amassed over the past decade and a half to bear on this critically important, yet often overlooked, disorder"-- Provided by publisher.

Contents:
Epidemiology : the good, the bad, and the ugly / Nathan D.L. Smith, Linda B. Cottler
Clinical characteristics / Donald W. Black
Older adults / Georgina M. Gross, Rani A. Hoff
Gender differences / Jon E. Grant, Samuel R. Chamberlain
Online gambling and gambling-gaming convergence / Daniel L. King, Sally M. Gainsbury, Paul H. Delfabbro
Legal and forensic aspects / Austin W. Blum, Jon E. Grant
Cognitive and behavioral underpinnings / Elijah Otis, Igor Yakovenko, Sherry H. Stewart
Neurobiology / Luis C. Farhat, Marc N. Potenza
Screening and assessment instruments / Randy Stinchfield
Understanding youth gambling problems : prevention and treatment strategies / Jeffrey L. Derevensky, Lynette Gilbeau
Psychosocial treatments / Brad W. Brazeau, David C. Hodgins
Pharmacological treatments / Jon E. Grant, Samuel R. Chamberlain.

Summary: The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians.

Contents:
Physiology of gametogenesis
Physiology of embryo development
Diabetes originated from embryo-fetal development
Cardiovascular disease originated from embryo-fetal development
Tumor originated from embryo-fetal development
Obesity originated from embryo-fetal development
Infertility originated from embryo-fetal development
Mental health originated from embryo-fetal development
Assisted reproductive technology (ART) and embryo-fetal origin of diseases
Adverse intrauterine environment and embryo-fetal origin of diseases.

Contents:
Gaming metrics before the game : citation and the bureaucratic virtuoso / Alex Csiszar
The transformation of the scientific paper : from knowledge to accounting unit / Yves Gingras
Playing and being played by the research impact game / Michael Power
The mismeasurement of quality and impact / Paul Wouters
Taking Goodhart's law meta : gaming, meta-gaming, and hacking academic performance metrics / James Griesemer
Global university rankings' impacts and applications / Barbara M. Kehm
Predatory publishing and the imperative of international productivity : feeding off and feeding up the dominant / Sarah de Rijcke & Tereza StÃckelová
Pressures to publish : what effects do we see? / Daniele Fanelli
Ghost-managing and gaming pharmaceutical knowledge / Sergio Sismondo
Retraction watch : what we've learned, and how metrics play a role / Ivan Oransky
PubPeer : scientific assessment without metrics / Boris Barbour & Brandon Stell
The Voinnet affair : testing the norms of scientific image management / Catherine Guaspare & Emmanuel Didier
Crossing the line : pseudonyms & snark in post-publication peer review / Paul S. Brookes
Ike Antkare, his publications and those of his disciples / Ike Antkare
Fake scientists on editorial boards can significantly enhance the visibility of junk journals / Burkhard Morgenstern
Altmetrics gaming : beast within or without? / Jennifer Lin
Why we could stop worrying about gaming metrics if we stopped using journal articles for publishing scientific research / Elizabeth Wager
Making people and influencing friends : citation networks and the appearance of significance / Finn Brunton
Crack open the make-believe : counterfeit, publication ethics and the Global South / Marie-André Jacob
Fake archives : the search for openness in scholarly communication platforms / Alessandro Delfanti
Humor, hoaxes and software : the carnivalesque in the search for academic misconduct / Alexandra Lippman.

Summary: The articles in this volume cover the various radiosurgical techniques used to treat benign and malignant intracranial tumors, cavernous malformations, and functional disorders, as well as a wide array of specific details on medical physics, neuroimaging, and anesthetic support. Particular emphasis is put on the optimal combination of microneurosurgery and radiosurgery for attaining the best functional results in patients with vestibular schwannomas, craniopharyngiomas, and pituitary adenomas, and on the most effective methods of treatment planning and radiation dosimetry in cases of metastatic brain tumors. The highlighted clinical aspects include indications for radiosurgery and the prediction of patients prognosis, along with analysis of outcomes in comparison with results achieved by other modalities in the context of multifaceted therapeutic strategies. In addition, possible options for applying advanced treatment using such modern devices as Leksell Gamma Knife PerfexionTM and IconTM are presented in depth. This information will interest both radiosurgical practitioners and neurosurgeons, and help them to provide optimal care and to achieve the greatest benefit of their patients.

Contents:

v. 1. Muscarinic and nicotinic stimulant actions at autonomic ganglia, by R. L. Volle.

Summary: This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.

Contents:
Intro
Preface
Carbohydrates: The Third Life Chain
Contents
Chapter 1: Glycosylation
1.1 General Aspect of Glycosylation
1.2 Classification of Protein Glycosylation and Posttranslational Modification
1.3 Glycosyltransferases
1.3.1 ABO Blood Type Model of Glycosyltransferases and Historical View
1.3.2 Enzyme Properties of Glycosyltransferases
References
Chapter 2: N-Glycan and O-Glycan Glycosylation in Eukaryotes
2.1 Dolichol-Linked Oligosaccharide (DLO) Biosynthesis for Initial Supplies in N-Glycans
2.2 N-Glycan Glycosylation in ER 3.5 Sulfotransferases for Modification of Carbohydrates
References
Chapter 4: Congenital Disorders of Glycosylation (CDG) of N-Glycoprotein
References
Chapter 5: Neuraminic Acids/Sialic Acids (N-acetyl- and N-glycolylneuraminic Acid)
5.1 Sialic Acids for Differentiation Between Animal and Plant Kingdom
5.2 Outlined Biological Function of Sialic Acids
5.3 Structural Diversity of Sialic Acid Species
5.4 Emerging SA-Containing Glycosphingolipids and Evolutional Occurrence of Methyl-SAs from Deuterosome Echinoderms During the...
References 7.6 Human Serum IgG Antibodies Kill Cultured Primary Leukemia Cells Fed with NeuGc Species
7.7 DCs Behavior During the Acquisition of NeuGc
7.8 The Functions of SA Residue and SA-Linked Carbohydrate Chain
References
Chapter 8: Gangliosides
8.1 General Aspects in Current Gangliobiology
8.1.1 The Immune Suppression and Escape Capacity of Cancer Gangliosides
8.1.2 Regulation of Growth Factor (GF)-GF Receptor (GFR)-Mediated Functions by Gangliosides in the Tumor Microenvironment
8.1.3 Gangliosides Inhibit Cell Cycle and Signaling Chapter 6: Biosynthesis of Sialic Acid
6.1 Hexosamine Pathway and CMP-SA Biosynthesis
6.2 Enzyme Properties of GNE, GFPT, and PGM3 and Utilization of Synthesized SA
References
Chapter 7: Neu5Gc (N-Glycolylneuraminic Acid)
7.1 Enzymatic Synthesis of Neu5Gc
7.2 Expression of Neu5Gc-Forming CMAH in Animals, But Not Humans
7.3 Biological Functions of the NeuGc in Normal System and Xeno-System
7.4 Tumor Immunogenicity of NeuGc Incorporation
7.5 Evolutionary Defense Mechanism of Neu5Gc Biosynthesis in Parasite Infection

Summary: Consists of the proceedings of international conference and symposia.

Summary: "This book presents a state-of-the-art report on recent advances concerning Ganoderma and where the field is going. Although some older work is also cited, the main focus is on advances made over the past 20 years in the research history, classification, chemical components and industry of Ganoderma. Ganoderma lucidum (Lingzhi) has been used as a traditional medicine in Asian countries to maintain health and to treat diseases for more than two thousand years. Recently, its value has been demonstrated in preventing and treating certain diseases, such as tumors, liver disorders, renal injury, hypercholesterolemia, obesity, cerebral ischemia reperfusion, bronchitis etc. In addition, laboratory and clinical studies have confirmed that the chemical components of Ganoderma, such as Ganoderma lucidum polysaccharide peptides and triterpenes isolated from the fruiting body of Ganoderma lucidum, produce diverse pharmacological effects. Ganoderma and its components play an important part in antioxidant stress, radical-scavenging, immunomodulation, and intracellular signaling regulation, and accordingly warrant further study. This book systematically reviews the latest advances in our understanding of Ganoderma's basic knowledge, history of modern research, species, cultivation, components, spore polysaccharide and industry of Ganoderma, and offers researchers and graduate students valuable new insights into the development and clinical applications of Ganoderma and related products"--Publisher's description.

Contents:
Ganoderma (Lingzhi) in traditional Chinese medicine and Chinese culture / Zhibin Lin
Classification, biological characteristics and cultivations of Ganoderma / Zhuo Du, Cai-Hong Dong, Ke Wang, Yi-Jian Yao
Chemical components of Ganoderma / Ting Gong, Renyi Yan, Jie Kang, Ruoyun Chen
Polysaccharide of Ganoderma and its bioactivities / Jingsong Zhang, Yanfang Liu, Qingjiu Tang, Shuai Zhou, Jie Feng, Hongyu Chen
Quantitative analysis of components in Ganoderma/ Ruoyun Chen, Jie Kang
Researches and application of Ganoderma spores powder / Jianhua Xu, Peng Li
Development and innovation of Ganoderma industry and products in China / Zhenhao Li, Jianlong Zhou, Zhibin Lin

Summary: This book presents a state-of-the-art report on recent advances concerning Ganoderma and where the field is going. Although some older work is also cited, the main focus is on advances made over the past 20 years in the pharmacology and clinical applications of Ganoderma. Ganoderma lucidum (Lingzhi) has been used as a traditional medicine in Asian countries to maintain health and to treat diseases for more than two thousand years. Recently, its value has been demonstrated in preventing and treating certain diseases, such as tumors, liver disorders, renal injury, hypercholesterolemia, obesity, cerebral ischemia reperfusion, bronchitis etc. In addition, laboratory and clinical studies have confirmed that the chemical components of Ganoderma, such as Ganoderma lucidum polysaccharide peptides and triterpenes isolated from the fruiting body of Ganoderma lucidum, produce diverse pharmacological effects. Ganoderma and its components play an important part in antioxidant stress, radical-scavenging, immunomodulation, and intracellular signaling regulation, and accordingly warrant further study. This book systematically reviews the latest advances in our understanding of pharmacology and clinical applications of Ganoderma, and offers researchers and graduate students valuable new insights into the pharmacology and clinical applications of Ganoderma and related products.

Contents:
Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism
Antitumor Effect of Ganoderma(Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application
Cellular and Molecular Mechanism of Ganoderma (Lingzhi) against Tumor
Protective Effect of Ganoderma on Radiation and Chemotherapy
Neuropharmacological Effect and Clinical Applications of Ganoderma
Preventive and Therapeutic Effect of Ganoderma on Brain Injury
Protective Effect of Ganoderma Lucidum on Cardiovascular System
Preventive and Therapeutic Effect of Ganoderma on Diabetes
Preventive and Therapeutic Effect of Ganoderma on Liver Injury
Preventive and Therapeutic Effect of Ganoderma Lucidum on Renal Diseases and Clinical Applications
Anti-osteoporosis Effect of Ganoderma (Lingzhi) by Inhibition of Osteoclastogenesis
Anti-oxidative and Free Radical Scavenging Activity of Ganoderma (Lingzhi)
Anti-aging Effect of Ganoderma with Health and Fitness
Preventive and Therapeutic Effect of Ganoderma on Skin Diseases and Care. .

Contents:
Section I. Cellular & molecular basis for medical physiology : General principles & energy production in medical physiology ; Overview of cellular physiology in medical physiology ; Immunity, infection, & inflammation ; Excitable tissue: nerve ; Excitable tissue: muscle ; Synaptic & junctional transmission ; Neurotransmitters & neuromodulators
Section II. Central & peripheral neurophysiology : Somatosensory neurotransmission: touch, pain, & temperature ; Vision ; Hearing & equilibrium ; Smell & taste ; Reflex & voluntary control of posture & movement ; Autonomic nervous system ; Electrical activity of the brain, sleep--wake states, & circadian rhythms ; Learning, memory, language, & speech
Section III. Endocrine & reproductive physiology : Basic concepts of endocrine regulation ; Hypothalamic regulation of hormonal functions ; The pituitary gland ; The thyroid gland ; The adrenal medulla & adrenal cortex ; Hormonal control of calcium & phosphate metabolism & the physiology of bone ; Reproductive development & function of the female reproductive system ; Function of the male reproductive system ; Endocrine functions of the pancreas & regulation of carbohydrate metabolism
Section IV. Gastrointestinal physiology : Overview of gastrointestinal function & regulation ; Digestion, absorption, & nutritional principles ; Gastrointestinal motility ; Transport & metabolic functions of the liver
Section V. Cardiovascular physiology : Origin of the heartbeat & the electrical activity of the heart ; The heart as a pump ; Blood as a circulatory fluid & the dynamics of blood & lymph flow ; Cardiovascular regulatory mechanisms ; Circulation through special regions
Section VI. Respiratory physiology : Introduction to pulmonary structure & mechanics ; Gas transport & pH ; Regulation of respiration
Section VII. Renal physiology : Renal function & micturition ; Regulation of extracellular fluid composition & volume ; Acidification of the urine & bicarbonate excretion.

Summary: "This histology atlas and text provides medical, dental, allied health, and biology students with an outstanding collection of histology images for all of the major tissue classes and body systems. This is a concise approach with relevant text and consistent format presentation of photomicrograph plates. It features a full-color art program comprising high-quality photomicrographs, scanning electron micrographs, and supporting illustrations. Didactic features in each chapter includes: Chapter Outline, Histophysiology, Clinical Considerations, Overview Diagrams, Atlas Plates, Review Plates, and Summary of Histologic Organization. Clinical-vignette style board-review questions have been added to the new edition as well as standard review questions."-- Provided by publisher

Contents:
Introduction to Histologic Techniques
Cell Biology
Epithelium and Glands
Connective Tissue
Cartilage and Bone
Blood and Hemopoiesis
Muscle
Nervous Tissue
Circulatory System
Lymphoid (Immune) System
Endocrine System
Integument
Respiratory System
Digestive System I
Digestive System II
Digestive System III
Urinary System
Female Reproductive System
Male Reproductive System
Special Sense - Appendix A: Tissues that Resemble Each Other - Appendix B: Answers to Chapter Review Questions.

Contents:
Shoulder arthroscopy concepts and tools
Operating room setup
Diagnostic arthroscopy and normal anatomy
Glenohumeral instability
Biceps tendon lesions
Stiffness
Arthrosis
Periarticular cysts and suprascapular nerve compression
Sepsis or infection
Impingement syndrome
Partial-thickness rotator cuff tears
Full-thickness rotator cuff tears
Massive rotator cuff tears
Irreparable rotator cuff tears
Acromioclavicular joint pathology
Calcific tendinitis
Fractures
Diagnostic ultrasonography
Rehabilitation.

Contents:
Bubbles in the body
Driving force of gas-bubble growth and dissolution
Rates of gas-bubble growth and dissolution in simple liquids
Estimating the radii and lifetimes of small gas bubbles suspended in simple liquids
AGEs in scuba diving and in DCS-like problems in breath-hold diving
Gas bubbles in soft tissue-like solids
The evils that bubbles do...
Compartmental decompression models and DCS risk estimation
Treating the evils that bubbles do
Gas-bubble dynamics in the treatment of gas-bubble disease.

Summary: The first overview of this topic begins with some historical aspects and a survey of the principles of the gas aggregation method. The second part covers modifications of this method resulting in different specialized techniques, while the third discusses the post-growth treatment that can be applied to the nanoparticles. The whole is rounded off by a review of future perspectives and the challenges facing the scientific and industrial communities. An excellent resource for anyone working with the synthesis of nanoparticles, both in academia and industry.

Contents:
Introduction to Gas Phase Aggregation Sources. History, Some Basics, and an Outlook / Hellmut Haberland
Principles of Gas Phase Aggregation / Patrice Mélinon
Types of Cluster Sources / José A De Toro, Peter S Normile, Christopher Binns
Modifications of Gas Phase Aggregation Sources. The Double-Laser Ablation Source Approach / Piero Ferrari, Jan Vanbuel, Yejun Li, Ting-Wei Liao, Ewald Janssens, Peter Lievens
In-Plane Multimagnetron Approach / Grant E Johnson, Julia Laskin
Adjustable Multimagnetron Approach / Lidia Martínez
Hollow Cylindrical Magnetron / Vitor Toshiyuki Abrao Oiko, Artur Domingues Tavares de Sá, Varlei Rodrigues
High-Flux DC Magnetron Sputtering / Marco César Maicas Ramos, María del Mar Sanz Lluch
High-Flux Metal Vapor Cell / Gail N Iles
Microwave Plasma Synthesis of Nanoparticles / Dieter Vollath
Enhanced Synthesis of Aggregates by Reduced Temperature, Pulsed Magnetron Sputtering, and Pulsed Buffer Gas Delivery / Vitezslav Stranak, Rainer Hippler
High-Power Pulsed Plasmas / Iris Pilch
High-Pressure and Reactive Gas Magnetron Sputtering / Lakshmi Kolipaka, Stefan Vajda
In-Flight Post-Growth Manipulation of Nanoparticles. Coating / Panagiotis Grammatikopoulos, Mukhles Sowwan
Nanostructuring, Orientation, and Annealing / Balamurugan Balasubramanian, David J Sellmyer
Deflection and Mass Filtering / Marcel Di Vece
In-Flight and Postdeposition Manipulation of Mass-Filtered Nanoparticles under Soft-Landing Conditions / Joachim Bansmann, Armin Kleibert, Hendrik Bettermann, Mathias Getzlaff
In-Flight Analysis / Sergio D'Addato
Perspectives. Nano- and Micromanufacturing with Nanoparticles Produced in the Gas Phase: An Emerging Tool for Functional and Length-Scale Integration / Paolo Milani, Luca G Bettini.

Contents:
Chapter 1. Fundamentals of Gasless Single-Port RoboSurgeon Surgery
Chapter 2. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Radical Nephrectomy
Chapter 3. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Partial Nephrectomy
Chapter 4. Gasless Two-Port Access RoboSurgeon Retroperitoneoscopic Radical Nephroureterectomy
Chapter 5. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Adrenalectomy
Chapter 6. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Radical Prostatectomy
Chapter 7. Gasless Single-Port RoboSurgeon Total Cystectomy with Urinary Diversion
Chapter 8. Gasless Single-Port RoboSurgeon Partial Cystectomy: A Hybrid Technique Combining an Intravesical and Extravesical approach
Chapter 9. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Pelvic Lymph Node Dissection and Inguinal Hernia Prevention
Chapter 10. Application of the RoboSurgeon System in Medical Care.

Summary: This book presents and describes the various uses of gastric bypass in bariatric and metabolic surgery and outlines the different techniques currently available. Furthermore, the possible complications with the procedure and ways to avoid them are also discussed. The use of the gastric bypass for the treatment of diabetes is emphasized and the new indications for the operative treatment of diabetes are featured in detail. Endoscopic uses concerning the gastric bypass are also addressed, covering preoperative evaluation, complications treatment, weight regain treatment and endoscopic treatment of obesity. The most advanced techniques and new technologies available for performing gastric bypass surgeries are presented in the most didactic possible way, making use of value-added learning features throughout the text. Gastric Bypass - Bariatric and Metabolic Surgery Perspectives is intended as a practical guide for all those interested and involved with bariatric surgery, including general surgeons, bariatric surgeons, GI surgeons and surgery residents.

Contents:
History of the gastric bypass
Gastric bypass
Mechanisms of functioning
Rationale for gastric bypass
Morbid obesity
Obesity and related diseases
Preparing the patient for gastric bypass
Preoperative weightloss in gastric bypass
Preoperative testing
Patient Selection in Metabolic Surgery
Psychological and psiquiatric issues
Sleep apnea management
The superobese patient
Airway evaluation and management
Positioning the patient before the procedure
Developing the laparoscopic Gastric Bypass
Systemic Inflammation in the Morbidly Obese Patient
Banded Gastric Bypass by Fobi Ring- Technique and Results
Psychological and psychiatric issues
Simplified gastric bypass
Roux-en-Y gastric bypass in the elderly patient
Gastric bypass reoperation for weight regain
Conversion of vertical banded gastroplasty to gastric bypass
Gastrojejunostomy testing
Closing the mesenteric defects
Preventing complications
^Laparoscopic gastric bypass
Tricks and tips
Psychiatric assistance in bariatric surgery
Intraoperative complications
Abdominal Pain after gastric bypass
Marginal ulceration after (laparoscopic) Roux-en-Y Gastric Bypass: Pathophysiology, Diagnostics, Treatment and Prevention
Rhabdomyolisis
Depressive Disorders, Alcohol Use Disorders and Suicidality in Bariatric Surgery
Nutritional complications
Eating disorders
Gallbladder stones and Choledocholitiasis
Hypoglycemia after Gastric Bypass
Dumping Syndrome
Endoscopic treatment of Roux en Y gastric bypass complications
Endoscopic treatment of weight regain
Laparoscopic Bariatric Surgery Training and the Credentialing Process
Training and Credentialing the Robotic Bariatric Surgeon
Mechanisms of control of diabetes 2 with gastric bypass
Type 2 diabetes and the gut
Shifts in The Intestinal Microbiota after Gastric Bypass
Selecting patients
^Gastric bypass in patients with metabolic syndrome^ 35kg/m2
Gastric bypass for type 2 diabetes BMI <35kg/m2
Postoperative care
Mini Gastric Bypass- Why it is better in India than gastric bypass?
Can Bariatric surgery improve the Microvascular Complications of Type 2 Diabetes?

Contents:
The Historical Perspective of Gastric Cancer
Epidemiology of Gastric Cancer
Molecular Mechanisms in Gastric Carcinogenesis
Pathology of Gastric Cancer
Role of HER2 in Gastric Cancers
Pathophysiology of Hereditary Diffuse Gastric Cancer
Western Perspective and Epidemiology of Gastric Cancer
Diagnosis, Staging and Workup of Gastric Cancer
Endoscopy and Endoscopic Ultrasound Examination of the Stomach
The Role of Staging Laparoscopy and Peritoneal Cytology in Gastric Cancer
Endoscopic Resection for Gastric Cancer
Methods of Reconstruction
BI, BII, Roux-en-Y, Jejunal Interposition, Proximal Gastrectomy and Pouch Reconstruction
Lymphadenectomy
D1, D2 and D3
Open Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy
Laparoscopic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy
Robotic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy
Managing Early and Late Postoperative Complications Following Gastric Surgery
Hereditary Diffuse Gastric Cancer
Surveillance after Gastric Resection
Surgical Trials for Gastric Cancer
Neoadjuvant and Adjuvant Treatment
Strategies and Clinical Trials
Western Perspective
Adjuvant and Neoadjuvant Treatment: Standard Treatment and Clinical Trials in the East
Radiation Treatment for Gastric Cancer
Targeted Therapy and Novel Agents for the Treatment of Gastric Cancer: A View towards the Future.

Summary: Twenty-five years ago, a monograph on gastric cancer was published by the Italian Society of Surgery: that book is recognized as a milestone in the management of these tumors in Italy. Oncological and surgical knowledge in the field of gastric cancer have changed dramatically over the last 25 years. The aim of this book is to offer an essential update on current diagnostic approaches and optimal treatment strategies. It gives comprehensive information on gastric cancer not neglecting the basic sciences, which can shed light on the carcinogenesis mechanisms involved in this pathology. The principles of tailored and multimodal treatment are examined according to the latest guidelines with the aim of providing a valuable synopsis for clinicians. The book not only reviews what has changed in the field of gastric cancer over the past quarter century but also offers the reader a glimpse of the future by describing the ongoing surgical and oncological trials which focus on new treatment frontiers such as immunotherapy and target therapy. It also seeks to incorporate the latest discoveries based on molecular classifications. Further, the book reflects the findings and experiences of Italian experts belonging to the GIRCG (Italian Research Group for Gastric Cancer) and will offer an excellent guide for oncological surgeons in their daily practice of caring for patients affected by gastric cancer.

Contents:
PART I. Epidemiology, Pathology and Diagnosis
Chapter 1. Epidemiology and risk stratification as a guide for an effective screening strategy in the west
Chapter 2. Carcinogenesis in the Era of Molecular Classifications
Chapter 3. Carcinogenesis in the Era of Molecular Classifications
Chapter 4. The new field of view of endoscopy and histological diagnosis
Chapter 5. Hereditary gastric cancer
Part II. Staging
Chapter 6. EGDS and EUS
Chapter 7. CT scan and PET/CT scan
Chapter 8. CT scan and PET/CT scan
Part III. Treatment
Chapter 9. Early Gastric Cancer
Chapter 10. Locally Advanced Gastric Cancer
Chapter 11. The uncertainty of real life
Chapter 12. Stage IV
Chapter 13. Synopsis of Treatment Indications
Part IV. New frontiers to improve prognosis
Chapter 14. Tailored Treatment strategies based on new molecular classifications
Chapter 15. Focus on Poorly Cohesive Gastric Cancer
Chapter 16. Target Therapy and Immunotherapy
Part V. Perioperative-management and Follow-up
Chapter 17. The weight of nutrition in the therapeutic course
Chapter 18. ERAS protocols
Chapter 19. Complications after gastrectomy
Chapter 20. Long-term outcome and follow-up
Part VI. Technical notes in gastric surgery (Video Content)
Chapter 21. Laparoscopic D2 dissection
Chapter 22. D3 open dissection
Chapter 23. Minimally invasive reconstruction in subtotal gastrectomy
Chapter 24. Minimally invasive reconstruction total gastrectomy
Chapter 25. PIPAC
Chapter 26. Indocyanine green fluorescence
Chapter 27. ESD.

Contents:
Intro; Preface; Contents; Introduction; References; Contributors; Part I: Gastric Tumorigenesis;
1: Gastric Tumorigenesis: Role of Inflammation and Helicobacter pylori;
2: Genetic and Epigenetic Mechanisms in Gastric Cancer; Part II: Clinical and Pathological Characteristics;
3: Diagnosis and Surveillance: Endoscopic Hallmarks;
4: Pathological Diagnosis and Classification of Gastric Epithelial Tumours;
5: Diagnostic, Prognostic, Predictive and Therapeutic Tissue Biomarkers in Gastric Cancer;
6: Serum Biomarkers in Gastric Cancer; Part III: Gastric Cancer Therapy: Multimodal Treatment Approach
7: New Agents in the Treatment of Advanced Gastric Cancer: Targeted Therapy and Immunotherap
y8: Combined Modality Treatment for Locally Advanced Gastric Cancer: Current Evidences and New Perspectives;
9: Surgical Strategies in Gastric Cancer; Part IV: Evolving Treatment Landscape in Gastric Cancer;
10: From Molecular Classification to Targeted Therapy for Gastric Cancer in the Precision Medicine Era; Part V: Future Medicine in Gastric Cancer;
11: Noncoding RNA in Gastric Cancer with Potential Prognostic and Predictive Role;
12: Immunomodulation and Immunotherapy for Gastric Cancer

Summary: This book is designed to present readers with comprehensive, high-quality research results on almost all aspects of this carcinoma in clinical management, from correct determination of the esophagogastric junction, issues on cardiac mucosa, epidemiology, and natural history, to clinical, endoscopic, and histopathologic features and diagnostic pitfalls of this carcinoma at both early and advanced stages. Once diagnosed and correctly staged, clinical management of this carcinoma at the early stage is addressed primarily with endoscopic therapy employing the latest endoscopic technology such as endoscopic submucosal dissection, in which detailed technical topics of the endoscopic therapy are written by experts in the field with sections from pre-resection staging and patient preparation to post-resection complications and management. Subsequently, clinical management of gastric cardiac carcinoma at advanced stages is discussed at length with a personalized, multidiscipline approach with strategies from surgical resections with various methods, to pre-, peri- and post-resection chemoradiation therapies as well as the most advanced immunotherapy. A state-of-art approach with the results of meta-analyses and large-scale randomized double-blinded clinical trials are employed throughout these chapters. For patients at the terminal ill stage, the appropriate palliative care plan is presented by experienced clinicians armed with the latest clinical practice guidelines to better manage and help those patients in the last period of their lives.

