Dr. Ramesh C. Gupta MD

Milk exosomes: A biogenic nanocarrier for small molecules and macromolecules to combat cancer

Raghuram Kandimalla, Farrukh Aqil, Neha Tyagi, Ramesh C. Gupta

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells.

Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta

Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome

Ashley M. Mudd, Tao Gu, Radha Munagala, Jeyaprakash Jeyabalan, Nejat K. Egilmez, Ramesh C. Gupta

Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial.

Morand, E., Bruce, I., Vital, E., Lawrence Ford, T., Hiepe, F., Santiago, M., Brohawn, P., Berglind, A., Tummala, R., , Furie, R., Manzi, S., Kalunian, K., Gupta, R.

Milk exosomes - Natural nanoparticles for siRNA delivery.

Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Al-Hassan Kyakulaga, Sarah A. Wilcher, Ramesh C. Gupta

Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells.

Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta

Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate.

Varun Kushwah, Sameer S. Katiyar, Ashish Kumar Agrawal, Isha Saraf, Inder Pal Singh, Dimitrios A. Lamprou, Ramesh C. Gupta, Sanyog Jain

A 6-month, multicenter, open-label study of fixed dose naproxen/esomeprazole in adolescent patients with juvenile idiopathic arthritis

Daniel J. Lovell, Jason Dare, Megan Francis-Sedlak, Julie Ball, Brian LaMoreaux, Emily von Scheven, Adam L Reinhardt, Rita Jerath, Oral Alpan, Ramesh Gupta, Donald P. Goldsmith, Andrew Zeft, Henry Naddaf, Beth Gottlieb, Lawrence Jung, Robert J. Holt

Co-delivery of docetaxel and gemcitabine by anacardic acid modified self-assembled albumin nanoparticles for effective breast cancer management

Varun Kushwah, Sameer S. Katiyar, Chander Parkash Dora, Ashish Kumar Agrawal, Dimitrios A. Lamprou, Ramesh C. Gupta, Sanyog Jain

Co-delivery of docetaxel and gemcitabine using PEGylated self-assembled stealth nanoparticles for improved breast cancer therapy.

Varun Kushwah, Sameer S. Katiyar, Ashish Kumar Agrawal, Ramesh C. Gupta, Sanyog Jain

Development of a goat model for evaluation of withaferin A: Cervical implants for the treatment of cervical intraepithelial neoplasia

Leslie C. Sherwood, Farrukh Aqil, Manicka V. Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay K. Srivastava, Inder Pal Singh, Scott D. Cambron, Martin G. O’Toole, Wendy A. Spencer, Lynn P. Parker, Ramesh C. Gupta

Exosomal delivery of berry anthocyanidins for the management of ovarian cancer

Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Al-Hassan Kyakulaga, Radha Munagala, Lynn P. Parker, Ramesh C. Gupta

Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin

Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ramesh C. Gupta

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A.

Karine Z. Oben, Sara S. Alhakeem, Mary K. McKenna, Jason A. Brandon, Rajeswaran Mani, Sunil K. Noothi, Liu Jinpeng, Shailaja Akunuru, Sanjit K. Dhar, Inder Pal Singh, Ying Liang, Chi Wang, Ahmed Abdel-Latif, Harold F. Stills, Daret K. St. Clair, Hartmut Geiger, Natarajan Muthusamy, Kaoru Tohyama, Ramesh C. Gupta, Subbarao Bondada

Novel Gemcitabine Conjugated Albumin Nanoparticles: a Potential Strategy to Enhance Drug Efficacy in Pancreatic Cancer Treatment

Varun Kushwah, Ashish Kumar Agrawal, Chander Parkash Dora, David Mallinson, Dimitrios A. Lamprou, Ramesh C. Gupta, Sanyog Jain

Milk-derived exosomes for oral delivery of paclitaxel

Ashish Kumar Agrawal, Farrukh Aqil, Jeyaprakash Jeyabalan, Wendy A. Spencer, Joshua Beck, Beth W. Gachuki, Sara S. Alhakeem, Karine Z. Oben, Radha Munagala, Subbarao Bondada, Ramesh C. Gupta

Exosomal formulation of anthocyanidins against multiple cancer types

Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ashley M. Mudd, Al Hassan Kyakulaga, Inder Pal Singh, Manicka V. Vadhanam, Ramesh C. Gupta

Chemoprevention of Rat Mammary Carcinogenesis by Apiaceae Spices

Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Srivani Ravoori, Manicka V. Vadhanam, David J. Schultz, Ramesh C. Gupta

Exosomal formulation enhances therapeutic response of celastrol against lung cancer

Farrukh Aqil, Hina Kausar, Ashish Kumar Agrawal, Jeyaprakash Jeyabalan, Al-Hassan Kyakulaga, Radha Munagala, Ramesh C. Gupta

Prevention of hormonal breast cancer by dietary jamun.

Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Inder Pal Singh, Ramesh C. Gupta

Exosomal miRNAs as biomarkers of recurrent lung cancer.

Radha Munagala, Farrukh Aqil, Ramesh C. Gupta

Bovine milk-derived exosomes for drug delivery.

Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ramesh C. Gupta

Stability of anthocyanins- and anthocyanidins-enriched extracts, and formulations of fruit pulp of Eugenia jambolana (‘jamun’)

Ram Jee Sharma, Ramesh C. Gupta, Saranjit Singh, Arvind K. Bansal, Inder Pal Singh

Controlled Delivery of Chemopreventive Agents by Polymeric Implants.

Farrukh Aqil, Ramesh C. Gupta

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Thomas Lener, Mario Gimona, Ludwig Aigner, Verena Börger, Edit I. Buzás, Giovanni Camussi, Nathalie Chaput, Devasis Chatterjee, Felipe A. Court, Hernando A. del Portillo, Lorraine O'Driscoll, Stefano Fais, Juan M. Falcón-Pérez, Ursula Felderhoff-Mueser, Lorenzo Fraile, Yong Song Gho, André Görgens, Ramesh C. Gupta, An Hendrix, Dirk M. Hermann, Andrew F. Hill, Fred H. Hochberg, Peter A. Horn, Dominique P.V. de Kleijn, Lambros Kordelas, Boris W. Kramer, Eva-Maria Krämer-Albers, Sandra Laner-Plamberger, Saara Laitinen, Tommaso Leonardi, Magdalena J. Lorenowicz, Sai Kiang Lim, Jan Lötvall, Casey A. Maguire, Antonio Marcilla, Irina Nazarenko, Takahiro Ochiya, Tushar Patel, Shona Pedersen, Gabriella Pocsfalvi, Stefano Pluchino, Peter J. Quesenberry, Ilona G. Reischl, Francisco J. Rivera, Ralf Sanzenbacher, Katharina Schallmoser, Ineke Slaper-Cortenbach, Dirk Strunk, Torsten Tonn, Pieter Vader, Bas W.M. van Balkom, Marca H. M. Wauben, Samir El Andaloussi, Clotilde Théry, Eva Rohde, Bernd Giebel

Potent chemopreventive/antioxidant activity detected in common spices of the Apiaceae family

Jeyaprakash Jeyabalan, Farrukh Aqil, Lisa Soper, David J. Schultz, Ramesh C. Gupta

Metabolite Fingerprinting of Eugenia jambolana Fruit Pulp Extracts using NMR, HPLC-PDA-MS, GC-MS, MALDI-TOF-MS and ESI-MS/MS Spectrometry.

Ram Jee Sharma, Ramesh C. Gupta, Arvind K. Bansal, Inder Pal Singh

Anti-cancer activity of withaferin A in B-cell lymphoma

Mary K. McKenna, BW Gachuki, Sara S. Alhakeem, KN Oben, Vivek M. Rangnekar, Ramesh C. Gupta, Subbarao Bondada

Effect of phytochemical intervention on dibenzo[a,l]pyrene-induced DNA adduct formation

Gilandra K. Russell, Ramesh C. Gupta, Manicka V. Vadhanam

Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer

Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ramesh C. Gupta

Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts.

Maryam Zahin, Iqbal Ahmad, Ramesh C. Gupta, Farrukh Aqil

Detection of Anthocyanins/Anthocyanidins in Animal Tissues

Farrukh Aqil, Manicka V. Vadhanam, Jeyaprakash Jeyabalan, Jian Cai, Inder Pal Singh, Ramesh C. Gupta

Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer.

Jeyaprakash Jeyabalan, Farrukh Aqil, Radha Munagala, Lakshmanan Annamalai, Manicka V. Vadhanam, Ramesh C. Gupta

Curcumin implants, not curcumin diet, inhibit estrogen-induced mammary carcinogenesis in ACI rats.

Shyam S. Bansal, Hina Kausar, Manicka V. Vadhanam, Srivani Ravoori, Jianmin Pan, Shesh N. Rai, Ramesh C. Gupta

Polymeric Implants for the Delivery of Green Tea Polyphenols

Pengxiao Cao, Jeyaprakash Jeyabalan, Farrukh Aqil, Srivani Ravoori, Ramesh C. Gupta, Manicka V. Vadhanam

Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants.

