- Apr 1 Steven Bochco, American TV producer and co-creator of Hill Street Blues, LA Law and NYPD Blue, dies at 74
- Apr 2 Susan Anspach, American actress (Grace-Yellow Rose, Hair, Five Easy Pieces, Play It Again Sam), dies at 75
- Apr 3 Lill-Babs [Barbro Margareta Svensson], Swedish pop singer, (Eurovision, 1961) actress, and television presenter, dies of heart failure while battling cancer at 80
- Apr 4 Gertrude Jeannette, African American taxi driver, playwright and film and stage actress (Shaft, Cotton Comes to Harlem), dies at 103
- Apr 5 Isao Takahata, Japanese anime film director, screenwriter and producer (Grave of the Fireflies, The Tale of the Princess Kaguya), dies of lung cancer at 82
- Apr 11 Mitzi Shore [Lillian Saidel], American owner of The Comedy Store and founder of The Comedy Channel, dies at 87
- Apr 13 Miloš Forman, Czech-American award-winning director (One Flew Over the Cuckoo's Nest; Amadeus; The Firemen's Ball), dies at 86
- Apr 15 R. Lee Ermey, American actor (Full Metal Jacket- Gunnery Sergeant Hartman), dies at 74
- Apr 16 Harry Anderson, American comic, magician, and actor (Night Court - "Judge Harry Stone"; Daves's World), dies at 65
Bruno Sammartino (1935-2018)
Apr 18 Italian-American strongman and professional wrestler, dies at 82
- Apr 21 Nelson Pereira dos Santos, Brazilian movie director (Como Era Gostoso o Meu Francês, Vidas Secas), dies at 89
- Apr 21 Verne Troyer, American actor (Mini-Me in Austin Powers movies), dies at 49
- Apr 22 Dave Nelson, American baseball infielder (MLB All Star 1973 Washington Senators/Texas Rangers) and broadcaster (Milwaukee Brewers Fox Sports Wisconsin), dies of liver cancer at 73
- Apr 27 Paul Junger Witt, American TV and film producer (Brian's Song; Soap; The Golden Girls; Dead Poets Society), dies of cancer at 77
- Apr 29 Robert Mandan, American actor best known for his role as Chester Tate in US sitcom "Soap", dies at 86
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