Dr. Ashok K. Chopra MD

Erratum to: Deletion of glucose-inhibited division (gidA) gene alters the morphological and replication characteristics of Salmonella enterica Serovar typhimurium.

Shippy, D.C., Heintz, J.A., Albrecht, R.M., Eakley, N.M., Chopra, A.K., Fadl, A.A.

Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity.

Edrous Alamer, Victor H. Carpio, Samad Ibitokou, Michelle L. Kirtley, Inaia Phoenix, Michael M. Opata, Kyle D. Wilson, Yingzi Cong, Sara M. Dann, Ashok K. Chopra, Robin Stephens

Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis

B. Kim Lee Sim, Minglin Li, Manuel Osorio, Yun Wu, Tint T. Wai, Johnny W. Peterson, Eric R. James, Sumana Chakravarty, Lixin Gao, Rui Xu, Natasha Kc, Richard E. Stafford, William S Lawrence, Linsey A. Yeager, Jennifer E. Peel, Satheesh K Sivasubramani, Ashok K. Chopra, Svetlana Filippova, Stephen L. Hoffman

Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy.

Tzipora C. Falik Zaccai, David Savitzki, Yifat Zivony-Elboum, Thierry Vilboux, Eric C. Fitts, Yishay Shoval, Limor Kalfon, Nadra Samra, Zohar Keren, Bella Gross, Natalia Chasnyk, Rachel Straussberg, James C. Mullikin, Jamie K. Teer, Dan Geiger, Daniel Kornitzer, Ora Bitterman-Deutsch, Abraham O. Samson, Maki Wakamiya, Johnny W. Peterson, Michelle L. Kirtley, Iryna V. Pinchuk, Wallace B. Baze, William A. Gahl, Robert Kleta, Yair Anikster, Ashok K. Chopra

New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague.

Eric C. Fitts, Jourdan A. Andersson, Michelle L. Kirtley, Jian Sha, Tatiana E. Erova, Sadhana Chauhan, Vladimir L. Motin, Ashok K. Chopra

Protective Immunity Elicited by Oral Immunization of Mice with Salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants

Tatiana E. Erova, Michelle L. Kirtley, Eric C. Fitts, Duraisamy Ponnusamy, Wallace B. Baze, Jourdan A. Andersson, Yingzi Cong, Bethany L. Tiner, Jian Sha, Ashok K. Chopra

Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague.

Bethany L. Tiner, Jian Sha, Yingzi Cong, Michelle L. Kirtley, Jourdan A. Andersson, Ashok K. Chopra

A mutated cholera toxin without the ADP-ribosyltransferase activity induces cytokine production and inhibits apoptosis of splenocytes in mice possibly via toll-like receptor-4 signaling.

Tie Liu, Yang Wei, Gang Liu, Bingyin Shi, Suarez Giovanni, Johnny W. Peterson, Ashok K. Chopra

A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates

Jian Sha, Michelle L. Kirtley, Curtis Klages, Tatiana E. Erova, Maxim V. Telepnev, Duraisamy Ponnusamy, Eric C. Fitts, Wallace B. Baze, Satheesh K Sivasubramani, William S Lawrence, Igor Patrikeev, Jennifer E. Peel, Jourdan A. Andersson, Elena V. Kozlova, Bethany L. Tiner, Johnny W. Peterson, David McWilliams, Snehal S. Patel, Eric Rothe, Vladimir L. Motin, Ashok K. Chopra

New role for FDA-approved drugs in combating antibiotic-resistant bacteria

Jourdan A. Andersson, Eric C. Fitts, Michelle L. Kirtley, Duraisamy Ponnusamy, Alex G. Peniche, Sara M. Dann, Vladimir L. Motin, Sadhana Chauhan, Jason A. Rosenzweig, Jian Sha, Ashok K. Chopra

Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis.

Duraisamy Ponnusamy, Elena V. Kozlova, Jian Sha, Tatiana E. Erova, Sasha R. Azar, Eric C. Fitts, Michelle L. Kirtley, Bethany L. Tiner, Jourdan A. Andersson, Christopher J. Grim, Richard P. Isom, Nur A. Hasan, Rita R. Colwell, Ashok K. Chopra

Intramuscular immunization of mice with a live-Attenuated triple mutant of yersinia pestis co92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague

Bethany L. Tiner, Jian Sha, Duraisamy Ponnusamy, Wallace B. Baze, Eric C. Fitts, Vsevolod L. Popov, Christina J. van Lier, Tatiana E. Erova, Ashok K. Chopra

High-Throughput, Signature-Tagged Mutagenic Approach To Identify Novel Virulence Factors of Yersinia pestis CO92 in a Mouse Model of Infection

Duraisamy Ponnusamy, Eric C. Fitts, Jian Sha, Tatiana E. Erova, Elena V. Kozlova, Michelle L. Kirtley, Bethany L. Tiner, Jourdan A. Andersson, Ashok K. Chopra

Combinational Deletion of Three Membrane Protein-Encoding Genes Highly Attenuates Yersinia pestis while Retaining Immunogenicity in a Mouse Model of Pneumonic Plague

Bethany L. Tiner, Jian Sha, Michelle L. Kirtley, Tatiana E. Erova, Vsevolod L. Popov, Wallace B. Baze, Christina J. van Lier, Duraisamy Ponnusamy, Jourdan A. Andersson, Vladimir L. Motin, Sadhana Chauhan, Ashok K. Chopra

Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages.

