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Combination of
HydrochlorothiazideThiazide diuretic
TriamterenePotassium-sparing diuretic
Clinical data
Trade namesMaxzide, Dyazide, others
Routes of
By mouth
Legal status
Legal status
  • In general: ℞ (Prescription only)

Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a combination medication of hydrochlorothiazide and triamterene.[1] It is used to treat high blood pressure and swelling.[1] Specifically it is used in those who develop low blood potassium when on only hydrochlorothiazide.[2] It is taken by mouth.[1]

Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps.[2] Other serious side effects may include high blood potassium.[2] Use in pregnancy and breastfeeding is not generally recommended.[2] Use in those with significant kidney problems is not recommended.[2] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[2]

The combination was approved for medical use in the United States in 1965.[2] A month supply in the United Kingdom costs the NHS about 0.95 £ per month as of 2019.[1] In the United States the wholesale cost of this amount is about 3.90 USD.[3] In 2017, it was the 101st most commonly prescribed medication in the United States, with more than seven million prescriptions.[4][5]


  1. ^ a b c d British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 76. ISBN 9780857113382.
  2. ^ a b c d e f g "Triamterene and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 5 March 2019.
  3. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  4. ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  5. ^ "Hydrochlorothiazide; Triamterene - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.