吴晓萍，暨南大学生命科学技术学院免疫生物学系研究员，生物医药博士生导师，免疫学硕士生导师。从事细胞因子与创伤修复、肿瘤的基础理论、临床应用及其相关基因工程药物的研发，主要涉及成纤维细胞生长因子（FGFs）家族的结构与功能关系、细胞效应与分子调控机制、FGFs规模化生产的关键技术、临床应用安全性等方面。成功研发了国家基因工程一类新药“重组人酸性成纤维细胞生长因子”。获国家科学技术发明二等奖、广东省科学技术发明一等奖、中华医学科技奖一等奖、中国药学科学技术一等奖和中国专利优秀奖等奖项共5项。主持或参与国家自然科学基金重点项目、国家863计划项目、国家重大生物医药专项、国家自然科学基金面上项目、省自然科学基金和省科技计划项目等各级项目17项，发表SCI论文46篇，获批发明专利3项，其中1项已实现产业化，产生了良好的社会和经济效益。参编著作3部（2部为副主编）。入选广东省千百十工程省级人才。担任国家基金委创新群体、国家自然科学基金、广东省自然科学基金、广东省科技计划项目等基金评审专家，教育部学位与研究生教育论文评审专家。先后任Breast Cancer Research、Applied Microbiology and Biotechnology、International Journal of Oncology等多种国际杂志审稿专家。 [1]
- 中文名
- 吴晓萍
- 毕业院校
- 暨南大学
- 学位/学历
- 博士
- 职 业
- 教师
- 专业方向
- 细胞因子与肿瘤发生发展的关联机制及靶向抗肿瘤药物研发
- 职 务
- 暨南大学博士生导师
1993.9～1996.6中山大学 生物化学专业 获理学硕士学位
1989.9～1993.6四川大学 生物化学专业 获理学学士学位
2011～2012Texas A&M Health Science Center，访问学者
2006～至今暨南大学组织移植与免疫研究中心/免疫生物学系，研究员，博导
1999～2006暨南大学医药生物技术研究开发中心，副研究员
[1]Wu Luo, Xiaomian Lin, Tianxiang Wang, Jialong Cai, Xiangfeng Zeng, Cairong Zhu, Rongzhen Li, Heng Wang,Xiaoping Wu*. Identification of a crucial amino acid responsible for the loss of specifying FGFR1–KLB affinity of the iodinated FGF21. J Cell Physiol. 2019, 234(3): 2500-2510.
[2] Hongjiao Liu, Xiaomian Lin, Tao Huang, Li Song, Cairong Zhu*, Hongmin Ma, Tianzhu Long, Huixuan Zeng, Rongzhen Li, Heng Wang, Yishan Huang, Liankuai Chen,Xiaoping Wu*. A short peptide reverses the aggressive phenotype of prostate cancer cells. Eur J Pharmacol. 2018, 838: 129-137.
[3] Jianzhang Wu, Shoubiao Wu, Lingyi Shi, Shanshan Zhang, Jiye Ren, Song Yao, Di Yun, Lili Huang, Jiabing Wang, Wulan Li,Xiaoping Wu, Peihong Qiu, Guang Liang. Design, synthesis, and evaluation of asymmetric EF24 analogues as potential anti-cancer agents for lung cancer. Eur J Med Chem. 2017, 125: 1321-1331.
[4]Xiaomian Lin, Li Song, Dan He, Xiangfeng Zeng, Jianzhang Wu, Wu Luo, Qi Yang, Jizhong Wang, Wang Tianxiang, Cai Jialong, Lin Yanling, Lai Fubin, Peng Wentao,Xiaoping Wu*. An FGF8b-mimicking peptide with potent antiangiogenic activity. Mol Med Rep. 2017, 16(1): 894-900.
[5]Jizhong Wang, Xiangpeng Tan, Qi Yang, Xiangfeng Zeng, Yuying Zhou, Wu Luo, Xiaomian Lin, Li Song, Jialong Cai, Tianxiang Wang,Xiaoping Wu*. Inhibition of autophagy promotes apoptosis and enhances anticancer efficacy of adriamycin via augmented ROS generation in prostate cancer cells. Int J Biochem Cell Biol. 2016, 77(Pt A): 80-90.