Christina J. van Lier, Bethany L. Tiner, Sadhana Chauhan, Vladimir L. Motin, Eric C. Fitts, Matthew B. Huante, Janice J. Endsley, Duraisamy Ponnusamy, Jian Sha, Ashok K. Chopra

Functional Genomic Characterization of Virulence Factors from Necrotizing Fasciitis-Causing Strains of Aeromonas hydrophila

Christopher J. Grim, Elena V. Kozlova, Duraisamy Ponnusamy, Eric C. Fitts, Jian Sha, Michelle L. Kirtley, Christina J. van Lier, Bethany L. Tiner, Tatiana E. Erova, Sandeep J. Joseph, Timothy D. Read, Joshua R. Shak, Sam W. Joseph, Ed Singletary, Tracy Felland, Wallace B. Baze, Amy J. Horneman, Ashok K. Chopra

Deletion of Braun Lipoprotein and Plasminogen-Activating Protease-Encoding Genes Attenuates Yersinia pestis in Mouse Models of Bubonic and Pneumonic Plague

Christina J. van Lier, Jian Sha, Michelle L. Kirtley, Anthony T. Cao, Bethany L. Tiner, Tatiana E. Erova, Yingzi Cong, Elena V. Kozlova, Vsevolod L. Popov, Wallace B. Baze, Ashok K. Chopra

The effects of modeled microgravity on growth kinetics, antibiotic susceptibility, cold growth, and the virulence potential of a Yersinia pestis ymoA-deficient mutant and its isogenic parental strain.

Abidat Lawal, Michelle L. Kirtley, Christina J. van Lier, Tatiana E. Erova, Elena V. Kozlova, Jian Sha, Ashok K. Chopra, Jason A. Rosenzweig

Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in aeromonas hydrophila SSU pathogenesis

Jian Sha, Jason A. Rosenzweig, Elena V. Kozlova, Shaofei Wang, Tatiana E. Erova, Michelle L. Kirtley, Christina J. van Lier, Ashok K. Chopra

Characterization of Aeromonas hydrophila Wound Pathotypes by Comparative Genomic and Functional Analyses of Virulence Genes

Christopher J. Grim, Elena V. Kozlova, Jian Sha, Eric C. Fitts, Christina J. van Lier, Michelle L. Kirtley, Sandeep J. Joseph, Timothy D. Read, Eileen M. Burd, Ben D. Tall, Sam W. Joseph, Amy J. Horneman, Ashok K. Chopra, Joshua R. Shak

Deletion of the Braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium.

Jian Sha, Michelle L. Kirtley, Christina J. van Lier, Shaofei Wang, Tatiana E. Erova, Elena V. Kozlova, Anthony T. Cao, Yingzi Cong, Eric C. Fitts, Jason A. Rosenzweig, Ashok K. Chopra

A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague.

Jian Sha, Jason A. Rosenzweig, Michelle L. Kirtley, Christina J. van Lier, Eric C. Fitts, Elena V. Kozlova, Tatiana E. Erova, Bethany L. Tiner, Ashok K. Chopra

Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new-generation recombinant plague vaccine.

Tatiana E. Erova, Jason A. Rosenzweig, Jian Sha, Giovanni Suarez, Johanna C. Sierra, Michelle L. Kirtley, Christina J. van Lier, Maxim V. Telepnev, Vladimir L. Motin, Ashok K. Chopra

WITHDRAWN: The majority of T cells, including Treg cells, are developed from CD4(-)CD8(-)T progenitor cells without the involvement of the CD4(+)CD8(+) stage in the thymus.

Tie Liu, Xia Huo, Gang Liu, Ashok K. Chopra

Mutated and bacteriophage T4 nanoparticle arrayed F1-V immunogens from Yersinia pestis as next generation plague vaccines.

Tao P, Mahalingam M, Kirtley ML, van Lier CJ, Sha J, Yeager LA, Chopra AK, Rao VB

Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila.

Adin Shniffer, Danielle D. Visschedyk, Ravikirand Ravulapalli, Giovanni Suarez, Zachari J. Turgeon, Anthony A. Petrie, Ashok K. Chopra, A. Rod Merrill

Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis.

Giovanni Suarez, Bijay K. Khajanchi, Johanna C. Sierra, Tatiana E. Erova, Jian Sha, Ashok K. Chopra

Impact of QseBC system in c-di-GMP-dependent quorum sensing regulatory network in a clinical isolate SSU of Aeromonas hydrophila.

Elena V. Kozlova, Bijay K. Khajanchi, Vsevolod L. Popov, Julie Wen, Ashok K. Chopra

Deletion of glucose-inhibited division (gidA) gene alters the morphological and replication characteristics of Salmonella enterica Serovar typhimurium.

Shippy DC, Heintz JA, Albrecht RM, Eakley NM, Chopra AK, Fadl AA

DNA adenine methyltransferase (Dam) controls the expression of the cytotoxic enterotoxin (act) gene of Aeromonas hydrophila via tRNA modifying enzyme-glucose-inhibited division protein (GidA).

Tatiana E. Erova, Valeri G. Kosykh, Jian Sha, Ashok K. Chopra

The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila

Bijay K. Khajanchi, Elena V. Kozlova, Jian Sha, Vsevolod L. Popov, Ashok K. Chopra

Biological and virulence characteristics of the YqhC mutant of Salmonella.

Eakley NM, Bochsler PN, Gopal Reddy P, Chopra AK, Fadl AA

Cethromycin-Mediated Protection against the Plague Pathogen Yersinia pestis in a Rat Model of Infection and Comparison with Levofloxacin

Jason A. Rosenzweig, Sheri M. Brackman, Michelle L. Kirtley, Jian Sha, Tatiana E. Erova, Linsey A. Yeager, Johnny W. Peterson, Ze Qi Xu, Ashok K. Chopra

Pathogenesis of Y.enterocolitica and Y.pseudotuberculosis in Human Yersiniosis

Cristi L. Galindo, Jason A. Rosenzweig, Michelle L. Kirtley, Ashok K. Chopra

Immunomodulatory and protective roles of quorum-sensing signaling molecules N-acyl homoserine lactones during infection of mice with Aeromonas hydrophila.

