HTN Usual starting & maintenance dose: 50 mg once daily. Some patients may receive additional benefit by increasing to 100 mg once daily (in the morning).
Hypertensive type II diabetic patients w/ proteinuria ≥0.5 g/day Usual starting dose: 50 mg once daily. May be increased to 100 mg once daily based on BP response from 1 mth onwards after treatment initiation.
Heart failure Usual initial dose: 12.5 mg once daily. Titrate at wkly intervals as tolerated by patient (ie, 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily). Max dose: 150 mg once daily.
Reduction in the risk of stroke in hypertensive patients w/ left ventricular hypertrophy documented by ECG Usual starting dose: 50 mg once daily. Add low dose hydrochlorothiazide &/or increase losartan dose to 100 mg once daily based on BP response.
Childn 6-18 yr weighing >50 kg 50 mg once daily; in exceptional cases, can be increased to 100 mg once daily,
weighing 20-50 kg 25 mg once daily; in exceptional cases, can be increased to 50 mg once daily.
Elderly >75 yr Consider initiating therapy w/ 25 mg.
Patient w/ intravascular vol depletion Starting dose: 25 mg once daily.