MAF
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遗传学术语
- 中文名
- MAF
- 外文名
- 应用功能
- 特 点
- 最小等位基因频率
- 实 质
- 给定人群中的不常见等位基因发生
MAF（Minor Allele Frequency）：最小的等位基因频率
Hapmap计划将MAF＞0.05的SNPs作为首要研究目标，MAF广泛应用于复杂疾病的全基因组关联研究。在关联研究中，较小的MAF将会使统计效能降低，从而造成假阴性的结果。为了研究人群中罕见突变与疾病的关联，通常通过加大样本量的方法来弥补MAF降低所带来的统计效能的损失。在研究中，这一突变位点往往属于同一基因或同一通路上一组罕见突变中的一个。
eg.G is a MAF=0.40 , freq(A)=1-freq(G)=1-0.40=0.60
so,
freq_(AA)=0.60*0.60
freq_(AG)=2*0.40*0.60
freq_(GG)=0.40*0.40
MAF（Maximum Aerobic Function ）
著名的《The Big Book of Endurance Training and Racing》一书提出的耐力训练方法。
4.Medical Device Master File (MAF)
U.S. FDA Medical Device Master File RequirementsA Medical Device Master File (MAF) is a way to preserve trade secrets of medical device companies and their suppliers. A medical device company often needs to submit information about their supplier's product, facility or process. The MAF allows each company to submit its own confidential data to FDA without it being disclosed to anyone outside FDA. A Medical Device Master File is a submission of information to the U.S. Food and Drug Administration by the Medical Device Master File holder. [1]
