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Identification
- Summary
Codeine is an opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
- Brand Names
- Ascomp, Cheratussin, Cheratussin Dac, Codar Ar, Codar D, Codar Gf, Codeine Contin, Covan, Damylin With Codeine, Fioricet With Codeine, Histex Ac, Linctus Codeine Blanc, M-clear Wc, M-end PE, Mar-cof BP, Mar-cof Cg, Mersyndol, Ninjacof Xg, Pseudodine C, Robaxacet-8, Robaxisal, Triacin-C, Trianal C, Triatec, Triatec-30, Triatec-8, Tusnel C, Tuxarin, Tuzistra, Tylenol With Codeine
- Generic Name
- Codeine
- DrugBank Accession Number
- DB00318
- Background
The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, Papaver somniferum (Papaveraceae).4
Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.Label,4
- Type
- Small Molecule
- Groups
- Approved, Illicit
- Structure
Structure for Codeine (DB00318)
- Weight
- Average: 299.3642
Monoisotopic: 299.152143543 - Chemical Formula
- C18H21NO3
- Synonyms
- (−)-Codeine
- (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
- 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol
- Codein
- Codeína
- Codéine
- Codeine anhydrous
- Codeine polistirex
- Codeinum
- L-Codeine
- Methylmorphine
- morphine 3-methyl ether
- Morphine monomethyl ether
- morphine-3-methyl ether
- O3-Methylmorphine
- External IDs
- IDS-NC-005(SECT.-2)
Pharmacology
- Indication
Codeine sulfate is a form of this drug that is commonly used. It is available in tablet form Label and indicated for the relief of mild to moderately severe pain, where the use of an opioid analgesic is appropriate Label.
The solution form is used by itself or combined in a syrup with other drugs and is used as a cough suppressant in adults aged 18 and above 14, 15.
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for symptomatic treatment of Common cold Combination Product in combination with: Chlorpheniramine (DB01114), Acetaminophen (DB00316) ••• ••• ••••••• Treatment of Cough •••••••••••• Used in combination to treat Coughing Combination Product in combination with: Thiocolchicoside (DB11582), Ephedrine (DB01364), Sodium citrate (DB09154) •••••••••••• ••••• Used in combination for symptomatic treatment of Flu caused by influenza Combination Product in combination with: Chlorpheniramine (DB01114), Acetaminophen (DB00316) ••• ••• ••••••• Treatment of Mild pain •••••••••••• Treatment of Moderate pain •••••••••••• Used in combination to treat Pain Combination Product in combination with: Naproxen (DB00788) •••••••••••• ••••••• •••••• Used in combination to treat Pain Combination Product in combination with: Diclofenac (DB00586) •••••••••••• ••••••• •••••••••••• Management of Pain •••••••••••• Used in combination for symptomatic treatment of Severe pain •••••••••••• Used in combination for symptomatic treatment of Tension headache Combination Product in combination with: Butalbital (DB00241), Acetaminophen (DB00316), Caffeine (DB00201) •••••••••••• ••••••• Used in combination for symptomatic treatment of Dry cough Combination Product in combination with: Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874) •••••••••••• ••••• Used in combination for symptomatic treatment of Dry cough Combination Product in combination with: Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874) •••••••••••• ••••• Used in combination for symptomatic treatment of Dry cough Combination Product in combination with: Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874) •••••••••••• ••••• Used in combination for symptomatic treatment of Dry cough Combination Product in combination with: Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874), Guaifenesin (DB00874) •••••••••••• ••••• Used in combination for symptomatic treatment of Dry cough Combination Product in combination with: Amlodipine (DB00381) •••••••••••• ••••••• Used in combination for symptomatic treatment of Mild pain •••••••••••• Used in combination for symptomatic treatment of Moderate pain •••••••••••• Used in combination for symptomatic treatment of Upper respiratory symptoms Combination Product in combination with: Guaifenesin (DB00874) •••••••••••• ••••• - Associated Therapies
- Contraindications & Blackbox Warnings
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General effects
Codeine is a weak narcotic pain reliever and cough suppressant that is similar to morphine and hydrocodone. A small amount of ingested codeine is converted to morphine in the body. Codeine increases tolerance to pain, reducing existing discomfort. In addition to decreasing pain, codeine also causes sedation, drowsiness, and respiratory depression 4.
Antitussive activity
This drug has shown antitussive activity in clinical trials 6 and has been effective in cough secondary to tuberculosis and insomnia due to coughing 4. Codeine suppresses the cough reflex through a direct effect on the cough center in the medulla 18.
