Macclesfield is a town in Edgecombe County, North Carolina, United States. It is part of the Rocky Mount, North Carolina Metropolitan Statistical Area. The population was 458 at the 2000 census.
Macclesfield is located at 35°45′6″N 77°40′18″W / 35.75167°N 77.67167°W / 35.75167; -77.67167 (35.751637, -77.671674).
According to the United States Census Bureau, the town has a total area of 0.5 square miles (1.3 km²), of which, 0.5 square miles (1.3 km²) of it is land and 1.96% is water.