Hi Marchlove,
high levels of estrogen might impact adrenals but one thing is certain and that is that I don't have high levels, however much I might apply to my skin, my plasma levels have always been low, rose slightly on increased estrogel and then dipped significantly on Estradot.
An even more tangible indication that my estrogen is too low is that I have developed osteopenia, despite doing resistence training, weights etc. That is another factor that doesn't help with anxiety and reason enough to increase my estrogen absorption as a matter or urgency - as also advised by Panay who recommends levels 400-800.
I have had thyroid, cortisol, ferritin, vitamin D and B tested and all are fine/optimal.
I know that many consider the NHS thyroid testing inadequate as it doesnt include thyroid antibodies and free T3 so I might test those additionally privately and possibly do the 4 point cortisol test but whatever the findings are I still urgently need more serum estradiol and testosterone.
x