Filmography
| Year | Title | Role |
| 2022 | Avatar: The Way of Water (2022) | Kiri |
| 2022 | Call Jane | Virginia |
| 2022 | Master Gardener (2023) | Norma Haverhill |
| 2021 | Ghostbusters: Afterlife (2021) | Dana Barrett |
| 2021 | The Good House (2022) | Hildy Good |
| 2020 | My Salinger Year (2021) | Margaret |
| 2016 | Ghostbusters (2016) | Rebecca Gorin |
| 2016 | Finding Dory | Herself |
| 2016 | A Monster Calls | Grandma |
| 2016 | The Beatles: Eight Days a Week - The Touring Years | Self |
| 2016 | The Assignment (2017) | Dr. Rachel Kay |
| 2015 | Chappie | Michelle Bradley |
| 2015 | Ingrid Bergman in Her Own Words | Self |
| 2014 | Exodus: Gods and Kings | Tuya |
| 2014 | All You Need Is Love | Narrator |
| 2014 | My Depression: The Up and Down and Up of It | Voice |
| 2012 | The Cold Light of Day | Carrack |
| 2012 | Red Lights | Margaret Matheson |
| 2012 | Vamps | Cisserus |
| 2011 | The Cabin in the Woods | The Director |
| 2011 | Cedar Rapids | Macy Vanderhei |
| 2011 | Rampart | Joan Confrey |
| 2011 | Tipping Point: The Age of the Oil Sands | Narrator |
| 2010 | You Again | Ramona |
| 2010 | Crazy on the Outside | Viki |
| 2009 | Avatar (2009) | Grace Augustine |
| 2009 | Cinema's Exiles: From Hitler to Hollywood | Narrator |
| 2009 | Prayers for Bobby | Mary Griffith |
| 2008 | Vantage Point | Rex Brooks |
| 2008 | WALL-E | Ship's Computer |
| 2008 | Be Kind Rewind | Ms. Lawson |
| 2008 | Baby Mama | Chaffee Bicknell |
| 2008 | The Tale of Despereaux | Narrator |
| 2007 | Happily N'Ever After | Frieda |
| 2007 | The Girl in the Park | Julia Sandburg |
| 2006 | Infamous (2006) | Babe Paley |
| 2006 | Snow Cake | Linda Freeman |
| 2006 | The TV Set | Lenny |
| 2004 | The Village | Alice Hunt |
| 2004 | Imaginary Heroes | Sandy Travis |
| 2003 | Holes | The Warden |
| 2003 | Alien: The Director's Cut - Giant Screen | Actor |
| 2003 | ArcLight Presents...Alien: Director's Cut | Actor |
| 2002 | Tadpole | Eve |
| 2002 | The Guys | Joan |
| 2001 | Heartbreakers | Angela Nardino/Max Conners/Ulga Yevanova |
| 1999 | Galaxy Quest | Gwen DeMarco/Lieutenant Tawny Madison |
| 1999 | A Map Of The World | Alice Goodwin |
| 1997 | The Ice Storm | Janey Carver |
| 1997 | Alien 4: Resurrection | Lt. Ellen Ripley |
| 1994 | Death and the Maiden | Paulina Escobar |
| 1993 | Dave | First Lady Ellen Mitchell |
| 1992 | Alien 3 (1992) | Ellen Ripley |
| 1992 | 1492: Conquest of Paradise | Queen Isabella I. |
| 1989 | Ghostbusters 2 | Dana Barrett |
| 1988 | Working Girl (Adult) | Katharine Parker |
| 1988 | Gorillas in the Mist | Dian Fossey |
| 1986 | Aliens | Lt. Ellen Ripley |
| 1984 | Ghostbusters (1984) | Dana Barrett/Zuul, The Gate Keeper |
| 1982 | The Year of Living Dangerously | Jillian Edith 'Jill' Bryant |
| 1981 | Eyewitness | Tony Sokolow |
| 1979 | Alien 45th Anniversary Re-Release (2024) | Warrant Officer Lt. Ellen L. Ripley |
