Sun Jung Kim, PhD, received her doctoral degree in immunology at Weill Cornell Graduate School of Medical Sciences, under the supervision of Dr. Keith Elkon and Dr. Xiaojing Ma. During this time with Dr. Elkon at the Hospital for Special Surgery, the fields of autoimmune disease and lupus were first introduced to her. Dr. Kim was fascinated by how the immune system was balanced by cytokines produced by innate immune cells, especially macrophage and dendritic cells. Her knowledge about cytokine regulation was further extended by studying with Dr. Ma during her thesis study. She and Dr. Ma identified a novel transcription factor, which is directly regulated by phagocytosis of apoptotic cells and inhibits pro-inflammatory cytokine, IL-12 p35 subunit in macrophage.
After joining Dr. Betty Diamond’s laboratory as a postdoctoral fellow at Columbia University, Dr. Kim studied disease-related research and focused on how dendritic cells contribute immune homeostasis and development of lupus in mouse models. At the Feinstein Institutes for Medical Research, she continued to work with Dr. Diamond along with a new collaborator, Dr. Peter K. Gregersen, studying human lupus risk SNP in dendritic cells and follicular helper T cells.
The focus of Dr. Kim’s laboratory research is to identify the regulatory mechanism of inflammatory function of dendritic cells under both homeostatic and inflammatory conditions. To understand the molecular mechanisms underlying inhibition of development of autoimmune diseases, particularly in systemic lupus and inflammatory bowel diseases, we are using an animal model of SLE which has a dendritic specific deletion of transcription factor, Blimp-1.
Dr. Kim recently expanded her research to the area of PRDM1 (human gene encoding Blimp-1) susceptibility loci to lupus and alteration of metabolism in follicular helper T cells and autoreactive B cells, which will further enhance the understanding of the mechanism in human diseases. Specific focuses are:
Kyungwoo Lee
Postdoctoral Fellow
Research: Repertoire of helper T cells in mouse model of lupus and DC metabolism
Vera Kim
Postdoctoral Fellow
Research: Functional alteration of follicular helper T17 (Tfh17) in lupus
Ivan Ramirez De Oleo
Rheumatology Fellow
Research: Pathogenic function of age-associated B cells (ABCs) in animal model of lupus
Hong Tian
Laboratory Technician
General Lab Manager
Seoul Women’s University; Seoul, Korea
Degree: BS
1994
Seoul Women’s University; Seoul, Korea
Degree: MS
1996
Weill Cornell Graduate School of Medical Sciences
Degree: PhD
2004
Field of study: Immunology
Columbia University
Degree: Postdoctoral fellow
2006
The Feinstein Institutes for Medical Research, Manhasset, NY
Degree: Postdoctoral fellow
2010