Contents:
Esophagogastric Junction
Cardiac Mucosa
Epidemiology and Risk Factors
Natural History
Clinical Molecular Pathology
Pathology of Early Gastric Cardiac Cancer
Pathology of Advanced Gastric Cardiac Cancer
Gastric Lymphoma
Diagnosis
Prognosis and Staging
Endoscopic Resection of Early Gastric Cardiac Carcinoma
Pathologic Evaluation of Endoscopic Resection Specimens
Surgical Therapy
Chemical Therapy
Radiotherapy and Chemoradiotherapy
Palliative Care.

Summary: In order to understand common conditions such as coeliac disease and Crohn's disease, one must view the gut in its evolutionary context. This is the novel approach to the gut and its diseases that is adopted in this book. The first part tells the story of the evolution of the gut itself - why it came about and how it has influenced the evolution of animals ever since. The second part focuses on the evolution of immunity and how the layers of immune mechanisms are retained in the gut, resembling the strata revealed in an archeological dig. The final part, 'The Gastro-Archeologist', ties the first two together and highlights how understanding the gut and immune system in their evolutionary context can help us understand diseases affecting them. Ambitious in its scope but telling a unique story from a refreshingly novel perspective, the book offers an informative and enjoyable read. As the story of the gut, immunity and disease unfolds, the author aims to endow readers with the same sense of awe and excitement that the subject evokes in him. Difficult concepts are illustrated using simple and colourful analogies, and the main content is supplemented with anecdotes and unusual and amusing facts throughout the book. The book is intended for anyone with an interest in the gut, its immunity and diseases, ranging from school and college biology and biomedical students, to professionals working in the field, and to patients suffering from intestinal diseases who want to understand more about their conditions.

Contents:
Selection of the Fattest: The Invention of Eating
The Gut Revolution
The Bowels of Existence. The Intestinal Palimpsest: The Rules of Social Engagement
The Orchestra of Life
The Layers of Time. The Gastro-Archeologist: 'What is Food to One is Rank Poison to Another': food allergy and Intolerances
The Evil bread: Coeliac disease and gluten related disorders
Back to the very Beginning: The Inflammatory Bowel Diseases.

Summary: "Dr. Richard Polin's Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient"--Publisher's description.

Contents:
Maturation of motor function in the preterm infant and gastroesophageal reflux / Anna Maria Hibbs
Development of gastrointestinal motility reflexes / Sreekanth Viswanathan, Sudarshan R. Jadcherla
Lipid and fatty acid delivery in the preterm infant : challenges and lessons learned from other critically ill populations / Camilia R. Martin, Steven D. Freedman
Human milk oligosaccharide / Ardythe L. Morrow, David S. Newburg
Donor milk trials / Sharon L. Unger, Julia B. Ewaschuk, Deborah L. O'Connor
Neonatal necrotizing enterocolitis : neonatology questions and controversies / Lauren Astrug, Erika Claud
Nutrition for the surgical neonate / Holly J. Engelstad, and Brad W. Warner
Controversies in short bowel syndrome / Jacqueline J. Wessel
New lipid strategies to prevent/treat neonatal cholestasis / Kathleen M. Gura
Neonatal gastrointestinal tract as a conduit to systemic inflammation / Mary W. Lenfestey, Josef Neu
Adult consequences of neonatal and fetal nutrition : mechanisms / Lisa A. Joss-Moore, Cheri Bantilan, Kjersti Aagaard-Tillery, Nicole Mitchell, Clotilde desRoberts, Robert H. Lane
What are the controversies, and where will the field be moving in the future? / Brenda Poindexter, Josef Neu.

Summary: This book fills a void in the market for specialists who are working in areas without the support of gastroenterologists. Due to a lack of local expertise, treatment decisions in the field of gastroenterology frequently have to be made by non-gastroenterologists. The book addresses this problem by providing clear instructions on the diagnosis, medical management and on-going treatment of the most common disease patterns encountered in gastroenterology. Written by leading experts in their respective fields, it offers up-to-date evidence and insights into these conditions to enable adequate decision-making and safe management of these conditions. -- Provided by publisher.

Summary: This extensively revised second edition of this essential work provides a comprehensive overview of Gastroesophageal Reflux (GER) in children. It contains detailed insight into the epidemiology and pathophysiology of the condition. Relevant diagnostic methods and treatment techniques are also covered. Heavily revised chapters discuss issues associated with GER in special patient populations and current approaches to GER diagnosis and management. New chapters cover relevant aspects of the microbiome, how nutrition can be key to successful treatment and the adverse effects of the latest therapeutic drugs presently available. The first part of the book is dedicated to introducing the condition, discussing epidemiology, symptoms and diagnosis. This is followed by addressing issues of the condition encountered in special patient populations such as in preterm infants, apnea, neulorogic patients and cystic fibrosis, among others. The final part of the book is dedicated to therapeutic approaches from medication to surgery and alternative approaches such as complementary medicine and hypnotherapy. The approaches and challenges in endoscopy are also detailed. Gastroesophageal Reflux in Children, Second Edition is edited by a leading world expert in the topic and written by a global team of authors from a range of associated disciplines, making the work a critical resource for pediatricians, gastroenterologists to pulmonologists, otolaryngologists and neurologists.

Contents:
Epidemiology
Pathophysiology--Gut brain communication
Pathophysiology--Esophageal clearance
Symptoms
Quality of life
Prognosis of GER
Diagnosis History
DiagnosisRadiology
DiagnosisEndoscopy / histology
Diagnosis--pH metry impedance
Diagnosismanometry
Diagnosis--Ultrasound and other techniques
GER in cystic fibrosis
GER in neurologically impaired
GER after esophageal surgery
GER in preterm
GER and allergy
GER and esonsophilic esophagitis
GER and dysphagia
GER and BRUE
ER and respiratory symptoms
GER and helicobacter
GER and duodeno-gastric reflux
Management of GER in infants
Management of GER in older children
Acid secretor blockers and adverse effects
GER and hypnotherapy
GER and complementary medicine
GER and GI microbiome
GER and surgery
GER and endoscopic procedures
Treatment nutrition
Adverse effects of drugs. .

Summary: This book presents research outcomes, providing a big picture of rheumatic diseases as systemic conditions, and exploring the correlation between liver dysfunction and gastrointestinal lesions. Each chapter presents the association between major rheumatic diseases and hepato-gastrointestinal lesions, including liver and gastrointestinal involvement in lupus erythematosus, dermatomyositis, systemic sclerosis, Bechet's disease, and IgG4-related disease. The chapters on PBC-CREST syndrome and immunosuppressive agents broaden readers understanding and enable them to view the diseases from a systematic perspective. Although the disease is rare, it has attracted considerable attention as an intractable disease, and despite the severity of the symptoms, little has been written on the topic. Adopting a multidisciplinary approach, this comprehensive volume thoroughly prepares readers for research in the field of systemic diseases. Gastrointestinal and Hepatic Manifestations of Rheumatic Diseases is a valuable resource not only for hepatologists and rheumatologists, but also clinical residents and medical students.

Contents:
1. Liver involvement in rheumatic diseases
2. Primary biliary cholangitis is associated with CREST syndrome
3. De novo hepatitis B virus infection
4. Dermatomyositis and gastrointestinal cancer
5. Portal hypertension in rheumatic diseases
6. Gastrointestinal manifestations of systemic lupus erythematosus
7. Rheumatoid Arthritis and Gastrointestinal Tract Lesions (NSAID ulcers, amyloidosis)
8. Gastrointestinal involvement of systemic sclerosis
9. Gastrointestinal involvement of systemic vasculitis
10. Gastrointestinal involvement of Behçet’s disease
11. Gastrointestinal involvement in IgG4-related disease
12. Immunosuppressive agents and intestinal involvement.

Summary: This guide provides the answers to patient questions that are frequently posed to practitioners who care for pregnant and non-pregnant women with GI and liver disorders. The first part of the text outlines gender-based differences in GI disorders, including GERD, liver disease, pancreatic disease, IBD, and IBS. The second part of the text reviews common GI and liver diseases that occur during pregnancy, while guiding clinicians through various diagnostic and therapeutic/management approaches. GI and liver diseases that are covered in this section include nausea and vomiting, viral hepatitis, and pregnancy-specific liver disorders such as preeclampsia, HELLP syndrome, and intrahepatic cholestasis. The text concludes with a chapter on the safety of GI procedures for the pregnant patient. Written by experts in the field, Gastrointestinal and Liver Disorders in Women's Health: A Point of Care Clinical Guide is a valuable resource for the busy clinician who needs the best evidence-based answers to patient questions at their fingertips. -- Provided by publisher.

Contents:
Part I: Gender-based differences in gastrointestinal disorders: 1. Differential diagnosis between primary eating disorders and disordered eating secondary to a primary gastrointestinal disorder / Jennifer Heinemann and Courtney Barry
2. Functional swallowing disorders / Livia A. Guadagnoli, John E. Pandolfino, and Rena Yadlapati
3. Gastroesophageal reflux disease / Rena Yadlapati and Abraham Khan
4. Cyclic vomiting syndrome : does gender matter? How does it affect the health of women? / Vishnu Charan Suresh Kumar and Thangam Venkatesan
5. Idiopathic gastroparesis / Dariush Shahsavari and Henry P. Parkman
6. Autoimmune hepatitis / Margarita N. German and Adnan Said
7. Diseases of the liver : primary biliary cholangitis / Paulina K. Phillips and Adnan Said
8. Diseases of the liver : liver masses (hemangioma, focal nodular hyperplasia, hepatic adenoma) / Parul D. Agarwal and Adnan Said
9. Pancreatic cystic neoplasms in women : mucinous cystic neoplasms, serous cystadenomas, and solid pseudopapillary neoplasms / Harkirat Singh and Asif Khalid
10. Obesity and bariatric surgery / Semeret Munie and Tammy Kindel
11. Celiac disease / Marium Khan and Daniel Stein
12. Inflammatory bowel disease : fertility, menses, and contraception / Reezwana Chowdhury and Sunanda V. Kane
13. Irritable bowel syndrome in women / Shanti Eswaran and Laura O'Donohue
14. Chronic constipation / Arnold Wald
15. Colorectal cancer screening and women / Katherine Hu and Carrie Y. Peterson. Part II: Gastrointestinal/liver diseases during pregnancy: 16. Nausea and vomiting of pregnancy and hyperemesis gravidarum / Sumona Saha
17. Viral hepatitis : hepatitis B, D, and E viruses / Aiman Ghufran
18. Pregnancy-specific liver disorders : preeclampsia and HELLP syndrome / Ashina Singh
19. Pregnancy-specific liver disorders : acute fatty liver / Archita Desai and Deeksha Seth
20. Intrahepatic cholestasis of pregnancy / Sheila Eswaran, Dharani Guttikonda, and Nancy Reau
21. Inflammatory bowel disease and pregnancy / Nedhi Patel and Andres Yarur
22. Gallstone and biliary disease / Gillian L. Fell and David Brooks
23. Safety of procedures during pregnancy / Bahar Adeli, Erkanda Ikonomi, and Asyia Ahmad.

Summary: This unique book is the first to focus on diagnostic and therapeutic endoscopy in gastrointestinal and pancreatico-biliary diseases. It provides an in-depth overview of the state of the art in diagnostic and therapeutic endoscopy of both the digestive tract and the pancreatico-biliary ductal system, and documents the latest innovations in the field. The first part of the book addresses advanced diagnostic and therapeutic endoscopy of the digestive tract, discussing bariatric endoscopic surgery, and the treatment of neoplasia and precancerous lesions of the upper and lower GI tract, motor disorders, GERD, strictures, fistulae and bleeding. The second part of the book is explores ERCP and EUS procedures, covering the diagnosis and therapy of biliary ductal system and pancreatic diseases. Each chapter includes an abundance of color images that document in detail the devices, operative techniques and outcomes. Written by leading internationally renowned experts, the book is a valuable resource for both specialists and residents in gastroenterology and surgery.

Contents:
Advanced imaging techniques and in vivo histology: current status and future perspectives (upper G.I.)
Endoscopic ultrasonography for preoperative staging upper G.I. tract lesions
Esophageal Neoplasia: Endoscopic Diagnosis and Treatment
Endoscopic resection of squamous cell carcinoma: techniques and outcomes
Management of Barretts Esophagus: State of the Art
Radiofrequency Ablation of Barretts Epithelium
Cryotherapy and argon ablation of Barretts epithelium
Resection techniques in Barretts esophagus
Endoscopic characterization of gastric and duodenal lesions and resection strategy
Endoscopic submucosal dissection of gastric lesions
Endoscopic Resection of Submucosal Lesions of the Upper GI Tract: Full-Thickness Resection (EFTR) and Submucosal Tunneling Resection (STER)
POET and CLEAN-NET for Submucosal Tumor
Vaters papilla neoplasia: endoscopic ultrasonography for preoperative staging
Endoscopic Snare Papillectomy
Endoscopic diagnosis of early duodenal epithelial neoplasias and therapeutic strategy
Enteroscopy: Techniques and Small Bowel Therapy
Advanced imaging techniques and in vivo histology: current status and future perspectives (lower G.I.)
Endoscopic characterization of colorectal lesions and resection strategy
Endoscopic Mucosal Resection of Colorectal Lesions
Endoscopic Submucosal Dissection of Colorectal Lesions
Hybrid technique for difficult colorectal lesions
Piecemeal EMR Versus ESD for Large Colorectal Lesions: Pros and Cons
Resection of submucosal lesions of the lower GI tract: full-thickness resection (EFTR), OVESCO
Endoscopic ultrasonography for preoperative staging of rectal lesions
Colonoscopy surveillance after adenoma removal: current guidelines
Management of colonic neoplasia: cost-effectiveness and outcomes of endoscopic therapy
Advanced techniques in colonoscopy in inherited cancer conditions
Advanced technique in colonoscopy in inflammatory bowel diseases
Future technologies for treatment of G.I. tract lesions
Artificial intelligence for diagnosing G.I. tract lesions
Endoscopic myotomy and septotomy for Zenkers diverticulum (Z-POEM)
Peroral endoscopic myotomy (POEM) for achalasia: indications, techniques and outcomes
Stenting and techniques alternative to POEM for achalasia
Peroral endoscopic myotomy (POEM) for esophageal motility disorders: indications, techniques and outcomes
Peroral endoscopic pyloro myotomy (G-POEM)
Per-rectal endoscopic myotomy
Transoral fundoplication for treatment of gastro-esophageal reflux disease
Antireflux mucosectomy (ARMS and ARMA): techniques and outcomes
Endoscopic radiofrequency (Stretta)
Endoscopic Treatment for Obesity and Weight Management: State of the Art
Intragastric occupying space devices
Endoscopic sleeve gastroplasty
Aspiration therapy for obesity
Duodenal resurfacing for treatment of type 2 diabetes
Endoscopic Management of Complications of Bariatric Therapy
Endoscopic Management of Weight Regain
Self expanding stents: present and future
Endoscopic management of malignant esophageal strictures
Endoscopic management of strictures of cervical esophagus
Endoscopic management of benign esophageal strictures
Biodegradable self-expandable stents for benign strictures: indications and outcomes
Endoscopic stenting for gastric outlet obstruction
Endoscopic Ultrasound (EUS)-Guided Gastroenterostomy (EUS-GE)
Enteroscope-assisted small bowel stenting
Endoscopic Management of Malignant Colorectal Strictures
Colorectal Stenting as Bridge to Surgery
Endoscopic Management of Benign Colorectal Strictures
Techniques for fistula repair in the G.I. tract
Stem Cells for Tissue Repair of the GI Tract
Endoscopic management of acute G.I. non variceal bleeding
Endoscopic Management of Variceal Bleeding
Endoscopic management of colonic angiodysplasias
Full-thickness closure of iatrogenic or post-interventional gastrointestinal defect by the use of flexible endoluminal suturing device
Difficult biliary cannulation and sphincterotomy: what to do
Pancreatic Sphincterotomy
Minor papilla cannulation and sphincterotomy
Biliary balloon sphincteroplasty
Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
ERCP in Surgically Altered Anatomy
EUS- and enteroscopy-assisted ERCP
EUS-Guided Pancreatic Duct Cannulation
Choledochoscopy: techniques and innovation
Pancreatoscopy: techniques and innovations
Advanced Intraductal Biliary Imaging
Treatment of sphincter of Oddi dysfunction
Treatment of benign biliary strictures
Treatment of Post-liver Transplant Strictures
Endoscopic Management of Primary Sclerosing Cholangitis
Treatment of Malignant Hilar Strictures
Treatment of malignant distal biliary strictures
Treatment of Concomitant Malignant Biliary Stricture and Gastric Outlet Obstruction
Treatment of biliary leaks and fistulae
Management of Complications of Biliary Stenting
Intraductal Ablation Therapy in the Biliary Ductal System
EUS-guided biliary drainage
EUS-guided bilio-enteric anastomosis
Advanced intraductal pancreatic imaging
Treatment of Acute Biliary Pancreatitis
Treatment of symptomatic pancreas divisum
Treatment of Pancreatic Leaks and Fistulae
Trans-papillary drainage of fluid collections
EUS-Guided Drainage of Fluid Collections
Treatment of Walled-Off Necrosis
Treatment of Chronic Obstructive Pancreatitis
Treatment of Pancreatic Intraductal Stones
Complications of Pancreatic Stents
Treatment of pancreatic cancer
Innovation in Pancreatic Stents
EUS-guided pancreatico-digestive anastomosis
Innovation in Lumen Apposing Metal Stents
Endoscopic Management and Follow-Up of Intraductal Papillary Mucinous Neoplasia (IPMN)
EUS-Guided Pancreatic Sampling
EUS Characterization of Focal Pancreatic Masses
EUS-Guided Thermal Ablation of Pancreatic Neoplasia
EUS-guided crio-thermal ablation of pancreatic neoplasia
EUS-guided celiac plexus neurolysis.

Summary: This unique book is the first to focus on diagnostic and therapeutic endoscopy in gastrointestinal and pancreatico-biliary diseases. It provides an in-depth overview of the state of the art in diagnostic and therapeutic endoscopy of both the digestive tract and the pancreatico-biliary ductal system, and documents the latest innovations in the field. The first part of the book addresses advanced diagnostic and therapeutic endoscopy of the digestive tract, discussing bariatric endoscopic surgery, and the treatment of neoplasia and precancerous lesions of the upper and lower GI tract, motor disorders, GERD, strictures, fistulae and bleeding. The second part of the book is explores ERCP and EUS procedures, covering the diagnosis and therapy of biliary ductal system and pancreatic diseases. Each chapter includes an abundance of color images that document in detail the devices, operative techniques and outcomes. Written by leading internationally renowned experts, the book is a valuable resource for both specialists and residents in gastroenterology and surgery.

Contents:
PART 1: DISEASES OF GASTROINTESTINAL TRACT: Diagnosis and therapy of upper G.I. neoplasia and pre-cancerous conditions: Advanced imaging techniques and in vivo histology: current status and future perspectives. Endoscopic ultrasonography for preoperative staging upper G.I. tract lesions. Endoscopic characterization of esophageal lesions and resection strategy. Endoscopic management of esophageal squamous cell carcinoma. Endoscopic resection of squamous cell carcinoma: techniques. Management of Barrett's esophagus. Radiofrequency ablation of Barrett's epithelium. Cryotherapy and argon ablation of Barrett's epithelium. Resection techniques in Barrett's esophagus. Endoscopic characterization of gastric and duodenal lesions and resection strategy. Endoscopic mucosal resection of gastric and duodenal lesions. Endoscopic submucosal dissection of gastric lesions. Resection of submucosal lesions of the stomach and duodenum: full-thickness resection (EFTR), submucosal tunneling resection (STER), and Ovesco. Vater's papilla neoplasia: endoscopic ultrasonography for preoperative staging. Papillectomy and ampullectomy
Diagnosis and therapy of lower G.I. neoplasia and pre-cancerous conditions: Enteroscopy: devices and techniques. Endoscopic therapy of small bowel lesions. Advanced imaging techniques and in vivo histology: current status and future perspectives. Innovations in colonoscopy. Endoscopic characterization of colorectal lesions and resection strategy. Endoscopic mucosal resection of colorectal lesions. Endoscopic submucosal dissection of colorectal lesions. Hybrid technique for difficult colorectal lesions. Endoscopic ultrasonography for preoperative staging of rectal lesions. Endoscopic resection of large rectal lesions: ESD vs TEM. Full-thickness resection of colo-rectal lesions: indications, techniques and outcomes. Piecemeal EMR vs ESD for large colo-rectal lesions; pros and cons. Colonoscopy surveillance after adenoma removal: current guidelines. Management of colonic neoplasia: cost-effectiveness and outcomes of endoscopic therapy. Endoscopic repair after resection and treatment of complications. Future technologies for treatment of G.I. tract lesions
Therapy of motor disorders of gastrointestinal tract: Endoscopic myotomy and septotomy for Zenker's diverticulum (Z-POEM). Peroral endoscopic myotomy (POEM) for achalasia: indications, techniques and outcomes. Stenting and techniques alternative to POEM for achalasia. Peroral endoscopic myotomy (POEM) for esophageal motility disorders: indications, techniques and outcomes. Endoscopic pyloromiotomy (G-POEM): indications, techniques and outcomes
Therapy of gastro-esophageal reflux disease: Transoral incisionless fundoplication. Antireflux mucosectomy: techniques and outcomes. Endoscopic augmentation of G-E junction by full-thickness suturing device. Stretta procedure
Bariatric endotherapy: Endoscopic treatment for obesity and weight management: state of the art. Intragastric ballons. Endoscopic sleeve gastroplasty. Endoscopic gastroplasty techniques. Aspiration therapy. Endoscopic duodenal techniques for treatment of obesity and type 2 diabetes. Endoscopic management of complications of bariatric therapy. Endoscopic management of weight regain. Therapy of gastrointestinal strictures: Self expanding stents: present and future. Endoscopic management of malignant esophageal strictures. Endoscopic management of cervical esophageal strictures. Endoscopic management of benign esophageal strictures. Biodegradable self-expandable stents for benign strictures: indications and outcomes. Endoscopic stenting for gastric outlet obstruction. Endoscopic ultrasound (EUS)-guided gastroenterostomy (EUS-GE). Enteroscope-assisted small bowel stenting. EUS-guided intestinal by-pass procedures. Endoscopic management of malignant colorectal strictures. Colorectal stenting as bridge to surgery. Endoscopic management of benign colorectal strictures
Therapy of fistulae and bleeding: Techniques for fistula repair in the G.I. tract. Stem cells for tissue repair in the G.I. tract. Techniques for management of acute G.I. non variceal bleeding. Stenting for variceal bleeding
PART 2: DISEASES OF PANCREAS AND BILIARY DUCTAL SYSTEM: Diagnosis and therapy of biliary ductal system diseases: Difficult biliary cannulation: definition and therapeutic algorithym. Precutting and septotomy techniques. ERCP in surgical altered anatomy. EUS- and enteroscopy-assisted ERCP. ERCP in childhood. Advanced intraductal biliary imaging: OCT, confocal endomicroscopy. Choledochoscopy: imaging, techniques and innovation. Treatment of sphincter of Oddi dysfunction. Treatment of difficult bile duct stones. Treatment of benign biliary strictures. Endoscopic management of primary sclerosing cholangitis. Stenting of malignant biliary strictures. Innovation in biliary stents. Intraductal radiofrequency (RFA) therapy in biliary neoplasia. Intraductal photodynamic therapy in biliary neoplasia. EUS-guided biliary drainage. EUS-guided bilio-enteric anastomosis. Treatment of biliary leaks and fistulae. Diagnosis and therapy of pancreatic diseases: Pancreatic sphincterotomy: technique. Minor papilla cannulation and sphincterotomy: technique. EUS-guided pancreatic duct cannulation. Advanced pancreatic intraductal imaging. Pancreatoscopy: imaging, techniques and innovations. Endoscopic management of acute recurrent pancreatitis. Endoscopic therapy of pancreas divisum. Endoscopic therapy of chronic pancreatitis. Innovation in pancreatic stents. Trans-papillary drainage of pseudocysts. EUS-guided drainage of pseudocysts. Endoscopic management of complications of acute pancreatitis. Endoscopic treatment of pancreatic leaks and fistulae. EUS-guided gastro-pancreatic anastomosis. Endoscopic treatment of "walled off" necrosis. EUS-guided management of pancreatic IPMN. US characterization of pancreatic masses. Endoscopic treatment of pancreatic cancer. EUS-guided termal ablation of pancreatic masses. EUS-guided crio-termal ablation of pancreatic masses.

Contents:
Stabilization of Patients Presenting with Upper Gastrointestinal Bleeding
Urgent Workup for Upper Gastrointestinal Bleeding
Management of Esophageal Variceal Bleeding
Management of Dieulafoy?s Lesions
Management of Bleeding Peptic Ulcer Disease
Management of Unusual Sources of Upper GI Bleeding
Mallory?Weiss Syndrome
Diagnosis and Management of Bleeding Small Bowel Tumors
Management of Bleeding from the Bile Duct
Management of Bleeding from the Pancreas
Urgent Workup of Lower Gastrointestinal Bleeding
Bleeding Hemorrhoids
Management of Colonic Diverticular Bleeding and Bleeding Colitis
Colonic Arteriovenous Malformations
Bleeding Colorectal Tumors
Evaluation of the Guaiac Positive Patient
Endoscopic Techniques for Evaluating Small Bowel Blood Loss: Video Capsule and Device-Assisted Enteroscopy
Provocative Angiography
The Unstable Patient with Obscure Gastrointestinal Bleeding: Surgical and Non-surgical Management. .

Summary: This text provides a state-of-the art review of the gastrointestinal complications of diabetes, their pathophysiology, clinical manifestations, diagnostic evaluation and management. Divided into six sections, the volume shows how diabetes affects the entire GI tract, from the oral cavity and esophagus to the large bowel and anorectal region. By offering a detailed diagnostic approach and featuring therapeutic algorithms at the end of each chapter, the text is a useful guideline and reference point for every day practice, specifically in recognizing and diagnosing patients with gastrointestinal complications of diabetes in a timely fashion. Written by experts in the field, Gastrointestinal Complications of Diabetes: A Comprehensive Guide is a valuable resource for physicians dealing with diabetes mellitus or gastrointestinal disorders, and researchers interested in this multidisciplinary problem.

