Hydrochlorothiazide-Lisinopril - Side Effects, Dosage, Interactions - Drugs - Everyday Health

What Is Hydrochlorothiazide-Lisinopril?

2 Stars

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Lisinopril is in an ACE inhibitor. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and lisinopril may also be used for purposes not listed in this medication guide.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).

If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

You should not use this medicine if you are allergic to hydrochlorothiazide or lisinopril, or if:

  • you have hereditary angioedema;
  • you are unable to urinate;
  • you recently took a heart medicine called sacubatril;
  • you have an allergy to sulfa drugs; or
  • you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril, trandolapril).

Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).

If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

You may also need to avoid taking hydrochlorothiazide and lisinopril with aliskiren if you have kidney disease.

To make sure hydrochlorothiazide and lisinopril is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);
  • cirrhosis or other liver disease;
  • glaucoma;
  • heart disease or congestive heart failure;
  • asthma or allergies;
  • gout;
  • lupus; or
  • an allergy to sulfa drugs or penicillin.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Lisinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Hydrochlorothiazide-Lisinopril Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • eye pain, vision problems;
  • little or no urination;
  • weakness, drowsiness, or feeling restless;
  • fever, chills, sore throat, mouth sores, trouble swallowing;
  • jaundice (yellowing of the skin or eyes);
  • high potassium--nausea, tingly feeling, chest pain, irregular heartbeats, loss of movement;
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling; or
  • low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Common side effects may include:

  • cough;
  • headache;
  • dizziness; or
  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Hydrochlorothiazide-Lisinopril Interactions

Drinking alcohol can further lower your blood pressure and may increase certain side effects of this medicine.

Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Other drugs may interact with hydrochlorothiazide and lisinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Hydrochlorothiazide-Lisinopril Dosage

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take each dose with a full glass of water.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.

While using hydrochlorothiazide and lisinopril, you may need frequent blood tests at your doctor's office. Your blood pressure will need to be checked often.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medicine that contains hydrochlorothiazide.

Store at room temperature away from moisture, heat, and light.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Hydrochlorothiazide-Lisinopril Pictures

001725032_PB, pink, round
001725033_PB, blue, round
001725034_PB, yellow, round
001850152_PB, white, round
001850173_PB, pink, round
001857100_PB, pink, round
003781012_PB, white, round
003782012_PB, yellow, round
003782025_PB, green, round
005910860_PB, pink, round
005910861_PB, blue, round
005910862_PB, pink, round
633040537_PB, yellow, round
HCT-Lisinopril 12.5 mg-10 mg-RAN, blue, round
HCT-Lisinopril 25 mg-20 mg-GG, peach, round
HCT-Lisinopril 25 mg-20 mg-RAN, peach, round
HCTZ-Lisinopril 12.5 mg-10 mg-TEV, peach, round
HCTZ-Lisinopril 12.5 mg-20 mg-TEV, white, round
HCTZ-Lisinopril 25 mg-20 mg-IVA, pink, round
HCTZ-Lisinopril 25 mg-20 mg-TEV, pink, round
Lisinopril-HCTZ 10-12.5 mg-APO, pink, oval
Lisinopril-HCTZ 20-12.5 mg-APO, white, oval
Lisinopril-HCTZ 20-25 mg-APO, pink, oval

Hydrochlorothiazide-Lisinopril FAQ

Q: I am taking lisinopril/hydrochlorothiazide. I occasionally have a coughing spell. Is this the dry cough side effect? And if so, should I continue to take it? My blood pressure is well-controlled.

A: Lisinopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Lisinopril is used for high blood pressure and in post heart attacks. Side effects that could occur include dizziness, stomach upset, nausea, and cough. Unfortunately, ACE inhibitors are well known to cause an annoying cough for patients taking the medication. It is usually described as a dry cough that develops after taking lisinopril for awhile. There is nothing that can be done to avoid the cough unless another ACE inhibitor is tried. Some physicians choose to stop the ACE inhibitor altogether and start their patient on a different class of blood pressure medication. A drug should not be stopped without consulting a physician. Make sure the physician is aware of the side effect and he/she can determine an appropriate drug regimen. Please visit Everyday Health at ////www.everydayhealth.com/drugs/ for more information on lisinopril and lisinopril/HCTZ. Kimberly Hotz, PharmD