Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome
Public Deposited- Creator
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Anselmo, A.C.
- Affiliation: Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics
- Other Affiliation: Massachusetts Institute of Technology
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McHugh, K.J.
- Other Affiliation: Massachusetts Institute of Technology
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Webster, J.
- Other Affiliation: Massachusetts Institute of Technology
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Langer, R.
- Other Affiliation: Massachusetts Institute of Technology
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Jaklenec, A.
- Other Affiliation: Massachusetts Institute of Technology
- Abstract
- Recent discoveries in biology and microbiology have highlighted the importance of the gastrointestinal (GI) microbiome in regulating human health and disease. Thus, the delivery of probiotics to influence and modulate microbiome compositions can potentially impact the treatment of a number of human diseases. Unfortunately, biological challenges encountered during oral delivery have limited the translation of many probiotic-delivering technologies. Here, we report a layer-by-layer (LbL) method for the encapsulation of probiotics to directly address these challenges by protecting probiotics from GI tract insults while facilitating both mucoadhesion and direct growth on intestinal surfaces.
- Date of publication
- 2016
- Keyword
- DOI
- Identifier
- https://dx.doi.org/10.1002/adma.201603270
- PMID 27616140
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Advanced Materials
- Journal volume
- 28
- Journal issue
- 43
- Page start
- 9486
- Page end
- 9490
- Language
- English
- Version
- Postprint
- ISSN
- 0935-9648
- Publisher
- Wiley-VCH Verlag
Relations
- Parents:
This work has no parents.
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