Contents:
Diabetes Mellitus
Chronic Complications of Diabetes
Summary
Esophageal and Gastric Function
Clinical Manifestations
Diagnostic Approach
Treatment
Intestinal Function
Clinical Manifestations
Diagnostic Approach
Treatment
Anorectal Function
Clinical Manifestations
Diagnostic Approach
Treatment
Exocrine Pancreatic Function in Diabetes
Clinical Manifestation
Diagnostic Approach
Treatment of Pancreatic Diseases
Liver Function
Clinical Manifestations of Liver Disease in Diabetes Mellitus
Diagnostic Approach
Nonalchoholic Fatty Liver Disease Treatment.

Summary: This book answers key questions asked by emergency clinicians faced with complex gastrointestinal and abdominal pain presentations. Instead of a traditional format that includes epidemiology, pathophysiology, diagnosis, and treatment options, this book takes an approach that mirrors the way clinicians interact with patients – by asking and answering specific clinical care questions. The book is organized into sections by presentation – gastrointestinal bleeding, for example – each of which contains chapters on specific questions, such as “What is the best clinical risk score for low risk GIB patients?” Each clinical question comes with a detailed, evidence-based response and a summary that gives best practices, recommendations, and references. Additionally, at the end of each section is a chapter titled “Expert Corner,” which asks the same clinical questions to a surgical or gastrointestinal specialist and includes key pearls these experts have for emergency medicine practitioners. Gastrointestinal Emergencies: Evidence-Based Answers to Key Clinical Questions is an essential guide for emergency medicine physicians, residents, and medical students who want to review and improve their care of acute gastrointestinal emergencies.

Contents:
General Approach to Management of Acute Abdominal Pain
Gastrointestinal Bleeding
Abdominal Pain in the Bariatric Surgery Patient
Colitis/Diverticulitis
Appendicitis
Abdominal Pain in Immunocompromised Patients
Abdominal Pain in the Pregnant Patient
Pancreatitis
IBD
Vomiting
Bowl Obstruction
Gallbladder
Liver
Mesenteric Ischemia
AAA/Dissection.

Summary: This comprehensive treatise on cutting edge tools and research provides a fascinating insight into the rapidly evolving field of diagnostic and therapeutic endoscopy. Accomplished international researchers and clinicians discuss the latest endoscopic advances in diverse areas including obesity and associated metabolic syndromes, management of peripancreatic fluid collections, endoluminal suturing techniques, fistula closure, management of Barrettℓ́ℓs epithelium, cholangioscopy, chromoendoscopy, high resolution manometry and endoscopic ultrasonography. Gastrointestinal Endoscopy: New Technologies and Changing Paradigms is a valuable resource on the evolving role of endoscopic management of gastrointestinal diseases and is a tremendous resource for gastroenterologists, endoscopists, GI surgeons, and medical residents.

Contents:
Barrett?s Esophagus
Cholangioscopy
Endoscopic Management of Peripancreatic Fluid Collections and Walled-Off Pancreatic Necrosis
Bariatric Endoscopy
Advances in Imaging and Evaluation of the Small Bowel and Colon
High-Resolution Manometry
Endoluminal Fistula and Perforation Closure
Advances in EUS
Endoscopic Submucosal Dissection
Colon Widefield EMR.

Contents:
Pharynx and esophagus
Stomach
Small bowel
Colon and appendix
Pancreas
Liver
Spleen
Bile ducts and gallbladder
Peritoneum and retroperitoneum
Multisystem and miscellaneous.

Summary: This volume provides a concise yet comprehensive overview of advanced techniques in interventional endoscopy beyond ERCP and EUS. Comprised of sections on endoscopic resection (including EMR, ESD, STER and EFTR), bariatric endoscopy, endoscopic myotomy (POEM, GPOEM, ZPOEM and PREM), endoscopic anti-reflux therapies, endoscopic tissue apposition, and advances in interventional EUS, the text highlights indications and technical details, assesses safety and efficacy, and provides quality metrics and training pathways for these endoscopic procedures. The book is also accompanied by multiple photos and videos illustrating these endoscopic techniques. Written by world renowned experts in the field, Gastrointestinal Interventional Endoscopy: Advanced Techniques is a valuable resource for gastroenterologists and surgeons interested in the latest advances in interventional endoscopy.

Contents:
Part I Endoscopic Resection 1 Endoscopic Lesion Recognition and Advanced Imaging ModalitiesJorge D. Machicado, Jennifer Kolb, Sachin B. Wani 2 Endoscopic Mucosal Resection of the EsophagusSamuel Han, Hazem Hammad 3 Gastric and Duodenal Endoscopic Mucosal ResectionRommel Romano, Pradermchai Kongkam 4 A Pragmatic Approach to Complex Colon PolypsMichael X. Ma, Michael J. Bourke 5 Endoscopic Tools and Accessories for ESD Calvin J. Koh, Dennis Yang, Peter V. Draganov 6 Esophageal ESD Lady Katherine Mejía Pérez, Seiichiro Abe, Raja Siva, John Vargo, Amit Bhatt 7 Gastric ESDTakuji Gotoda 8 Colonic ESDVikneswaran Namasivayam, Yutaka Saito 9 Endoscopic Full Thickness Resection (EFTR) and Submucosal Endoscopic Resection (STER)Mingyan Cai, Marie Ooi, Pinghong Zhou 10 EMR Versus ESD: Pros and ConsVijay Kanakadandi, Mojtaba Olyaee, Amit Rastogi 11 Training and Competency in Endoscopic ResectionDaniel S. Strand, Andrew Y. Wang Part II Bariatric Endoscopy 12 Intra-gastric Balloons and Aspiration TherapyChetan Mittal, Shelby Sullivan 13 Endoscopic Sleeve Gastroplasty (ESG)Gontrand Lopez-Nava, Inmaculada Bautista-Castaño 14 Emerging Endoscopic Therapies for Weight Loss Thomas J. Wang, Marvin Ryou 15 Endoscopic Therapy of Post-Bariatric Surgery Strictures, Leaks and FistulasFilippo Filicori, Lee L. Swanström 16 Endoscopic Management of Weight RegainEric J. Vargas, Andrew C. Storm, Fateh Bazerbachi, Barham K. Abu Dayyeh Part III Endoscopic Myotomy 17 POEM: Pre-procedural work-up and IndicationsJoseph Rayfield Triggs, John E. Pandolfino 18 Peroral Endoscopic Myotomy: Endoscopic TechniquesChetan Mittal, Mihir S. Wagh 19 POEM: Efficacy, Safety, Training and Competency Juergen Hochberger, Volker Meves 20 Endoscopic Myotomy for Zenker's Diverticulum (Z-POEM) Alessandro Fugazza, Roberta Maselli, Alessandro Repici 21 Per-oral Endoscopic Pyloromyotomy (G-POEM) and Per-rectal Endoscopic Myotomy (PREM) Amol Bapaye, Amit Maydeo Part IV Endoscopic Anti-Reflux Therapies 22 History of Endoscopic Anti-reflux Therapies
Lessons Learned Zaheer Nabi, D. Nageshwar Reddy 23 Transoral Fundoplication for Treatment of Gastroesophageal Reflux DiseasePier Alberto Testoni, Sabrina Gloria Giulia Testoni, Giorgia Mazzoleni, Lorella Fanti 24 Radiofrequency Ablation and Anti-Reflux Mucosectomy for Gastroesophageal Reflux DiseaseBryan Brimhall, Amit Maydeo, Mihir S. Wagh, Hazem Hammad Part V Endoscopic Tissue Apposition 25 Techniques for Endoscopic Suturing Olaya I. Brewer Gutierrez, Stuart K. Amateau 26 Endoscopic Clips and GluesRoupen Djinbachian, Daniel von Renteln Part VI Advances in Interventional EUS 27 Interventional EUS: PancreasVinay Dhir, Ankit Dalal, Carmen Chu 28 Interventional EUS: Bile Duct and GallbladderAnthony Yuen Bun Teoh, Kenjiro Yamamoto, Takao Itoi 29 Interventional Vascular EUSJason B. Samarasena, Kyle J. Fortinsky, Kenneth J. Chang.

Contents:
Gastric and small bowel tumors / L. Mark Knab, Anthony Yang
Pathologic features of esophageal and gastric malignancies / Eduard Matkovic, Michael Schwalbe, Kristina A. Matkowskyj
Pathologic features of miscellaneous foregut malignancies / Eduard Matkovic, Michael Schwalbe, Kristina A. Matkowskyj
Management controversies and treatment strategies for borderline resectable pancreatic cancer / Mark S. Talamonti
Pathologic features of primmary pancreatic malignancies / Ashley M. Cunningham, Patrick S. Rush, Kristina A. Matkowskyj
Gall bladder cancer / Audrey E. Ertel, David Bentrem, Daniel E. Abbott
Diagnosis and management of intrahepatic and extrahepatic cholangiocarcinoma / Jason Ho, Steven A. Curley
Hepatocellular carcinoma: surgical management and evolving therapies / Olga Kantor, Marshall S. Baker
Clinical features of metastatic hepatic malignancies / Ramiro Fernandez, Sam G. Pappas, David J. Bentrem
Repeat hepatectomy for colorectal liver metastases / Vikrom Dhar, Ryan M. Thomas, Syed A. Ahmad
Minimally invasive surgery of the liver / Michael White, Yuman Fong, Laleh Melstrom
Locoregional therapies for primary and secondary hepatic malignancies / Ahsun Riaz, Robert J. Lewandowski, Riad Salem
Pathologic features of primary and metastatic hepatic malignancies / Kristina A. Matkowskyj, M. Sambasiva Rao, Guang-Yu Yang
Robotic rectal cancer surgery / Kurt Melstrom
Pathologic features of primary colon, rectal, and anal malignancies / Kaitlin E. Sundling, Ranran Zhang, Kristina Matkowskyj
Importance of adequate lymphadenectomy in gastrointestinal cancer / Andrew Benjami, Ryan P. Merkow
Circulating tumor cells in gastrointestinal cancer: current practices anbd future directions / Colin M. Court, Jacob S. Ankeny, Shonan Sho, James S. Tomlinson
Cost-effectiveness analysis in cancer care / Alex Chang, Daniel E. Abbott
Gastrointestinal malignancy: genetic implications to clinical applications / Nicole E. Lopez, Jen Jen Yeh.

Summary: "This book is intended to help with the microscopic evaluation and the formulation of a differential diagnosis when interpreting gastrointestinal (GI) biopsies (including methods of cytologic acquisition) in the context of the clinical and endoscopic presentation. It is also intended to help gastroenterologists optimize the acquision, and initial handling of biopsy specimens to facilitate an informative diagnosis The goal is to provide a companion to the diagnostic pathologists and to teach pathology residents /fellows, as well as gastroenterologists, the importance of correlating clinical impression, endoscopic findings and microscopic interpretation (with an emphasis on inflammatory and infectious lesions, rather than neoplasms). To assure that the presentation of the material matches "real-life" a standardized format is used for each major entity reported: Clinical presentation, endoscopic appearance and expectations by the gastroenterologist; specific methods, locations, and numbers of biopsy samples needed for specific conditions, and specific handling requirements for specific conditions; the pathologic part of the text will be classic with description of significant architectural changes, but with emphasis on "pathognomonic" characteristics and secondary features; differential diagnosis presented sequentially presented on a) clinical presentation; b) microscopic appearance and c) results of ancillary studies (when performed); suggestions for reporting (i.e., key elements to include in the pathology reports) are offered where appropriate; simple clinical management clues based on the pathologic will conclude each section"-- Provided by publisher.

Contents:
PRINCIPAL of BIOSPYDIAGNOSI
ESOPHAGUS-Inflammatory Conditions
ESOPHAGUS-Neopastic Conditions
STOMACH- Inflammatory Conditions
STOMACH-Polypoid Lesions
STOMACH- Neoplastic Conditions
DUODENUM- Inflammatory Conditions
SMALL INTESTINE-Inflammatory Conditions
SMALL INTESTINE- Neoplastic Conditions
COLON Inflammatory Conditions
COLON-Polypoid Lesions
COLON-Neoplastic Conditions
ANUS Inflammatory Conditions
ANUS- Neoplastic Conditions.

Summary: Gastrointestinal Physiology, a volume in the Mosby Physiology Monograph Series, explains the fundamentals of gastrointestinal physiology in a clear and concise manner. Ideal for your systems-based curriculum, this fully updated medical textbook provides you with a basic understanding of how the GI system functions in both health and disease. New to this edition: Stay abreast of the latest research and findings in physiology with coverage of the physiological significance of gastrointestinal peptides; the regulation of mucosal growth and cancer; details surrounding acid secretion and peptic ulcers; and more. Access new gastrointestinal information on the regulation of pancreatic secretion and gallbladder contraction; the transport processes for the absorption of nutrients; facts about fat absorption; and the regulation of food intake.

Contents:
Regulation : peptides of the gastrointestinal tract
Regulation : nerves and smooth muscle
Swallowing
Gastric emptying
Motility of the small intestine
Motility of the large intestine
Salivary secretion
Gastric secretion
Pancreatic secretion
Bile secretion and gallbladder function
Digestions and absorption
Fluid and electrolyte absorption
Regulation of food intake.

Summary: Gastrointestinal Physiology explains the operation and performance of one of the body's most crucial systems. Using clear, compelling language, the book's presentation makes it easy to absorb the content and integrate it as you learn the physiology of other bodily systems. Written to help you understand essential concepts rather than merely memorize facts, this unique text examines many medically relevant facets of this important body system, including anatomy, pathophysiology, and therapeutics, in concert with physiological information.

Contents:
Functional anatomy of the GI tract and organs draining into it
Neurohumoral regulation of gastrointestinal function
Gastric secretion
Pancreatic and salivary secretion
Water and electrolyte absorption and secretion
Intestinal mucosal immunology and ecology
Esophageal motility
Gastric motility
Intestinal motility
Functional anatomy of the liver and biliary system
Bile formation and secretion
Gallbladder function
Bilirubin formation and excretion by the liver
Ammonia and urea
Carbohydrate, protein and water soluble vitamin assimilation
Lipid assimilation.

Contents:
Regulation : peptides of the gastrointestinal tract
Regulation : nerves and smooth muscle
Swallowing
Gastric emptying
Motility of the small intestine
Motility of the large intestine
Salivary secretion
Gastric secretion
Pancreatic secretion
Bile secretion and gallbladder function
Digestion and absorption
Regulation of food intake.

Summary: This volume provides a practical hands on guide to gastrointestinal physiology. The book emphasizes an appreciation of basic physiological concepts and their application to novel clinical situations. It exposes the physician-in-training to fundamental principles that are useful in treating patients and lays the groundwork for more advanced study in the future. The authors present relevant cases which incorporate newer adult learning strategies in medical education. These cases provide a forum in which the student can apply acquired knowledge, skills and attitudes. Connections are made to reader's life, whether in the classroom, on the wards or out and about town. Designed for medical students who are studying gastrointestinal physiology for the first time, Gastrointestinal Physiology: A Clinical Approach provides a superb review for upper level medical students and house officers. Nursing and allied health professions students will also find this text to be a useful guide. GI fellows and attending physicians in need of a concise review of fundamental GI physiology principles will also benefit from reading this book.

Contents:
Clinical Gastrointestinal Physiology: A Systems Approach
Form and Function: The Physiological Implications of the Anatomy of the Gastrointestinal System
Brain-Gut Axis and Regional Gastrointestinal Tract Motility
Gastrointestinal Secretion: Aids in Digestion and Absorption
Physiology of the Liver, Gallbladder and Pancreas: "Getting By" with Some Help from Your Friends
Nutrient Exchange: Matching Digestion and Absorption
Salt and Water: Intestinal Water and Electrolyte Transport
Gastrointestinal Manometry: Tales of the Intrepid Transducer.

Summary: This book offers one of the most comprehensive reviews in the field of gastrointestinal (GI) physiology, guiding readers on a journey through the complete digestive tract, while also highlighting related organs and glandular systems. It is not solely limited to organ system physiology, and related disciplines like anatomy and histology, but also examines the molecular and cellular processes that keep the digestive system running. As such, the book provides extensive information on the molecular, cellular, tissue, organ, and system levels of functions in the GI system. Chapters on the roles of the gut as an endocrine, exocrine and neural organ, as well as its microbiome functions, broaden readers' understanding of the multi-organ networks in the human body. To help illustrate the interconnections between the physiological concepts, principles and clinical presentations, it outlines clinical examples such as pathologies that link basic science with clinical practice in special "clinical correlates" sections. Covering both traditional and contemporary topics, it is a valuable resource for biomedical students, as well as healthcare and scientific professionals.

Contents:
Intro; Preface; Key Features; Target Groups; Contents; About the Author; 1 History of Development of Gastrointestinal Physiology: From Antiquity to Modern Period and the Birth of Modern Digestive Physiology; Abstract; 1.1 Introduction; 1.2 Organization of the GI System, Periods of Development of Knowledge on the Digestive Physiology; 1.3 Evolutionary Emergence of the Gastrointestinal System; 1.4 Digestive Physiology in Antiquity; 1.5 Digestive Physiology During the Renaissance; 1.6 Digestive Physiology in Modern History; 1.7 The Beginning of Modern Digestive Physiology. 1.8 Current and Emerging Trends in the Study of Physiology1.8.1 The Pendulum of Investigation of Physiological Systems Is Swinging Toward Integrative Approach. The Physiome and Giome Projects; 1.8.2 Bedside-to-Bench or Bench-to-Bedside Physiology-The Cornerstone of Translational Physiology or Medicine; 1.9 Conclusion; Bibliography; 2 Structural and Functional Organization of the Gastrointestinal Tract; Abstract; 2.1 Introduction; 2.2 Structural Architecture of the Gastrointestinal Tract; 2.2.1 Regions of the Gastrointestinal Tract; 2.2.2 Layers of the Gastrointestinal Tract. 2.4.2 Anatomical Architecture of the Lymphatic System2.4.3 Pattern of Lymphatic Drainage of the Gut; Characteristics and Composition of Chyle; Chyle Flow Rate and the Lymphatic Pump; 2.5 Nerve Supply of the Gastrointestinal Tract; 2.6 Functions of the Gastrointestinal Tract; 2.7 Conclusion; Bibliography; 3 Cellular Organization of the Gastrointestinal Tract; Abstract; 3.1 Introduction; 3.2 Brief Historical Background; 3.3 Types of Gastrointestinal Tract Cells; 3.3.1 Muscle Cells of the Gut; 3.3.2 Neurons and Glial Cells of the Gut; 3.3.3 Connective Tissue Cells. 3.3.4 Accessory Cells of the Gastrointestinal Tract3.3.5 Cells of the Accessory Organs of the Digestive System; 3.3.6 Major Types of Gastrointestinal Epithelial Cells; Absorptive Columnar Enterocytes; Mucin-Secreting Cells; Enzyme-Secreting Cells; Acid-Secreting Cells; Neuro-(Entero)endocrine Cells; Gastrointestinal Opioid-Secreting Cells; Gastrointestinal Epithelial Immune Sensor Cell: Paneth Cell; Metaplasia and Dysplasia; 3.4 Structural Composition and Functions of the Cell; 3.4.1 Plasma Membrane; Components of the Plasma Membrane; Lipids; Proteins; Carbohydrates. Tunica Mucosa (Mucous Layer)Tunica Submucosa (Submucous Layer); Tunica Muscularis (Muscle Layer); Tunica Serosa/Adventitia (Serous/Adventitial Layer); 2.2.3 Epithelium of the Gastrointestinal Tract; 2.2.4 Microarchitecture of the Mucosa; 2.2.5 Accessory Organs of Digestion; 2.3 Gastrointestinal Circulation; 2.3.1 Gastrointestinal Venous Circulation; 2.3.2 Gastrointestinal Blood (Arterial) Supply; 2.3.3 Gastrointestinal Perfusion; Regulation of Gastrointestinal Perfusion; Factors Affecting Gastrointestinal Perfusion; 2.4 Gastrointestinal Lymphatic Drainage; 2.4.1 Brief Historical Background.

Summary: This book provides a comprehensive and up-to-date overview of gastrointestinal stromal tumors (GISTs). GISTs represent the most common mesenchymal neoplasms arising within the gastrointestinal tract. The causative gene of this disease was originally discovered in Japan by Prof. Seichi Hirota in 1998, and since then numerous important advances – from basic to clinical aspects – have been reported from Japan. Professionals involved in the management of GISTs inevitably cite significant evidence and the state-of-the-art treatments from the Asian region, where has there is and inherently high prevalence of gastrointestinal cancers. Each expert author elucidates the cutting-edge knowledge on pathophysiology, diagnosis, and treatment of GISTs, especially focusing on the highly valuable data from Japan. This attractive collection benefits not only oncologists but also basic researchers, general physicians and surgeons, as well as paramedical staff and medical students who are dealing with GISTs.

Contents:
Etiology/Epidemiology
Pathology
Molecular Genetics of GIST
Pediatric GIST/Inheritable Disease
Natural History
Radiographic Imaging
Endoscopic Evaluation
Prognostic Factors for Localized Disease
Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection
Surgery for Localized GIST
Minimally Invasive Surgery for GIST
Neoadjuvant Rx and Surgical Consolidation
Imatinib
Management of Locally Advanced GIST
Prognostic Factors for Advanced GIST
Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy
Surgical Debulking of Metastatic GIST
Liver Resection/Ablation of Metastatic GIST
Palliative Care.

Contents:
Tracheo-esophageal Fistula
Esophageal strictures refractory to endoscopic dilatation
Esophgeal anastomotic leak
Transhiatal esophagectomy: intraoperative disasters
Chyle leak after esophageal surgery
Management of airway, hoarseness and vocal cord dysfunction after esophagectomy
Severe reflux induced esophagitis
Introperative solutions for gastric conduit that will not reach
Injury to the right gastroepiploic artery
Intraoperative solutions for ischemic gastric conduit
Jejunal feeding tube complications
Bile reflux and gastroparesis
Gastric surgery: dealing with dumping syndrome
Afferent loop syndrome
Duodenal stump blowout
Postoperative complications after surgery for gastric cancer: Anastomotic leakage
Hepatobiliary and pancreatic surgery: postoperative hepatic insufficiency
Biliary leaks and thoracobiliary fistula
Contralateral bile duct injury during hepatic resection
Massive Intra-operative Hemorrhage During Hepato-Biliary and Pancreatic Surgery
Hepatobiliary and Pancreatic Surgery: Intraoperative injury to Hepatic Arterial Structures
Hepatobiliary and pancreatic surgery: hepatic abscess
Hepaticojejunostomy anastomotic strictures
Stricture at Pancreatico-Jejunostomy or Pancreatico-Gastrostomy
Postoperative Portal, Mesenteric and Splenic Vein Thrombosis
Post-pancreatectomy Hemorrhage: Early and Late
Major Disruptions of Pancreaticojejunostomy
Persistent Pancreatic Fistula
Management of Chyle Leaks Following Pancreatic Resection
Hepatobiliary and Pancreatic Surgery: Preventing Pancreatic Fistula following Distal Pancreatectomy
Pearls for the Small Bowel and Colon That Will Not Reach
Anastomotic Leak / Pelvic Abscess
Management of Anastomotic Stricture
Colorectal Surgery: Intraoperative Ureteral Injury
Colorectal surgery: Prostatic Urethral Injury
Vaginal Injury During Stapled
Anastomosis
Management of rectovaginal fistula
Management of Presacral / Pelvic Bleeding
Breakdown / Nonhealing of Perineal Wound
Complications after TEM (Transanal Endoscopic Microsurgery) and TAMIS Maria
Parastomal hernia
Stoma Retraction/Ischemia/Stenosis
Incontinence after Lateral Internal Sphincterotomy/ Fistulotomy
Anal Stenosis after Hemorrhoidectomy: Avoidance and Management
Delivering Bad News: Conversations with My Surgeon.

Summary: This book presents a comprehensive approach to the diagnostic evaluation of gastroparesis and the medical and surgical treatment options available for this disorder. The initial chapters address the different etiologies, pathophysiology and diagnostic evaluation of this disease. Medical management, nutritional support and co-morbid conditions are also discussed. Subsequent chapters focus on endoscopic and surgical options for management and the current outcomes data for these procedures. A brief review of the existing literature addressing the particular topic is included in each section. Written by experts in the field, Gastroparesis covers each of these treatment sections that address patient selection, technical conduct and complications of the most common endoscopic procedures and operations, and anticipated outcomes of therapy. .

Contents:
Normal Gastric Motility
Etiology and Clinical Presentation of Gastroparesis
Diagnostic Evaluation of Gastroparesis
Medical Management of Gastroparesis
Endoluminal Management of Gastroparesis
Gastric Electrical Stimulation
Laparoscopic Pyloroplasty
Post-Surgical Gastroparesis
Management of Gastroparesis in the setting of Gastroesophageal Reflux Disease
Managing Gastroparesis in the Setting of Obesity.

Contents:
Historical perspectives on gastric motility and gastroparesis
Epidemiology of gastroparesis
Clinical presentations of gastroparesis
Natural history of patients with gastroparesis
Gastric dysmotility at the organ level in gastroparesis
Cellular pathogenesis of gastroparesis
Sensory dysfunction in gastroparesis
Pathology of gastroparesis: ICC, enteric neurons and fibrosis
Gastroparesis and the brain-gut axis
Autonomic neuropathies and gastroparesis
Gastric emptying scintigraphy
The use of wireless motility capsule in the diagnosis and monitoring of gastroparesis
Breath tests for the assessment of gastroparesis
Magnetic resonance imaging for gastric motility and function
Electrogastrography for suspected gastroparesis
Antroduodenal manometry for the evaluation of patients with suspected gastroparesis
Ancillary testing including barostat, SPECT, and satiety testing
Diabetic gastroparesis
Postsurgical gastroparesis
Idiopathic gastroparesis
Gastroparesis from other causes
Pediatric gastroparesis
Dietary therapy for gastroparesis
Prokinetic agents for gastroparesis
Antiemetic therapy for gastroparesis
Abdominal pain in gastroparesis: Prevalence, potential causes and management
Psychiatric aspects of gastroparesis
Alternative, complementary medicine and cannabinoids for gastroparesis
Enteric tube placement for gastroparesis: Gastrostomy, gastrojejunostomy and jejunostomy
Gastric electrical stimulation for gastroparesis
Surgical management of gastroparesis
Studies from the NIH Gastroparesis Clinical Research Consortium: Towards improving our understanding and treatment of gastroparesis
Evaluating response in gastroparesis: Patient reported outcome measures and survey instruments
The pyloric revolution: Patient selection
Endoscopic full-thickness gastric biopsy: Ready for prime time?
Distinguishing between functional dyspepsia and gastroparesis: Does it matter?
Female predominance in gastroparesis
A brief history and future directions of permanent, temporary, and endoscopic GES
Cell transplantation for gastroparesis
A vision of the future for gastroparesis
Resources for the gastroparesis patient.

