Filmography
| Year | Title | Role |
| 2023 | Leave the World Behind (2023) | Amanda Sandford |
| 2022 | Ticket to Paradise (2022) | Georgia |
| 2018 | Ben is Back | Holly Burns |
| 2017 | Smurfs: The Lost Village | SmurfWillow |
| 2017 | Wonder | Isabel |
| 2016 | Money Monster | Patty Fenn |
| 2016 | Mother's Day | Miranda |
| 2015 | Secret in Their Eyes | Jess |
| 2014 | The Normal Heart | Dr. Emma Brookner |
| 2013 | August: Osage County | Barbara Weston |
| 2012 | Mirror Mirror (2012) | The Queen |
| 2011 | Larry Crowne | Mercedes Tainot |
| 2011 | Jesus Henry Christ | Executive Producer |
| 2010 | Valentine's Day (2010) | Capt. Kate Hazeltine |
| 2010 | Eat Pray Love | Liz Gilbert |
| 2009 | Duplicity | Claire Stenwick |
| 2008 | Kit Kittredge: An American Girl | Executive Producer |
| 2008 | Fireflies in the Garden | Lisa |
| 2007 | Charlie Wilson's War | Joanne Herring |
| 2006 | Charlotte's Web (2006) | Charlotte |
| 2006 | The Ant Bully | Hova |
| 2004 | Ocean's Twelve | Tess Ocean |
| 2004 | Closer | Anna |
| 2004 | Tell Them Who You Are | Self |
| 2004 | Samantha: An American Girl Holiday | Executive Producer |
| 2003 | Mona Lisa Smile | Katherine Watson |
| 2002 | Full Frontal | Francesca/Catherine |
| 2002 | Confessions of a Dangerous Mind | Patricia |
| 2001 | The Mexican | Samantha Barzel |
| 2001 | America's Sweethearts | Kiki Harrison |
| 2001 | Ocean's Eleven (1960) | Tess Ocean |
| 2000 | Erin Brockovich | Erin Brockovich |
| 1999 | Notting Hill | Anna Scott |
| 1999 | Runaway Bride | Maggie Carpenter |
| 1998 | Stepmom | Isabel Kelly |
| 1997 | Conspiracy Theory | Alice Sutton |
| 1997 | My Best Friend's Wedding (1997) | Julianne Potter |
| 1996 | Everyone Says I Love You | Von Sidell |
| 1996 | Michael Collins | Kitty Kiernan |
| 1994 | Pret-a-Porter | Anne Eisenhower |
| 1993 | The Pelican Brief | Darby Shaw |
| 1991 | Hook | Tinkerbell |
| 1991 | Sleeping With the Enemy | Sara Waters/Laura Burney |
| 1990 | Flatliners (1990) | Rachel Mannus |
| 1990 | Pretty Woman | Vivian 'Viv' Ward |
| 1989 | Steel Magnolias 35th Anniversary | Shelby Eatenton Latcherie |
| 1988 | Mystic Pizza | Daisy Arujo |
| 1988 | Satisfaction | Daryle |