Farrukh Aqil, Hua Shen, Jeyaprakash Jeyabalan, Xing Xin, Hans-Joachim Lehmler, Gabriele Ludewig, Larry W. Robertson, Ramesh C. Gupta

MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention

Radha Munagala, Farrukh Aqil, Manicka V. Vadhanam, Ramesh C. Gupta

Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets.

Hina Kausar, Radha Munagala, Shyam S. Bansal, Farrukh Aqil, Manicka V. Vadhanam, Ramesh C. Gupta

Multi-layer polymeric implants for sustained release of chemopreventives

Farrukh Aqil, Jeyaprakash Jeyabalan, Hina Kausar, Shyam S. Bansal, Ram Jee Sharma, Inder Pal Singh, Manicka V. Vadhanam, Ramesh C. Gupta

Vaginal cells of smokers are more resistant to human papillomavirus infection than that of non-smokers.

Afsoon Moktar, Srivani Ravoori, Manicka V. Vadhanam, Jianmin Pan, Shesh N. Rai, Alfred B. Jenson, Lynn P. Parker, Ramesh C. Gupta

Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells.

Hina Kausar, Jeyaprakash Jeyabalan, Farrukh Aqil, Deepika Chabba, Jasmeen Sidana, Inder Pal Singh, Ramesh C. Gupta

Oxidative DNA adducts detected in vitro from redox activity of cigarette smoke constituents.

Manicka V. Vadhanam, Jose T Thaiparambil, C. Gary Gairola, Ramesh C. Gupta

Quantitative NMR: An Applicable Method for Quantitative Analysis of Medicinal Plant Extracts and Herbal Products

Siddheshwar K. Chauthe, Ram Jee Sharma, Farrukh Aqil, Ramesh C. Gupta, Inder Pal Singh

Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk

Farrukh Aqil, Radha Munagala, Manicka V. Vadhanam, Hina Kausar, Jeyaprakash Jeyabalan, David J. Schultz, Ramesh C. Gupta

Controlled-release systemic delivery - a new concept in cancer chemoprevention.

Ramesh C. Gupta, Shyam S. Bansal, Farrukh Aqil, Jeyaprakash Jeyabalan, Pengxiao Cao, Hina Kausar, Gilandra K. Russell, Radha Munagala, Srivani Ravoori, Manicka V. Vadhanam

Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer

Miranda Y. Fong, Shunying Jin, Madhavi J. Rane, Raj Kumar Singh, Ramesh C. Gupta, Sham S. Kakar

Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry.

Srivani Ravoori, Manicka V. Vadhanam, Farrukh Aqil, Ramesh C. Gupta

Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (‘jamun’, the Indian Blackberry)

Farrukh Aqil, Akash Gupta, Radha Munagala, Jeyaprakash Jeyabalan, Hina Kausar, Ram Jee Sharma, Inder Pal Singh, Ramesh C. Gupta

Controlled systemic delivery by polymeric implants enhances tissue and plasma curcumin levels compared with oral administration

Shyam S. Bansal, Hina Kausar, Manicka V. Vadhanam, Srivani Ravoori, Ramesh C. Gupta

Enhanced activity of punicalagin delivered via polymeric implants against benzo[a]pyrene-induced DNA adducts.

Farrukh Aqil, Manicka V. Vadhanam, Ramesh C. Gupta

Oxidative DNA damage following microsome/Cu(II)-mediated activation of the estrogens, 17β-estradiol, equilenin, and equilin: role of reactive oxygen species.

Wendy A. Spencer, Manicka V. Vadhanam, Jeyaprakash Jeyabalan, Ramesh C. Gupta

Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants.

Jeyaprakash Jeyabalan, Manicka V. Vadhanam, Srivani Ravoori, Ramesh C. Gupta

Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells.

Radha Munagala, Hina Kausar, Charu Munjal, Ramesh C. Gupta

Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid.

Manicka V. Vadhanam, Srivani Ravoori, Farrukh Aqil, Ramesh C. Gupta

Cigarette smoke condensate-induced oxidative DNA damage and its removal in human cervical cancer cells

Afsoon Moktar, Rajesh Singh, Manicka V. Vadhanam, Srivani Ravoori, James W. Lillard, C. Gary Gairola, Ramesh C. Gupta

Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention

Shyam S. Bansal, Mehak Goel, Farrukh Aqil, Manicka V. Vadhanam, Ramesh C. Gupta

Sustained systemic delivery of green tea polyphenols by polymeric implants significantly diminishes benzo[a]pyrene-induced DNA adducts.