[6] Tao Huang, Xiaomian Lin, Quchou Li, Wu Luo, Li Song, Xiangpeng Tan, Wenhui Wang, Xiaokun Li,Xiaoping Wu*. Selection of a novel FGF23-binding peptide antagonizing the inhibitory effect of FGF23 on phosphate uptake. Appl Microbiol and Biotechnol. 2015, 99(7): 3169-3177.
[7] Wu Luo, Yonglin Yu, Ruixue Wang, Dan He, Cong Wang, Xiangfeng Zeng, Xilei Chen, Xiangpeng Tan, Tao Huang,Xiaoping Wu*. P7 peptides targeting bFGF sensitize colorectal cancer cells to CPT-11. Int J Mol Med. 2014, 33(1): 194-200.
[8] Xiangpeng Tan, Xilei Chen, Tao Huang, Wu Luo, Dan He, Xiaomian Lin, Li Song,Xiaoping Wu*. Mechanism of bFGF-binding Peptide Reversing Adriamycin Resistance in Human Gastric Cancer Cells. Int J Pept Res Ther. 2014, 20(4): 427–434.
[9] Wenhui Wang, Xilei Chen, Tao Li, Yanmei Li, Ruixue Wang, Dan He, Wu Luo, Xiaokun Li,Xiaoping Wu*. Screening a phage display library for a novel FGF8b-binding peptide with anti-tumor effect on prostate cancer. Exp Cell Res. 2013, 319(8): 1156-1164.
[10]Tao Li, Wu Luo, Dan He, Ruixue Wang, Yadong Huang, Xiangfeng Zeng, Wenhui Wang, Xilei Chen, Susu Gao, Yonglin Yu, Xiaokun Li,Xiaoping Wu*. A short peptide derived from the gN helix domain of FGF8b suppresses the growth of human prostate cancer cells. Cancer Lett. 2013, 339(2): 226-236.
[11] Ruixue Wang, Wu Luo, Xiangfeng Zeng, Jingfang Di, Yonglin Yu, Chuan Wang, Wenhui Wang, Xilei Chen, Dan He, Tao Li,Xiaoping Wu*. A bFGF Antagonist Peptide with Anti-angiogenesis Properties in Non-small Cell Lung Cancer Cells. Int J Pept Res Ther. 2013, 19(3): 295-302.
[12]Yonglin Yu, Susu Gao, Quchou Li, Cong Wang, XinqiangLai, Xilei Chen, Ruixue Wang, JingfangDi, TaoLi, Wenhui Wang,Xiaoping Wu*. The FGF2-binding peptide P7 inhibits melanoma growth in vitro and in vivo.J Cancer Res Clin Oncol.2012, 138:1321–1328.
[13] Susu Gao, Yonglin Yu, Xinqiang Lai, Tao Li, Quchou Li, Xilei Chen, Ruixue Wang, Wenhui Wang,Xiaoping Wu*. Anti-Proliferation Effect of a Short Peptide on bFGF-Induced Human Gastric Cancer Cells. Int J Pept Res Ther. 2012,18 (4): 299-304.
[14] Quchou Li, Susu Gao, Yonglin Yu, Wenhui Wang, Xilei Chen, Ruixue Wang, Tao Li, Cong Wang, Xiaokun Li,Xiaoping Wu*. A novel bFGF antagonist peptide inhibits breast cancer cell growth.Mol Med Report.2012, 6(1): 210-214.
[15]Xiaoping Wu,Qiuxia Yan,Yadong Huang,Huixian Huang,Zhijian Su,Jian Xiao,Yaoying Zeng,Yi Wang,Changjun Nie,Yongguang Yang*,Xiaokun Li*. Isolation of a novel basic FGF-binding peptide with potent antiangiogenetic activity.J Cell Mol Med.2010, 14(1-2): 351-356.
