Filmography
| Year | Title | Role |
| 2023 | Asteroid City (2023) | Stanley Zak |
| 2023 | My Big Fat Greek Wedding 3 (2023) | Producer |
| 2022 | Elvis (2022) | Colonel Tom Parker |
| 2022 | A Man Called Otto (2022) | Otto Anderson |
| 2021 | Finch (2021) | Finch |
| 2020 | Greyhound | Captain Krause |
| 2020 | News of the World (2020) | Captain Kidd |
| 2019 | Toy Story 4 | Woody |
| 2019 | A Beautiful Day in the Neighborhood | Fred Rogers |
| 2018 | Mamma Mia! Here We Go Again | Executive Producer |
| 2017 | The Circle (2017) | Eamon Bailey |
| 2017 | The Post (2017) | Ben Bradlee |
| 2016 | Inferno | Robert Langdon |
| 2016 | My Big Fat Greek Wedding 2 | Producer |
| 2016 | A Hologram for the King | Alan Clay |
| 2016 | Sully | Chesley "Sully" Sullenberger |
| 2016 | Defying the Nazis: The Sharps' War | Waitstill Sharp |
| 2016 | California Typewriter | Self |
| 2015 | Bridge of Spies | James Donovan |
| 2015 | Everything Is Copy | Actor |
| 2015 | Ithaca | Matthew Macauley |
| 2013 | Captain Phillips | Capt. Richard Phillips |
| 2013 | Saving Mr. Banks | Walt Disney |
| 2013 | Parkland | Producer |
| 2013 | Toy Story OF TERROR! | Actor |
| 2012 | Cloud Atlas | Zachry |
| 2012 | Game Change | Executive Producer |
| 2012 | Radioman | Actor |
| 2011 | Larry Crowne | Larry Crowne |
| 2011 | Toy Story Toons: Hawaiian Vacation | Woody |
| 2011 | Extremely Loud & Incredibly Close | Thomas Schell |
| 2011 | He Has Seen War | Executive Producer |
| 2010 | Toy Story 3 | Woody |
| 2009 | Angels & Demons | Robert Langdon |
| 2009 | Where the Wild Things Are | Producer |
| 2009 | My Life in Ruins | Executive Producer |
| 2008 | City of Ember | Producer |
| 2008 | The Great Buck Howard | Mr. Gable |
| 2008 | Mamma Mia! (2008) | Executive Producer |
| 2007 | Evan Almighty | Executive Producer |
| 2007 | The Simpsons Movie | Self |
| 2007 | Charlie Wilson's War | Charlie Wilson |
| 2006 | The Da Vinci Code | Robert Langdon |
| 2006 | The Ant Bully | Producer |
| 2006 | Neil Young: Heart of Gold | Producer |
| 2006 | Starter for 10 | Producer |
| 2005 | Magnificent Desolation: Walking on the Moon | Producer |
| 2004 | The Ladykillers (2004) | Goldthwait Higginson Dorr III, Ph.D. |
| 2004 | The Polar Express | Hero Boy/Father/Conductor/Hobo/Scrooge/Santa Claus |
| 2004 | The Terminal | Viktor Navorski |
| 2003 | Concert for George | Mountie |
| 2002 | Road to Perdition | Michael Sullivan |
| 2002 | Catch Me if You Can | FBI Agent Carl Hanratty |
| 2002 | My Big Fat Greek Wedding | Producer |
| 2000 | Cast Away | Chuck Noland |
| 1999 | The Green Mile | Paul Edgecomb |
| 1999 | Toy Story 2 | Woody |
| 1998 | Saving Private Ryan | Captain John H. Miller |
| 1998 | Return With Honor: A Missionary Homecoming | Narrator |
| 1998 | You've Got Mail | Joe Fox |
| 1996 | The Celluloid Closet | Actor |
| 1996 | That Thing You Do! | Mr. White |
| 1995 | Toy Story (1995) | Woody |
| 1995 | Apollo 13 (2002 re-release) | Jim Lovell |
| 1994 | Forrest Gump | Forrest Gump |
| 1993 | Sleepless in Seattle (1993) | Sam Baldwin |
| 1993 | Philadelphia | Andrew Beckett |
| 1992 | A League of Their Own | Jimmy Dugan |
| 1992 | Radio Flyer | Older Mike |
| 1990 | Joe Versus the Volcano | Joe |
| 1990 | The Bonfire of the Vanities | Sherman McCoy |
| 1989 | The 'Burbs | Ray Peterson |
| 1989 | Turner & Hooch | Det. Scott Turner |
| 1988 | Big (1988) | Josh |
| 1988 | Punchline | Steven Gold |
| 1987 | Dragnet | Det. Pep Streebek |
| 1986 | Nothing in Common | David Basner |
| 1986 | The Money Pit | Walter Fielding, Jr. |
| 1985 | The Man With One Red Shoe | Richard Harlan Drew |
| 1984 | Splash | Allen Bauer |
| 1984 | Bachelor Party (1984) | Rick Gassko |
| 1982 | Mazes and Monsters | Robbie Wheeling |
| 1980 | He Knows You're Alone | Elliot |