Pengxiao Cao, Manicka V. Vadhanam, Wendy A. Spencer, Jian Cai, Ramesh C. Gupta

Curcumin implants for continuous systemic delivery: safety and biocompatibility.

Shyam S. Bansal, Hina Kausar, Farrukh Aqil, Jeyaprakash Jeyabalan, Manicka V. Vadhanam, Ramesh C. Gupta, Srivani Ravoori

Promising molecular targeted therapies in breast cancer.

Radha Munagala, Farrukh Aqil, Ramesh C. Gupta

Development and In Vitro-In Vivo Evaluation of Polymeric Implants for Continuous Systemic Delivery of Curcumin

Shyam S. Bansal, Manicka V. Vadhanam, Ramesh C. Gupta

Oxidatively generated DNA damage after Cu(II) catalysis of dopamine and related catecholamine neurotransmitters and neurotoxins: Role of reactive oxygen species.

Wendy A. Spencer, Jeyaprakash Jeyabalan, Sunita Kichambre, Ramesh C. Gupta

Protective effects of selenium against DNA adduct formation in Inuit environmentally exposed to PCBs.

Srivani Ravoori, Cidambi Srinivasan, Daria Pereg, Larry W. Robertson, Pierre Ayotte, Ramesh C. Gupta

Clinicopathological, but not socio-demographic factors affect the prognosis in cervical carcinoma.

Radha Munagala, Shesh N. Rai, Selvaluxmy Ganesharajah, Nagarajan Bala, Ramesh C. Gupta

Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue.

Sibele I. Meireles, Gustavo H. Esteves, Roberto Hirata, Suraj Peri, Karthik Devarajan, Michael Slifker, Stacy Mosier, Jing Peng, Manicka V. Vadhanam, Harrell E. Hurst, E. Jordão Neves, Luiz F. L. Reis, C. Gary Gairola, Ramesh C. Gupta, Margie L. Clapper

Berries and Ellagic Acid Prevent Estrogen-Induced Mammary Tumorigenesis by Modulating Enzymes of Estrogen Metabolism

Harini S. Aiyer, Ramesh C. Gupta

Effect of green tea catechins and hydrolyzable tannins on benzo[a]pyrene-induced DNA adducts and structure-activity relationship.

Pengxiao Cao, Jian Cai, Ramesh C. Gupta

Cigarette smoke-induced DNA damage and repair detected by the comet assay in HPV-transformed cervical cells

Afsoon Moktar, Srivani Ravoori, Manicka V. Vadhanam, C. Gary Gairola, Ramesh C. Gupta

Oxidative DNA adducts after Cu2+-mediated activation of dihydroxy PCBs: Role of reactive oxygen species

Wendy A. Spencer, Hans-Joachim Lehmler, Larry W. Robertson, Ramesh C. Gupta

Prevention of oxidative DNA damage by bioactive berry components.

Harini S. Aiyer, Sunita Kichambare, Ramesh C. Gupta

Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats.

Harini S. Aiyer, Cidambi Srinivasan, Ramesh C. Gupta

Dietary Berries and Ellagic Acid Prevent Oxidative DNA Damage and Modulate Expression of DNA Repair Genes

Harini S. Aiyer, Manicka V. Vadhanam, Radka Stoyanova, Gerard D. Caprio, Margie L. Clapper, Ramesh C. Gupta

DNA damage associated with PCBs in the whole blood cells of Inuit.

Srivani Ravoori, Pierre Ayotte, Cidambi Srinivasan, Daria Pereg, Larry W. Robertson, Gilandra K. Russell, Jeyaprakash Jeyabalan, Ramesh C. Gupta

Dose-dependent reduction of 3,2′-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib

Srivani Ravoori, Yi Feng, Jason R. Neale, Jeyaprakash Jeyabalan, Cidambi Srinivasan, David W. Hein, Ramesh C. Gupta

Time-Dependent Formation of 8-Oxo-deoxyguanosine in the Lungs of Mice Exposed to Cigarette Smoke

Jose T Thaiparambil, Manicka V. Vadhanam, Cidambi Srinivasan, C Gary Gairola, Ramesh C. Gupta

Mammary tumor induction in ACI rats exposed to low levels of 17β-estradiol

Srivani Ravoori, Manicka V. Vadhanam, Sunati Sahoo, Cidambi Srinivasan, Ramesh C. Gupta

Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1

Mary E. Kushman, Sandra L. Kabler, Melissa H. Fleming, Srivani Ravoori, Ramesh C. Gupta, Johannes Doehmer, Charles S. Morrow, Alan J. Townsend

