Filmography
| Year | Title | Role |
| 2024 | Beetlejuice Beetlejuice (2024) | Actor |
| 2024 | Nosferatu (2024) | Professor Albin Eberhart Von Franz |
| 2023 | Asteroid City (2023) | Saltzburg Keitel |
| 2023 | Inside (2023) | Nemo |
| 2023 | Poor Things (2023) | Dr. Godwin Baxter |
| 2023 | The Boy and the Heron (2023) | Noble Pelican |
| 2022 | The Northman (2022) | Heimir the Fool |
| 2022 | Dead for a Dollar (2022) | Joe Cribbens |
| 2021 | Spider-Man: No Way Home (2021) | Norman Osborn/Green Goblin |
| 2021 | Nightmare Alley (2021) | Clem Hoatley |
| 2021 | Zack Snyder's Justice League (2021) | Nuidis Vulko |
| 2021 | River (2023 Documentary) | Narrator |
| 2020 | The Last Thing He Wanted | Richard McMahon |
| 2020 | The Card Counter (2021) | Major John Gordo |
| 2020 | Roy's World: Barry Gifford's Chicago | Narrator |
| 2019 | Love, Antosha | Self |
| 2019 | The Lighthouse (2019) | Thomas Wake |
| 2019 | Motherless Brooklyn | Paul |
| 2019 | Manou the Swift | Yves |
| 2019 | Tommaso | Tommaso |
| 2018 | Aquaman | Vulko |
| 2018 | BALLAD OF A RIGHTEOUS MERCHANT | Self |
| 2018 | At Eternity's Gate | Vincent van Gogh |
| 2018 | Vox Lux | Narrator |
| 2017 | Murder on the Orient Express (2017) | Gerhard Hardman |
| 2017 | Julian Schnabel: A Private Portrait | Self |
| 2017 | The Florida Project | Bobby |
| 2017 | Death Note (2017) | Ryuk |
| 2017 | Do Donkey's Act? | Narrator |
| 2017 | Piazza Vittorio | Self |
| 2017 | Mountain (2018) | Narrator |
| 2016 | The Great Wall (2017) | Ballard |
| 2016 | Dog Eat Dog | Mad Dog |
| 2016 | A Family Man | Ed Blackridge |
| 2015 | My Hindu Friend | Diego Fairman |
| 2014 | The Grand Budapest Hotel | Jopling |
| 2014 | The Fault in Our Stars | Peter Van Houten |
| 2014 | A Most Wanted Man | Tommy Brue |
| 2014 | John Wick | Marcus |
| 2014 | Pasolini | Pier Paolo Pasolini |
| 2013 | Out of the Furnace | John Petty |
| 2013 | Odd Thomas | Chief Wyatt Porter |
| 2012 | John Carter | Tars Tarkas |
| 2012 | Tomorrow You're Gone | The Buddha |
| 2011 | 4:44 Last Day on Earth | Cisco |
| 2011 | The Hunter | Martin David |
| 2010 | Miral | Eddie |
| 2010 | mindFLUX | Actor |
| 2010 | A Woman | Max Oliver |
| 2009 | Fantastic Mr. Fox | Rat |
| 2009 | Daybreakers | Lionel 'Elvis' Cormac |
| 2009 | Cirque du Freak: The Vampire's Assistant | Gavner Purl |
| 2009 | Antichrist | He |
| 2009 | My Son, My Son, What Have Ye Done | Detective Hank Havenhurst |
| 2009 | L'affaire Farewell | Feeney |
| 2008 | Adam Resurrected | Commandant Klein |
| 2008 | Fireflies in the Garden | Charles |
| 2008 | La Poussiere du Temps | A |
| 2007 | Spider-Man 3 (2007) | Norman Osborn/Green Goblin |
| 2007 | Mr. Bean's Holiday | Carson Clay |
| 2007 | The Walker | Larry Lockner |
| 2007 | Go Go Tales | Ray Ruby |
| 2007 | Anamorph | Stan Aubray |
| 2006 | Inside Man (2006) | Capt. Darius |
| 2006 | American Dreamz | Wally Brown |
| 2006 | Paris Je T'aime | Le cow-boy |
| 2005 | XXX: State of the Union | George Deckert |
| 2005 | Manderlay | Grace's Father |
| 2005 | Before It Had A Name | Leslie |
| 2004 | Spider-Man 2 (2004) | Norman Osborn/Green Goblin |
| 2004 | The Clearing | Arnold Mack |
| 2004 | The Aviator | Tabloid editor |
| 2004 | THE LIFE AQUATIC WITH STEVE ZISSOU / THE ADVENTURES | Klaus Daimler |
| 2003 | Once Upon a Time in Mexico | Barrillo |
| 2003 | Finding Nemo | Gill |
| 2002 | Spider-Man (2002) | Norman Osborne/Green Goblin |
| 2002 | Auto Focus | John Carpenter |
| 2001 | Pavilion Of Women | Andre |
| 2001 | Edges Of The Lord | Priest |
| 2000 | American Psycho | Donald Kimball |
| 2000 | Shadow of the Vampire | Max Schreck |
| 2000 | Animal Factory | Earl Copen |
| 2000 | Bullfighter | Father Ramirez |
| 1999 | eXistenZ | Gas |
| 1999 | The Boondock Saints (2006 Re-release) | Paul Smecker |
| 1998 | New Rose Hotel | X |
| 1998 | Lulu on the Bridge | Dr. Van Horn |
| 1997 | Affliction | Rolfe Whitehouse |
| 1996 | Basquiat | The Electrician |
| 1996 | The English Patient | David Caravaggio |
| 1994 | Clear and Present Danger | John Clark |
| 1993 | Faraway, So Close! | Emit Flesti |
| 1992 | North on Evers | Self |
| 1992 | Body of Evidence | Frank Dulaney |
| 1992 | Light Sleeper | John LeTour |
| 1990 | Wild at Heart | Bobby Peru |
| 1989 | Born on the Fourth of July | Charlie (Villa Dulce) |
| 1989 | Hineni's Triumph of the Spirit | Salamo Arouch |
| 1988 | Off Limits | Buck McGriff |
| 1988 | Film Club: The Last Temptation of Christ | Jesus of Nazareth |
| 1988 | Mississippi Burning | Agent Alan Ward |
| 1986 | Platoon | Sgt. Elias Grodin |
| 1985 | To Live and Die in L.A. | Eric 'Rick' Masters |
| 1984 | Streets of Fire | Raven Shaddock |
| 1983 | The Hunger | 2nd Phone Booth Youth |
| 1983 | The Loveless | Vance |