Effects on intestinal motility
Codeine may reduce intestinal motility through both a local and possibly central mechanism of action 19. This may possibly lead to constipation 18. The chronic use of opioids, including codeine sulfate, may lead to obstructive bowel disease, particularly in patients with underlying disorders of intestinal motility Label.
Effects on the central nervous system
Codeine phosphate is an opioid analgesic with uses similar to those of morphine, but is much less potent as an analgesic. Its primary site of action is at the mu opioid receptors distributed throughout the central nervous system. The sedative activities of codeine are less potent than those of morphine 18. Codeine may cause respiratory system depression by the activation of μ-opioid receptors at specific sites in the central nervous system 8.
Effects on blood pressure
This drug poses an increased risk of compromised ability to maintain blood pressure due to peripheral vasodilation and other mechanisms Label.
Effects on chronic cancer pain and other types of pain
Codeine is an opioid analgesic with similar indications to those of morphine, however, is much less potent in its pain alleviating properties. Its primary action takes place at the mu opioid receptors, which are distributed throughout the central nervous system. The average duration of action is about 4 hours 18.
Regular dosing of opioid analgesics such as codeine in patients with severe cancer pain has been well documented to improve symptoms 4, 7.
- Mechanism of action
Although the exact mechanism of action of codeine is still unknown, it is generally thought to be mediated through the agonism of opioid receptors, particularly the mu-opioid receptors.4 Morphine was previously postulated to contribute to the analgesic effect of codeine due to the O-demethylation of codeine to morphine by CYP2D6. Particularly, CYP2D6 poor metabolizer did not experience the analgesic effect of codeine.2,10 However, this is unlikely to be the main mechanism of action of codeine as only 5% of codeine is metabolized to morphine.2 Other hypotheses also postulate that codeine-6-glucuronide, the main metabolite of codeine, mediates the analgesic effect of codeine as it not only has an affinity to the mu receptors as codeine but also can be metabolized to morphine-6-glucuronide, which was observed to be more potent than morphine.3
Binding to the mu receptors by codeine activates the G-proteins Gαi, causing a decrease in intracellular cAMP and Ca2+ level.11,12 This causes hyperpolarization of nociceptive neurons, thus imparing the transmission of pain signals.11,12
Target Actions Organism AMu-type opioid receptor agonistregulatorHumans AKappa-type opioid receptor agonistHumans ADelta-type opioid receptor agonistHumans - Absorption
Absorption
Codeine is absorbed from the gastrointestinal tract. The maximum plasma concentration occurs 60 minutes after administration Label.
Food Effects
When 60 mg codeine sulfate was given 30 minutes post-ingestion of a high high-calorie meal, there was no significant change in the absorption of codeine Label.
Steady-state concentration
The administration of 15 mg codeine sulfate every 4 hours for 5 days lead to steady-state concentrations of codeine, morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) within 48 hours Label.
- Volume of distribution
Apparent volume of distribution: about 3-6 L/kg, showing an extensive distribution of the drug into tissues Label.
- Protein binding
7-25% bound to plasma proteins Label.
- Metabolism
Approximately 70 to 80% of the ingested dose of codeine is metabolized in the liver by conjugation with glucuronic acid to codeine-6 glucuronide (C6G) and by O-demethylation to morphine (about 5-10%) and N-demethylation to norcodeine (about 10%) respectively. UDP-glucuronosyltransferase (UGT) 2B7 and 2B4 are the major metabolic enzymes mediating the glucurodination of codeine to the metabolite, codeine 6 glucuronide.
Cytochrome P450 2D6 is the major enzyme responsible for the transformation of codeine to morphine and P450 3A4 is the main enzyme mediating the conversion of codeine to norcodeine. Morphine and norcodeine are then further metabolized by conjugation with glucuronic acid. The glucuronide metabolites of morphine are morphine-3-glucuronide (M3G) and_ morphine-6-glucuronide _(M6G). Morphine and M6G have been proven to have analgesic activity in humans. The analgesic activity of C6G in humans is not known at this time. Norcodeine and M3G are generally not considered to have analgesic properties Label.
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- Route of elimination
About 90% of the total dose of codeine is excreted by the kidneys. Approximately 10% of the drug excreted by the kidneys is unchanged codeine Label.
The majority of the excretion products can be found in the urine within 6 hours of ingestion, and 40-60 % of the codeine is excreted free or conjugated, approximately 5 to 15 percent as free and conjugated morphine, and approximately 10-20% free and conjugated norcodeine 18.