Modulation of novel DNA adducts during human uterine cervix cancer progression

Srivani Ravoori, Manicka V. Vadhanam, Diane D. Davey, Cidambi Srinivasan, Bala Nagarajan, Ramesh C. Gupta

Lung DNA Adducts Detected in Human Smokers Are Unrelated to Typical Polyaromatic Carcinogens

Jamal M. Arif, Carolyn M. Dresler, Margie L. Clapper, C. Gary Gairola, Cidambi Srinivasan, Ronald A. Lubet, Ramesh C. Gupta

Ochratoxin a causes DNA damage and cytogenetic effects but no DNA adducts in rats

Angela Mally, Gaetano Pepe, Srivani Ravoori, Mario Fiore, Ramesh C Gupta, Wolfgang Dekant, Pasquale Mosesso

Formation of benzylic-DNA adducts resulting from 7,12-dimethylbenz[a]anthracene in vivo.

M N V Ravi Kumar, Manicka V. Vadhanam, Jamie Horn, James W. Flesher, Ramesh C. Gupta

Characterization of Sac10a, a Hyperthermophile DNA-Binding Protein from Sulfolobus acidocaldarius†

Stephen P. Edmondson, Mebrahtu A. Kahsai, Ramesh Gupta, John W. Shriver

Selective digestion and novel cleanup techniques for detection of benzo[a]pyrene diol epoxide-DNA adducts by capillary electrophoresis/mass spectrometry.

Lynn Gennaro, Manicka V. Vadhanam, Ramesh C. Gupta, Paul Vouros

Artifactual formation of 8-oxo-2'-deoxyguanosine: role of fluorescent light and inhibitors

Jamal M. Arif, Ramesh C. Gupta

Detection of benzylic adducts in DNA and nucleotides from 7-sulfooxymethyl-12-methylbenz[a]anthracene and related compounds by 32P-postlabeling using new TLC systems

Manicka V. Vadhanam, Jamie Horn, James W. Flesher, Ramesh C. Gupta

Interaction of benzoquinone- and hydroquinone-derivatives of lower chlorinated biphenyls with DNA and nucleotides in vitro.

Jamal M. Arif, Hans-Joachim Lehmler, Larry W. Robertson, Ramesh C. Gupta

A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro.

Praveen Srinivasan, Manicka V. Vadhanam, Jamal M. Arif, Ramesh C. Gupta

DNA adduction by polychlorinated biphenyls: adducts derived from hepatic microsomal activation and from synthetic metabolites

Daria Pereg, Larry W. Robertson, Ramesh C. Gupta

Effect of cigarette smoke exposure on the modulation of 8-oxo-2'-deoxyguanosine in rat lungs as analyzed by 32P-postlabeling and HPLC-ECD

Jamal M. Arif, Manicka V. Vadhanam, Anton J.L. de Groot, Albert A. van Zeeland, C. Gary Gairola, Ramesh C. Gupta

Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7.

Wendy A. Smith, James W. Freeman, Ramesh C. Gupta

An Improved 32P-Postlabeling Assay for the Sensitive Detection of 8-Oxodeoxyguanosine in Tissue DNA

Ramesh C. Gupta, Jamal M. Arif

Identification and characterization of a novel benzo[a]pyrene-derived DNA adduct.

Annette H. Fang, Wendy A. Smith, Paul Vouros, Ramesh C. Gupta

1,2‐dithiole‐3‐thione and its structural analogue oltipraz are potent inhibitors of dibenzo[a,l]pyrene‐DNA adduction in female Sprague‐Dawley rats

Wendy A. Smith, Jamal M. Arif, Ramesh C. Gupta

Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol.

Jamal M. Arif, C. Gary Gairola, Gary J. Kelloff, Ronald A. Lubet, Ramesh C. Gupta

DNA adduct formation and persistence in rat tissues following exposure to the mammary carcinogen dibenzo[a,l]pyrene.

Jamal M. Arif, Wendy A. Smith, Ramesh C. Gupta

32P-Postlabeling analysis of lipophilic DNA adducts resulting from interaction with (±)-3-hydroxy-trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene

Jamal M. Arif, Nancy W. Shappell, Harish C. Sikka, Subodh Kumar, Ramesh C. Gupta

Determining efficacy of cancer chemopreventive agents using a cell-free system concomitant with DNA adduction

Wendy A. Smith, Ramesh C. Gupta

Enhancement of pre-existing DNA adducts in rodents exposed to cigarette smoke.

R. C. Gupta, Jamal M. Arif, C. G. Gairola

Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz.

