In the book The Friar and the Maya, by Matthew Restall, Amara Solari, John F. Chuchiak IV, and Traci Ardren, the authors describe in detail the brutal inquisition led by the friar Diego de Landa against the Mayas of Yucatan in response to accusations of "idolatry":

Within a few months, over 4,500 Maya men and women had been questioned under torture, another 6,300 given various punishments (including ritual humiliation, public flogging, and forced servitude), at least 157 (and possibly several hundred) had died at the hands of their interrogators, 32 were permanently maimed, and dozens had committed suicide—all as the campaign spread menacingly across the colony. It was, in short, a war of terror against a subject population.

In addition to this, numerous Maya codices and other works were burned. The authors of the book don't use the term, but would this fit the definition of cultural genocide?