Summary: "The first edition of Non-Epileptic Seizures was published in 1993 and edited by Drs. A. James Rowan and John R. Gates. Based on a 1990 symposium called "The Dilemma of Non-Epileptic (Pseudoepileptic) Seizures," this instant classic synthesized the available knowledge and hypotheses regarding all facets of nonepileptic seizures into four sections: neurological, psychiatric and neuropsychological aspects, and fundamentals of treatment. The second edition was published in 2000 and reflected the continued outgrowth of the 1993 symposium as well as a second conference - "Non-Epileptic Seizures: A Consensus Conference on Diagnosis and Treatment - held in Bethesda in 1996. A third conference, "The 2005 Psychogenic Nonepileptic Seizures (PNES) Treatment Workshop, sponsored by the NINDS, the NIMH, and the American Epilepsy Society and organized by W. Curt LaFrance, Jr., brought together experts from around the world, representing many disciplines. The enthusiasm emanating from that landmark meeting reverberated widely amongst professionals interested in the evaluation and treatment of persons with PNES. Sadly, the field soon afterwards lost its pioneers: John Gates on September 28, 2005 and Jim Rowan on August 27, 2006"--Provided by publisher.

Summary: This book provides in-depth information on all key aspects of geminivirus biology, e.g. the genetics and evolution, global diversity and spread of these plant pathogens, as well as the molecular mechanisms underlying their virulence. Geminiviridae is one of the largest viral families, comprising numerous plant-infecting viruses that cause diseases in crops and weeds. These diseases have been reported from nearly all continents, in particular Asia, Europe, Africa and America. The book summarizes the current state of knowledge on the interactions between plant host and virus. In addition, it discusses advances regarding the trans-replication of satellite molecules and its effect on geminiviral pathogenesis, as well as pest management strategies to combat these diseases in the field. Given its scope, the book is a must-read reference guide for all researchers and advanced students working in virology, agriculture and plant biotechnology.

Contents:
Intro; Preface; Contents; List of Contributors; Classification, Taxonomy and Gene Function of Geminiviruses and Their Satellites; 1 Family: Geminiviridae; 1.1 Geminivirus Taxonomy; 1.1.1 Genus: Becurtovirus; 1.1.2 Genus: Begomovirus; 1.1.3 Genus: Capulavirus; 1.1.4 Genus: Curtovirus; 1.1.5 Genus: Eragrovirus; 1.1.6 Genus: Grablovirus; 1.1.7 Genus: Mastrevirus; 1.1.8 Genus: Topocuvirus; 1.1.9 Genus: Turncurtovirus; 1.2 Biological Functions of Geminivirus Components; 1.2.1 DNA-A Component; 1.2.2 DNA-B Component; 1.2.3 Betasatellites; 1.2.4 Alphasatellites; 1.2.5 Deltasatellites; References 1.1 Geminiviruses1.2 Geminivirus Evolution; 1.3 Disease Symptoms; 2 Geminiviruses Occurrence in Australia, China, Europe, and the Middle East Countries; 2.1 Geminiviruses in Australia; 2.2 Geminiviruses in China; 2.3 Geminiviruses in Europe; 2.4 Geminiviruses in the Middle East Countries; 3 Future Aspects; References; Mastreviruses in the African World: Harbouring Both Monocot and Dicot Species; 1 Introduction; 2 Mastreviruses: Distribution and Diversity; 2.1 Maize Streak Virus; 2.2 Panicum Streak Virus; 2.3 Chickpea Chlorotic Dwarf Virus; 2.4 Urochloa Streak Virus; 2.5 Sugarcane Streak Virus 3 Geminivirus Transcription4 Transcript Mapping in Geminiviruses; 5 Geminiviruses Promoter; 5.1 Early Promoter; 5.2 Late Promoters; 6 Transactivator C2/AC2 Regulation; 7 Concluding Remarks; References; Distribution of Geminivirus in the Indian Subcontinent; 1 Introduction; 2 Family Geminiviridae; 3 Geminiviruses in Indian Subcontinent; 4 Genus Capulavirus (Type Species: Caput-Medusae Latent Virus, CMLV); 4.1 Introduction; 4.2 Important Capulavirus in Indian Subcontinent; 4.2.1 French Bean Severe Leaf Curl Virus; 5 Genus Mastrevirus (Type Species: Maize Streak Virus, MSV); 5.1 Introduction 5.2 Important Mastreviruses of the Indian Subcontinent5.2.1 Wheat Dwarf India Virus; 5.2.2 Chickpea Chlorotic Dwarf Virus; 5.2.3 Sugarcane Streak Virus; 6 Genus Begomovirus (Type Species: Bean Golden Mosaic Virus, BGMV); 6.1 Introduction; 6.2 Important Crops Affected by Begomovirus in the Indian Subcontinent; 6.2.1 Tomato; 6.2.2 Okra; 6.2.3 Legumes; 6.2.4 Chilli; 6.2.5 Cassava; 6.2.6 Cucurbits; 6.2.7 Cotton; 6.2.8 Papaya; 6.2.9 Mesta; 6.2.10 Radish; 6.2.11 Jatropha; 7 Conclusion; References; Geminivirus Occurrence in Australia, China, Europe, and the Middle Eastern Countries; 1 Introduction Rolling Circle Replication and Transcription Processes in Geminiviruses1 Geminivirus Replication; 1.1 Rolling Circle Replication; 1.1.1 Viral Proteins Involved in Replication Process; 1.2 Recombination-Dependent Replication; 2 Interactions with Rep Protein and Its Implication on Viral DNA Accumulation; 2.1 Plant Retinoblastoma-Related Proteins (RBR); 2.2 Proliferating Cell Nuclear Antigen (PCNA); 2.3 Replication Factor C (RFC); 2.4 Replication Protein A-32 (RPA-32); 2.5 Recombination Enzymes; 2.6 Sumoylation-Conjugating Enzyme-1; 2.7 Histones; 2.8 NAC Domain-Containing Proteins

Summary: "Our newest generation, Generation Z, or Zoomers, are coming of age in a world rife with amazing new opportunities and unprecedented challenges. Born around the time the World Wide Web made its public debut in 1995, they are "digital natives," the first generation never to know the world without the Internet. They have grown up alongside powerful global networks that offer endless information and connectivity. They have also had the clear realization that their elders know no better than they do how to navigate ongoing crises; that they and their planet have been badly betrayed by decisions which preceded them. In Gen Z, Explained, a team of social scientists set out to take a comprehensive look at this generation, drawing on wide and lively interviews, surveys, and comprehensive linguistic analysis (deploying the authors' proprietary iGen Corpus, a 70-million word collection of Gen-Z-specific English language scraped from social media, time-aligned video transcriptions, and memes). It paints a portrait of an extraordinarily challenged, thoughtful, and promising generation--while sounding a warning to their elders. The authors show that despite all the seemingly insurmountable difficulties they face, this generation continues to be idealistic about the future and highly motivated to make change"-- Provided by publisher.

Contents:
Introduction
Technology shapes postmillenial life
Fine-grained identity
Being authentic
Finding my fam
OK Boomer
The difficulty of being a Gen Zer
Conclusion : the art of living in a digital age.

Contents:
Introduction
1.Sex Differences in Normal Pulmonary Structure and Function at Rest and during Exercise
2.Sex Hormone Signaling In The Lung In Health And Disease: Airways, Parenchyma And Pulmonary Vasculature
3.Women and COPD
4.Sex, gender, and asthma
5.Sex hormones, sex, gender and pulmonary hypertension
6.Pulmonary Fibrosis
7.Sex-Specific Differences in Lung Cancer
8.Lymphangioleiomyomatosis
9.Developmental Lung Disease. .

Contents:
Facial feminization surgery : a global approach / Luis Capitan, Daniel Simon
Speech modification / James P. Thomas
Top surgery / Britt Colebunders, Salvatore D'Arpa, Stan J. Monstrey
Combined hysterectomy, oophorectomy, and chest reconstruction in the female-to male transgender patient / Christopher J. Salgado, Renee Gasgarth, Lydia A. Fein, Christopher Estes
Male-to-female gender affirmation skin-flap vaginoplasty / Miroslav L. Djordjevic, Dusan Stanojevic, Marta Bizic
Male-to-female gender affirmation colon vaginoplasty : total laparoscopic
Sigmoid vaginoplasty / Mark-Bram Bouman, Wouter B. van der Sluis, Marlon E. Buncamper, Wilhelmus J.H.J. Meijerink
Female-to-male gender affirmation metoidioplasty / Marci L. Bowers, Borko Stojanovic, Marta Bizic
Female-to-male gender affirmation phalloplasty : radial forearm flap / Christopher J. Salgado, Harvey Chim, Varsha R. Sinha, Piet Hoebeke, Stan J. Monstrey
Anterolateral thigh flap phalloplasty / Stan J. Monstrey, Salvatore D'Arpa, Britt Colebunders, Nicolaas Lumen, Piet Hoebeke
Expert commentary / Curtis Crane, Klara Sputova
Female-to-male gender affirmation phalloplasty : latissimus dorsi flap / Miroslav L. Djordjevic, Sinisa Kojic, Borko Stojanovic
Testicular and erectile implants in transmen after phalloplasty / Piet Hoebeke, Nicolaas Lumen
Management of unfavorable urologic sequelae following phalloplasty in
Transgender patients / Yuka Yamaguchi, Jamie P. Levine, Lee C. Zhao
Unfavorable results in phalloplasty surgery / Salvatore D'Arpa, Nicolaas Lumen, Piet Hoebeke, Christopher J. Salgado, Vishal K. Sinha, Natalie Joumblat, Stan J. Monstrey
Medical treatment of the adolescent transgender patient / Daniel E. Shumer, Norman P. Spack
Adult hormonal therapy in the transsexual patient / Melany Castillo, Roy E. Weiss
Mental health care for transgender and gender-nonconforming children, adolescents, and adults / Walter O. Bockting, Amir Adam Tarsha, Yasmina Zoghbi, Clara Alvarez-Villalba
Sexual health issues following surgery for transgender individuals / Marilyn K. Volker, Lydia A. Fein
Gender expression and image / Michelle Horne, Lydia A. Fein.

Summary: This book comprehensively reviews the characteristics of the body reflected in the skin due to differences in gender. It investigates the genetic and hormonal differences that can affect skin structure and function, and resulting in variations between women and men. The aging process and exogenous factors that differ according to differences in lifestyle between the sexes are also covered. Gender and Dermatology comprehensively outlines the various aspects of physiological differences between the skin of women and men using practical examples and review of the basic science. It is therefore an important clinically-relevant review for both the trainee and experienced practitioner in dermatology, primary care, geriatrics and immunology, while also being of interest to researchers in genetics and metabolic medicine. .

Summary: This book focuses on the influence of sex and gender in migraine, presenting new insights in basic science as well as their clinical relevance. As migraine is roughly three times more common in women than in men, and also highly depends on hormonal milestones – such as menarche, menstruation, pregnancy and menopause – particular attention is devoted to the role of female sex hormones in this disease. The first chapters present general data on gender-related differences in migraine such as epidemiology, comorbidities and related risks. Furthermore, while several chapters focus on the role of female sex hormones in migraine-triggering mechanisms at a basic scientific level (e.g. cranial circulation), ample attention is also paid to the clinical relevance of such mechanisms and to the best clinical treatment for migraine patients. As the first book entirely devoted to this topic, it will be of interest to researchers and practitioners in the fields of neurology, internal medicine, endocrinology, physiology and pharmacology.

Contents:
Intro; Foreword; Preface; Contents;
Chapter 1: Epidemiology of Migraine in Men and Women; 1.1 Introduction; 1.2 Prevalence of Migraine; 1.2.1 Subtypes of Migraine; 1.2.2 Incidence and Age at Onset; 1.3 Natural History/Prognosis; 1.4 Phenotype; 1.5 The Impact of Migraine; 1.5.1 Individual Burden; 1.5.2 Societal Burden; References;
Chapter 2: Cardiovascular Risk of Migraine in Men and Women; 2.1 Introduction; 2.2 Epidemiological Outcomes of Cardiovascular Risks in Migraineurs; 2.3 Pathophysiological Mechanisms of Migraine and Cardiovascular Disease; 2.3.1 Endothelial Dysfunction 2.3.2 Platelet Abnormalities2.3.3 Microemboli; 2.3.4 Shared Genetic Markers; 2.4 Gender Differences in Migraine and Cardiovascular Risk; 2.4.1 The Role of Hormones; 2.5 Biomarkers and Markers of Subclinical Vascular Disease; 2.6 Consequences for the Clinical Practice and for Healthcare Professionals; 2.7 Gaps and Future Research; 2.8 Conclusions; References;
Chapter 3: Sex- and Gender-Specific Aspects of Migraine Treatment; 3.1 Gender Differences in Migraine Prevalence; 3.2 Female-Specific Migraine Subtypes; 3.2.1 Migraine During Perimenopause and Postmenopause 3.3 Hormonal Fluctuations Throughout the Menstrual Cycle3.3.1 Role for Hormonal Fluctuations in Migraine; 3.3.2 Current Knowledge on Sex Hormone Levels in Women with Migraine; 3.4 Female-Specific Migraine Treatments; 3.4.1 Acute Migraine Treatment Options in PMM and MRM; 3.4.1.1 Acute Non-migraine-Specific Treatments; 3.4.1.2 Acute Migraine-Specific Treatments; 3.4.2 Short-Term Prophylactic Treatment Options in PMM and MRM; 3.4.2.1 Short-Term Non-migraine-Specific Treatments; 3.4.2.2 Short-Term Migraine-Specific Treatments; 3.4.3 Female-Specific Prophylactic Treatment Options 3.4.3.1 Oral Contraceptives3.4.3.2 Other Female-Specific Prophylactic Migraine Treatments; 3.4.4 Migraine Treatment in Perimenopausal and Postmenopausal Women; 3.5 Summary and Conclusion; References;
Chapter 4: Headache and Pregnancy; 4.1 Introduction; 4.2 Clinical Headache Phenotypes and Observational Studies in Pregnancy; 4.2.1 Primary Headaches; 4.2.1.1 Migraine; 4.2.1.2 Tension-Type Headache; 4.2.1.3 Cluster Headache; 4.2.2 Secondary Headaches; 4.2.2.1 Preeclampsia and Eclampsia; 4.2.2.2 Cerebral Venous Thrombosis; 4.2.2.3 Ischemic Stroke; 4.2.2.4 Subarachnoid Hemorrhage 4.2.2.5 Arterial Dissection4.2.2.6 Reversible Cerebral Vasoconstriction Syndrome; 4.2.2.7 Posterior Reversible Encephalopathy Syndrome; 4.2.2.8 Idiopathic Intracranial Hypertension; 4.2.2.9 Pituitary Apoplexy; 4.3 Treatment of Headaches in Pregnancy and Breastfeeding Women; 4.3.1 Non-pharmacological Treatment; 4.3.2 Symptomatic Treatment; 4.3.2.1 Paracetamol/Acetaminophen; 4.3.2.2 Aspirin; 4.3.2.3 Caffeine; 4.3.2.4 Nonsteroidal Anti-inflammatory Drugs; 4.3.2.5 Triptans; 4.3.2.6 Oxygen; 4.3.2.7 Lidocaine; 4.3.2.8 Corticosteroids; 4.3.2.9 Opioids; 4.3.2.10 Ergots and Ergots Alkaloids

Summary: Gender confirming surgery represents one of many therapies for individuals with gender dysphoria and can be pivotal in allowing individuals to become their true selves. An emerging field, this text represents a continuing evolution of surgical techniques, as well as a framework around which surgical therapies are based. Providing a fundamental understanding of the surgical principles while also recognizing the fast-paced nature of the advances in technique, Gender Confirmation Surgery touches upon the challenges and complexities in the surgical care of transgender individuals, featuring detailed sections for transwomen and transmen surgeries, non-surgical options, and establishing educational programs. Written as a guide primarily for surgeons in plastics, urology, and gynecology, this book can also appeal to primary care practitioners, mental health professionals, and endocrinologists. By representing an evolution of technique and advances in the field, Gender Confirmation Surgery offers a framework around which practitioners can familiarize themselves with gender surgery.

Contents:
CH 1 History, Societal Attitudes, Contexts
CH 2 Etiology of Gender Dysphoria
CH 3 The Mental Health Assessment for Surgery
CH 4 Primary Care for the Transgender and Gender Nonconforming Patient
CH 5 Hormone Therapy for Transgender Women
CH 6 Hormone Therapy for Transgender Men
CH 7 Medical Management of the Adolescent Individual with Gender Dysphoria
Ch 8 Establishment of a Gender Confirmation Program
CH 9 Male-to-Female Breast Augmentation and Body Contouring
CH 10 The Importance of Facial Gender Confirmation Surgery
CH 11 Facial Gender Confirmation Surgery: Facial Feminization Surgery and Facial Masculinization Surgery
CH 12 Fertility Preservation Options for Transgender Men Planning Hysterectomy
CH 13 Penile Inversion Vaginoplasty
CH 14 Intestinal Vaginoplasty
CH 15 Female-to-Male Chest Reconstruction
CH 16 Urethral Anatomy, Urethral Construction in Phalloplasty and Metoidioplasty
CH 17 MLD Musculo-Cutaneous Latissimus Dorsi) Phalloplasty
CH 18 Radial Forearm (RF) and Anterolateral Thigh (ALT) Phalloplasty Reconstruction
CH 19 Management of Urethral Complications Following Metoidioplasty and Phalloplasty
CH 20 Strategies to Optomize Sexual Function After Genital Gender Affirming Surgery
CH 21 Post Operative Care from the Primary Care Perspective
CH 22 Religious Attitudes Toward Gender Confirmation Surgery
CH 23 History of Gender Identity and Surgical Alteration of the Genitalia
CH 24 Terminology, Spectrum of Gender Identity and Expression.

Summary: This book reviews all aspects of the diagnosis and management of heart disease in women, covering areas such as gender differences in metabolic syndrome, hypertension and atherogenesis. Gender differences in cardiovascular diseases are widespread, but while gender medicine takes into account the effects of sex and gender on the health of women and men, traditionally, women have been underrepresented in cardiovascular clinical trials, in management of different cardiac diseases and drug use. Gender Differences in the Pathogenesis and Management of Heart Disease deals with the gender-specific differences in cardiac physiology and diseases and brings into perspective the critical significance of gender in management of cardiovascular disease presentations and management. As such it is of enormous use to all clinical staff who manage women with cardiovascular disease.

Summary: "In 2014, Maia Kobabe, who uses e/em/eir pronouns, thought that a comic of reading statistics would be the last autobiographical comic e would ever write. At the time, it was the only thing e felt comfortable with strangers knowing about em. Now, Gender Queer is here. Maia's intensely cathartic autobiography charts eir journey of self-identity, which includes the mortification and confusion of adolescent crushes, grappling with how to come out to family and society, bonding with friends over erotic gay fanfiction, and facing the trauma and fundamental violation of pap smears. Started as a way to explain to eir family what it means to be nonbinary and asexual, Gender Queer is more than a personal story: it is a useful and touching guide on gender identity--what it means and how to think about it--for advocates, friends, and humans everywhere."--Amazon.

Summary: "This one-of-a-kind, comprehensive workbook will help you navigate your gender identity and expression at home, in school, and with peers, "--Amazon.com.

Contents:
Gender identity
Gender expression
Family
School and work
Friends and other peers
Dating and sex
Balancing multiple identities
Dealing with the hard stuff.

Summary: The Pulitzer Prize-winning author draws on his scientific knowledge and research to describe the magisterial history of a scientific idea, the quest to decipher the master-code of instructions that makes and defines humans; that governs our form, function, and fate; and that determines the future of our children. The story of the gene begins in earnest in an obscure Augustinian abbey in Moravia in 1856 where Gregor Mendel, a monk working with pea plants, stumbles on the idea of a "unit of heredity." It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms postwar biology. It invades discourses concerning race and identity and provides startling answers to some of the most potent questions coursing through our political and cultural realms. It reorganizes our understanding of sexuality, gender identity, sexual orientation, temperament, choice, and free will, thus raising the most urgent questions affecting our personal realms. Above all, the story of the gene is driven by human ingenuity and obsessive minds--from Mendel and Darwin to Francis Crick, James Watson, and Rosalind Franklin to the thousands of scientists working today to understand the code of codes. Woven through the book is the story of Mukherjee's own family and its recurring pattern of schizophrenia, a haunting reminder that the science of genetics is not confined to the laboratory but is vitally relevant to everyday lives. The moral complexity of genetics reverberates even more urgently today as we learn to "read" and "write" the human genome--unleashing the potential to change the fates and identities of our children and our children's children.--Adapted from dust jacket.

Contents:
Prologue: Families
"The missing science of heredity" 1865-1935
"In the sum of the parts, there are only the parts" 1930-1970
"The dreams of geneticists" 1970-2001
"The proper study of mankind is man" 1970-2005
Through the looking glass 2001-2015
Post-genome 2015-...
Epilogue: Bheda, Abheda.

Summary: In this book, leading experts provide detailed descriptions of the exciting treatments that are expected to become part of the ophthalmologist?s arsenal within the next 10?20 years. The treatments discussed relate to a wide variety of conditions, including macular degeneration, Leber?s congenital amaurosis, retinitis pigmentosa and choroideremia. The authors explain clearly how different gene and cell therapies work and provide first-hand accounts of the difficulties that they have faced in bringing these technologies to clinical trial, such as issues relating to funding and ownership. Results achieved to date are presented, and the further steps required before the treatment in question can become a routine option are considered. Gene- and Cell-Based Treatment Strategies for the Eye is unique in showing the organic development of cutting-edge science into potential treatments for eye disease without compromising on accurate reporting of scientific facts. It will persuade the average practitioner or researcher ? whether ophthalmologist, health worker, or scientist ? that change is indeed coming and is not just a hollow promise of the tabloid media.

Contents:
Introduction
Gene Therapy for Leber?s Congenital Amaurosis due to RPE65 Mutations
Gene Therapy for Choroideremia
Gene Therapy for Dominantly Inherited Retinal Degeneration
Age-Related Macular Degeneration: The Challenges
Neovascular Age Related Macular Degeneration: Secretion Gene Therapy
Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration
Restoring Physiologic Barriers Against Neovascular Invasion.

Contents:
1. Clinical features of β-thalassemia and sickle cell disease
2. Genetic basis and genetic modifiers of β-thalassemia and sickle cell disease
3. Current standards of care and long term outcomes for thalassemia and sickle cell disease
4. Allogeneic/matched related transplantation for β-thalassemia and sickle cell anemia
5. Alternative donor/unrelated donor transplants for the β-thalassemia and sickle cell disease
6. Gene addition strategies for β-thalassemia and sickle cell anemia
7. Reactivation of fetal hemoglobin for treating β-thalassemia and sickle cell disease
8. Genome editing for β-hemoglobinopathies
9. Gene and cell therapy for β-thalassemia and sickle cell disease with induced pluripotent stem cells (iPSCs): the next frontier
Index.

Summary: Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.

Contents:
Part I: Gene Therapy
Part II: Cell Therapy - "With emphasis on gene modified cell therapies."

Summary: Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Contents:
The History of Cellular Therapies
Basics of Immunity
Biology of CAR T cells
Cell types used for CAR generation
Combination therapeutics with CART cell therapy
Safety switches used for cellular therapies
Off-the-shelf CAR-T
Manufacturing of CAR-T Cells: the Assembly Line
Navigating Regulations in Gene and Cell Immunotherapy
Bringing CAR-T to the Clinic
CAR T-Cell Complications
Mechanisms of Resistance and Relapse after CAR T cell therapy
Tumor infiltrating lymphocytes (TIL): from bench to bedside
T-cell Receptor (TCR) Engineered Cells and Their Transition to Clinic
Viral Cytotoxic T Lymphocytes (CTLs): from Bench to Bedside
Biology of NK cells and NK cells in clinic
Biology and Clinical Evaluation of T/NK Cell Engagers
Roadmap for Starting an Outpatient Cellular Therapy Program.

Contents:
RecTEPsy-mediated recombineering in Pseudomonas syringae / Bryan Swingle - Genome manipulations with bacterial recombineering and site-specific integration in Drosophila / Yi Zhang, William Schreiner, and Yikang S. Rong
Multiple genetic manipulations of DT40 cell line / Akira Motegi and Minoru Takata
Gene targeting of human pluripotent stem cells by homologous recombination / Sara E. Howden and James A. Thomson
Methods for the assessment of ssODN-mediated gene correction frequencies in muscle cells / Carmen Bertoni
Small fragment homologous replacement (SFHR) : sequence-specific modification of genomic DNA in eukaryotic cells by small DNA fragments/ Andrea Luchetti, Arianna Malgieri, and Federica Sangiuolo
Preparation and application of triple helix forming oligonucleotides and single strand oligonucleotide donors for gene correction / Md. Rowshon Alam ... [et al.]
Triplex-mediated genome targeting and editing / Faisal Reza and Peter M. Glazer
Targeting piggyBac transposon integrations in the human genome / Daniel L. Galvan, Claudia S. Kettlun, and Matthew H. Wilson
Gene targeting in human-induced pluripotent stem cells with adenoviral vectors / Kohnosuke Mitani
Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus / Melissa A. Bartel and David V. Schaffer
Lentiviral vectors encoding zinc-finger nucleases specific for the model target locus HPRT1 / Laetitia P.L. Pelascini and Manuel A.F.V. Gonçalves
Designing and testing the activities of TAL effector nucleases / Yanni Lin, Thomas J. Cradick, and Gang Bao
Bacterial one-hybrid system to isolate homing endonuclease variants with altered DNA target specificities / Rakesh Joshi and Frederick S. Gimble
Design and analysis of site-specific single-strand nicking endonucleases for gene correction / Michael J. Metzger and Michael T. Certo
CRISPR-Cas-mediated targeted genome editing in human cells / Luhan Yang ... [et al.]
RNA-guided genome editing of mammalian cells / Neena K. Pyzocha ... [et al.]
Nuclease-mediated double-strand break (DSB) enhancement of small fragment homologous recombination (SFHR) gene modification in human- induced pluripotent stem cells (hiPSCs) / R. Geoffrey Sargent, Shingo Suzuki, and Dieter C. Gruenert
AAV-mediated gene editing via double-strand break repair / Matthew L. Hirsch and R. Jude Samulski
Genetic modification stimulated by the induction of a site- specific break distant from the locus of correction in haploid and diploid yeast Saccharomyces cerevisiae / Samantha Stuckey and Francesca Storici
Southern blot protocol to detect chimeric nuclease- mediated gene repair / Céline J. Rocca ... [et al.]
High-throughput cellular screening of engineered nuclease activity using the single-strand annealing assay and luciferase reporter / Thomas J. Cradick, Christopher J. Antico, and Gang Bao
Unbiased method for detection of genome-wide off- target effects in cell lines treated with zinc finger nucleases / Cory R. Lindsay and David B. Roth
Identification of off-target cleavage sites of zinc finger nucleases and TAL effector nucleases using predictive models / Eli J. Fine, Thomas J. Cradick, and Gang Bao
Method for retinal gene repair in neonatal mouse / Marilyn Dernigoghossian ... [et al.]
In utero delivery of oligodeoxynucleotides for gene correction / Lingzhi Cai ... [et al.]
Portal vein delivery of viral vectors for gene therapy for hemophilia / Alexandra Sherman ... [et al.]
Gene correction of induced pluripotent stem cells derived from a murine model of x-linked chronic granulomatous disorder / Sayandip Mukherjee and Adrian J. Thrasher
Efficient transduction of hematopoietic stem cells and its potential for gene correction of hematopoietic diseases / Dolly Thomas and Gustavo Mostoslavsky.

