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Combination of
LisinoprilACE inhibitor
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesZestoretic, Prinzide, others
AHFS/Drugs.comMultum Consumer Information
  • US: D (Evidence of risk)
Routes of
By mouth
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)

Lisinopril/hydrochlorothiazide, sold under the trade name Zestoretic among others, is a combination of the medications lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic.[1] It is used to treat high blood pressure.[1] Typically, it becomes an option once a person is doing well on the individual components.[2] It is taken by mouth.[1]

Common side effects include dizziness, headache, cough, and feeling tired.[3] Severe side effects may include angioedema and low blood pressure.[3] Use during pregnancy may harm the baby.[3]

The combination was approved for medical use in the United States in 1989.[1] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[4] It is available as a generic medication.[2] In the United States the wholesale cost per dose is less than US$0.05 as of 2018.[5] In the United Kingdom it costs the NHS about GB£0.40 per dose as of 2017.[2] In 2017, it was the 44th most commonly prescribed medication in the United States, with more than 16 million prescriptions.[6][7]


  1. ^ a b c d "Hydrochlorothiazide and lisinopril Uses, Side Effects & Warnings". Cerner Multum. Retrieved 26 December 2018.
  2. ^ a b c British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. 166. ISBN 978-0857112989.
  3. ^ a b c "Lisinopril and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Solco Healthcare LLC.
  4. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. ^ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services. Retrieved 22 December 2018.
  6. ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  7. ^ "Hydrochlorothiazide; Lisinopril - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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