Bijay K. Khajanchi, Michelle L. Kirtley, Sheri M. Brackman, Ashok K. Chopra

Progress on plague vaccine development.

Jason A. Rosenzweig, Olufisayo Jejelowo, Jian Sha, Tatiana E. Erova, Sheri M. Brackman, Michelle L. Kirtley, Cristina J. van Lier, Ashok K. Chopra

Biological and virulence characteristics of Salmonella enterica serovar Typhimurium following deletion of glucose-inhibited division (gidA) gene.

Shippy DC, Eakley NM, Bochsler PN, Chopra AK, Fadl AA

Quorum sensing and c-di-GMP-dependent alterations in gene transcripts and virulence-associated phenotypes in a clinical isolate of Aeromonas hydrophila

Elena V. Kozlova, Bijay K. Khajanchi, Jian Sha, Ashok K. Chopra

Characterization of an F1 Deletion Mutant of Yersinia pestis CO92, Pathogenic Role of F1 Antigen in Bubonic and Pneumonic Plague, and Evaluation of Sensitivity and Specificity of F1 Antigen Capture-Based Dipsticks

Jian Sha, Janice J. Endsley, Michelle L. Kirtley, Sheri M. Foltz, Matthew B. Huante, Tatiana E. Erova, Elena V. Kozlova, Vsevolod L. Popov, Linsey A. Yeager, Irina V. Zudina, Vladimir L. Motin, Johnny W. Peterson, Kristin L. DeBord, Ashok K. Chopra

Role of Hcp, a type 6 secretion system effector, of Aeromonas hydrophila in modulating activation of host immune cells.

Giovanni Suarez, Johanna C. Sierra, Michelle L. Kirtley, Ashok K. Chopra

Unraveling the mechanism of action of a new type III secretion system effector AexU from Aeromonas hydrophila

Johanna C. Sierra, Giovanni Suarez, Jian Sha, Wallace B. Baze, Sheri M. Foltz, Ashok K. Chopra

Emergence of anthrax edema toxin as a master manipulator of macrophage and B cell functions.

Bryan T. Gnade, Scott T. Moen, Ashok K. Chopra, Johnny W. Peterson, Linsey A. Yeager

Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis

Johnny W. Peterson, Scott T. Moen, Daniel P. Healy, Jennifer Pawlik, Joanna Taormina, Jason Hardcastle, John M. Thomas, William S Lawrence, Cindy Ponce, Bagram M. Chatuev, Bryan T. Gnade, Sheri M. Foltz, Stacy L. Agar, Jian Sha, Gary R. Klimpel, Michelle L. Kirtley, Tonyia Eaves-Pyles, Ashok K. Chopra

Global Transcriptional Response of Macrophage-Like THP-1 Cells to Shiga Toxin Type 1

Dinorah Leyva-Illades, Rama P. Cherla, Cristi L. Galindo, Ashok K. Chopra, Vernon L. Tesh

Comparative Global Gene Expression Profiles of Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant at Flea and Human Body Temperatures

Cristi L. Galindo, Jian Sha, Scott T. Moen, Stacy L. Agar, Michelle L. Kirtley, Sheri M. Foltz, Lauren J. McIver, Elena V. Kozlova, Harold R. Garner, Ashok K. Chopra

Distribution of Virulence Factors and Molecular Fingerprinting of Aeromonas Species Isolates from Water and Clinical Samples: Suggestive Evidence of Water-to-Human Transmission

Bijay K. Khajanchi, Amin A. Fadl, Mark A. Borchardt, Richard L. Berg, Amy J. Horneman, Mary E. Stemper, Sam W. Joseph, Nelson P. Moyer, Jian Sha, Ashok K. Chopra

An enteric pathogen Salmonella enterica serovar Typhimurium suppresses tumor growth by downregulating CD44high and CD4T regulatory (Treg) cell expression in mice: the critical role of lipopolysaccharide and Braun lipoprotein in modulating tumor growth.

Tie Liu, Ashok K Chopra

Stimulated Innate Resistance of Lung Epithelium Protects Mice Broadly against Bacteria and Fungi

Scott E. Evans, Brenton L. Scott, Cecilia G. Clement, Derek T. Larson, Dimitrios P. Kontoyiannis, Russell E. Lewis, P. Rocco LaSala, Jennifer Pawlik, Johnny W. Peterson, Ashok K. Chopra, Gary R. Klimpel, Gabriela Bowden, Magnus Höök, Yi Xu, Michael J. Tuvim, Burton F. Dickey

A Type VI Secretion System Effector Protein, VgrG1, from Aeromonas hydrophila That Induces Host Cell Toxicity by ADP Ribosylation of Actin

Giovanni Suarez, Johanna C. Sierra, Tatiana E. Erova, Jian Sha, Amy J. Horneman, Ashok K. Chopra

Deletion of Braun lipoprotein gene (lpp) attenuates Yersinia pestis KIM/D27 strain: Role of Lpp in modulating host immune response, NF-κB activation and cell death

Tie Liu, Stacy L. Agar, Jian Sha, Ashok K. Chopra

N-Acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila

Bijay K. Khajanchi, Jian Sha, Elena V. Kozlova, Tatiana E. Erova, Giovanni Suarez, Johanna C. Sierra, Vsevolod L. Popov, Amy J. Horneman, Ashok K. Chopra

Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models.

Jennilee B. Robinson, Maxim V. Telepnev, Irina V. Zudina, Donald H. Bouyer, John A. Montenieri, Scott W. Bearden, Kenneth L. Gage, Stacy L. Agar, Sheri M. Foltz, Sadhana Chauhan, Ashok K. Chopra, Vladimir L. Motin

Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin.