Contents:
Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System
Lentiviral Vectors for Gene Delivery to the Nervous System
Gene Therapy for Parkinson's Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)
Gene Delivery and Gene Therapy for Alzheimer's Disease
Gene Therapy for Huntington's Disease
Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury
Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors
Targeted Gene Therapy for Ischemic Stroke
Adeno-Associated Viral Gene Therapy for Retinal Disorders
Gene Therapy for Epilepsies
AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement
Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice
Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?
Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models

Contents:
Microarray Transposon Tracking for the Mapping of Conditionally Essential Genes in Campylobacter jejuni
Identifying Essential Streptococcus sanguinis Genes Using Genome-Wide Deletion Mutation
Defining Essential Genes and Identifying Virulence Factors of Porphyromonas gingivalis by Massively-Parallel Sequencing of Transposon Libraries (Tn-seq)
Identification of Essential Genes and Synthetic Lethal Gene Combinations in Escherichia coli K-12
Identification of Genes Essential for Leptospirosis
Identifying Essential Genes in Mycobacterium tuberculosis by Global Phenotypic Profiling
Essential Genes in the Infection Model of Pseudomonas aeruginosa-PCR-Based Signature-Tagged Mutagenesis
Genome-Wide Synthetic Genetic Screening by Transposon Mutagenesis in Candida albicans
An Integrated Machine-Learning Model to Predict Prokaryotic Essential Genes
A Statistical Framework for Improving Genomic Annotations of Transposon Mutagenesis (TM) Assigned Essential Genes
A Proposed Essential Gene Discovery Pipeline: A Campylobacter jejuni Case Study
Computational Prediction of Essential Metabolic Genes Using Constraint-Based Approaches
Three Computational Tools for Predicting Bacterial Essential Genes
Gene Essentiality Analysis Based on DEG 10, an Updated Database of Essential Genes
Discovering Essential Domains in Essential Genes.

Contents:
--
v. 2. Eucaryotic chromosomes.

Contents:
The Present State and Future Direction of Integrated Gene Function Analysis
Performing Integrative Functional Genomics Analysis in GeneWeaver.org
Functional Annotation of Differentially Regulated Gene Set Using WebGestalt: A Gene Set Predictive of Response to Ipilimumab in Tumor Biopsies
Integrative Data-Mining Tools to Link Gene and Function
Detection of Driver Protein Complexes in Breast Cancer Metastasis by Large-Scale Transcriptome-Interactome Integration
Pattern Identification in Time-Course Gene Expression Data with the CoGAPS Matrix Factorization
Statistical Tools and R Software for Cancer Driver Probabilities
Predicting the Functional Consequences of Somatic Missense Mutations Found in Tumors
Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells
Reverse Engineering Transcriptional Gene Networks
Integrating In Silico Resources to Map a Signaling Network
A Method for Inducible Gene Over-Expression and Down-Regulation in Emerging Model Species Using Pogostick
Construction and Application of Site-Specific Artificial Nucleases for Targeted Gene Editing
Selection of Recombinant Antibodies from Antibody Gene Libraries
Construction of Simple and Efficient siRNA Validation Systems for Screening and Identification of Effective RNAi-Targeted Sequences from Mammalian Genes
Rapid Genetic Modification of Mouse Embryonic Stem Cells by Inducible Cassette Exchange Recombination
In Ovo Electroporation of miRNA-Based-Plasmids to Investigate Gene Function in the Developing Neural Tube
Proteomic Strategies: SILAC and 2D-DIGE--Powerful Tool to Investigate Cellular Alterations
Conditional Gene-Trap Mutagenesis in Zebrafish.

Summary: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Contents:
Eukaryotic Gene Expression by RNA Polymerase II / Geetha Durairaj, Shivani Malik, Sukesh R Bhaumik*
Epigenetic Code / Arunoday Bhan, Paromita Deb, Subhrangsu S Mandal
Histone Lysine Methylation, Demethylation, and Hormonal Gene Regulation / Yaling Huang, Briana Dennehey, Xiaobing Shi
The Role of HATs and HDACs in Cell Physiology and Disease / Irene Santos-Barriopedro, Helena Raurell-Vila, Alejandro Vaquero
The Short and Medium Stories of Noncoding RNAs: microRNA and siRNA / Arunoday Bhan, Paromita Deb, Milad Soleimani, Subhrangsu S Mandal
Long Noncoding RNA (lncRNA): Functions in Health and Disease / Arunoday Bhan, Milad Soleimani, Subhrangsu S Mandal
Histone Variants: Structure, Function, and Implication in Diseases / Francisca Alvarez, Alejandra Loyola
Genomic Imprinting in Mammals: Origin and Complexity of an Epigenetically Regulated Phenomenon / Elena de la Casa-Esperón
Centromere and Kinetochore: Essential Components for Chromosome Segregation / Shreyas Sridhar, Arti Dumbrepatil, Lakshmi Sreekumar, Sundar Ram Sankaranarayanan, Krishnendu Guin, Kaustuv Sanyal
Nuclear Receptors and NR-coregulators: Mechanism of Action and Cell Signaling / Arunoday Bhan, Subhrangsu S Mandal
Estrogen and Progesterone Receptor Signaling and Action / Linda I Perrotti
Gonadal Steroid Hormones and Brain Protection / Meharvan Singh, Courtney Brock, Rebecca Cunningham, Chang Su
Glucocorticoid Receptor-Mediated Signaling and Stress Metabolism / Rosalie M Uht, Shreyas A Bhave
Targeting Androgen Signaling in Prostate Cancer / Paul H Chung, Preethi Ravindranathan, Bishoy A Gayed, Ganesh V Raj
Role of Peroxisome Proliferator-Activated Receptors in Inflammation and Angiogenesis / Suchismita Acharya
RAR/RXR-Mediated Signaling / Jörg Mey
On the Trail of Thyroid Hormone Receptor Epigenetics / Pradip K Sarkar
Insulin Signaling, Epigenetics, and Human Diseases / Ragitha Chruvattil, Muskaan Belani, Tushar P Patel, Sarita Gupta
Endocrine Disruptors and Epigenetics / John D Bowman, Shaikh Mizanoor Rahman, Mahua Choudhury
Endocrine Disruptors / Paromita Deb, Subhrangsu S Mandal.

Summary: This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies. Edited by pioneering researchers, this volume presents extensive information to principal investigators, researchers, postdocs, and clinicians for examining the wide varieties of pathological conditions both inside and outside the liver. Providing not only the basic and clinical aspects of therapy, this volume is special in that it focuses on the administrative and regulatory difficulties of actual clinical application and legal regulations in different parts of the globe. By indicating the advantages and limitations of the most promising gene and cell therapies targeting the liver, this book will inspire readers to develop a feasible treatment in the next generation.

Contents:
1. Liver-Targeted Gene and Cell Therapies: An Overview
Part I. Cell Therapy
2. Macrophage Therapy for Liver Fibrosis and Regeneration
3. Liver Regeneration Therapy Using Autologous Bone Marrow-Derived Cells for Cirrhotic Patients
4. Novel Immunotherapy Using Liver Natural Killer Cells for Preventing Recurrence of Hepatocellular Carcinoma in Liver Transplantation
5. Cell-Based Immunotherapy for HCC: Our Experiences and Future Directions
Part II. Gene Therapy
6. AAV Vector-Mediated Liver Gene Therapy and Its Implementation for Hemophilia
7. Potential Usage of Human Artificial Chromosome for Regenerative Medicine
8. Image-Guided Hydrodynamic Gene Delivery to the Liver: Toward Clinical Applications
Part III. Legal Regulation 9. The Way to Clinical Applications of Human Pluripotent Stem Cells
10. Regulation for Gene and Cell Therapy Medicinal Products in Europe
11. IPSC-Derived Products: Current Regulations.- 12. Critical Path Initiative for Regenerative Medicine in Japan
13. Aseptic Manufacturing of Regenerative Medicine Products Using Isolator Technology
14. Cell and Vector Production Facility for Gene Therapy and Cell Therapy.

Contents:
Gene therapies for hepatitis C virus / Monique M.A. Verstegen, Qiuwei Pan, and Luc J.W. van der Laan
Recent advances in use of gene therapy to treat hepatitis B virus infection / Kristie Bloom, Abdullah Ely, and Patrick Arbuthnot
U1interference (U1i) for antiviral approaches / Lorea Blázquez and Puri Fortes
Gene therapy strategies to block HIV-1 replication by RNA interference / Elena Herrera-Carrillo and Ben Berkhout
HIV and ribozymes / Robert J. Scarborough and Anne Gatignol
Editing CCR5: a novel approach to HIV gene therapy / Tatjana I. Cornu, Claudio Mussolino, Kristie Bloom, and Toni Cathomen
Synthetic DNA approach to cytomegalovirus vaccine/immune therapy / Stephan J. Wu, Daniel O. Villarreal, Devon J. Shedlock, and David B. Weiner
Vector-mediated antibody gene transfer for infectious diseases / Bruce C. Schnepp and Philip R. Johnson
HIV latency and the non-coding RNA therapeutic landscape / Sheena Saayman, Thomas C. Roberts, Kevin V. Morris, and Marc S. Weinberg
C peptides as entry inhibitors for gene therapy / Lisa Egerer, Hans-Peter Kiem, and Dorothee von Laer
Aptamer-siRNA chimeras for HIV / Mayumi Takahashi, John C. Burnett, and John J. Rossi
Index.

Contents:
Essentials of viruses and their suitability for treatment ssing gene therapy
Harnessing RNAi to silence viral gene expression
Engineering sequence-specific DNA binding proteins for antiviral gene editing
Viral vectors for delivery of antiviral sequences
Delivery of antiviral nucleic acids with nonviral vectors
Gene therapy for chronic hepatitis B virus infection
Gene therapy for hepatitis C virus infection
Gene therapy for HIV-1 infection
Gene therapy for respiratory viral infections
Gene therapy for infection with hemorrhagic fever viruses
Gene transfer for prophylaxis and therapy of viral infections
Antiviral gene therapy : summary and perspectives.

Summary: Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system.

Summary: This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.

Contents:
Principles of gene therapy in reconstructive and regenerative surgery
Gene therapy in skin and wound healing
Gene therapy in pathologic scars
Gene therapy in skeletal muscle repair and regeneration
Gene therapy in cartilage repair and regeneration
Gene therapy in tendon repair and regeneration
Gene therapy and free flaps for therapeutic reconstructive surgery-- Developing a gene therapy clinical trial : tips and tricks
Future directions in reconstructive and regenerative surgery.

Contents:
Aptamer targeting the ERBB2 receptor tyrosine kinase for applications in tumor therapy / Georg Mahlknecht, Michael Sela, and Yosef Yarden
Gene gun her2/neu DNA vaccination : evaluation of vaccine efficacy in a syngeneic her2/neu mouse tumor model / Tam Nguyen-Hoai, Antonio Pezzutto, and Jörg Westermann
MIDGE technology for the production of a fourfold gene-modified, allogenic cell-based vaccine for cancer therapy / Manuel Schmidt, Barbara Volz, Patrick Grossmann, Kerstin Heinrich, and Burghardt Wittig
Evaluation of bystander cell killing effects in suicide gene therapy of cancer : engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis / Takeya Sato, Anton Neschadim, Ryo Nakagawa, Teruyuki Yanagisawa, and Jeffrey A. Medin
Oncoleaking : use of the pore-forming Clostridium perfringens enterotoxin (CPE) for suicide gene therapy / Jessica Pahle, Jutta Aumann, Dennis Kobelt, and Wolfgang Walther
iCaspase 9 suicide gene system / Xiaoou Zhou, Antonio Di Stasi, and Malcolm K. Brenner
p53-encoding pDNA purification by affinity chromatography for cancer therapy / Ângela Sousa, João A. Queiroz, and Fani Sousa
Phase 2, open-label, randomized study of pexa-vec (JX-594) administered by intratumoral injection in patients with unresectable primary hepatocellular carcinoma / Caroline J. Breitbach, Anne Moon, James Burke, Tae-Ho Hwang, and David H. Kirn
Antiangiogenic metargidin peptide (AMEP) tene therapy in disseminated melanoma / Iben Spanggaard and Julie Gehl
Clinical evaluation of ErbB-targeted CAR T-cells, rollowing intracavity delivery in patients with ErbB-expressing solid tumors / Sophie Papa, May van Schalkwyk, and John Maher.

Contents:

v. 1. Production and in vivo applications of gene transfer vectors. Preparation and quantification of pseudotyped retroviral vector / Hong Yu and Young Jik Kwon. Production of retroviral vectors for clinical use / Kenneth Cornetta, Lilith Reeves, and Scott Cross. Methods for the production of helper-dependent adenoviral vectors / Donna J. Palmer and Philip Ng. Methods for the production of first generation adenoviral vectors / Donna J. Palmer and Philip Ng. Large-scale production of recombinant adeno-associated viral vectors / Alejandro Negrete and Robert M. Kotin. Construction and production of recombinant herpes simplex virus vectors / William F. Goins ... [et al.] Plasmid-based gene transfer in mouse skeletal muscle by electroporation / Jonathan D. Schertzer and Goron S. Lynch. Chitosan nanoparticle-mediated gene transfer / Dongwon Lee and Shyam S. Mohapatra. PEG-PEI copolymers for oligonucleotide delivery to cells and tissues / Gordon J. Lutz, Shashank R. Sirsi, and Jason H. Williams. Non-viral gene delivery with cationic liposome-DNA complexes / Kai K. Ewert ... [et al.] Applications of lentiviral vectors in noninvasive molecular imaging / Abhijit De ... [et al.] Retroviral modification of mesenchymal stem cells for gene therapy of hemophilia A / Christopher B. Doering. Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells / Lucienne M. Ide, Elisabeth Javazon, and H. Trent Spencer. Assessment of CFTR function after gene transfer in vitro and in vivo / Uta Griesenbach ... [et al.] Oncolytic adenoviruses for cancer gene therapy / Ta-Chiang Liu, Stephen H. Thorne, and David H. Kirn. Design of trans-splicing adeno-associated viral vectors for Duchenne muscular dystrophy gene therapy / Yi Lai ... [et al.] Prevention of type 1 diabetes in NOD mice by genetic engineering of hematopoietic stem cells / Jessamyn Bagley, Charoui Tian, and John Iacomini. Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells / Mingjie Li and John J. Rossi. Nanoparticle-mediated gene delivery to the lung / Rajagopal Ramesh. Retroviral-mediated gene therapy for the differentiation of primary cells into a mineralizing osteoblastic phenotype / Jennifer E. Phillips and Andrés J. García. In vivo siRNA delivery to the mouse hypothalamus shows a role of the co-chaperone XAP2 in regulating TRH transcription / Stéphanie Decherf, Zahra Hassani, and Barbara A. Demeneix. Efficient retroviral gene transfer to epidermal stem cells / Pedro Lei and Stelios T. Andreadis.

Summary: In The Genealogy of a Gene, Myles Jackson uses the story of the CCR5 gene to investigate the interrelationships among science, technology, and society. Mapping the varied "genealogy" of CCR5 -- intellectual property, natural selection, Big and Small Pharma, human diversity studies, personalized medicine, ancestry studies, and race and genomics -- Jackson links a myriad of diverse topics. The history of CCR5 from the 1990s to the present offers a vivid illustration of how intellectual property law has changed the conduct and content of scientific knowledge, and the social, political, and ethical implications of such a transformation. The CCR5 gene began as a small sequence of DNA, became a patented product of a corporation, and then, when it was found to be an AIDS virus co-receptor with a key role in the immune system, it became part of the biomedical research world -- and a potential moneymaker for the pharmaceutical industry. When it was further discovered that a mutation of the gene found in certain populations conferred near-immunity to the AIDS virus, questions about race and genetics arose. Jackson describes these developments in the context of larger issues, including the rise of "biocapitalism," the patentability of products of nature, the difference between U.S. and European patenting approaches, and the relevance of race and ethnicity to medical research.

Contents:
The story of the CCR5 gene
The CCR5 patent(s)
Gene patenting and the product-of-nature doctrine
The CCR5 patent and intellectual property law
The European response to the CCR5 patent
CCR5 and HIV/AIDS diagnostics and therapeutics
Race, place, and pathogens
Race, difference, and genes
Epilogue: the end of an error?

Summary: The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014) focused on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments providing an international forum for the latest scientific discoveries, medical practices and care initiatives. This volume focuses on the bioinformatics and computational biology-related sessions

Contents:
1. Optoacoustics as a Bioengineering Model for Neuroscience Discovery / Vasilis Ntziachristos
2. Respiratory Particle Deposition Probability Due to Sedimentation with Variable Gravity and Electrostatic Forces / Ioannis Haranas, Ioannis Gkigkitzis, George D. Zouganelis, Maria K. Haranas, and Samantha Kirk
3. Sequence Patterns Mediating Functions of Disordered Proteins / Konstantinos P. Exarchos, Konstantina Kourou, Themis P. Exarchos, Costas Papaloukas, Michalis V. Karamouzis, and Dimitrios I. Fotiadis
4. Management and Modeling of Balance Disorders Using Decision Support Systems: The EMBALANCE Project / Themis P. Exarchos, Christos Bellos, Iliana Bakola, Dimitris Kikidis, Athanasios Bibas, Dimitrios Koutsouris, and Dimitrios I. Fotiadis
5. A Computer-Aided Diagnosis System for Geriatrics Assessment and Frailty Evaluation / Charalampos Vairaktarakis, Vasilis Tsiamis, Georgia Soursou, Filippos Lekkas, Markella Nikolopoulou, Emmanouilia Vasileiadou, Konstantinos Premtsis, and Athanasios Alexiou
6. Exploiting Expert Systems in Cardiology: A Comparative Study / George-Peter K. Economou, Efrosini Sourla, Konstantina-Maria Stamatopoulou, Vasileios Syrimpeis, Spyros Sioutas, Athanasios Tsakalidis, and Giannis Tzimas
7. Modeling Protein Misfolding in Charcot-Marie-Tooth Disease / Georgia Theocharopoulou and Panayiotis Vlamos
8. The Effect of the Shape and Size of Gold Seeds Irradiated with Ultrasound on the Bio-Heat Transfer in Tissue / Ioannis Gkigkitzis, Carlos Austerlitz, Ioannis Haranas, and Diana Campos
9. Clinical Decision Support System for the Diagnosis of Adolescence Health / Irene Moutsouri, Amalia Nikou, Machi Pampalou, Maria Lentza, Paulos Spyridakis, Natassa Mathiopoulou, Dimitris Konsoulas, Marianna Lampou, and Athanasios Alexiou
10. Mitochondrial Fusion Through Membrane Automata / Konstantinos Giannakis and Theodore Andronikos
11. A Mathematical Model for the Blood Plasma Flow Around Two Aggregated Low-Density Lipoproteins / Maria Hadjinicolaou
12. Translation of Two Aggregated Low-Density Lipoproteins Within Blood Plasma: A Mathematical Model / Maria Hadjinicolaou and Eleftherios Protopapas
13. Chaotic Attractors in Tumor Growth and Decay: A Differential Equation Model / Michael Harney and Wen-sau Yim
14. Modeling k-Noncrossing Closed RNA Secondary Structures via Meandric Compression / Antonios Panayotopoulos and Panayiotis Vlamos
15. Exploring the Online Satisfaction Gap of Medical Doctors: An Expectation-Confirmation Investigation of Information Needs / Panos E. Kourouthanassis, Patrick Mikalef, Margarita Ioannidou, and Adamantia Pateli
16. A Cloud-Based Data Network Approach for Translational Cancer Research / Wei Xing, Dimitrios Tsoumakos, and Moustafa Ghanem.

Summary: The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu, Greece, 10-13 April 2014. This volume focuses on the sessions that address geriatrics.

Contents:
Geriatrics
Neurodegenerative Diseases
Geriatric Psychiatry
Mechanisms of Aging
Metabolic Aging
Cognititon and Aging
Immunity and Aging
End-of-Life Care
Aging and Enviornmental Interaction.

Summary: The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014) focused on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments providing an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies were discussed along with their implications for various research, implementation and policy concerns. This volume focuses on neurodegenerative disease sessions.

Contents:
Neurodegenerative Diseases
Brain Disorders
Preclinical and Clinical Studies
Diagnostic Protocols and Tests
Drug Discoveries
Neuropharmacology
Neuroimaging.

Summary: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.

Contents:
Sis and Validation of Publications in Bioinformatics ation of new technologies in the production of pharmaceutical olive oil
A survey of evolutionary games in biology
DTCo: An ensemble SSL algorithm for X-rays classification
Cognitive Enhancement and Brain-Computer Interfaces. Potential Boundaries and Risks
Informatics and cognitive assessment: a RUDAS scale paradigm
Effective stochastic algorithm in disease prediction
A Systems Biology Approach for the Identification of Active Molecular Pathways during the Progression of Alzheimers Disease
A brief survey of the Prisoners' Dilemma game and its potential use in biology
Validation of modeling and simulation methods in computational biology
An improved self-labeled algorithm for cancer prediction
eHealth application for e-bloodanalysis, e-diagnosis and digital diet guidance
Modeling the critical activation of chaperone machinery in protein folding
ANTISOMA: A computational pipeline for the reduction of the aggregation propensity of monoclonal antibodies
A microscale mathematical blood flow model for understanding cardiovascular diseases
Blockchain For Mobile Health Applications Acceleration With GPU Computing
Finite Size Effects in Networks of Coupled Neurons
Detecting common pathways and key molecules of Neurodegenerative Diseases from the topology of molecular networks
Robotic Systems involved in the diagnosis of Neurodegenerative diseases
Undergraduate Students Brain Activity in Visual and Textual Programming
Fuzzy logic Systems and Medical Applications
Apache Spark Implementations for String Patterns in DNA Sequences
Big Data Analysis and Genetic Liability to Neuropsychiatric Disease
Mathematical models and computer simulation of chemical carninogenesis process and its inhibition by antocarcinogenic substances
Transitioning knowledge levels through problem-solving methods
Cellular phone users age or the duration of calls moderate autonomic nervous system? A meta-analysis
Logical Analy.

Summary: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.

Contents:
In Silico and In Vivo Studies on Quercetin as Potential Anti- Parkinson Agent
Exhaled Breath Condensate (EBC). Is it a viable source of biomarkers for lung diseases?
Treatment development for Alzheimer's disease: how are we doing?
Microbiome hijacking towards an integrative pest management pipeline
Regulation and roles of autophagy in the brain
Three-dimensional models for studying neurodegenerative and neurodevelopmental diseases
Assessment of factors contributing to the enhancement of memory and cognitive abilities in the context of neurosciences
Buccal Mucosa Biomarkers in Alzheimers Disease
Engaging social interest and creating awareness for the behavioural and psychological symptoms of dementia
Structural study of the DNA
Clock/Bmal1 complex provides insights for the role of cortisol, hGR and HPA axis in stress management and sleep disorders
The Effects of Quantum Entanglement on Chromatin and Gene Expression
Olive Oil Polyphenols in Neurodegenerative Pathologies
Human pluripotent stem cells as in vitro models of neurodegenerative diseases
Nutritional Lipidomics in Alzheimer's Disease
Alzeheimers Disease Therapeutic Approaches
Stress and Wellbeing of Psychiatry Trainees: A Literature Review
Brief Cognitive Tests in the case of Dementia and Alzheimers Disease Early Diagnosis
Synthesis, Molecular Docking studies and Biological Evaluation of N-Acylarylhydrazones as Anti-inflammatory agents
Exosome biomarkers revolutionize preclinical diagnosis of neurodegenerative diseases and assessment of treatment responses in clinical trials
Biomarkers as a different approach in prevention and treatment of drug addiction (preliminary study)
Sleep disorders and Restless Leg Syndrome in hemodialysis patients in Greece: a cross-sectional study
Craniofacial and neurological phenotype in a patient with de novo 18q microdeletion and 18p microduplication
What do recent clinical trials teach us about the et iology of AD
Developmental Biology and Transgenic Avian Embryology: Body Alterity Bioart Wet Lab
Gene editing, sexual reproduction and the arts: the present, the future and the imagined
Amyotrophic Lateral Sclerosis: Current status in diagnostic biomarkers
Synthesis and Characterization of Biologically Significant, 5-[N,N-dialkylamino alkoxy] azaindole 2-one,3- thiosemicarbazones and 5-[N,N-dialkylamino alkoxy] azaindole 3-hydrazone, 2-ones
Genetic counseling for adult-onset spinal and bulbar muscular atrophy (Kennedy syndrome). Multiple cases of prenatal testing in a family
Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis
Ocimum Sanctum Linn: A Potential Adjunct Therapy for Hyperhomocysteinemia
Induced Vascular Dementia
Alzheimer's disease: The role of mutations in protein folding.

Summary: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.

Contents:
A hypothesis of circulated microRnas implication in high incidence of atrial fibrillation and other electrocardiographic abnormalities in cancer patients
Central Line-associated Bloodstream Infections (CLABSI) Incidence and the role of obesity: a prospective, observational study in Greece
Number of brain states in an N-body dynamical scenario according to the universal Bekenstein entropy bound
Burden and sleeping disorders of family caregivers of Hemodialysis patients with Chronic Kidney Disease-End Stage. A cross-sectional study
Quality of life in type 2 diabetes mellitus patients with neuropsychological deficits
A framework for assessing the impact of information seeking behavior on cancer patients long-term prognosis
Sleeping Disorders and Health Related Quality of Life in Hemodialysis patients with Chronic Renal Disease in Greece
Subjective Quality of Life, Religiousness and Spiritual Experience in Greek Orthodox Christians: Data from Healthy Aging and Patients with Cardiovascular Disease
Mini-Mental State Examination: Greek normative data stratified by age and education in a large sample of 925 community-dwelling healthy participants
The role of the family in the care of Alzheimer patients
Prevalence of Stroke Cases in Warangal, Telangana Region, India: A Hospital-Based Case Study
Compliance of Patients with Acute Coronary Syndrome with treatment following their hospitalization from the Cardiac Coronary Unit
Using a Virtual Reality Serious Game to Assess the Performance of Older Adults with Frailty
Characteristics and survival rates in ward patients requiring evaluation by Intensivist in Greece.

Summary: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. Computational methodologies for implementation on the discovery of biomarkers for neurodegenerative diseases are extensively discussed. This volume focuses on the sessions from the conference regarding computational biology and bioinformatics.

Summary: The 4th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The relation between genetics and its effect on several diseases are thoroughly examined in this volume. This volume focuses on the sessions from the conference on Genetics and Neurodegenerative Diseases.

Summary: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.

Summary: Aimed at the practising clinician, this book, now in its third edition, provides a welcome detailed overview of the medical and surgical conditions that affect patients seen in everyday dental practice. With patients surviving longer due to medical advances, dentists are increasingly faced with complex conditions and possibly some that they have not previously encountered. Here, treatment advice, drug interactions, and the impact of general medical and surgical conditions on treatment planning in the dental context are all covered with a comprehensive but practical approach. In addition to chapters on the implications for dental practice of disorders of each of the different body systems and immunological and infectious diseases, important aspects in particular patient groups, including cancer patients, the elderly, and the paediatric population, are identified. Overall, this book provides dentists with a practical, logical, and convenient guide of great value, helping to update knowledge and foster improved patient care.

