Electrochemical-induced solvent-tuned selective C(sp3)–H bond activation towards the synthesis of C3-functionalized chromone derivatives

Ying Gao; Mingxu Wang; Jingxian Sun; Xiao-Jing Zhao; Yonghui He

doi:10.1039/D4CC00919C

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Electrochemical-induced solvent-tuned selective C(sp³)–H bond activation towards the synthesis of C3-functionalized chromone derivatives†

Ying Gao,^a Mingxu Wang,^a Jingxian Sun,^a Xiao-Jing Zhao

*^a and Yonghui He

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education; Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission, School of Ethnic Medicine, Yunnan Minzu University, Kunming, China
E-mail: zhaoxj@ymu.edu.cn, heyonghui@ymu.edu.cn

Abstract

An unprecedented solvent-tuned electrochemical method for selective C(sp³)–H bond activation towards the synthesis of C3 functionalized chromone derivatives has been developed. This electrosynthesis protocol provides an efficient and green way to access various C3-functionalized chromones by avoiding traditionally employed transition metals and high temperatures. The swappable chemoselectivity was controlled mainly by altering the solvent and the current. A plausible reaction mechanism has been proposed with the help of radical capture and cyclic voltammetry experiments.

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Article information

DOI: https://doi.org/10.1039/D4CC00919C
Article type: Communication
Submitted: 28 Feb 2024
Accepted: 11 Apr 2024
First published: 12 Apr 2024

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Chem. Commun., 2024, Advance Article

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Electrochemical-induced solvent-tuned selective C(sp³)–H bond activation towards the synthesis of C3-functionalized chromone derivatives

Y. Gao, M. Wang, J. Sun, X. Zhao and Y. He, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC00919C

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