John M. Thomas, Scott T. Moen, Bryan T. Gnade, Diego A. Vargas-Inchaustegui, Sheri M. Foltz, Giovanni Suarez, Hans W. Heidner, Rolf König, Ashok K. Chopra, Johnny W. Peterson

CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4+ Treg cells

Tie Liu, Lynn Soong, Gang Liu, Rolf König, Ashok K. Chopra

Deletion of Braun lipoprotein gene (lpp) and curing of plasmid pPCP1 dramatically alter the virulence of Yersinia pestis CO92 in a mouse model of pneumonic plague

Stacy L. Agar, Jian Sha, Wallace B. Baze, Tatiana E. Erova, Sheri M. Foltz, Giovanni Suarez, Shaofei Wang, Ashok K. Chopra

ATP Depletion Via Mitochondrial F1F0 Complex by Lethal Factor is an Early Event in B. Anthracis-Induced Sudden Cell Death.

Mitchell W. Woodberry, Leopoldo Aguilera-Aguirre, Attila Bacsi, Ashok K. Chopra, Alexander Kurosky, Johnny W. Peterson, Istvan Boldogh

Phospholipase A2-activating protein (PLAA) enhances cisplatin-induced apoptosis in HeLa cells.

Fan Zhang, Giovanni Suarez, Jian Sha, Johanna C. Sierra, Johnny W. Peterson, Ashok K. Chopra

Bacillus anthracis Edema Toxin Suppresses Human Macrophage Phagocytosis and Cytoskeletal Remodeling via the Protein Kinase A and Exchange Protein Activated by Cyclic AMP Pathways

Linsey A. Yeager, Ashok K. Chopra, Johnny W. Peterson

SURFACE-EXPRESSED ENOLASE CONTRIBUTES TO THE PATHOGENESIS OF CLINICAL ISOLATE SSU OF AEROMONAS HYDROPHILA

Jian Sha, Tatiana E. Erova, Rebecca A. Alyea, Shaofei Wang, Juan P. Olano, Vijay Pancholi, Ashok K. Chopra

Characterization of the rat pneumonic plague model: infection kinetics following aerosolization of Yersinia pestis CO92.

Stacy L. Agar, Jian Sha, Sheri M. Foltz, Tatiana E. Erova, Kristin G. Walberg, Wallace B. Baze, Giovanni Suarez, Johnny W. Peterson, Ashok K. Chopra

Comparative Analyses of Transcriptional Profiles in Mouse Organs Using a Pneumonic Plague Model after Infection with Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant

Cristi L. Galindo, Scott T. Moen, Elena V. Kozlova, Jian Sha, Harold R. Garner, Stacy L. Agar, Ashok K. Chopra

Levofloxacin Rescues Mice from Lethal Intra-nasal Infections with Virulent Francisella tularensis and Induces Immunity and Production of Protective Antibody

Gary R. Klimpel, Tonyia Eaves-Pyles, Scott T. Moen, Joanna Taormina, Johnny W. Peterson, Ashok K. Chopra, David W. Niesel, Paige Carness, Judith Haithcoat, Michelle L. Kirtley, Abdelhakim Ben Nasr

Mutation in the S-ribosylhomocysteinase (luxS) gene involved in quorum sensing affects biofilm formation and virulence in a clinical isolate of Aeromonas hydrophila.

Elena V. Kozlova, Vsevolod L. Popov, Jian Sha, Sheri M. Foltz, Tatiana E. Erova, Stacy L. Agar, Amy J. Horneman, Ashok K. Chopra

Characterization of a mouse model of plague after aerosolization of Yersinia pestis CO92

Stacy L. Agar, Jian Sha, Sheri M. Foltz, Tatiana E. Erova, Kristin G. Walberg, Todd E. Parham, Wallace B. Baze, Giovanni Suarez, Johnny W. Peterson, Ashok K. Chopra

Cold Shock Exoribonuclease R (VacB) Is Involved in Aeromonas hydrophila Pathogenesis

Tatiana E. Erova, Valeri G. Kosykh, Amin A. Fadl, Jian Sha, Amy J. Horneman, Ashok K. Chopra

Braun Lipoprotein (Lpp) Contributes to Virulence of Yersiniae: Potential Role of Lpp in Inducing Bubonic and Pneumonic Plague

Jian Sha, Stacy L. Agar, Wallace B. Baze, Juan P. Olano, Amin A. Fadl, Tatiana E. Erova, Shaofei Wang, Sheri M. Foltz, Giovanni Suarez, Vladimir L. Motin, Sadhana Chauhan, Gary R. Klimpel, Johnny W. Peterson, Ashok K. Chopra

Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila.

Giovanni Suarez, Johanna C. Sierra, Jian Sha, Shaofei Wang, Tatiana E. Erova, Amin A. Fadl, Sheri M. Foltz, Amy J. Horneman, Ashok K. Chopra

Transcriptional profiling of murine organ genes in response to infection with Bacillus anthracis Ames spores.

Scott T. Moen, Linsey A. Yeager, William S Lawrence, Cindy Ponce, Cristi L. Galindo, Harold R. Garner, Wallace B. Baze, Giovanni Suarez, Johnny W. Peterson, Ashok K. Chopra

Immunological responses against Salmonella enterica serovar Typhimurium Braun lipoprotein and lipid A mutant strains in Swiss-Webster mice: potential use as live-attenuated vaccines.

