- Robert Downey Jr.
- Dr. John Dolittle, Executive Producer
- Antonio Banderas
- King Rassouli
- Michael Sheen
- Dr. Blair Müdfly
- Jim Broadbent
- Lord Thomas Badgley
- Jessie Buckley
- Queen Victoria
- Harry Collett
- Tommy Stubbins
- Emma Thompson
- Poly
- Rami Malek
- Chee-Chee
- John Cena
- Yoshi
- Kumail Nanjiani
- Plimpton
- Octavia Spencer
- Dab-Dab
- Tom Holland
- Jip
- Craig Robinson
- Kevin
- Ralph Fiennes
- Barry
- Selena Gomez
- Betsy
- Marion Cotillard
- Tutu
- Kasia Smutniak
- Lily Dolittle
- Carmel Laniado
- Lady Rose
- Frances de la Tour
- Dragon
- Jason Mantzoukas
- James the Dragonfly
- Ralph Ineson
- Arnall Stubbins
- Joanna Page
- Bethan Stubbins
- Stephen Gaghan
- Director, Screenwriter
- Dan Gregor
- Screenwriter
- Doug Mand
- Screenwriter
- Robert Downey Jr.
- Dr. John Dolittle, Executive Producer
- Sarah Bradshaw
- Executive Producer
- Zachary Roth
- Executive Producer
- Joe Roth
- Producer
- Jeff Kirschenbaum
- Producer
- Susan Downey
- Producer
- Jonathan Liebesman
- Executive Producer
- Guillermo Navarro
- Cinematographer
- Craig Alpert
- Film Editing
- Chris Lebenzon
- Film Editing
- Danny Elfman
- Original Music
- Dominic Watkins
- Production Design
- Matthew Gray
- Supervising Art Direction
- Tom Whitehead
- Art Director
- Tom Weaving
- Art Director
- Will Coubrough
- Art Director
- Peter Dorme
- Art Director
- Alex Smith
- Art Director
- Lee Sandales
- Set Decoration
- Jenny Beavan
- Costume Design
- Lucy Bevan
- Casting