Contents:
History and Examination in the Clothed Patient in the Dental Surgery
The Cardiovascular System and Dental Practice
The Respiratory System and Dental Practice
The Gastrointestinal System and Dental Practice
Neurological Disorders and Dental Practice
Liver Disease and Dental Practice
The Endocrine System and Dental Practice
Renal Disorders and Dental Practice
The Musculoskeletal System and Dental Practice
Haematology and Patients with Bleeding Problems and Dental Practice
Metabolic Disorders and Dental Practice
Skin Disorders and Dental Practice
Psychiatry and Dental Practice
Cancer, Radiotherapy and Chemotherapy and Dental Practice
The Paediatric Patient and Dental Practice
The Older Patient and Dental Practice
Medical Emergencies in Dentistry
Infections and Infection Control in Dental Practice
Immunology and the Dental Practitioner.

Summary: This volume of the Orthopaedic Study Guide Series provides the foundation of general orthopedic and basic science. Chapters of this book cohere around three aspects of the musculoskeletal system, anatomy, physiology, and pathology. Next to basic principles, case reports underline key information relating to disorders, diagnosis, and treatment options. Written by leading experts, this volume is a concise guide designed as quick reference, thereby it presents a useful resource for orthopedic residents and fellows. .

Summary: The second edition of this book concisely covers the most recent developments in orthopedics and trauma. It features detailed descriptions, x rays, clinical and therapeutic pathway diagrams for a number of commonly encountered disorders including fractures, metabolic disorders, bone tumors, and amputations enabling the reader to develop a deep understanding of the latest information on how to successfully diagnose and treat these patients. General Principles of Orthopedics and Trauma is an ideal resource for trainees and junior surgeons seeking an easy to follow clinical guide on how to successfully diagnose and treat patients with orthopedic and trauma disorders. It is also of use to the experienced practitioner seeking a practically applicable text on the latest advances in the field.

Summary: This book highlights common similarities between the various schools of psychotherapy. It provides psychotherapists with the underlying neurophysiological, developmental psychological and relationship-oriented matrix (basic needs and their regulation, deficits, trauma and conflict processing patterns, including accompanying exercises) as well as opportunities for healing correction and stabilisation - and the ways in which to apply these methods in a therapeutically mindful way for the benefit of the patient. The new university-based psychotherapy training covers the four fundamental schools of psychotherapy, i.e. the previous standard approaches plus the systemic and humanistic ones. Focusing on the common ground builds bridges of understanding and encourages collaboration. This expanded, new range of methods to access patients constitutes a substantial development in the field of psychotherapy and will also influence the psychotherapy practice of experienced colleagues. Written for medical and psychological psychotherapists, psychosomatic doctors, psychiatrists and other specialists with additional psychotherapeutic qualifications, and for students of psychotherapy. .

Contents:
Intro
Preface
Contents
Acknowledgements
General Psychotherapy
1: Psychotherapy Between Tradition and Awakening and Between Multiplicity and Integrity
1.1 Psychotherapy as Science During a Period of Upheaval and the Search for Common Ground
1.1.1 What Is Psychotherapy and Where Does It Belong as a Field?
1.1.2 The Multiplicity of Our Psychotherapeutic Approaches - Confusion or Abundance?
1.1.3 The Risk: When Research Turns into the Plaything of Competing Associations
1.1.4 Are There Any Interdisciplinary Common Factors? 1.2 "Objectivity" - The Uncontroversial Main Feature of "Scientific Character"
1.2.1 The Belief in Reason - A Gift from the Enlightenment
1.2.2 The Drawback of Bias
1.2.3 The Temptation to Define "Science" Using Currently Available Measurement Tools
1.3 The "Necessary" Rediscovery of Subjectivity and Its Stake with Regard to Healing Therapy
1.3.1 The Lack of Emotion Creates a New Abundance
1.3.2 In Praise of Setting Limits: Crisis Intervention for Traumatic Inundation
1.3.3 The Birth of Resource Perception, Encounters and Searching for Meaning 1.3.4 The Acceptance of Creativity, Physical Comfort and Role Play
1.3.5 Simultaneous Fascination and Anti-establishment Sentiment: The Humanist Wave Hits Germany
1.3.6 The Convincing Triumph of Empathy and Its Social Commitment
1.4 The Discovery of the Abundance of Interspaces and Interpersonal Multi-person Structures
1.4.1 The Apparent "Gaps" in Relationships
1.4.2 The Pioneering Spirit of the First Generation of Couple, Family Therapy and Organisational Counsellors 1.5 The Unconscious - A Treasure Trove or an Unpredictable Sphinx? Discoveries in the Depths and Distance of Consciousness
1.5.1 The Multifaceted Nature of the Unconscious
1.5.2 Historical Milestones
1.5.3 Hypnosis, Trance and Hypnotherapy
1.6 "Artificial Intelligence" and the Complexity of Natural Brain Activity
1.7 Mindfulness - The Borderline Impact of Transcendental Spaces
1.7.1 Historical Waves of Encounters Between the "West" and the "Far East"
1.7.2 Current Interest in "Mindfulness-Based" Therapy Approaches
1.8 The "New Science of Psychotherapy" 1.8.1 Diversity with Common Reference Sciences
1.8.2 General Development Trends
1.8.3 Abandoned Aspects of Therapy
1.8.4 The Zeitgeist in Upheaval
1.8.5 Opportunities for Synopsis
Literature
2: Efficacies and Common Factors
2.1 Mindful Awareness: As an Organ of Perception and as a Creative Force
2.1.1 Two Consciousness-Modifying Forms of Being from One Basic Substance: The Focusing-Separating "Materialising-Locating" Pole - and the Interconnected-Oscillating, Non-local, Potentially Information-Receiving Pole with Floating Mixed States of Di

Summary: "Each year, general surgery residents across the county spend hundreds of hours studying for the American Board of Surgery certifying exam, also known as general surgery oral boards. This test is the final obstacle for general surgery residents on their journey to become board certified, practicing general surgeons in an easy to reference study guide with information covering the most commonly tested topics. This book is compiled based on ACS curriculum outlie making it helpful for medical students interested in surgery, general surgery residents, and practicing general surgeons. For each disease process, we include the relevant points of the history and physical, work-up, staging, treatment options, key surgical steps, and post-operative care. The unique format we use makes this book optimal for quick referencing and self-study. While this book was initially designed as a tool to study for the oral boards, it will also be extremely useful for residents and practicing surgeons as a quick reference guide in daily practice to brush up on procedural steps or the work up of complex conditions"-- Provided by publisher.

Contents:
Sleep apnea / Ashley Willoughby
Malignant hypertension / Harry Aubin
FUSE : fire during temporal artery biopsy / Paul Wetstein
Argon gas embolism / Roger Eduardo
FLS : aortic trocar perforation / Megan Bowen
Advanced laparascopy notes / Mark A. Gromski and Kai Matthes
Robotic-assisted surgery / Brenda Schmidt and Gordon Wisbach
Single incision and troubleshooting robotic surgery / Shah and Kudsi
Ethical/legal issues, decision making / Steve Alcazar and Shawn Tsuda
End of life care / Lam and Tsuda
Skin cancer / Jigesh A. Shah and Omar Yusef Kudsi
Decubitus ulcers / Pamela C. Masella and Mark K. Markarian
Melanoma / Amber E. Ritenour
Sarcoma and lymphoma / Joshua S. Ritenour
Thoracic surgery, lung cancer, cough / Ashraf A. Sabe
Abdominal wall reconstruction / Terri L. Carlson
Hernia, umbilical/ventral with cirrhosis / Richard M. Peterson
Asymptomatic inguinal hernia / Anez-Bustillos
Femoral hernia / Harry T. Aubin
Postoperative inguinal pain / Harry Aubin and Eric Balent
Inguinal neuralgia / Aubin and Balent.

Summary: Written by internationally acclaimed specialists, General Surgery Risk Reduction expands on complications associated with surgery and how to reduce them, the availability of relevant information and the rapid advancements of surgical technology. Chapters provide pertinent and concise procedure descriptions creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Complications are reviewed when appropriate for the organ system and problem. The text is illustrated throughout by line drawings and photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume General Surgery Risk Reduction provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.

Contents:
1. Introduction
2. General Peri-operative Complications
3. Surgical Infection
4. Pre-Operative Risk Assessment and Intra-Operative Monitoring
5. Anaesthesia Complications
6. Intensive Care Complications
7. Acute Peri-Operative Pain: Mechanisms and Management
8. Systems, Safety and Quality : Harm, Error and Litigation
9. Risk Management and Human Factors
10. Medico-Legal Risk Management in Surgery
11. Evaluation of Surgical Safety and Efficacy
12. Accreditation, Credentialing, Scope of Practice and Outcome Evaluation.

Summary: All European countries, including those that have recently joined the European Union or are candidates for membership, currently show a clear trend towards an increasing number of accidental injuries. This holds true for a range of injuries, including accidents among the elderly, sports injuries, and trauma due to traffic accidents. The increase in the number of injuries is accompanied by rising expectations among patients, who anticipate good functional results even after serious injuries. Despite these developments, trauma surgery is not yet established as an independent field in all European countries. Against this background, there is a clear need for a book that covers the state of the art in trauma surgery. This volume, which focuses on basics in trauma surgery is intended to help to meet this need. It will also serve to harmonize the practice of trauma surgery within the European Union and to prepare for the UEMS EBSQ trauma surgery.

Contents:
Trauma Care Systems
Prehospital Trauma Care
Trauma Scores
Response to Major Incidents and Disasters: An Important Part of Trauma Management
Polytrauma: Pathophysiology, Priorities, and Management
Anesthesia and Pain Relief in Trauma Patients
Contemporary Intensive Care Treatment for Patients with Severe Multiple Trauma
Systemic Infections and Sepsis
Necrotizing Soft-Tissue Infections
Soft-Tissue Trauma
Compartment Syndrome
Plastic Surgery in Trauma
Burn Injury
Thromboembolism
Muscle Injuries
Tendon Injuries
Treatment Principles of Nonunion
Osteitis
Pathologic Fractures.

Summary: Generative Artificial Intelligence: What Everyone Needs to Know ? equips readers with the knowledge to answer pressing questions about the impact of generative artificial intelligence on every facet of society.

Contents:
Cover
Generative Artificial Intelligence
Copyright
Dedication
Contents
Acknowledgments
Introduction
1 The History of Artificial Intelligence
What is Artificial Intelligence?
Where did the term "Artificial Intelligence" originate?
What were the Dartmouth conference participants hoping to accomplish?
How did early AI researchers approach the problem?
What is the "physical symbol system hypothesis"?
What is Machine Learning?
How did Machine Learning arise?
What are some notable historical milestones in AI?
2 Generative Artificial Intelligence (GAI) What are Large Language Models (LLMs)?
How do Large Language Models work?
What are "embeddings"?
How do word embeddings represent meaning?
What are Artificial Neural Networks?
What is a Transformer?
How do Transformers use word embeddings to express complex ideas?
What are "tokens"?
How are LLMs applied to non-​linguistic problems?
What are "emergent properties" and do LLMs exhibit them?
What is "jailbreaking" and why is it a difficult problem?
What is "hallucination" and why do LLMs have them?
What other techniques are used for GAI? How will future GAIs communicate with each other?
What are some potential future proficiencies of GAIs?
3 Likely Impact
What historical precedents are benchmarks for the impact of GAI?
How will GAI change healthcare?
How will GAI change the legal system?
How will GAI change education?
How will GAI change software engineering?
How will GAI change creative arts and industries?
4 Future of Work
Will GAI increase unemployment?
How does automation affect labor markets?
Which jobs are likely to fade away?
Which jobs will not be affected? Which jobs will thrive and grow?
What new industries and professions are likely to arise?
What is "technological unemployment"?
5 Risks and Dangers
How will GAI be used to promote disinformation and propaganda?
What is "algorithmic bias"?
Will people turn from humans to machines for emotional support?
How will GAIs impact the way we communicate?
What is the "alignment problem"?
Are "killer robots" just around the corner?
Should we be concerned about "superintelligence" and the "singularity"?
6 The Legal Status of GAIs Can a computer program enter into agreements and contracts?
Should people bear full responsibility for their intelligent agents' actions?
Should a GAI be granted legal rights, such as to own property?
Can a GAI commit a crime?
How can a GAI be held accountable for criminal acts?
Why can't we just program GAIs to obey the law and other rules?
7 Regulation, Public Policy, Global Competition
Are GAIs protected by free-​speech laws?
Can the output of a GAI be copyrighted?
What regulatory schemes are being considered? What new laws and regulations are appropriate for GAIs?
8 Philosophical Issues and Implications
What is philosophy of Artificial Intelligence?
Can a computer think?
Can a computer be creative?
Can a computer have free will?
Can a computer be conscious?
Can a computer feel?
9 Outroduction
Notes
Index

Summary: Generic drugs are now familiar objects in clinics, drugstores, and households around the world. We like to think of these tablets, capsules, patches, and ointments as interchangeable with their brand-name counterparts: why pay more for the same? And yet they are not quite the same. They differ in price, in place of origin, in color, shape, and size, in the dyes, binders, fillers, and coatings used, and in a host of other ways. Claims of generic equivalence, as physician-historian Jeremy Greene reveals, are never based on being identical to the original drug in all respects, but in being the same in all ways that matter. How do we know what parts of a pill really matter? Decisions about which differences are significant and which are trivial in the world of therapeutics are not resolved by simple chemical or biological assays alone. Questions of therapeutic similarity and difference are also always questions of pharmacology and physiology, of economics and politics, of morality and belief. Greene chronicles the social, political, and cultural history of generic drugs, narrating the evolution of the generic drug industry from a set of mid-twentieth-century "schlock houses" and "counterfeiters" into an agile and surprisingly powerful set of multinational corporations in the early twenty-first century. The substitution of bioequivalent generic drugs for more expensive brand-name products is a rare success story in a field of failed attempts to deliver equivalent value in health care for a lower price. Greene's history sheds light on the controversies shadowing the success of generics: problems with the generalizability of medical knowledge, the fragile role of science in public policy, and the increasing role of industry, marketing, and consumer logics in late-twentieth-century and early twenty-first century health care.

Contents:
Introduction: The same but not the same
What's in a name?
No such thing as a generic drug?
The sciences of similarity
Laws of substitution
Paradoxes of generic consumption
The generic alternative.

Contents:
Molecular genetics of the myeloproliferative neoplasms / Philip A Beer
Acute myeloid leukaemia / Dr Matthew L. Smith & Dr Thomas McKerrell
Molecular genetics of pediatric acute myeloid leukemia (AML) / M.M. van den Heuvel-Eibrink, J.D.E. de Rooij, and C.M. Zwaan
Acute lymphoblastic leukemia / Anna Andersson, Anthony V. Moorman, Christine J. Harrison and Charles Mullighan
The genetics of mature b-cell malignancies / Jonathan C. Strefford, Jude Fitzgibbon, Matthew J.J. Rose-Zerilli and Csaba Bödör
The genetics of chronic myelogenous leukaemia / Philippa C. May, Jamshid S. Khorashad, Mary Alikian, Danilo Perrotti and Alistair G. Reid.

Summary: This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. Such conditions are typically multifactorial or complex, with involvement of more than one gene as well as environmental influences. A sound grasp of this framework is ever more important, given the emergence of consumer genomics, including direct-to-consumer genetic testing. Dental professionals now need to understand why one person is susceptible to a particular oral health condition while a first-degree relative either does not develop the condition or does so in a less severe form. Knowledge of how genes operate in the susceptible host is essential if patients are to be offered accurate advice about their risks. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies. It will enable the practitioner to explain the extent to which a patients condition is pure "bad luck", whether that bad luck can be changed by behavioral choices, and how many of our behaviors are influenced by genes.

Contents:
Complex Inheritance in Oral Health Conditions
Genetic Basis of Enamel and Dentin Defects
Genetic Basis of Tooth Agenesis, Supernumerary Teeth, and Other Dental Abnormalities
Genetic Basis of Dental Caries and Periapical Pathology
Genetic Basis of Periodontitis and Tooth Loss
Genetic Basis of Dental Implant Failure and Alveolar Ridge Resorption
Genetic Basis of Craniofacial Deformities and Malocclusion, Oral Clefts, and Craniosynostosis
Genetic Basis of Lichen Planus and Oral Cancer
Genetic Basis of Orofacial Pain and Temporomandibular Joint Dysfunction
Genetic Influence on Behavior and the Impact on Oral Health Conditions.

Summary: This book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease. Written and edited by leading clinicians and scientists involved in the analysis and therapy of genetic cardiac disorders, it discusses the genetic causes of a variety of cardiac diseases, such as the complex genetics and etiology of congenital heart diseases. It also explores sex differences in prevalent diseases, genetics-based therapeutic strategies and the use of various animal models and alternatives. The book is intended for research scientists and clinical scientists in the cardiovascular field, human geneticists and cardiologists.

Contents:
Genetics of adult and fetal forms of Long QT Syndrome
The genetic landscape of cardiomyopathies. Genetic basis of mitochondrial cardiomyopathy
The Genetics of Coronary Heart Disease
Complex genetics and the etiology of human congenital heart disease-Familial Hypercholesterolemia
Long non-codingRNAs in cardiovascular disease
Mouse models to study inherited cardiomyopathy
Interrogating cardiovascular genetics in zebrafish
Human induced pluripotent stem cells as a platform for functional examination of cardiovascular genetics in a dish
Systems medicine as a transforming tool for cardiovascular genetics
Sex differences in prevalent cardiovascular disease in the general population.

Summary: "Genetic counseling is poised to play an increasingly important role in society as genome sequencing becomes a routine aspect of clinical assessment of both infants and adults. This volume examines the changing role of genetic counselors in the genomic age and the ways in which genetic counseling can be integrated into modern medicine"-- Provided by publisher.

Summary: Will I end up just like my parent? Will the children get it too? Why is this happening to me? The adult patient diagnosed with or at risk for a neurogenetic disease has many questions and concerns for the genetic counselor, the neurologist, and other practitioners. Because of the emotional and potentially life-altering impact of these diseases on the patient and family, counseling can be especially challenging. A rare hands-on guide to the subject, Genetic Counseling for Adult Neurogenetic Disease deals with core issues that differentiate adult neurogenetic counseling from its more familiar pediatric counterpart. This innovative book with accompanying videos is designed to fill in deficits in this area typical of training programs in genetic counseling (which have pediatrics and prenatal concentrations) and neurology (which rarely cover genetic counseling). For each condition featured, chapters include a detailed overview of genetic symptoms, diagnostic criteria, and management, plus guidelines for asking, and answering, pertinent questions. The major concentration, however, is on genetic counseling issues and case histories illustrating these issues. As an added dimension, the accompanying videos depict representative issues and challenges in genetic counseling for specific diseases in addition to the basics of a neurological examination. Among the conditions discussed: Movement disorders, including Parkinson's disease. Dementias, including Alzheimer's disease. Stroke. Motor neuron diseases. Neuropathies and channelopathies. Adult muscular dystrophies. Neurocutaneous syndromes. Plus a section on neurological and neuropsychological evaluation. This is information that will stay relevant as technologies change and genetic understanding evolves. Genetic Counseling for Adult Neurogenetic Disease offers advanced clinical wisdom for genetic counselors as well as neurologists, neuropsychologists, and other referring clinicians.

Contents:
Part 1:The Movement Disorders
1. Overview
2. Huntington Disease
3. Parkinson Disease
4. Dystonia
5. Ataxia
Part 2:The Dementias
6. Overview
7. Alzheimer?s Disease
8. Frontotemporal Degeneration
9. Prion Diseases
Part 3:Stroke
10. Overview of Cerebrovascular Disease and Stroke Risk Factors
11. CADASIL
Part 4:The Motor Neuron Diseases
12. Overview
13. Amyotrophic Lateral Sclerosis
14. Spinal Bulbar Muscular Atrophy: Kennedy?s Disease
15. Hereditary Spastic Paraplegia
Part 5:The Neuropathies and Channelopathies
16. Charcot Marie Tooth
17. Channelopathies
18. Overview
19. The Myopathies
20. The Muscular Dystrophies
21. The Myotonic Dystrophies
Part 7:Neurocutaneous Syndromes
22. Overview
23. Neurofibromatosis
24. Tuberous sclerosis
Part 8:The Clinical Evaluation
25. The Neurological Examination and Testing
26. The Neuropsychological Evaluation.

Summary: "Rapid increases in tests and technologies, media attention, and the expansion of genetic medicine and testing beyond conditions that are exclusively genetic in nature to common chronic illnesses with both genetic and environmental components (e.g., diabetes, heart disease, cancer), have raised demand for genetic counselling services and changing the scope of practice. Genetic counselors help individuals and families understand complex medical information, including diagnosis, prognosis, management options, risk, and heredity issues. They aid patients in decision-making while respecting ethical, familial, and cultural standards"-- Provided by publisher.

Contents:
Introduction / Bonnie S. LeRoy, Patricia Mccarthy Veach, and Nancy P. Callanan
Complicated shadows : the limitations of autonomy in genetic counseling / Robert G. Resta
Actively engaging with patients in decision-making / Andrea Shugar and Cheryl Shuman
Risk assessment and communication : a complex process / Shannan Delany Dixon, MaryAnn W. Campion, and Claire N. Singletary
A genetic counselor's guide to understanding grief / Nadia Ali and Cecelia Bellcross
Patient anger : insights and strategies / Lynn Schema
Resistance and adherence : understanding the patient's perspective / Krista Redlinger-Grosse
Countertransference : making the unconscious conscious / Krista Redlinger-Grosse
Supporting family communication about genetic conditions / Marion Mcallister, Rhona Macleod, and Alison Metcalfe
Developmentally-based approaches for counseling children and adolescents / Stephanie Austin and Kelly Schoch
Cultural competency and genetic counseling : key concepts / Nancy Steinberg Warren
Cultural competency : application to genetic counseling / Nancy Steinberg Warren
Education in genetic counseling : the impacts of genetic literacy and adult learning / Andrea L. Durst and Rachel Mills
Adapting genetic counseling practice to different models of service delivery / Angela Trepanier and Dawn C. Allain
"Oh the places you'll go!" The genetic counselor professional development journey / Catherine A. Reiser
Development of the genetic counseling profession : a professionalization process / Bonnie Jeanne Baty

Contents:
Developing research questions
Finding sources
Writing a review of literature
Ethics in research
Choosing a paradigm
Designing a quantitative study
Quantitative data analysis : I've got data, how do I get answers?
Conducting qualitative genetic counseling research
Preparing a manuscript for publication
Guidelines for directing research.

Summary: There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to aging, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. This book provides a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Contents:
Structure of chromatin in spermatozoa
Genomic changes in spermatozoa of aging male
Chromosomal aberrations and aneuploidies of spermatozoa
The sperm epigenome: implications for the embryo
Environmental epigenetics and effects on male fertility
Protamine alterations in human spermatozoa
Sperm DNA fragmentation and base oxidation
Iatrogenic enetic damage of spermatozoa
Sperm cryopreservation: effect on chromatin structure
Sperm selection: effect on sperm DNA quality
Effect of antioxidant on sperm genetic damage.

Summary: There are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Contents:
Genetic factors affecting sperm chromatin structure
Mechanisms of origin of chromosome deletions and rearrangements in spermatozoa
The sperm epigenome: implications for ART outcomes
Epigenetic transgenerational inheritance
Environmental genetic and epigenetic sperm alterations
Sperm DNA fragmentation: mechanisms of origin
Sperm DNA fragmentation: consequences for reproduction
Oxidative damage to sperm DNA: attack and defence
Interventions to prevent sperm DNA damage effects on reproduction.-Cryopreservation of sperm: effects on chromatin and strategies to prevent them
Effect on sperm DNA quality following sperm selection for ART: new insights
Sperm DNA damage in cancer patients
Index.

Contents:
Mechanisms of mutation
A clinical guide to monogenic diabetes
Hypoglycemia
Functioning pituitary adenomas
Diabetes insipidus
States of pituitary hypofunction
Congenital defects of thyroid hormone synthesis
Developmental abnormalities of the thyroid
Syndromes of impaired sensitivity to thyroid hormone
Molecular diagnosis of thyroid cancer
Genetics of hyperparathyroidism including parathyroid cancer
Genetic diagnosis of skeletal dysplasias
Vitamin d disorders
Congenital adrenal hyperplasia
Genetics of adrenocortical tumors (ACT) and hypersecretory syndromes
Hereditary syndromes involving pheochromocytoma and paraganglioma
Genetic conditions associated with congenital adrenocortical insufficiency or glucocorticoid and/or mineralocorticoid resistance
Genetic considerations in the evaluation of menstrual cycle irregularities
Disorders of sex development
Androgen insensitivity due to mutations of the androgen receptor
Obesity
Syndromes of severe insulin resistance and/or lipodystrophy
Lipodystrophies
Multiple endocrine neoplasia type 1 (MEN1)
Genetics of polyglandular failure
Genetic diagnosis of growth failure
Cost-effectiveness of genetic testing for monogenic diabetes
Genetic counseling: the role of genetic counselors on healthcare provider and endocrinology teams
Setting up a laboratory
Introduction to applications of genomic sequencing.

Summary: This book in the series "Sustainable Development and Biodiversity" contains peer-reviewed chapters from leading academicians and researchers around the world in the field of horticulture, plant taxonomy, plant biotechnology, genetics and related areas of biodiversity science centered on genetic diversity. This book includes original research reviews (national, regional and global) and case studies in genetic diversity in fruits and vegetables, horticulture, and ecology from sub-tropical and tropical regions. It is unique as it covers a wide array of topics covering global interests and will constitute valuable reference material for students, researchers, extension specialists, farmers and certification agencies who are concerned with biodiversity, ecology and sustainable development.

Contents:
Section 1: Biology and Phylogenetic Diversity
1. Augmentation of Plant Genetic Diversity in Synecoculture: Theory and Practice in Temperate and Tropical Zones; Masatoshi Funabashi
2. Amplified Fragment Length Polymorphism based Phylogenetic Relationships of Heirloom Tomato and Dark Green Vegetable Accessions; Ahmad Naseer Aziz
3. Molecular and Quantitative Genetics of Stone Pine (Pinus pinea); Mutke Regneri Sven et al
4. Sweetpotato Genetic Resources
Today and Tomorrow; Robert L. Jarret et al
Section 2: Genetic Diversity
5. Genetic Diversity in Vegetable Crops; Dilip Nandwani et al
6. The Genetic Diversity of Popular African Leafy Vegetables in Western Kenya; Christine Ndinya-Omboko
7. Genetic Diversity in African Eggplant: A Key Resource for Improving the Crop; Michael Kwabena Osei
8. Genetic Diversity in Nutritious Leafy Green Vegetable
Chaya (Cnidoscolus aconitifolius); Roland Ebel et al
9. Genetic Diversity in Taro (Colocasia esculenta); Susan C. Miyasaka et al
10. Genetic Diversity in Pitaya; Aroldo Cisneros, Noemi Tel-Zur
11. Genetic Diversity in Banana; Sanjit Debnath et al
Section 3. Agrobiodiversity Utilization
12. The role of agrobiodiversity in sustainable food systems design and management; Ciaccia Corrado et al
13. Induced Genetic Diversity in Banana; Suprasanna Penna, Mohan Jain
14. Exploration and Utilization of Genetic Diversity in Tomato; Michael Kwabena Osei et al
15. Agro-biodiversity adaptation in India for resilience to climate change; Thomas Abraham et al
Index.