Tie Liu, Rolf König, Jian Sha, Stacy L. Agar, Chien Te K. Tseng, Gary R. Klimpel, Ashok K. Chopra

ALTERATION IN THE ACTIVATION STATE OF NEW INFLAMMATION-ASSOCIATED TARGETS BY PHOSPHOLIPASE A2-ACTIVATING PROTEIN (PLAA)

Fan Zhang, Jian Sha, Thomas G. Wood, Cristi L. Galindo, Harold R. Garner, Mark F. Burkart, Giovanni Suarez, Johanna C. Sierra, Stacy L. Agar, Johnny W. Peterson, Ashok K. Chopra

Further characterization of a type III secretion system (T3SS) and of a new effector protein from a clinical isolate of Aeromonas hydrophila—Part I

Jian Sha, Shaofei Wang, Giovanni Suarez, Johanna C. Sierra, Amin A. Fadl, Tatiana E. Erova, Sheri M. Foltz, Bijay K. Khajanchi, Adam C. Silver, Joerg Graf, Catherine H. Schein, Ashok K. Chopra

Identification of a new hemolysin from diarrheal isolate SSU of Aeromonas hydrophila.

Tatiana E. Erova, Jian Sha, Amy J. Horneman, Mark A. Borchardt, Bijay K. Khajanchi, Amin A. Fadl, Ashok K. Chopra

Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila—Part II

Johanna C. Sierra, Giovanni Suarez, Jian Sha, Sheri M. Foltz, Vsevolod L. Popov, Cristi L. Galindo, Harold R. Garner, Ashok K. Chopra

Human Monoclonal Antibody AVP-21D9 to Protective Antigen Reduces Dissemination of the Bacillus anthracis Ames Strain from the Lungs in a Rabbit Model

Johnny W. Peterson, Jason E. Comer, Wallace B. Baze, David M. Noffsinger, Autumn Wenglikowski, Kristin G. Walberg, Jason Hardcastle, Jennifer Pawlik, Kathryn Bush, Joanna Taormina, Scott T. Moen, John A. Thomas, Bagram M. Chatuev, Laurie E. Sower, Ashok K. Chopra, Lawrence R. Stanberry, Ritsuko Sawada, Wolfgang Scholz, Jagadish Sircar

Interaction between innate immune cells and a bacterial type III secretion system in mutualistic and pathogenic associations

Adam C. Silver, Yoshitomo Kikuchi, Amin A. Fadl, Jian Sha, Ashok K. Chopra, Joerg Graf

Global transcriptional responses of wild-type Aeromonas hydrophila and its virulence-deficient mutant in a murine model of infection

Amin A. Fadl, Cristi L. Galindo, Jian Sha, Fan Zhang, Harold R. Garner, Hui Qun Wang, Ashok K. Chopra

Intranasal Immunization with synthetic peptides corresponding to the E6 and E7 oncoproteins of Human Papillomavirus type 16 induces systemic and mucosal cellular immune responses and tumor protection

Pallavi R. Manuri, Bharti P. Nehete, Pramod N. Nehete, Rose Reisenauer, Seth Wardell, Amy N. Courtney, Ratish Gambhira, Dakshyani Lomada, Ashok K. Chopra, K. Jagannadha Sastry

Genome Sequence of Aeromonas hydrophila ATCC 7966T: Jack of All Trades

Rekha Seshadri, Sam W. Joseph, Ashok K. Chopra, Jian Sha, Jonathan G. Shaw, Joerg Graf, Daniel H. Haft, Martin Wu, Qinghu Ren, M. J. Rosovitz, Ramana Madupu, Luke J. Tallon, Mary Kim, Shaohua Jin, Hue Vuong, O. Colin Stine, Afsar Ali, Amy J. Horneman, John F. Heidelberg

Aldose Reductase Mediates the Lipopolysaccharide-induced Release of Inflammatory Mediators in RAW264.7 Murine Macrophages

Kota V. Ramana, Amin A. Fadl, Ravinder Tammali, Aramati B.M. Reddy, Ashok K. Chopra, Satish K. Srivastava

Mutations within the catalytic motif of DNA adenine methyltransferase (Dam) of Aeromonas hydrophila cause the virulence of the Dam-overproducing strain to revert to that of the wild-type phenotype.

Tatiana E. Erova, Amin A. Fadl, Jian Sha, Bijay K. Khajanchi, Lakshmi L. Pillai, Elena V. Kozlova, Ashok K. Chopra

Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin.

Rajat Sapra, Sara P. Gaucher, J. S. Lachmann, G. M. Buffleben, Gabriela S. Chirica, Jason E. Comer, Johnny W. Peterson, Ashok K. Chopra, Anjali Singh

Murine macrophage transcriptional and functional responses to Bacillus anthracis edema toxin

Jason E. Comer, Cristi L. Galindo, Fan Zhang, Autumn Wenglikowski, Katie L. Bush, Harold R. Garner, Johnny W. Peterson, Ashok K. Chopra

Molecular and functional characterization of a ToxR-regulated lipoprotein from a clinical isolate of Aeromonas hydrophila.

Lakshmi Pillai, Jian Sha, Tatiana E. Erova, Amin A. Fadl, Bijay K. Khajanchi, Ashok K. Chopra

Alterations in the virulence potential of enteric pathogens and bacterial-host cell interactions under simulated microgravity conditions.

V. Chopra, Amin A. Fadl, Jian Sha, S. Chopra, Cristi L. Galindo, Ashok K. Chopra

Global gene expression of a murein (Braun) lipoprotein mutant of Salmonella enterica serovar Typhimurium by microarray analysis.

Amin A. Fadl, Cristi L. Galindo, Jian Sha, Gary R. Klimpel, Vsevolod L. Popov, Ashok K. Chopra

Evaluation of the protective effects of quinacrine against Bacillus anthracis Ames.

Jason E. Comer, David M. Noffsinger, D. J. McHenry, D. M. Weisbaum, Bagram M. Chatuev, Ashok K. Chopra, Johnny W. Peterson

Deletion of the genes encoding the type III secretion system and cytotoxic enterotoxin alters host responses to Aeromonas hydrophila infection.

