You have a 12 hour time difference between Boston and Hong Kong, which is a lot when considering jet lag. Compared to travelling to Europe, it is twice as much difference (eg. Boston to Paris is a 6 hour difference). You are also going to be flying for more than 15 hours, and that is a long time in a plane pressurised to levels way above what you are used to at sea level in Boston.
When you arrive, take it easy. Don't make any important decisions or spend significant sums of money. Make sure you know exactly how to get from the airport to your hotel.
When you arrive very early in the morning, your internal clock will be telling you it is mid morning. Staying out in daylight is important to overcoming jet lag, so I suggest you go to your hotel and leave your luggage (if you can't do an early check in). Don't go to your room and lie down - it will only make the problem worse. Then do some easy sightseeing (avoiding crowds) which is outdoors, and stay outdoors until it gets dark. Try to eat at the approximately normal times for eating in Hong Kong. When you get tired, sit down on a seat which does not have a back, so you aren't too comfortable, and have a small nap.
You can then go to bed after dark, but early, and make sure you have an alarm clock or a wakeup call from the hotel, at a reasonable hour in the next morning. (I once slept for 13 hours straight because I was jet lagged).
As you say, everyone is different, but you are going to have a much greater time difference that you are used to when going to Europe from the east coast US. But it will get easier every day.