[16] Cong Wang, Shaoqiang Lin, Yanfang Nie, Xinglong Jia, Jing Wang, Jian Xiao, Jianzhang Wu, Xiaokun Li*,Xiaoping Wu*. Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cells. Cancer Sci. 2010. 101(5): 1212-1218.
[17]Xiaoping Wu,Haishan Tian,Yadong Huang,Sixian Wu,Xiaoju Liu,Cong Wang,Xiaojie Wang,Zhifeng Huang,Jian Xiao,Wenke Feng,Xiaokun Li*. Large-scale production of biologically active human keratinocyte growth factor-2.Appl Microbiol Biotechnol.2009, 82(3): 439-444.
[18]Xiaoping Wu,Changjun Nie, ZhifengHuang, YanfangNie,Qiuxia Yan,Yecheng Xiao,Zhijian Su,Yadong Huang,Jian Xiao,Yaoying Zeng,Yi Tan,Wenke Feng*,Xiaokun Li*. Expression and Purification of Human Keratinocyte Growth Factor 2 by Fusion with SUMO.Mol Biotechnol.2009, 42(1): 68-74.
[19]Xiaoping Wu, Xiaoju Liu, Yecheng Xiao, Zhifeng Huang, Jian Xiao, Shaoqiang Lin, Lu Cai, Wenke Feng*, Xiaokun Li*. Purification and modification by polyethylene glycol of a new human basic fibroblast growth factor mutant-hbFGFSer25,87,92. J Chromatogr A, 2007,1161(1-2): 51-55.
[20] Xiaokun Li, LijuanJiang, YiWang, YechengXiao, YadongHuang, QiongfengYao, YongguangYang*,XiaopingWu*. Inhibition of angiogenesis by a novel small peptide consisting of the active fragments of platelet factor-4 and vasostatin.Cancer Lett.2007, 256(1): 29-32. [1]
- 1.国家自然科学基金面上项目（81573334）：bFGF通过Galectin-1介导胃癌化疗耐药的分子机制及相关靶向新药研究。主持
- 2.国家自然科学基金面上项目（81071800）：P7逆转结肠癌细胞化疗耐药的作用机制研究。主持
- 3.国家自然科学基金面上项目（30973671）：新型bFGF结合肽拮抗bFGF的作用机制研究。主持
- 4.国家863计划项目(2007AA02Z110)子课题:提高角化生长因子（KGF-2）表达量及稳定性的关键技术研究。主持
- 5.国家重大生物医药专项（2002AA2Z3318，2004AA2Z3C60）子课题：重组人成纤维细胞生长因子改构体新药研究。主持
- 6.国家863计划项目（2001AA215131）：新型非促分裂重组成纤维细胞生长因子改构体的研究。参与
- 7.国家自然科学基金重点项目（30730087）：妊娠期调节性T细胞来源及在母-胎免疫耐受中的作用。参与
- 8.国家自然科学基金面上项目（30500450）：中国人TLR4基因单核苷酸多态性图谱的构建及其临床应用。参与
- 9.广东省科技计划项目（2015A020211017）：抗三阴性乳腺癌的新型bFGF拮抗肽药物的研发。主持
- 10.广东省自然科学基金面上项目（9151064001000031）：bFGF活性拮抗短肽的抗肿瘤作用机制研究。主持 [1]
- 1.特异性结合碱性成纤维细胞生长因子受体的肽，ZL201010525955.0，2013.
- 2.抑制由碱性成纤维细胞生长因子诱导的细胞增殖及血管增生的环肽，ZL201010525954.6，2012.
- 3.分泌表达酸性成纤维细胞生长因子的方法，ZL00114010.8，2004.（已实现产业化） [1]
免疫学实验技术（硕士生）
省级青年人才
2.教育部学位与研究生教育论文评审专家。
3. Breast Cancer Research、Applied Microbiology and Biotechnology、International Journal ofOncology 等多种国际杂志审稿专家。 [1]