Amin A. Fadl, Cristi L. Galindo, Jian Sha, Tatiana E. Erova, C. W. Houston, Juan P. Olano, Ashok K. Chopra

Potential involvement of galectin-3 and SNAP23 in Aeromonas hydrophila cytotoxic enterotoxin-induced host cell apoptosis

Cristi L. Galindo, C. Gutierrez, Ashok K. Chopra

Human Monoclonal Anti-Protective Antigen Antibody Completely Protects Rabbits and Is Synergistic with Ciprofloxacin in Protecting Mice and Guinea Pigs against Inhalation Anthrax

Johnny W. Peterson, Jason E. Comer, David M. Noffsinger, Autumn Wenglikowski, Kristin G. Walberg, Bagram M. Chatuev, Ashok K. Chopra, Lawrence R. Stanberry, Angray S. Kang, Wolfgang W. Scholz, Jagadish Sircar

DNA Adenine Methyltransferase Influences the Virulence of Aeromonas hydrophila

Tatiana E. Erova, Lakshmi Pillai, Amin A. Fadl, Jian Sha, Shaofei Wang, Cristi L. Galindo, Ashok K. Chopra

Direct Inhibition of T-Lymphocyte Activation by Anthrax Toxins In Vivo

Jason E. Comer, Ashok K. Chopra, Johnny W. Peterson, Rolf König

Attenuation of Salmonella enterica Serovar Typhimurium by altering biological functions of murein lipoprotein and lipopolysaccharide.

Amin A. Fadl, Jian Sha, Gary R. Klimpel, Juan P. Olano, Cristi L. Galindo, Ashok K. Chopra

The type III secretion system and cytotoxic enterotoxin alter the virulence of Aeromonas hydrophila.

Jian Sha, Lakshmi Pillai, Amin A. Fadl, Cristi L. Galindo, Tatiana E. Erova, Ashok K. Chopra

Microarray and proteomics analyses of human intestinal epithelial cells treated with the Aeromonas hydrophila cytotoxic enterotoxin.

Cristi L. Galindo, Amin A. Fadl, Jian Sha, Lakshmi Pillai, C. Gutierrez, Ashok K. Chopra

GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis.

Jason E. Comer, Cristi L. Galindo, Ashok K. Chopra, Johnny W. Peterson

Murein Lipoprotein Is a Critical Outer Membrane Component Involved in Salmonella enterica Serovar Typhimurium Systemic Infection

Amin A. Fadl, Jian Sha, Gary R. Klimpel, Juan P. Olano, David W. Niesel, Ashok K. Chopra

A two-codon mutant of cholera toxin lacking ADP-ribosylating activity functions as an effective adjuvant for eliciting mucosal and systemic cellular immune responses to peptide antigens.

Dakshayani Lomada, Ratish Gambhira, Pramod N. Nehete, Faisal A. Guhad, Ashok K. Chopra, Johnny W. Peterson, K. Jagannadha Sastry

Aeromonas hydrophila cytotoxic enterotoxin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal epithelial cells.

Cristi L. Galindo, Amin A. Fadl, Jian Sha, Celso Gutierrez, Vsevolod L. Popov, Istvan Boldogh, Bharat B. Aggarwal, Ashok K. Chopra

Microarray analysis of Aeromonas hydrophila cytotoxic enterotoxin-treated murine primary macrophages.

Cristi L. Galindo, Amin A. Fadl, Jian Sha, Ashok K. Chopra

The two murein lipoproteins of Salmonella enterica serovar Typhimurium contribute to the virulence of the organism.

Jian Sha, Amin A. Fadl, Gary R. Klimpel, David W. Niesel, Vsevolod L. Popov, Ashok K. Chopra

Molecular characterization of a glucose-inhibited division gene, gidA, that regulates cytotoxic enterotoxin of Aeromonas hydrophila.

Jian Sha, Elena V. Kozlova, Amin A. Fadl, Juan P. Olano, C. W. Houston, Johnny W. Peterson, Ashok K. Chopra

Identification of Aeromonas hydrophila Cytotoxic Enterotoxin-induced Genes in Macrophages Using Microarrays

Cristi L. Galindo, Jian Sha, Deborah A. Ribardo, Amin A. Fadl, Lakshmi Pillai, Ashok K. Chopra

Differential expression of the enolase gene under in vivo versus in vitro growth conditions of Aeromonas hydrophila

Jian Sha, Cristi L. Galindo, Vijay Pancholi, Vsevolod L. Popov, Y. Zhao, C. W. Houston, Ashok K. Chopra

Role of melittin-like region within phospholipase A2-activating protein in biological function

Deborah A. Ribardo, Kristine R. Kuhl, Johnny W. Peterson, Ashok K. Chopra

ROLE OF VARIOUS ENTEROTOXINS IN AEROMONAS HYDROPHILA - INDUCED GASTROENTERITIS: GENERATION OF ENTEROTOXIN GENE - DEFICIENT MUTANTS AND EVALUATION OF THEIR ENTEROTOXIC ACTIVITY

Jian Sha, Elena V. Kozlova, Ashok K. Chopra

Early cell signaling by the cytotoxic enterotoxin of Aeromonas hydrophila in macrophages.

Deborah A. Ribardo, Kristine R. Kuhl, Istvan Boldogh, Johnny W. Peterson, C. W. Houston, Ashok K. Chopra

Phospholipase A2-activating protein--an important regulatory molecule in modulating cyclooxygenase-2 and tumor necrosis factor production during inflammation.

Deborah A. Ribardo, Johnny W. Peterson, Ashok K. Chopra

Regulation of the cytotoxic enterotoxin gene in Aeromonas hydrophila: characterization of an iron uptake regulator.