Summary: Genetic Enhancement of Crops for Tolerance to Abiotic Stress: Mechanisms and Approaches, Volume I provides a consolidated update of the approaches taken to deepen our understanding of plants' morphological, physiological and molecular responses to various abiotic stresses and progresses made in unraveling and understanding the regulatory mechanisms, signaling pathways and cross talk among mechanisms operating under abiotic stress situations in various crops. The book includes articles on the diverse tools and technological approaches the use of which has improved our understanding of the intricate mechanisms operating in crop plants under abiotic stress conditions. The chapters describe the use of various 'omics' platforms such as transcriptomics, metabolomics, proteomics, microRNA and heat shock proteins as molecular players, phytohormone (s) regulation of stress signalling pathways, and various functional genomics approaches adopted by scientists to collate a wealth of information to understand abiotic stress tolerance mechanisms for crop improvement. In addition, chapters have been contributed on the burning topic of the role of chromatin remodeling under stress conditions and on the epigenetic dynamics via histones modifications that can improve stress tolerance in crops by enhancing the stress memory. We are very hopeful that the topics will be useful to a broad community of scientists working in similar areas and the outcomes discussed can provide useful leads to build strategies to generate abiotic stress tolerant varieties.

Contents:
Preface
Acknowledgements
1. Functional Genomics Approach Towards Dissecting out Abiotic Stress Tolerance Trait in Plants; Sneh L. Singla-Pareek
2. Plant miRNAome: Cross Talk in Abiotic Stressful Times; P. Suprasanna
3. Epigenetic Response of Plants to Abiotic Stress: Nature, Consequences and Applications in Breeding; Manoj. K. Dhar
4. Effect of Drought Stress and Utility of Transcriptomics in Identification of Drought Tolerance Mechanisms in Maize; T. Nepolean
5. Physiological and Molecular Basis of Abiotic Stress Tolerance in Wheat; H.M. Mamrutha
6. Molecular Chaperones: Key Players of Abiotic Stress Response in Plants; A. Pareek
7. Role of Chromatin Assembly and Remodeling in Water Stress Responses in Plants; N. Asharaf
8. The 'Omics' Approach for Crop Improvement Against Drought Stress; D. Jain
9. Genomic Strategies for Improving Abiotic Stress Tolerance in Crop Plants; N.R. Yadav
10. Genomics of Arsenic Stress Tolerance in Plants; P.K. Trivedi
11. Phytohormones Regulating the Master Regulators of CBF Dependent Cold Stress Signaling Pathway; R. Deswal
Index.

Contents:
Understanding staphylococcal nomenclature / Christina N. Krute and Jeffrey L. Bose
Restriction-modification systems as a barrier for genetic manipulation of Staphylococcus aureus / Marat R. Sadykov
Complementation plasmids, inducible gene-expression systems, and reporters for Staphylococci / Ralph Bertram
De novo assembly of plasmids using yeast recombinational cloning / Ameya A. Mashruwala and Jeffrey M. Boyd
Splicing by overlap extension PCR to obtain hybrid DNA products / Justin A. Thornton
Method for preparation and electroporation of S. aureus and S. epidermidis / Melinda R. Grosser and Anthony R. Richardson
Rapid isolation of DNA from staphylococcus / Kelsey L. Krausz and Jeffrey L. Bose
Bacteriophage transduction in Staphylococcus aureus : broth-based method / Kelsey L. Krausz and Jeffrey L. Bose
Bacteriophage transduction in Staphylococcus aureus / Michael E. Olson
Batch transduction of transposon mutant libraries for rapid phenotype screening in staphylococcus / Katherine L. Maliszewski
Conjugative transfer in Staphylococcus aureus / Cortney R. Halsey and Paul D. Fey
Allelic exchange / McKenzie K. Lehman, Jeffrey L. Bose, and Kenneth W. Bayles
Creation of staphylococcal mutant libraries using transposon Tn917 / Kelly C. Rice
Generation of a transposon mutant library in Staphylococcus aureus and staphylococcus epidermidis using bursa aurealis / Vijaya Kumar Yajjala ... [et al.]
Chemical and UV mutagenesis / Jeffrey L. Bose
Pulse field gel electrophoresis / Batu K. Sharma-Kuinkel, Thomas H. Rude, and Vance G. Fowler Jr.
RNA-sequencing of Staphylococcus aureus messenger RNA / Ronan K. Carroll, Andy Weiss, and Lindsey N. Shaw
Quantitative real-time PCR (qPCR) workflow for analyzing Staphylococcus aureus gene expression / April M. Lewis and Kelly C. Rice
Electrophoretic mobility shiftaAssays / Sarah E. Rowe and James P. O'Gara
Rapid amplification of cDNA ends for RNA transcript sequencing in staphylococcus / Eric Miller.

Summary: This book details basics in genetic linkage mapping, step-by-step procedures to perform marker assisted selection (MAS), achievements made so far in different crops, and the limitations and prospects of MAS in plant breeding.

Contents:
Intro
Preface (Second Edition)
Contents
About the Author
1: Genetic Mapping and Marker-Assisted Selection: Setting the Background
1.1 Setting the Background
1.2 Trends in Agricultural Product Demand: Functional Foods and Value-Added Products
1.3 Evolving New Crop Cultivars: Promises of Conventional Plant Breeding Programs
1.3.1 Achievements
1.3.2 Conventional Plant Breeding: Obstacles and Challenges
1.3.3 Germplasm Exchange: International Laws and Governance
1.3.4 Biotech Crops and Biosafety Issues 1.3.4.1 Evolving New Cultivars Using Tools of Biotechnology
1.3.4.2 Plant Tissue Culture-Based Approaches
1.3.4.3 Genetic Engineering and Transgenic Plants
1.3.4.4 Biosafety and Other Issues Related to Transgenic Crops
1.4 Alternative Approach: MAS
1.5 Scope of Genetic Mapping and Marker-Assisted Selection
1.6 Need for This Book: What Can Be Expected?
Critical Thinking Questions
Bibliography
Literature Cited
Additional Readings
2: Germplasm Characterization: Utilizing the Underexploited Resources
2.1 Types of Plant Germplasm: Natural Versus Man-Made 2.1.1 Conservation of Naturally Prevailing Plant Germplasm
2.1.1.1 In Situ Conservation
2.1.1.2 Ex Situ Conservation
2.1.2 Conservation of Man-Made Plant Germplasm
2.1.2.1 Crop-Specific Germplasm Repository
2.1.2.2 Mutagenized Population
2.1.2.3 Global Germplasm Resources
2.2 Germplasm Characterization: Phenotyping for Morphological and Agronomic Characters
2.2.1 Conventional Methods of Phenotyping: Biotic and Abiotic Stress Resistance, Yield, and Quality Traits
2.2.2 Recent Developments in Phenomics and Way Forward 2.2.3 Case Study in Rice Germplasm Characterization for Drought Resistance: Formation of the Fundamental Requirements
2.2.4 Traits Useful for Germplasm Characterization in Rice
2.3 Allele Mining
2.3.1 Allele Mining: Basic Considerations
2.3.2 Insertional Mutagenesis
2.3.3 Genome Editing Tools and Induced Variations
2.3.4 TILLING, EcoTILLING, and Self-EcoTILLING
2.3.5 Mutant-Assisted Gene Identification and Characterization (MAGIC)
2.3.6 Allele Mining: Challenges and Troubleshooting Perspectives
2.4 Genetic Diversity and Clustering 2.4.1 Software for Genetic Diversity Analysis
2.4.2 Principle Behind the Genetic Diversity Analysis
2.4.3 Principle of Measuring Goodness-of-Fit of a Classification
2.5 Issues in Genetic Diversity Analysis Using Molecular Markers
2.5.1 Co-dominant Markers and Similarity Measures
2.5.2 Dominant Markers and Similarity Measures
2.6 Diversity and Phylogenetic Tree: Importance in Mapping Population Development
2.7 DNA Barcoding and Its Utilization in Germplasm Exploitation
2.8 Parental Selection
Critical Thinking Questions
Bibliography
Literature Cited

Summary: "Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including an overview of genetic models of ASDs, phenotypic modeling of ASD symptoms, molecular mechanisms of NF1 model of ASD symptoms, ube3a gene dosage disorders, molecular and circuit mechanisms of ASD, circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more"--Publisher's description.

Contents:
Overview of genetic models of autism spectrum disorders / Jheel Patel, Jodi L. Lukkes, Anantha Shekhar
Neurofibromatosis type 1 as a model system to study molecular mechanisms of autism spectrum disorder symptoms / Andrei I. Molosh, Anantha Shekhar
ERK/MAPK signaling and autism spectrum disorders / Joseph Vithayathil, Joanna Pucilowska, Gary E. Landreth
From bedside to bench and back: Translating ASD models / Hayley P. Drozd, Sotirios F. Karathanasis, Andrei I. Molosh, Jodi L. Lukkes, ... Anantha Shekhar
Studying child development in genetic models of ASD / Shruti Garg, Jonathan Green
Measurement considerations in pediatric research on autism spectrum disorders / Karin S. Walsh, Srishti Rau.

Contents:
Section 1 Muscular Dystrophies
Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy carrier
Becker Muscular Dystrophy
Emery-Dreifuss Muscular Dystrophy type 1
Emery-Dreifuss Muscular Dystrophy type 2
Limb Girdle Muscular Dystrophy type 1B
Limb Girdle Muscular Dystrophy type 1C
Limb Girdle Muscular Dystrophy type 1F
Limb Girdle Muscular Dystrophy type 2A
Limb Girdle Muscular Dystrophy type 2B
Limb Girdle Muscular Dystrophy type 2C
Limb Girdle Muscular Dystrophy type 2D
Limb Girdle Muscular Dystrophy type 2E
Limb Girdle Muscular Dystrophy type 2F
Limb Girdle Muscular Dystrophy type 2I
Limb Girdle Muscular Dystrophy type 2K
Limb Girdle Muscular Dystrophy type 2N
Congenital Muscular Dystrophy type 1A
Congenital Muscular Dystrophy type 1C
Congenital Muscular Dystrophy with rigid spine
Congenital Muscular Dystrophy with integrin-alpha-7 deficiency
Congenital Muscular Dystrophy, Ullrich type
Bethlem myopathy
Facio Scapulo Humeral Muscular Dystrophy type 1A
Facio Scapulo Humeral Muscular Dystrophy type 2
Section 2: Congenital Myopathies
Congenital Multi-Mini-Core Myopathy
Congenital Central-Core Myopathy with Malignant Hyperthermia
Congenital Centronuclear Myopathy type 1
Congenital Hyaline Body Myopathy
Congenital Myotubular Myopathy
Congenital Nemaline Myopathy type 2
Congenital Fiber Type Disproportion type 1
Congenital Fiber Type Disproportion
Congenital Myofibrillar Myopathy type 1
Congenital Myofibrillar Myopathy type 6
Congenital Tubular Aggregate Myopathy
Hereditary Inclusion Body Myopathy type 2
Section 3: Ion Channel Disorders
Myotonic Dystrophy type 1, Steinert Disease
Congenital Myotonic Dystrophy
Myotonic Dystrophy type 2, Proximal Myotonic Myopathy
Congenital Myotonia, Thomsen Disease
Hyperkalemic Periodic Paralysis
Hypokalemic Periodic Paralysis type 1
Slow-channel Congenital Myasthenic Syndrome
Congenital Myasthenic Syndrome
Brody Disease
Section 4: Metabolic Myopathies
Glycogenosis type 2, Pompe Disease
Glycogenosis type 3, Cori-Forbes Disease
Glycogenosis type 5, McArdle Disease
Danon Disease
Kearns-Sayre Syndrome
Chronic Progressive External Ophthalmoplegia
MELAS (Myopathy, Encephalopathy, Lactic Acidosis, Stroke-like)
Leigh Syndrome due to COX Deficiency
Mitochondrial Encephalopathy with COX Deficiency
Coenzyme Q10 Deficiency
Multiple Symmetrical Lipomatosis
NARP (Neuropathy, Ataxia, Retinitis Pigmentosa)
SANDO (Sensory Ataxic Neuropathy, Dysarthria, Ophthalmoparesis)
Systemic Primary Carnitine Deficiency
Neutral Lipid Storage Disease with Ichthyosis
Neutral Lipid Storage Disease with Myopathy
Multiple Acyl-CoA Dehydrogenase Deficiency
Carnitine-Palmitoyl-Transferase-II Deficiency
Niemann-Pick Disease type C1
Section 5: Neurogenic Disorders
Spinal Muscular Atrophy type 1, Werdnig-Hoffmann Disease
Spinal Muscular Atrophy type 2
Spinal Muscular Atrophy type 3, Kugelberg-Welander Disease
Spinal Bulbar Muscular Atrophy, Kennedy Disease
Charcot-Marie-Tooth Disease type 1A
Charcot-Marie-Tooth Disease type 1B
Charcot-Marie-Tooth Disease neuronal type
Charcot-Marie-Tooth Disease type 4A
Charcot-Marie-Tooth Disease with pyramidal features
Charcot-Marie-Tooth Disease type X1
Distal Spinal Muscular Atrophy
Hereditary Neuropathy with Pressure Palsies
Friedreich Ataxia
Spastic Ataxia, Charlevoix-Saguenay type
Ataxia-Telangiectasia, Louis-Bar Syndrome
Spastic Paraparesis type 4
Spastic Paraparesis type 7
Optic Atrophy Plus Syndrome
Amyotrophic Lateral Sclerosis type 1
Amyotrophic Lateral Sclerosis.

Summary: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.

Contents:
Chapter 1. Polymorphisms and Mutation: What is difference?
Chapter 2. Single nucleotide polymorphisms and pharmacogenomics
Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility
Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer
Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes
Chapter 6. Role of Genetic Polymorphisms in Breast Cancer
Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer
Chapter 8. Thyroid Cancer and genetic polymorphism
Chapter 9. SNPs of TLRs and Bladder Cancer
Chapter 10. Role of genetic polymorphisms in Lung Cancer.

Contents:
v. 1. Mental and physical traits of a thousand gifted children / L.M. Terman, assisted by B.T. Baldwin, and others
v. 2. The early mental traits of three hundred geniuses / C.M. Cox, assisted by L.O. Gillan and others
v. 3. The promise of youth; follow-up studies of a thousand gifted children / B.S. Burks and others
v. 4. The gifted child grows up; twenty-five years' follow-up of a superior group / L.M. Terman and M.H. Oden
v. 5. The gifted group at mid-life; thirty-five years' follow-up of the superior child / L.M. Terman and M.H. Oden.

Summary: Genetic transformation is a key technology, in which genes are transferred from one organism to another in order to improve agronomic traits and ultimately help humans. However, there is apprehension in some quarters that genetically modified crops may disturb the ecosystem. A number of non-governmental organizations continue to protest against GM crops and foods, despite the fact that many organisms are genetically modified naturally in the course of evolution. In this context, there is a need to educate the public about the importance of GM crops in terms of food and nutritional security. This book provides an overview of various crop plants where genetic transformation has been successfully implemented to improve their agronomically useful traits. It includes information on the gene(s) transferred, the method of gene transfer and the beneficial effects of these gene transfers and agronomic improvements compared to the wild plants. Further, it discusses the commercial prospects of these GM crops as well as the associated challenges. Given its scope, this book is a valuable resource for agricultural and horticultural scientists/experts wanting to explain to the public, politicians and non-governmental organizations the details of GM crops and how they can improve crops and the lives of farmers.

Contents:
Chapter 1.Genetic tinkering of crops for sustainable development - 2020 and Beyond
Chapter 2.Genetic improvement of rice for food and nutritional security 3.Improvement of wheat (Triticum spp.) through gene manipulation
Chapter 4. Transgenic finger millet [Eleusine coracana (L.) Gaertn.] for crop improvement
Chapter 5. Transgenic pigeon pea [Cajanus cajan (L). Millsp.]
Chapter 6. Genetically engineered chickpea: Potential of an orphan legume to achieve food and nutritional security by 2050
Chapter 7. Progress in genetic engineering of cowpea for insect pest and virus resistance
Chapter 8. Peanut (Arachis hypogaea L.) transgenic plants for abiotic stress tolerance
Chapter 9. Genetic engineering of sunflower (Helianthus annuus L.) for important agronomic traits
Chapter 10. Genetic engineering in safflower (Carthamus tinctorius L.): Retrospect and prospect
Chapter 11. Nutritional value, in vitro regeneration and development of transgenic Cucurbita pepo and C. maxima for stress tolerance: An overview
Chapter 12. Sugarcane transgenics: Developments and opportunities .

Summary: Genetic transformation is a key technology, in which genes are transferred from one organism to another in order to improve agronomic traits and ultimately help humans. However, there is concern in some quarters that genetically modified crops may disturb the ecosystem. A number of non-governmental organizations continue to protest against GM crops and foods, despite the fact that many organisms are genetically modified naturally in the course of evolution. In this context, there is a need to educate the public about the importance of GM crops in terms of food and nutritional security. This book provides an overview of various crop plants where genetic transformation has been successfully implemented to improve their agronomically useful traits. It includes information on the gene(s) transferred, the method of gene transfer and the beneficial effects of these gene transfers and the agronomic improvements compared to the wild plants. Further, it discusses the commercial prospects of these GM crops as well as the associated challenges. Given its scope, this book is a valuable resource for agricultural and horticultural scientists/experts wanting to explain to the public, politicians and non-governmental organizations the details of GM crops and how they can improve crops and the lives of farmers. It also appeals to researchers and postgraduate students. This volume focuses on the transgenics of mungbean, cowpea, chickpea, cotton, mulberrry, Jatropha, fingermillet, papaya, citrus plants and cassava. It also discusses CRISPR edited lines. .

Contents:
Chapter 1. Transgenic tomatoes for abiotic stress tolerance and fruit traits: A review of progress and a preview of potential
Chapter 2.Genetically modified brinjal (Solanum melongena L.) and Beyond
Chapter 3. Biotechnology of red pepper
Chapter 4. Non-host armor against insect: Characterization and application of Capsicum annuum protease inhibitors in developing insect tolerant plants
Chapter 5. Transgenic banana: Current status, opportunities and challenges
Chapter 6. Transgenic papaya
Melaine Randle and Paula Tennant
Chapter 7. Genetically modified citrus: Current status, prospects and future challenges
Chapter 8. Genetically modified cassava; the last hope that could help to feed the world: Recent advances
Chapter 9. Transgenics for targeted trait manipulation: The current status of genetically engineered mulberry crop
Chapter 10. Genetically engineered Jatropha: A new bioenergy crop
Chapter 11. GM crops for plant virus resistance: A review.

Summary: Recent genetic studies of the spine has enhanced the understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. These findings are discussed in this timely review of scoliosis and developmental studies of the spine.

Contents:
Intro; Dedication; Preface; Contents; Contributors;
Chapter 1: Developmental andFunctional Anatomy oftheSpine; Introduction; Embryonic Origins oftheSpine; Establishing theIntersomitic Boundary; Somite Epithelialization; Rostral/Caudal Polarity ofSomites; The Anatomy andDevelopment oftheVertebrae andIntervertebral Discs; Functional Anatomy oftheVertebrae andIV Discs; Development oftheVertebrae; Rostral/Caudal Patterning; Formation oftheIV Discs; The Anatomy andDevelopment ofSpinal Muscles; Functional Anatomy oftheSpinal Muscles; Development ofSpinal Muscles. Nongenetically Linked Conditions Characterized byAxial Skeletal DefectsSpina Bifida; The VATER Association; Environmental Factors That Cause Axial Skeletal Dysmorphogenesis; Valproic Acid; Hypoxia; Carbon Monoxide; Diabetes; Retinoic Acid; Hyperthermia; Arsenic; Ethanol; Methanol; Conclusion; References;
Chapter 3: Congenital Scoliosis andSegmentation Defects oftheVertebrae intheGenetic Clinic; Introduction; Spondylocostal Dysostosis, Somitogenesis, andtheNotch Signalling Pathway; Varied Use ofClinical Terminology; Spondylocostal Dysostosis; Klippel-Feil Syndrome. Syndromes Containing CS PhenotypeAlagille Syndrome; VACTERL Association; Congenital NAD Deficiency Disorders; Facio-Auriculo-Vertebral Spectrum; Perspective; References;
Chapter 5: Animal Models ofIdiopathic Scoliosis; Introduction; Normal Spine Function Requires theIntegration ofMultiple Musculoskeletal Tissues; Spine Form Follows Dysfunction; What Makes aGood Animal Model ofDisease?; Animal Models; Mechanical Models ofIS; Environmental Models; Genetic/Heritable Models ofIS; Aquatic Models ofIS; Mouse Models; Distinct Elements oftheMammalian Spine. Tendon DevelopmentSummary; References;
Chapter 2: Environmental Factors andAxial Skeletal Dysmorphogenesis; Introduction; Vertebral Dysmorphogenesis inHuman Congenital Scoliosis; Normal Development oftheAxial Skeleton; Experimental Axial Skeletal Teratology; Pathogenesis ofAbnormal Axial Development; Overview ofAgents andConditions Associated withAxial Skeletal Teratogenesis; Recreational Teratogens; Pharmaceutical Teratogens; Industrial andEnvironmental Teratogens; Agricultural Teratogens; Infectious Diseases; Metabolic Conditions. The Genetics andClinical Description ofSCD SubtypesSCD1; SCD2; STD: Spondylothoracic Dysostosis; SCD3; SCD4; SCD5: Autosomal Dominant; SCD6; TBX6, Congenital Scoliosis, andMURCS; A New Classification andRadiological Reporting System forSDV; References;
Chapter 4: The Genetics Contributing toDisorders Involving Congenital Scoliosis; Introduction; Background; Embryological Basis ofCS; Approaches inUnderstanding theGenetic Etiology ofCS; TBX6 Variants Contributing toCS; Syndromes andDisorders Associated withVMs; Spondylocostal Dysostosis; Klippel-Feil Syndrome.

Contents:
Recent developments in the definition and official names of virus species / M.H.V. Van Regenmortel
A theory-based pragmatism for discovering and classifying newly divergent species of bacterial pathogens / F.M. Cohan, Sarah Kopac
Population structure of pathogenic bacteria / C.P. Andam, L. Challagundla, T. Azarian, W.P. Hanage, D.A. Robinson
Epidemiology and evolution of fungal pathogens in plants / P. Gladieux, E.J. Byrnes III, G. Aguileta, M. Fisher, R.B. Billmyre, J. Heitman, T. Giraud
Clonal evolution / T. de Meeûs, F. Prugnolle
Coevolution of host and pathogen / A.D. Morgan, B. Koskella
Microbes as tracers of past human demography and migrations / J.-P. Rasigade, A. Gilabert, T. Wirth
Phylogenetic analysis of pathogens / D.A. Morrison
Evolutionary responses of infectous diseases / G. Cochran, H. Harpending
Infectous disease genomics / Y.-T. Liu
Proteomics and host-pathogen interactions / D.G. Biron, D. Nedelkov, D. Missé, P. Holzmuller
The evolution of antibiotic resistance / F. González-Candelas, I. Comas, J.L. Martinez, J.C. Galán, F. Baquero
Modern morphometrics of medically important anthropods / J.-P. Dujardin
Evolution of resistance to insecticide in disease vectors / P. Labbé, J.-P. David, H. Alout, P. Milesi, L. Djogbénou, N. Pasteur, M. Weill
Genetics of major insect vectors / P.L. Dorn, S. Justi, E.S. Krasfur, G.C. Lanzaro, A.J. Cornel, Y. Lee, C.A. Hill
Multilocus sequence typing of pathogens / M. Pérez-Losada, M. Arenas, E. Castro-Nallar
Next-generation sequencing, bioinformatics, and infectous diseases / R. van Aerle, M. van der Giezen
Genomics of infectous diseases and private industry / G. Vernet
Current progress in the pharmacogenetics of infectous disease tehrapy / E. Elliot, T. Mahungu, A. Owen
Genetic exchange in trypanosomatids and its relevance to epidemiology / W. Gibson, M.D. Lewis, M. Yeo, M.A. Miles
Genomic insights into the past, current, and future evolution of human parasites of the genus plasmodium / C.J. Sutherland, S.D. Polley
Integrated genetic epidemiology of chagas disease / M. Tibayrenc, M.A. Shaw
Adaptive evolution of the mycobacterium tuberculosis complex to different hosts / E. Broset, J. Gonzalo-Asensio
The evolution and dynamics of methicillin-resistant staphylococcus aureus / M.M.H. Adelbary, P. Basset, D.S. Blanc, E.J. Feil
Origin and emergence of HIV/AIDS / M. D'arc, L. Etienne, E. Delaporte, M. Peeters
Evolution of SARS coronavirus and the relevance of modern molecular epidemiology / Z. Shi, L.-F. Wang
Ecology and evolution of avian influenza viruses / A.C. Hurt, R.A.M. Fouchier, D. Vijaykrishna.

Summary: "Genetics and Genomics in Medicine is a new textbook written for undergraduate and graduate students, as well as medical researchers, which explains the science behind the uses of genetics and genomics in medicine today. It is not just about rare inherited and chromosomal disorders, but how genetics affects the whole spectrum of human health and disease. DNA technologies are explained, with emphasis on the modern techniques that have revolutionized the use of genetic information in medicine and are indicating the role of genetics in common complex diseases. The detailed, integrative coverage of genetic approaches to treatment and prevention includes pharmacogenomics and the prospects for personalized medicine. Cancers are essentially genetic diseases and are given a dedicated chapter that includes new insights from cancer genome sequencing. Clinical disorders are covered throughout and there are extensive end-of-chapter questions and problems"--Provided by publisher.

Summary: Linum (flax) is a genus of about 200 species in the flowering plant family Linaceae. The genus includes common flax, which is one of the best fibers to produce linen, the seeds to produce linseed oil and has health-related properties of flax in human and animal nutrition. This book describes the genetics and genomics of Linum including the development of extensive experimental resources (e.g. whole genome sequence, efficient transformation methods, insertional mutant collections, large germplasm collections, resequenced genomes) that have led much progress and its economic importance. The methods and use of Linum to address a wide range of applications (e.g. disease resistance, cell wall composition, abiotic stress tolerance, floral development, natural diversity) is also discussed.