Jamal M. Arif, C. G. Gairola, Howard P. Glauert, Gary J. Kelloff, Ronald A. Lubet, R. C. Gupta

Effect of cancer chemopreventive agents on microsome-mediated DNA adduction of the breast carcinogen dibenzo[a,l]pyrene.

Wendy A. Smith, Jamal M. Arif, Ramesh C. Gupta

Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling.

Jamal M. Arif, Ramesh C. Gupta

Tissue distribution of DNA adducts in rats treated by intramammillary injection with dibenzo[a,l]pyrene, 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene

Jamal M. Arif, Wendy A. Smith, Ramesh C. Gupta

Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer.

Gregory G. Oakley, Udaya-sankar Devanaboyina, Larry W. Robertson, Ramesh C. Gupta

Detection of DNA-reactive metabolites in serum and their tissue distribution in mice exposed to multiple doses of carcinogen mixtures: role in human biomonitoring.

Jamal M. Arif, Ramesh C. Gupta

Use of a microsome-mediated test system to assess efficacy and mechanisms of cancer chemopreventive agents

Wendy A. Smith, Ramesh C. Gupta

Sensitive detection of 8-hydroxy-2′-deoxyguanosine in DNA by 32P-postlabeling assay and the basal levels in rat tissues

Udaya-sankar Devanaboyina, Ramesh C. Gupta

High-resolution anion-exchange and partition thin-layer chromatography for complex mixtures of 32P-postlabeled DNA adducts

Glenda G. Spencer-Beach, Andrew C. Beach, Ramesh C. Gupta

Natural and endogenous DNA adducts as detected by 32P-postlabeling.

Ramesh C. Gupta, Glenda G. Spencer-Beach

Analysis of polychlorinated biphenyl-DNA adducts by 32P-postlabeling

Greg G. Oakley, Larry W. Robertson, Ramesh C. Gupta

Detection of PCB adducts by the 32P-postlabeling technique.

Mitch R. McLean, Larry W. Robertson, Ramesh C. Gupta

THE ROLE OF ACETYLATION IN BENZIDINE METABOLISM AND DNA ADDUCT FORMATION IN DOG AND RAT LIVER

Vijaya M. Lakshmi, Terry V. Zenser, H. D. Goldman, G. G. Spencer, Ramesh C. Gupta, Fong-Fu Hsu, B B Davis

32P-postlabeling analysis of DNA adducts formed in vitro and in rat skin by methylenediphenyl-4,4'-diisocyanate (MDI)

Esther H. Vock, Sergio Cantoreggi, Ramesh C. Gupta, Werner K. Lutz

DNA adducts of the ubiquitous environmental contaminant cyclopenta[cd]pyrene.

Andrew C. Beach, Ramesh C. Gupta

Mechanism of aralkyl-DNA adduct formation from benzo[a]pyrene in vivo.

Kevin H. Stansbury, James W. Flesher, Ramesh C. Gupta

Reaction of cyclopenta[c,d]pyrene-3,4-epoxide with DNA and deoxynucleotides

Andrew C. Beach, Satish C. Agarwal, Guy R. Lambert, Stephen Nesnow, Ramesh C. Gupta

Improved thin-layer chromatographic separation of 32P-postlabeled DNA adducts

Glenda G. Spencer, Andrew C. Beach, Ramesh C. Gupta

Interception of reactive, DNA adduct-forming metabolites present in rodent serum following carcinogen exposure: implications for use of body fluids in biomonitoring.

A. Garg, Andrew C. Beach, Ramesh C. Gupta

DNA adducts and induction of sister chromatid exchanges in the rat following benzo[b]fluoranthene administration

Jeffrey A. Ross, Garret B. Nelson, Katrina L. Holden, Andrew D. Kligerman, Gregory L. Erexson, Miriam F. Bryant, Karen Earley, Andrew C. Beach, Ramesh C. Gupta, Stephen Nesnow

Human biomonitoring and the 32P-postlabeling assay.

Andrew C. Beach, Ramesh C. Gupta

DNA adducts in carp exposed to artificial diesel-2 oil slicks.

Branko Kurelec, A. Garg, Sanja Krča, Smiljana Britvić, Davor Lucić, Ramesh C. Gupta

Carcinogen-DNA adducts in cultures of rat and human hepatocytes.

D.K. Monteith, Ramesh C. Gupta

Significance of multiple HPV infection in cervical cancer patients and its impact on treatment response.