Jian Sha, Muping Lu, Ashok K. Chopra

Effects of extracellular pH on tumour necrosis factor-α production by resident alveolar macrophages

Thomas A. Heming, Sanat K. Davé, Divina M. Tuazon, Ashok K. Chopra, Johnny W. Peterson, Akhil Bidani

Cholera toxin-induced PGE2 activity is reduced by chemical reaction with L-histidine

Johnny W. Peterson, David J. King, Edward L. Ezell, Mark E. Rogers, Deborah L. Gessell, Jennifer Hoffpauer, Luis Reuss, Ashok K. Chopra, David G. Gorenstein

Cholera Toxin Induces Prostaglandin Synthesis via Post-Transcriptional Activation of Cyclooxygenase-2 in the Rat Jejunum

Eckhard Beubler, Rufina Schuligoi, Ashok K. Chopra, Deborah A. Ribardo, Bernhard A. Peskar

Post-transcriptional effects of extracellular pH on tumour necrosis factor-α production in RAW 246.7 and J774 A.1 cells

Thomas A. Heming, Divina M. Tuazon, Sanat K. Davé, Ashok K. Chopra, Johnny W. Peterson, Akhil Bidani

Innate gastrointestinal immunity: characterization of broadly active viral inhibitors.

Indra P. Singh, Dorian H. Coppenhaver, Ashok K. Chopra, Samuel Baron

Prostaglandin Levels in Stimulated Macrophages Are Controlled by Phospholipase A2-activating Protein and by Activation of Phospholipase C and D

Deborah A. Ribardo, Sheila E. Crowe, Kristine R. Kuhl, Johnny W. Peterson, Ashok K. Chopra

Innate antiviral defenses in body fluids and tissues.

Samuel Baron, Indra P. Singh, Ashok K. Chopra, Dorian H. Coppenhaver, Jingzhi Pan

Broad antiviral activity in tissues of crustaceans.

Jingzhi Pan, Alexander Kurosky, Bo Xu, Ashok K. Chopra, Dorian H. Coppenhaver, Indra P. Singh, Samuel Baron

Melittin-mediated release of [3H]-oleic acid from E. coli cells is dependent upon heat- and trypsin-sensitive factor(s) in human serum

Shamsher S. Saini, Ashok K. Chopra, Johnny W. Peterson

The Cytotoxic Enterotoxin of Aeromonas hydrophila Induces Proinflammatory Cytokine Production and Activates Arachidonic Acid Metabolism in Macrophages

Ashok K. Chopra, X. J. Xu, Deborah A. Ribardo, M. Gonzalez, Kristine R. Kuhl, Johnny W. Peterson, C. W. Houston

Melittin activates endogenous phospholipase D during cytolysis of human monocytic leukemia cells.

Shamsher S. Saini, Ashok K. Chopra, Johnny W. Peterson

Role of Salmonella enterotoxin in overall virulence of the organism

Ashok K. Chopra, J. H. Huang, X. J. Xu, K. Burden, David W. Niesel, M. W. Rosenbaum, Vsevolod L. Popov, Johnny W. Peterson

Lipoproteins account for part of the broad non-specific antiviral activity of human serum

Indra P. Singh, Ashok K. Chopra, Dorian H. Coppenhaver, G.M Ananatharamaiah, Samuel Baron

Cholera toxin B subunit activates arachidonic acid metabolism

Johnny W. Peterson, Richard A. Finkelstein, Juan Cantu, Deborah L. Gessell, Ashok K. Chopra

Molecular characterization of cDNA for phospholipase A2-activating protein

Ashok K. Chopra, Deborah A. Ribardo, Thomas G. Wood, Deborah Prusak, X. J. Xu, Johnny W. Peterson

Antisera to selected outer membrane proteins of Vibrio cholerae protect against challenge with homologous and heterologous strains of V. cholerae

Margaret Das, Ashok K. Chopra, Juan Cantu, Johnny W. Peterson

Protection against exotoxin A (ETA) and Pseudomonas aeruginosa infection in mice with ETA-specific antipeptide antibodies.

Haissam S. El-Zaim, Ashok K. Chopra, Johnny W. Peterson, Michael L. Vasil, John P. Heggers

Cloning, sequencing and expression of the flagellin core protein and other genes encoding structural proteins of the Vibrio cholerae flagellum

Margaret Das, Ashok K. Chopra, Thomas G. Wood, Johnny W. Peterson

Role of a Cytotoxic Enterotoxin in Aeromonas-Mediated Infections: Development of Transposon and Isogenic Mutants

Xin J. Xu, Monique R. Ferguson, Vsevolod L. Popov, C. W. Houston, Johnny W. Peterson, Ashok K. Chopra

A host defense role for a natural antiviral substance in the nervous system

Samuel Baron, Ashok K. Chopra, Dorian H. Coppenhaver, Benjamin B. Gelman, Joyce Poast, Indra P. Singh

Anti-inflammatory and antisecretory potential of histidine in Salmonella-challenged mouse small intestine

Johnny W. Peterson, Istvan Boldogh, Vsevolod L. Popov, Shamsher S. Saini, Ashok K. Chopra

Generation of Neutralizing Antipeptide Antibodies to the Enzymatic Domain of Pseudomonas aeruginosa Exotoxin A

Haissam S. El-Zaim, Ashok K. Chopra, Johnny W. Peterson, Rick Goodheart, John P. Heggers

Acute haemodynamic effects of nicorandil in patients with chronic severe regurgitant valvular lesions.

Yadav R, Bhargava B, Aggarwal R, Narang R, Chopra A, Sapra R, Manchanda SC

Hyperproduction, purification, and mechanism of action of the cytotoxic enterotoxin produced by Aeromonas hydrophila.

