Filmography
| Year | Title | Role |
| 2024 | Ghostbusters: Frozen Empire (2024) | Dr. Raymond Stantz |
| 2023 | RL Stine's Zombie Town (2023) | Len Carver |
| 2021 | Ghostbusters: Afterlife (2021) | Dr. Raymond Stantz |
| 2016 | Ghostbusters (2016) | Cabbie |
| 2016 | Good Fortune (2017) | Self |
| 2014 | Legends of Oz: Dorothy Returns 3D | Scarecrow |
| 2014 | Tammy | Don |
| 2014 | Get On Up (2014) | Ben Bart |
| 2013 | Behind the Candelabra | Seymour Heller |
| 2013 | The Game Changer | Detective Spencer |
| 2012 | The Campaign | Wade Motch |
| 2010 | Yogi Bear | Yogi |
| 2010 | Unbeaten | Narrator |
| 2010 | Flip, Flop, and Fly, 40 Years of the Downchild Blues Band | Actor |
| 2009 | Monty Python: Almost the Truth - The Lawyers Cut | Actor |
| 2008 | War, Inc. | Mr. Vice President |
| 2007 | I Now Pronounce You Chuck and Larry | Capt. Tucker |
| 2007 | Shortcut to Happiness | Julius Johnson |
| 2007 | Let's All Hate Toronto | Actor |
| 2004 | 50 First Dates | Dr. Keats |
| 2004 | Christmas with the Kranks | Vic Frohmeyer |
| 2004 | Intern Academy (Screening) | Dr. Cyrill Kipp |
| 2003 | Bright Young Things | Lord Monomark |
| 2002 | Crossroads (2006) | Pete |
| 2002 | Unconditional Love | Max Beasley |
| 2001 | Pearl Harbor | Captain Thurman |
| 2001 | The Curse of the Jade Scorpion | Chris Magruder |
| 2001 | On The Nose | Dr. Barry Davis |
| 2000 | Loser | Dad |
| 2000 | Stardom | Barry Levine |
| 2000 | The House of Mirth | Gus Trenor |
| 1998 | Antz | Chip |
| 1998 | Blues Brothers 2000 | Elwood Blues |
| 1997 | Grosse Pointe Blank | Grocer |
| 1996 | My Fellow Americans | President William Haney |
| 1995 | Tommy Boy | Ray Zalinsky |
| 1993 | Coneheads | Beldar Conehead/Donald R. DeCicco |
| 1992 | Sneakers | Mother |
| 1992 | Chaplin | Mack Sennett |
| 1991 | Nothing But Trouble | Judge Alvin "J.P" Valkenheiser/Bobo |
| 1991 | My Girl | Harry Sultenfuss |
| 1989 | Ghostbusters 2 | Doctor Raymond Stantz |
| 1989 | Driving Miss Daisy (1989) | Boolie Werthan |
| 1988 | The Great Outdoors | Roman Craig |
| 1987 | Dragnet | Sgt. Joe Friday |
| 1985 | Into the Night | Herb |
| 1985 | Spies Like Us | Austin Millbarge |
| 1984 | Ghostbusters (1984) | Doctor Raymond Stantz |
| 1984 | Indiana Jones and the Temple of Doom (1984) | Weber |
| 1984 | Nothing Lasts Forever (1984) | Buck Heller |
| 1983 | Trading Places | Louis Winthorpe III |
| 1983 | Doctor Detroit | Clifford Skridlow / Doctor Detroit |
| 1981 | Neighbors (1981) | Vic |
| 1980 | The Blues Brothers | Elwood Blues |
| 1979 | 1941 | Sgt. Frank Tree |