Radha Munagala, M Gabriella Donà, Shesh N. Rai, Alferd B Jenson, Nagarajan Bala, Shin J Ghim, Ramesh C. Gupta

DNA Adducts of the Antitumor Agent Diaziquone

Ramesh C. Gupta, Achal Garg, Karen Earley, Satish C. Agarwal, Guy R. Lambert, Stephen Nesnow

DNA adducts in rat lung, liver and peripheral blood lymphocytes produced by i.p. administration of benzo[a]pyrene metabolites and derivatives.

Jeffrey A. Ross, Garret B. Nelson, Gregory L. Erexson, Andrew D. Kligerman, Karen Earley, Ramesh C. Gupta, Stephen Nesnow

Isolation of the mutagenic and DNA adduct-inducing components from a commercial preparation of HC blue 1 using Salmonella (TA98) bioassay-directed HPLC fractionation.

A. Abu-Shakra, L. Johnson, K. Earley, C.W. Jameson, F.W. Kari, Ramesh C. Gupta, Robert Langenbach

The potential of carp to bioactivate benzo[a]pyrene to metabolites that bind to DNA.

B. Kurelec, S. Krca, A. Garg, Ramesh C. Gupta

Metabolism of benzo[a]pyrene and persistence of DNA adducts in the brown bullhead (Ictalurus nebulosus).

Harish C. Sikka, A.Ruth Steward, Chithan Kandaswami, Joel P. Rutkowski, Jan Zaleski, Subodh Kumar, Karen Earley, Ramesh C. Gupta

Formation and persistence of novel benzo(a)pyrene adducts in rat lung, liver, and peripheral blood lymphocyte DNA.

Jeffrey A. Ross, Garret B. Nelson, Andrew D. Kligerman, Gregory L. Erexson, Miriam F. Bryant, Karen Earley, Ramesh C. Gupta, Stephen Nesnow

Formation and persistence of DNA adducts in the liver of brown bullheads exposed to benzo[a]pyrene

Harish C. Sikka, Joel P. Rutkowski, Chithan Kandaswami, Subodh Kumar, K. Earley, Ramesh C. Gupta

Formation and removal of DNA adducts in target and nontarget tissues of rats administered multiple doses of 2-acetylaminophenanthrene.

Ramesh C. Gupta, Karen Earley, Nancy F. Fullerton, Frederick A. Beland

Natural environment surpasses polluted environment in inducing DNA damage in fish.

Branko Kurelec, Achal Garg, Sanja Krča, Mary Chacko, Ramesh C. Gupta

Sensitivity of rat and mouse peripheral blood lymphocytes to BaP adduction and SCE formation.

Andrew D. Kligerman, Stephen Nesnow, Gregory L. Erexson, Karen Earley, Ramesh C. Gupta

Formation of cigarette smoke-induced DNA adducts in the rat lung and nasal mucosa.

Ramesh C. Gupta, Mohan L. Sopori, C. G. Gairola

DNA adduct formation, metabolism, and morphological transforming activity of aceanthrylene in C3H10T1/2CL8 cells

Stephen Nesnow, Jeffrey A. Ross, N. Mohapatra, Avram Gold, Ramiah Sangaiah, Ramesh C. Gupta

32P-adduct assay: short- and long-term persistence of 2-acetylaminofluorene-DNA adducts and other applications of the assay.

Ramesh C. Gupta

Evaluation of DNA damage in the oral mucosa of tobacco users and non-users by 32P-adduct assay.

Mary Chacko, Ramesh C. Gupta

Hepatic DNA adduct formation in rats treated with benzo[f]quinoline.

Harish C. Sikka, Chithan Kandaswami, Subodh Kumar, Joel P. Rutkowski, Sushil K. Dubey, K. Earley, Ramesh C. Gupta

Analysis of DNA Adducts in Putative Premalignant Hepatic Nodules and Nontarget Tissues of Rats during 2-Acetylaminofluorene Carcinogenesis

Ramesh C. Gupta, Karen Earley, Frederick F. Becker

32P-adduct assay: comparative recoveries of structurally diverse DNA adducts in the various enhancement procedures.

Ramesh C. Gupta, Karen Earley

Nucleotide sequence of the 18S rDNA from the microalga Nanochlorum eucaryotum.

Malcolm L. Sargent, Rudolf K. Zahn, Bonnie Walters, Ramesh C. Gupta, Brian P. Kaine

Use of human peripheral blood lymphocytes to measure DNA binding capacity of chemical carcinogens

Ramesh C. Gupta, K Earley, S. Sharma

32P-postlabeling analysis of liver DNA adducts in rats chronically fed a choline-devoid diet.

