Greenville, South Carolina, is anchored by what Forbes Magazine calls one of America's Best Downtowns. Featuring a one-of-a-kind "floating" suspension bridge and set against the scenic Blue Ridge Mountains, Greenville boasts a thriving arts scene, hundreds of restaurants, shops and boutiques, popular annual festivals, numerous historic sites and museums housing significant art collections. Excellent interstate service and a user-friendly international airport make access easy.

Gatlinburg, at the heart of Great Smoky Mountains National Park, is an ideal base for a family looking to explore the park's numerous offerings. After you've gone hiking, fishing, rafting or horseback riding, ride an elevator 342 feet to the top of the Gatlinburg Space Needle for stunning views of the Smokies. There's also an amusement center next door with nifty rides and games.

Saint Augustine is a luxurious, romantic vacation spot—you’ll find classic hotels and intimate restaurants. Those can be a dime a dozen, though. What sets Saint Augustine apart is its history—it’s the oldest European settlement in the U.S. And nowhere else in the world can you taste the waters of the Fountain of Youth Archeological Park (where Ponce de Leon may have landed). Who knows, if you vacation here, maybe you won’t need that Botox!

Each year, horse enthusiasts hoof it to Louisville and Churchill Downs, the legendary home of the Kentucky Derby. In addition to equestrian endeavors and bluegrass roots, Louisville boasts a range of exciting attractions the whole family can enjoy. Stroll through Central Park, in the historic district, to people-watch and get a real feel for the city. Visit other nearby parks for hiking, biking and fossil finding. Baseball fans will love the Louisville Slugger Museum, a celebration of the sport's legends. The museum is easy to spot, just look for the humongous bat that leans against the building.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Detroit is an amazing destination for your next weekend getaway. If exploring is your thing, hop on a bike and meet new friends on the Slow Roll bike tour (you’ll find a unique perspective on the city, and the slow pace is perfect for all skill levels). And while you may not think of Detroit as wine country, the newly opened Detroit Vineyards is one of the country’s largest urban wineries, crafting superior wines right in the heart of the city. Grab your glass and make a toast to the weekend!

The windy city is a cornucopia of modern art, fine dining, cutting edge comedy, and die-hard sports fans. Snap a photo of your reflection in the silver Cloud Gate sculpture at Millennium Park before heading to Grant Park to get hit with the refreshing spray of Buckingham Fountain. There are dozens of museums and theater companies in Chicago, so a cultural experience is never hard to find. You’re sure to laugh your head off at the Second City Theater, the professional launch pad of many famous comedians.

You've probably heard that Guinness tastes better in Dublin (fresh from the factory), but what you may not know is that Dublin is a perfect destination for the whole family. No, we're not suggesting you let the kiddies drink a pint. Instead, take them to the Dublin Zoo, to feed the ducks in Stephen's Green or on a picnic in Phoenix Park. Scholars enjoy walking in the literary footsteps of such writers as Yeats and Joyce, while discerning shoppers have their pick of designer boutiques.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

This city, full of colorful homes, canals and bridges, is one of Europe's most picturesque capitals. Must-sees on any visitor's itinerary include the Anne Frank House, the Van Gogh Museum and the world's only floating flower market. Rent a bike and join thousands of locals navigating Amsterdam's labyrinthine streets, or just take in the sights on foot. For an unusual and memorable alternative to hotels, consider staying in a houseboat.