Filmography
| Year | Title | Role |
| 2024 | Kung Fu Panda 4 (2024) | Chameleon |
| 2023 | The Hunger Games: The Ballad of Songbirds and Snakes (2023) | Dr. Volumnia Gaul |
| 2023 | Air (2023) | Deloris Jordan |
| 2023 | Silver Dollar Road (2023) | Executive Producer |
| 2022 | Black Adam (2022) | Amanda Waller |
| 2022 | The Woman King (2022) | Nanisca |
| 2021 | The Suicide Squad (2021) | Amanda Waller |
| 2021 | The Unforgivable (2021) | Liz Ingram |
| 2020 | Ma Rainey's Black Bottom (2020) | Ma Rainey |
| 2019 | Emanuel | Producer |
| 2019 | A Touch of Sugar | Narrator |
| 2019 | Troop Zero | Miss Rayleen |
| 2019 | On Broadway (2021) | Self |
| 2018 | Widows (2018) | Veronica |
| 2016 | Suicide Squad (2016) | Amanda Waller |
| 2016 | Fences | Rose Maxson |
| 2016 | Custody (2016) | Martha Schulman |
| 2015 | Blackhat | Carol Barrett |
| 2015 | Lila & Eve | Lila Walcott |
| 2014 | Get On Up (2014) | Susie Brown |
| 2013 | Ender's Game | Maj. Gwen Anderson |
| 2013 | Beautiful Creatures | Amma |
| 2013 | Prisoners | Nancy Birch |
| 2013 | The Disappearance of Eleanor Rigby | Professor Lillian Friedman |
| 2013 | The Disappearance of Eleanor Rigby: Him | Professor Lillian Friedman |
| 2013 | The Disappearance of Eleanor Rigby: Her | Professor Lillian Friedman |
| 2011 | The Help | Aibileen |
| 2011 | Extremely Loud & Incredibly Close | Abby Black |
| 2010 | Knight and Day | Director George |
| 2010 | Eat Pray Love | Delia Shiraz |
| 2010 | It's Kind of a Funny Story | Dr. Eden Minerva |
| 2010 | Trust (2011) | Gail Friedman |
| 2009 | State of Play | Dr. Judith Franklin |
| 2009 | Tyler Perry's Madea Goes to Jail | Ellen |
| 2009 | Law Abiding Citizen | Mayor |
| 2008 | Nights in Rodanthe | Jean |
| 2008 | Doubt | Mrs. Miller |
| 2005 | Get Rich or Die Tryin' | Grandma |
| 2002 | Antwone Fisher | Eva |
| 2002 | Solaris | Gordon |
| 2002 | Far From Heaven | Sybil |