Ramesh C. Gupta, Karen Earley, Joseph Locker, Benito Lombardi

Enhanced Sensitivity of 32P-Postlabeling Analysis of Aromatic Carcinogen:DNA Adducts

Ramesh C. Gupta

Distribution of initial and persistent 2-acetylaminofluorene-induced DNA adducts within DNA loops

Ramesh C. Gupta, Nutan R. Dighe, Kurt Randerath, Harold C. Smith

Postlabeling Methods for Carcinogen-DNA Adduct Analysis

Kurt Randerath, Erika Randerath, Hari P. Agrawal, Ramesh C. Gupta, M E Schurdak, M V Reddy

32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.

Ramesh C. Gupta, Sudhir K. Goel, Karen Earley, Balbir Singh, Janardan K. Reddy

Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo

Ramesh C. Gupta

Formation and removal of DNA adducts in rat liver treated with N-hydroxy derivatives of 2-acetylaminofluorene, 4-acetylaminobiphenyl, and, 2-acetylaminophenanthrene

Ramesh C. Gupta, Nutan R. Dighe

32P-postlabeling test for covalent DNA binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agents.

M.Vijayaraj Reddy, Ramesh C. Gupta, Erika Randerath, Kurt Randerath

Nucleotide sequence of a reiterated rat DNA fragment

Ramesh C. Gupta

32P-postlabeling analysis of non-radioactive aromatic carcinogen — DNA adducts

Ramesh C. Gupta, M V Reddy, Kurt Randerath

32P-labeling test for DNA damage.

Kurt Randerath, M V Reddy, Ramesh C. Gupta

Lack of a specific ribose methylation at guanosine 17 in Morris hepatoma 5123D tRNASer1IGA.

Erika Randerath, A. S. Gopalakrishnan, Ramesh C. Gupta, Hari P. Agrawal, Kurt Randerath

Isolation and sequence analysis of two major leucine transfer ribonucleic acids (anticodon Mm-A-A) from a rat tumor, Morris hepatoma 5123D.

Erika Randerath, Ramesh Gupta, Harold P. Morris, Kurt Randerath

Sequence of human glycine transfer ribonucleic acid (anticodon CCC). Determination by a newly developed thin-layer readout sequencing technique and comparison with other glycine transfer ribonucleic acids.

Ramesh C. Gupta, Bruce A. Roe, Kurt Randerath

3H and 32P derivative methods for base composition and sequence analysis of RNA.

Kurt Randerath, Ramesh C. Gupta, Erika Randerath

Ribosome binding site analysis of ovalbumin messenger ribonucleic acid.

Harry W. Schroeder, Charles D. Liarakos, Ramesh C. Gupta, Kurt Randerath, Bert W. O'Malley

The nucleotide sequence of human tRNAGly (anticodon GCC).

Ramesh C. Gupta, Bruce A. Roe, Kurt Randerath

Rapid print-readout technique for sequencing of RNA's containing modified nucleotides.

Ramesh C. Gupta, Kurt Randerath

Use of specific endonuclease cleavage in RNA sequencing - an enzymic method for distinguishing between cytidine and uridine residues

Ramesh C. Gupta, Kurt Randerath

Use of specific endonuclease cleavage in RNA sequencing

Ramesh C. Gupta, Kurt Randerath

Sequence analysis of small amounts of nonradioactive oligoribonucleotides containing ribose-methylated nucleosides by a combination of 3H- and 32P-labeling techniques☆

Ramesh C. Gupta, Kurt Randerath, Erika Randerath

A double-labeling procedure for sequence analysis of picomole amounts of nonradioactive RNA fragments

Ramesh C. Gupta, Erika Randerath, Kurt Randerath

Sequence studies on tRNAPhe from human placenta: Comparison with known sequences of tRNAPhe from other normal mammalian tissues

Bruce A. Roe, M.P.J.S. Anandaraj, L.S.Y. Chia, Erika Randerath, Ramesh C. Gupta, Kurt Randerath

Tritium sequence analysis of oligoribonucleotides: a combination of post-labeling and thin-layer chromatographic techniques for the analysis of partial snake venom phosphodiesterase digests

Muthumalayan Sivarajan, Ramesh C. Gupta, Li-Li S.Y. Chia, Erika Randerath, Kurt Randerath

Sequence analysis of nonradioactive RNA fragments by periodate-phosphatase digestion and chemical tritium labeling: characterization of large oligonucleotides and oligonucleotides containing modified nucleosides

Kurt Randerath, Erika Randerath, L.S.Y. Chia, Ramesh C. Gupta, M. Sivarajan