Contents:
Table of Contents (DRAFT) Preface 1. Taxonomy and Natural History of Linum Possible Authors: Axel Diederichsen and/or Yong Bi Fu 2. The gene pool of Linum usitatissimum and immediate progenitor Linum bienne Possible Authors: Axel Diederichsen and/or Yong Bi Fu (Flax variety descriptors Possible authors: L. Maggioni and/or M. Pavelek) 3. Flax breeding and variety release Possible Authors: Scott Duguid & /or Helen Booker 4. The flax genome sequence: a core resource for flax genomics Possible Author: Michael Deyholos<5. The assembly of the flax genomes into chromosomes Authors: Frank You & Sylvie Cloutier 6. Comparisons between oil-seed and fiber flax genomes Author: C. Cullis 7. The Linum transcriptome Possible author: R Datla 8. Mapping resources
molecular markers, mapping populations Possible author: S. Cloutier 9. Flax transposable elements Possible author(s): L. Galindo and M Deyholos 10. Flax small RNAs Possible author(s): T.Y Moss and C. Cullis 11. Gene mutagenesis systems in the fatty acid pathway Possible Authors: Alan Green for fatty acid mutants 12. Gene mutagenesis systems and resources for the flax
TILLING, transposons Possible Authors: M. Deyholos 13. QTL mapping Possible Authors: S. Cloutier 14. Flax cell walls and fiber Possible Authors: N. Carpita or M. Deyholos/Luca Comai 15. Flax transformation Authors: N. Bastaki and C Cullis 16. Linum Bioinformatics Resources Author: Deyholos and Cloutier 17. Flax disease resistance genes Possible author: Jeff Ellis 18. Genomic and phenotypic responses of flax to stress Author: C. Cullis 19. Flax secondary products Author: Selvaraj 20. Flax cyclic peptides Author: Datla 21. Medicinal uses of flax Possible author: Stephanie P.B. Caligiuri Author: Datla 22. Transgenic flax and the Triffid affair Possible author: J. Smyth 22. Fundamental insights into plant biology that might be offered by Linum Author: C. Cullis Index.

Contents:
Core concepts in human genetics : understanding the complex phenotype of sport performance and susceptibility to sport injury / Gibson, W.T
Nature versus nurture in determining athletic ability / Yan, X., Papadimitriou, I., Lidor, R., Eynon, N
Recent research in the genetics of exercise training adaptation / Venezia, A.C., Roth, S.M
Genes and athletic performance : an update / Ahmetov, I.I., Egorova, E.S., Gabdrakhmanova, L.J., Fedotovskaya, O.N
The future of genomic research in athletic performance and adaptation to training / Wang, G., Tanaka, M., Eynon, N., North, K.N., Williams, A.G., Collins, M., Moran, C.N., Britton, S.L., Fuku, N., Ashley, E.A., Klissouras, V., Lucia, A., Ahmetov, I.I., de Geus, E., Alsayrafi, M., Pitsiladis, Y.P
Genetics of musculoskeletal exercise-related phenotypes / Collins, M., O'Connell, K., Posthumus, M
Genes and musculoskeletal soft-tissue injuries / Rahim, M., Collins, M., September, A
Genetic testing for sports performance, responses to training and injury risk : practical and ethical considerations / Williams, A.G., Wackerhage, H., Day, S.H.

Contents:
Genome-wide association studies in type 2 diabetes / Beer, N.L.; McCarthy, M.I.
Fine mapping type 2 diabetes susceptibility loci / Morris, A.P.
Whole genome and exome sequencing of type 2 diabetes / Gaulton, K.; Flannick, J.; Fuchsberger, C.
Genome-wide association studies of glycaemic traits : a magical journey / Florez, J.C.; Barroso, I.
Genome-wide association studies of obesity and related traits / Mohlke, K.L.; Lindgren, C.M.
Next-generation sequencing for the diagnosis of monogenic diabetes and discovery of novel aetiologies / Ellard, S.; De Franco, E.
Whole-exome sequencing of patients with severe disorders of insulin action / Semple, R.; Barroso, I.
Epigenetic modifications and type 2 diabetes in humans / Ling, C.
Insights into ?-cell biology and type 2 diabetes pathogenesis from studies of the islet transcriptome / van de Bunt, M.; Morán, I.; FerrerJ.; McCarthy, M.I.
Genomics of adipose tissue / Pinnick, K.E.; Karpe, F.
Translating genetic association signals for diabetes and metabolic traits into molecular mechanisms for disease / Rees, M.G.; Gloyn, A.L.
Understanding molecular mechanisms for diabetes and obesity through mouse models / Merkestein, M.; Cox, R.; Ashcroft, F.
Genetics of drug response in diabetes / Pearson, E.R.; Florez, J.C.
Translating advances in our understanding of the genetics of diabetes into the clinic / Gardner, D.S.; Owen, K.R.; Gloyn, A.L.

Summary: "The birthplace of modern humans, Africa, has the highest genetic diversity in the world, yet it remains vastly understudied. With biomedical research increasingly focused on human variation, studying the large population size and number of mutations in African genomes could unravel the complexity of phenotypic traits underlying the biology of our species and hold huge potential for scientific and medical advances. An initial chapter 'conceptualizes Africa', providing relevant terminology. The first section covers genetic history and population structure. The next section looks at the genetic basis of common infectious diseases, such as leishmaniasis, malaria and tuberculosis, with a final part considering common non-communicable diseases, such as diabetes, hypertension, obesity, heart disease and cancer. Gene environment interaction under globalization and the burden of diseases of lifestyle are included. For researchers and graduate students in biological anthropology, genetic anthropology, human and population genetics, and public health"--Provided by publisher.

Contents:
1 Reflections on Conceptualizing Africa for Biological Studies with a Historical Component: A Small Essay
1.1 Prolegomenon
1.2 ''Blackness'' and Notions of Africa
1.3 Raciotypological Thinking
1.4 Africa: Evolution and Peopling
1.5 Human Variation in Africa
1.6 Defining versus Describing Africa/Africans
1.7 Biological Variation and Social Organization
1.8 Summary
Acknowledgments
References --2 History and Genetics in Africa: Multidisciplinary Efforts
2.1 Introduction
2.2 Genetics and Bantu Speakers
2.3 Genes, Food Production, and Afrasan
2.4 Genes, Ethno-Population Origins, and Identity
2.5 Genetics and the Northern Nile Valley: Egypt
2.6 The Case of the Nilotes/Nilotics: Considerations for Population History
2.7 Brief Discussion and Conclusions
Acknowledgments
References 3 Disease, Selection, and Evolution in the African Landscape
3.1 The Peculiarity of Genetic Structure In and Out of Africa
3.2 Population Structure Drift and Culture3.3 Food Culture and Genetic Variation
3.4 Inbreeding
3.5 Natural Selection and Disease
3.6 Biological Network and Genetic Borrowing
3.7 Epigenetics, an Added Layer of Complexity in the Selection Plateau
References
4 Genetic Susceptibility to Visceral Leishmaniasis
4.1 Leishmaniasis
4.2 Genetic Susceptibility to Visceral Leishmaniasis
4.3 Candidate Gene Studies
4.3.1 SLC11A1 (Formerly NRAMP1)
HLA as a Candidate Gene Region
Chromosome 17q11.1-q12
Chromosome 5q31-q33
4.3.2 IFNG and IFNGR1
4.3.3 IL2RB and IL1B
4.3.4 CXCR1 and CXCR2
4.4 Genome-Wide Linkage Studies
4.5 Genome Wide Association Studies
4.6 Conclusion and Future Perspectives
References 5 Genetics of Infection in Sub-Saharan Africa: What Can the Study of Mendelian Immunodeficiency Disorders Contribute?
5.1 Introduction: The Burden of Infectious Diseases in African Populations
5.2 Genetic Susceptibility to Infectious Diseases: Historical Perspectives
5.3 More Recent Approaches to Mapping TB Susceptibility Genes: What Have We Learned from Monogenic Disorders?
5.4 Molecular Basis of Mendelian Susceptibility to Mycobacterial Disease in Humans
5.4.1 Resistance to infection conferred by single-gene defects at the population level and the role of natural selection
5.5 Future Directions
References
6 Pharmacogenomics and Infectious Diseases in Africa: An Evolutionary Perspective
6.1 Introduction
6.2 The Burden of Infectious Diseases in Africa
6.2.1 Malaria
6.2.2 Human African Trypanosomiasis
6.2.3 Human Immunodeficiency Virus
6.2.4 Lassa Fever
6.2.5 Tuberculosis
6.3 Traditional Herbal Medicine
6.4 Progressing Toward Genomic Medicine in Africa
6.5 Conclusion
Acknowledgments
References

Contents:
Genetics and deafness : a view from the inside / Blankmeyer Burke, T. Snoddon, K., Wilkinson, E.
Hearing loss in older age and its effect on the individuals, their families, and the community / McMahon, C.M
Audiological assessment and management in the era of precision medicine / Munro, K.J., Newton, V.E., Moore, D.R
Next-generation newborn hearing screening / Shen, J., Morton, C.C
Clinical challenges in diagnosing the genetic etiology of hearing loss / Birkeland, A.C., Lesperance, M.M.
Genetic elucidation of nonsyndromic hearing loss in the high-throughput sequencing era / Vona, B., Hofrichter, M.A.H., Chioza, B.A., Crosby, A.H., Nanda, I., Haaf, T.
Genetic modifiers of hearing loss / Yousaf, R., Friedman, T.B., Riazuddin, S.
Genetics of age-related hearing loss / Dawes, P., Payton, A.
Genetic modifiers of hearing loss in mice : the case of phenotypic modification in homozygous cdh23ahl age-related hearing loss / Kikkawa, Y., Miyasaka, Y.
Using zebrafish to study human deafness and hearing regeneration / Varshney, G.K., Pei, W., Burgess, S.M.
Current understanding and potential of gene therapy for hearing restoration in humans / Akil, O., Lustig, L.

Summary: This book provides a comprehensive overview of the genetic basis underlying endocrine diseases. It covers both the molecular and clinical consequences of these genetic defects, as well as the relevance for clinical care, highlighting issues of genetic counseling. Several endocrine diseases have a genetic background, and contemporary research in the field plays a crucial role in the clinical care of endocrine diseases. In recent years, there have been major developments in our understanding of the genetic basis of endocrine diseases. Several novel genes and mutations predisposing individuals to monogenic endocrine diseases have been discovered, and with the advent of next generation sequencing, a huge amount of new data has become available. Further, novel molecular mechanisms, such as genomic imprinting, have been implicated in the pathogenesis of endocrine diseases. A better understanding of the genetic background of these diseases is relevant not only from the research perspective, but also in terms of clinical care. As such, this book is an essential read for both researchers and clinicians working in the field.

Contents:
Intro; Preface; Contents; Editors and Contributors; List of the Most Commonly Used Abbreviations; Part I: Basics of Genetics;
Chapter 1: Basic Concepts of Genetics; 1.1 Introduction; 1.2 Basic Terms of Genetics; 1.3 Mutations; 1.4 Chromosomes; 1.5 Proto-oncogenes and Tumor Suppressors; 1.6 DNA Variations; 1.7 Epigenetics; References;
Chapter 2: Brief Description of Inheritance Patterns; 2.1 Introduction; 2.2 Autosomal Dominant Inheritance; 2.3 Autosomal Recessive Inheritance; 2.4 X-Linked Dominant Inheritance; 2.5 X-Linked Recessive Inheritance; 2.6 Conclusions; References 6.3 The Glucocorticoid Signaling Pathway; 6.4 Primary Generalized Glucocorticoid Resistance (PGGR) or "Chrousos Syndrom"; 6.5 Beyond NR3C1 Genetic Defects; 6.6 NR3C1 Polymorphisms; 6.7 Concluding Remarks; References; Part III: Endocrine Diseases Inherited as Monogenic Traits: Hereditary Diseases Predisposing to Endocrine Tumors;
Chapter 7: Overview of Genetically Determined Diseases/Multiple Endocrine Neoplasia Syndromes Predisposing to Endocrine Tumors; 7.1 Introduction; 7.2 Multiple Endocrine Neoplasia Syndromes; 7.2.1 Multiple Endocrine Neoplasia Type 1
Chapter 3: Family Screening and Genetic Counseling; References;
Chapter 4: Brief Summary of the Most Important Molecular Genetic Methods (PCR, qPCR, Microarray, Next-Generation Sequencing, e ... ; 4.1 Introduction; 4.2 DNA Isolation and Quality Control; 4.3 Polymerase Chain Reaction (PCR); 4.4 Multiplex Ligation-Dependent Probe Amplification (MLPA); 4.5 Sanger Sequencing; 4.6 Array-Based Methods; 4.7 Next-Generation Sequencing; 4.8 Conclusion; References; Part II: Endocrine Diseases Inherited as Monogenic Traits: Hormone Resistance Syndromes.

Summary: This book provides comprehensive information on the genetics of eye diseases affecting various parts of the eye, and addresses a range of genetic etiologies. These diseases include several hereditary disorders of anterior and posterior segment, and with different genetic etiologies. The genetics of eye diseases is a field that has been rapidly growing over the last two decades, and comprises a vast area with considerable clinical and genetic heterogeneity. The main goal of this work is to discuss the status quo of genetics for each of the disorders covered, and to highlight unusual or atypical patterns of inheritance and genetic associations. For each relevant gene, it describes the pathogenic associations and variants, genotype-phenotype correlations, and functions at the cellular and molecular level. Genetics of Eye Diseases offers a valuable reference guide for geneticists and clinicians alike, while also providing a comprehensive overview of the field for graduate and doctoral-level students. In addition to sharing essential information on the genetics of each disease, it highlights recent advances that are representative of the developments in the field as a whole.

Contents:
Genetic basis of male and female infertility / R. Mallepaly, P.R. Butler, A.S. Herati, D.J. Lamb
Genetics of premature ovarian failure : new developments in etiology opportunity / Y. Qin, J.L. Simpson, Z.-J. Chen
Genetics of Klinefelter syndrome : experimental exploration / J. Wistuba, C. Brand, M. Zitzmann, O.S. Damm
Human Y chromosome and male infertility : forward and back from azoospermia factor chromatin structure to azoospermia factor gene function / P.H. Vogt, U. Bender, J. Zimmer, T. Strowitzki
Genetics and pathophysiology of the cystic fibrosis transmembrane conductance regulator in male reproduction : new evidence of a direct effect on the male germline / A. Touré
The genetics of androgen receptor signalling in male fertility / L. O'Hara, L.B. Smith
The genetics of postmeiotic male germ cell differentiation from round spermatids to mature sperm / T. Lehtiniemi, N. Kotaja
The epigenetics of sperm chromatin / M.B. Shamsi, L. Simon, D.T. Carrell
Characteristic features of male germline development in primates / R. Behr
Genetic and epigenetic mouse models of human male infertility / M. Godmann, S. Zemter, C. Kosan
In vitro spermatogenesis and its potential clinical implication for patients / J.-B. Stukenborg, K. Jahnukainen.

Summary: This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Contents:
Part I: The Genetic Basis of Reproduction
The Molecular Genetics of Testis Determination
Molecular Regulation of Sperm Production Cascade
Spermatozoal Chromatin Structure: Role in Sperm Functions and Fertilization
Genetic Basis of Endocrine Regulation of Spermatogenesis
Epidemiology of Genetic Disorders in Male Infertility
Genetic Evaluation of Male Infertility
Part II: Impact of Genetics on the Sperm Cell
Genetic Basis of Sperm Morphologic Defects: Head Defects, Body and Tail Defects
Mitochondrial Function and Male Infertility
Sperm DNA Fragmentation and Male Infertility
The Sperm Epigenome and Potential Implications for the Developing Embryo
Part III: Clinical Case Scenarios
Klinefelter Syndrome
Chromosomal Translocations and Inversion in Male Infertility
Genetics of Vas Aplasia
Anomalies of the Y Chromosome
Infertility and Cryptorchidism
Kartagener and Immotile Cilia Syndrome
Persistent Müllerian Duct Syndrome
Disorders of Sex Determination
Endocrine Genetic Defects
Sperm Aneuploidy
Part IV: Genetic Infertility: Is There Any Hope?- Sperm DNA Fragmentation
The Potential of CRISPR/Cas Gene Editing to Correct Male Infertility.

Summary: In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.

Contents:
Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies
Genetic Obesity Syndromes
Genome-Wide Association Studies of Obesity
Copy Number Variants and their Contribution to the Risk of Obesity
Genetics of Childhood Obesity
Genetic Pleiotropies of Obesity
Functional Follow-up of Genetic Variants Using FTO as the Prime Example.

Summary: The book focuses on describing the importance of genetics in eye diseases in a comprehensive and concise manner. Mutations in different set of genes have been detected and incriminated in complex mechanisms of causing leading eye diseases such as cataract and glaucoma. This book written by well-established ophthalmologists and geneticists presents a complicated subject in simple and easy to understand manner. Chapters cover the concept of gene therapy which is an emerging subject with high potential. The book includes a separate chapter on genetic counseling, which has become an integral component of ophthalmology. The book will assist the practicing ophthalmologists in early diagnosis of genetic eye diseases as well as help the geneticists in understaning the basic concepts. It will also be useful for students who are preparing for MD, MS, DNB and FRCS examinations.

Contents:
A perspective of genes and genetics in ophthalmology
Genetics of corneal dystrophies
Genetics of keratoconus
Genetics of cataract
Genetics of congenital glaucoma
Genetics of glaucoma
Genetics of retinoblastoma
Genetics of RP
Genetics of AMD
Genetics of high myopia
Genetics of ROP
Gene therapy in DR
Genetics of RD
Genetics of strabismus
Genetics of dry eye disease
Genetic counseling.

Summary: The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçets disease, Sjogrens syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.

Contents:
Preface
I Connective tissue diseases
1 Systemic lupus erythematosus (Possible contributors: Maria Teruel & Marta Alarcón)
2 Systemic sclerosis (Possible contributors: Elena Lopez-Isac & Marialbert Acosta)
3 Behçets disease (Possible contributors: Lourdes Ortiz & Francisca Gonzalez-Ecribano)
4 Sjogren's síndrome (Possible contributors: Pers JO, Renaudineau Y. & Xavier Marriet)
5 Polymiositis/Dermatomyositis (Possible contributors: Ana Márquez & Albert Selva)
II Autoimmune Vasculitis
6 ANCA-associated Vasculitis (Possible contributors: Augusto Vaglio)
7 Giant Cell Arteritis (Possible contributors: F. David Carmona & Miguel Ángel Gónzalez-Gay)
8 Takayasus Arteritis (Possible contributors: Amr H. Sawalha)
9 Kawasakis Disease (Possible contributors: David Burgner)
III Gastrointestinal and Liver/hepatic Autoimmune Conditions
10 Primary Biliary Cirrhosis, Sclerosing Cholangitis, and Autoimmune Hepatitis (Possible contributors: G.J. Webb & G.M. Hirschfield)
IV Central and Peripheral Nervous System
11 Multiple Sclerosis (Possible contributors: Antonio Alcina & Fuencisla Matesanz)
12 Myastenia Gravis (Possible contributors: Güher Saruhan Direskeneli)
V Shared Gentetic Component
13 Common Genetic Component in Autoimmunity (Possible contributors: Alexandra Sasha)
Subject Index.

Summary: The book illuminates the complex problems in genetic studies of substance use and addiction. It provides a comprehensive overview that fills the gap in the literature and points out future directions. The book includes three sections that apply to any complex traits and disorders, particularly psychological and psychiatric. The first section covers the traits and phenotypes that are the target of genetic research in substance use and addiction. Following this, the second section analyzes the methods and results of biometric genetic studies in this area. The third section reviews research in gene mapping and epigenetics. Genetics of Substance Use is a first-of-its-kind monograph that presents contemporary solutions and methods for a wide range of researchers and practitioners across disciplines.

Contents:
Substance use phenotyping
Substance use: disorders and continuous traits
Neurobiological systems in substance use
Psychological mechanisms of substance use
Biometric genetic studies in substance use
Twin studies
Family and adoption studies
Genomic studies in substance use
Gene mapping in complex disorders
Linkage and association studies
Epigenomic studies
Conclusions.

Contents:
Genital anatomy / Libby Edwards
Terminology and classification of genital disorders / Peter J Lynch
General principles of diagnosis and therapy / Peter J Lynch
Diagnostic and therapeutic procedures / Libby Edwards
Skin colored lesions / Peter J. Lynch
Red lesions: patches and plaques / Peter J Lynch, Libby Edwards
Red papules and nodules / Peter J. Lynch
White lesions / Libby Edwards
Dark colored lesions : brown, blue, gray or black disorders / Peter J. Lynch
Blistering and pustular diseases / Libby Edwards
Erosions and ulcers / Libby Edwards, Peter J. Lynch
Edema / Peter J. Lynch
Pruritus / Peter J. Lynch
Pediatric genital disease / Libby Edwards
Vaginitis and balanitis / Libby Edwards
Special issues in genital dermatology, psychosexual aspects, immunosuppression, and aging / Peter J. Lynch, Libby Edwards.

Summary: This book addresses the most pressing current questions in the management of urologic malignancies. Placing the rapid advances in imaging and molecular markers into a clinical context, it explains their effects on prognosis and treatment planning. Similarly, it carefully examines advances in immunotherapy, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, it reviews the impacts of care coordination pathways and enhanced recovery after surgery protocols. Futher, the book includes an enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The final two chapters are devoted to testicular cancer: the first discusses recent advances in prognostication, while the second elucidates contemporary medical and surgical management.

Contents:
New Imaging Techniques in Prostate Cancer
Targeted ablative therapies for prostate cancer
Prostate cancer markers
Prognostic value of CTC's in urologic cancers
Management of Small Renal Masses
Advances in the Treatment of Metastatic Renal Cell Carcinoma.-Imaging in urologic cancers
Molecular prognostication in Bladder cancer
Early cystectomy for high risk non-muscle invasive disease
Care-coordination pathway after radical cystectomy
Current role of checkpoint inhibitors in urologic cancers
) The Cancer Genome Atlas Project
Prognostic models in germ cell tumors
Modern management of testicular cancer.

Summary: Covering all modalities currently used as well as emerging novel imaging tools, each chapter covers an aspect of Genitourinary Imaging with a comprehensive coverage of subspeciatlies. Genitourinary Imaging - A Case Based Approach closely mimics day to day clinical practice, and allows retention of pertinent practice information in an easy to understand format. Providing Genitourinary specific content in a portable form that can be used in close proximity to the PACS workstation, Genitourinary Imaging - A Case Based Approach is the perfect book for residents both in training and practicing as well as genitourinary radiologists worldwide.

Contents:
1. Adrenal Gland
2. Kidneys
3. Ureters
4. Bladder and Urethra.-5. Retroperitoneum
6. Female Pelvis
7. Male Pelvis.

Contents:
Contrast media
Kidneys (native and transplant)
Adrenal glands
Upper tract (pelvicalyceal system and ureter)
Lower tract (bladder and urethra)
Male genital (prostate, penis, scrotum)
Female genital i (uterus and cervix)
Female genital ii (ovary, fallopian tube, vagina, and vulva)
Retroperitoneum
Review and miscellaneous.

Contents:
An introduction to radiologic methods
The kidney and retroperitoneum : anatomy and congenital abnormalities / Raymond Dyer
Renal masses / Ronald Zagoria
The kidney : the diffuse parenchymal abnormality / Raymond Dyer
The renal sinus, pelvocalyceal system, and ureter / Ronald Zagoria
The lower urinary tract / Christopher Brady
The female genital tract / Christopher Brady
The male genital tract / Raymond Dyer
Imaging of the adrenal glands / Christopher Brady
Interventional genitourinary radiology / Ronald Zagoria.

Contents:
Nonneoplastic diseases of the prostate / Kiril Trpkov
Neoplastic diseases of the prostate / Ming Zhou, Cristina Magi-Galluzzi
Nonneoplastic diseases of the urinary bladder / Fang-Ming Deng, Jonathan Melamed
Neoplasms of the urinary bladder / Jesse K. McKenney, Ming Zhou, Cristina Magi-Galluzzi
Nonneoplastic diseases of the kidney / Stephen M. Bonsib
Neoplasms of the kidney / Ming Zhou, Eyas M. Hattab, John N. Eble, Liang Cheng
Introduction to renal biopsy / Laura Barisoni, Lois J. Arend, David B. Thomas
Diseases of the ureter and renal pelvis / Ximing J. Yang
Diseases of penis, urethra, and scrotum / Rajal B. Shah
Nonneoplastic diseases of the testis / Cristina Magi-Galluzzi, Howard S. Levin
Neoplasms of the testis / Charles C. Guo.

Summary: This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms. Discussion of the clinical implications of pathological findings is contributed by renowned clinicians in the field. This handsome volume guides the reader through the intricacies of genitourinary tumor pathology, diagnosis, reporting, and prognosis. Written by experts in the field, Genitourinary Pathology: Practical Advances is of great value to anatomic pathologists, urologists, fellows in genitourinary pathology, as well as upper level residents training in pathology .

Contents:
Anatomy of the Prostate Revisited: Implications for Prostate Biopsy and Zonal Origins of Prostate Cancer
Contemporary Gleason Grading System
Contemporary Prostate Cancer Staging
Prostate Cancer Reporting on Biopsy and Radical Prostatectomy Specimens
Unusual Epithelial and Non-Epithelial Neoplasms of the Prostate
Management Implications Associated with Unusal Morphologic Entities of the Prostate
Nomograms for Prostate Cancer Decision-Making
Genetic Determinants of Familial and Hereditary Prostate Cancer
New Molecular Markers of Diagnosis and Prognosis in Prostate Cancer
Intraoperative Consultation for Prostate Tumors: Challenges and Implications for Treatment
Genomics and Epigenomics of Prostate Cancer
Anatomy of the Urinary Bladder Revisited: Implications for Diagnosis and Staging of Bladder Cancer
Classification and Histologic Grading of Urothelial Neoplasms by the WHO 2004 (ISUP 1998) Criteria
Reporting of Bladder Cancer in TURBT and Cystectomy Specimens
Urothelial Carcinoma Variants: Morphology and Association with Outcomes
Independent Predictos of Clinical Outcomes and Prediction Models on Bladder and Upper Urinary Tract Cancer
Familial Urothelial Carcinomas
New Molecular Markers with Diagnostic and Prognostic Values in Bladder Cancer
Intraoperative Consultation for Bladder Tumors: Challenges and Implications for Treatment
Genetic and Epigenetic Alterations in Urothelial Carcinoma
Urine Cytology
Anatomy of the Kidney Revisited: Implications for Diagnosis and Staging of Renal Cell Carcinoma
Classification of Adult Renal Tumors and Grading of Renal Cell Carcinoma
Tumor Staging for Renal Pathology
Surgical Pathology Reporting of Renal Cell Carcinomas
Newly Described Entities in Renal Tumor Pathology
Clinical and Management Implications Associated with Histologic Subtypes of Renal Cell Carcinomas
Independent Predictors of Clinical Outcomes and Prediction Models for Renal Tumor Pathology
Pathology of Inherited Forms of Renal Carcinoma
The Utility of Immunohistochemistry in the Differential Diagnosis of Renal Cell Carcinomas
Intraoperative Consultations for Renal Masses: Challenges and Implications for Treatment
Genetic and Epigenetic Alterations in Renal Cell Carcinoma
Role of Needle Biopsy in Renal Masses: Past, Present, Future
Anatomy of the Testis and Staging of its Cancers: Implications for Diagnosis
Classification of Testicular Tumors
Testicular Cancer Reporting on Radical Orchiectomy and Retroperitoneal Lymph Node Dissection After Treatment
Difficult or Newly Described Morphologic Entities in Testicular Neoplasia
Clinical Implications of the Differnt Histologic Subtypes of Testicular Tumors
Familial Syndromes Associated with Testicular Tumors
Molecular and Immunohistochemical Markers of Diagnostic and Prognostic Value in Testicular Tumors
Intraoperative Consultations for Testicular Tumors: Challenges and Implications for Treatment
Genetic and Epigenetic Alterations in Testicular Tumors.