Monique R. Ferguson, X. J. Xu, C. W. Houston, Johnny W. Peterson, Dorian H. Coppenhaver, Vsevolod L. Popov, Ashok K. Chopra

Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity.

Shamsher S. Saini, Johnny W. Peterson, Ashok K. Chopra

Molecular and biochemical characterization of a heat-labile cytotonic enterotoxin from Aeromonas hydrophila.

Ashok K. Chopra, Johnny W. Peterson, Xin J. Xu, Dorian H. Coppenhaver, C. W. Houston

Phospholipase A2 activating protein and idiopathic inflammatory bowel disease

Johnny W. Peterson, W. D. Dickey, Shamsher S. Saini, W. Gourley, Gary R. Klimpel, Ashok K. Chopra

Cholera toxin induces synthesis of phospholipase A2-activating protein.

Peterson JW, Saini SS, Dickey WD, Klimpel GR, Bomalaski JS, Clark MA, Xu XJ, Chopra AK

Effect of cloned Salmonella typhimurium enterotoxin on rabbit intestinal motility

Vonda G. Reeves-Darby, John A. Turner, Rajendra Prasad, Ashok K. Chopra, Parvathi Chary, Mary H. Clench, Johnny W. Peterson, John R. Mathias

A ROLE FOR STEM CELL FACTOR AND C-KIT IN THE MURINE INTESTINAL TRACT SECRETORY RESPONSE TO CHOLERA TOXIN

Gary R. Klimpel, Ashok K. Chopra, Keith Langley, Jette Wypych, Charles A. Annable, Dominique Kaiserlian, Peter B. Ernst, Johnny W. Peterson

Vertebrate brains contain a broadly active antiviral substance.

Indra P. Singh, Ashok K. Chopra, Dorian H. Coppenhaver, Edna Smith, Joyce Poast, Samuel Baron

Amino-acid residues involved in biological functions of the cytolytic enterotoxin from Aeromonas hydrophila

Monique R. Ferguson, X. J. Xu, C. W. Houston, Johnny W. Peterson, Ashok K. Chopra

Interactions of intestinal mediators in the mode of action of cholera toxin

Johnny W. Peterson, Ying Lu, S. Duncan, Juan Cantu, Ashok K. Chopra

Improved synthesis of Salmonella typhimurium enterotoxin using gene fusion expression systems

Ashok K. Chopra, A. R. Brasier, Margaret Das, Xir Xin-Jing, J. W. Petersoir

Salmonella typhimurium enterotoxin epitopes shared among bacteria.

Ashok K. Chopra, X. J. Xu, Johnny W. Peterson

Molecular characterization of an enterotoxin from Salmonella typhimurium

Ashok K. Chopra, Johnny W. Peterson, Parvathi Chary, Rajendra Prasad

Molecular Mediators Formed in the Small Intestine in Response to Cholera Toxin

Johnny W. Peterson, Juan Cantu, Scott Duncan, Ashok K. Chopra

Fatal septicemia and bullae caused by non-01 Vibrio cholerae

Catherine C. Newman, Mary E. Shepherd, Mark D. Woodard, Ashok K. Chopra, Stephen K. Tyring

Location of the enterotoxin gene from Salmonella typhimurium and characterization of the gene products

Parvathi Chary, Rajendra Prasad, Ashok K. Chopra, Johnny W. Peterson

CLONING, EXPRESSION, AND SEQUENCE ANALYSIS OF A CYTOLYTIC ENTEROTOXIN GENE FROM AEROMONAS HYDROPHILA

Ashok K. Chopra, C. W. Houston, Johnny W. Peterson, Gui-F. Jin

Generalized occurrence of the broadly antiviral substance UTI beta in mammalian sera.

Indra P. Singh, Dorian H. Coppenhaver, Ashok K. Chopra, Samuel Baron

Expression and characterization of the cloned Salmonella typhimurium enterotoxin.

Rajendra Prasad, Ashok K. Chopra, Parvathi Chary, Johnny W. Peterson

Further characterization of a broad-spectrum antiviral substance in human serum

Indra P. Singh, Dorian H. Coppenhaver, Ashok K. Chopra, Samuel Baron

Cloning and sequence analysis of hydrogenase regulatory genes (hydHG) from Salmonella typhimurium.

Ashok K. Chopra, Johnny W. Peterson, Rajendra Prasad

Nucleotide sequence analysis of purH and purD genes from Salmonella typhimurium

Ashok K. Chopra, Johnny W. Peterson, Rajendra Prasad

Fine mapping of the rrnE, purHD, and hydGH operons on the Escherichia coli chromosome.

Johnny W. Peterson, Ashok K. Chopra, Rajendra Prasad

Enterotoxin-associated DNA sequence homology between Salmonella species and Escherichia coli.

Chopra AK, Peterson JW, Houston CW, Pericas R, Prasad R

Purification and partial characterization of a soluble suppressor factor from papillomavirus-infected patients.

V. Chopra, Ashok K. Chopra, S. Tyring

Biological and immunological characterization of a cloned cholera toxin-like enterotoxin from Salmonella typhimurium.

Rajendra Prasad, Ashok K. Chopra, Johnny W. Peterson, R. Pericas, C. W. Houston

Recently described innate broad spectrum virus inhibitors

Samuel Baron, David W. Niesel, Indra P. Singh, Louese McKerlie, Joyce Poast, Ashok K. Chopra, Guido Antonelli, Ferdinando Dianzani, Dorian H. Coppenhaver

Cloning and expression of the Salmonella enterotoxin gene.

Ashok K. Chopra, C. W. Houston, Johnny W. Peterson, Rohit Prasad, John J. Mekalanos