- Half-life
Plasma half-lives of codeine and its metabolites have been reported to be approximately 3 hours Label.
- Clearance
Renal clearance of codeine was 183 +/- 59 ml min-1 in a clinical study 5.
Renal impairment may decrease codeine clearance Label.
- Adverse Effects
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Oral LD50: 427 mg kg-1 (rat) MSDS.
Overdose/toxicity
Symptoms of opioid toxicity may include confusion, somnolence, shallow breathing, constricted pupils, nausea, vomiting, constipation and a lack of appetite. In severe cases, symptoms of circulatory and respiratory depression may ensue, which may be life-threatening or fatal 13, Label.
Teratogenic effects
This drug is classified as a pregnancy Category C drug. There are no adequate and well-controlled studies completed in pregnant women. Codeine should only be used during pregnancy if the potential benefit outweighs the potential risk of the drug to the fetus Label.
Codeine has shown embryolethal and fetotoxic effects in the hamster, rat as well as mouse models at about 2-4 times the maximum recommended human dose Label. Maternally toxic doses that were about 7 times the maximum recommended human dose of 360 mg/day, were associated with evidence of bone resorption and incomplete bone ossification. Codeine did not demonstrate evidence of embrytoxicity or fetotoxicity in the rabbit model at doses up to 2 times the maximum recommended human dose of 360 mg/day based on a body surface area comparison Label.
Nonteratogenic effects
Neonatal codeine withdrawal has been observed in infants born to addicted and non-addicted mothers who ingested codeine-containing medications in the days before delivery. Common symptoms of narcotic withdrawal include irritability, excessive crying, tremors, hyperreflexia, seizures, fever, vomiting, diarrhea, and poor feeding. These signs may be observed shortly following birth and may require specific treatment Label.
Codeine (30 mg/kg) given subcutaneously to pregnant rats during gestation and for 25 days after delivery increased the rate of neonatal mortality at birth. The dose given was 0.8 times the maximum recommended human dose of 360 mg/day Label.
The use in breastfeeding/nursing
Codeine is secreted into human milk. The maternal use of codeine can potentially lead to serious adverse reactions, including death, in nursing infants Label.
- Pathways
Pathway Category Codeine Metabolism Pathway Drug metabolism Codeine Action Pathway Drug action - Pharmacogenomic Effects/ADRs
Interacting Gene/Enzyme Allele name Genotype(s) Defining Change(s) Type(s) Description Details Cytochrome P450 2D6 CYP2D6*4 (A;A) A Allele, homozygote Effect Directly Studied Patients with this genotype have reduced metabolism of codeine. Details Cytochrome P450 2D6 CYP2D6*6 (-;-) T deletion, homozygote Effect Directly Studied Patients with this genotype have reduced metabolism of codeine. Details Cytochrome P450 2D6 CYP2D6*5 Not Available Whole gene deletion, homozygote Effect Directly Studied Patients with this genotype have reduced metabolism of codeine. Details Cytochrome P450 2D6 CYP2D6*3 Not Available 2549delA Effect Directly Studied The presence of this polymorphism in CYP2D6 results in non-functioning enzyme variant and may be associated with reduced drug mtabolism or reduced therapeutic response when treated with codeine. Details Cytochrome P450 2D6 CYP2D6*4 Not Available A allele Effect Directly Studied The presence of this polymorphism in CYP2D6 is associated with poor metabolism of codeine. Details Cytochrome P450 2D6 CYP2D6*5 Not Available Whole-gene deletion Effect Directly Studied The presence of this polymorphism in CYP2D6 is associated with poor metabolism of codeine and lack of therapeutic response from codeine. Details Cytochrome P450 2D6 CYP2D6*6 (-;T) / (-;-) 1707delT Effect Directly Studied The presence of this polymorphism in CYP2D6 is associated with poor metabolism of codeine. Details Cytochrome P450 2D6 CYP2D6*7 Not Available 2935A>C Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*8 Not Available 1758G>T Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*11 Not Available 883G>C Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*12 Not Available 124G>A Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*13 Not Available CYP2D7/2D6 hybrid gene structure Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*14A Not Available 1758G>A Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*15 Not Available 137insT, 137_138insT Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*19 Not Available 2539_2542delAACT Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*20 Not Available 1973_1974insG Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*21 Not Available 2573insC Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*31 Not Available -1770G>A / -1584C>G … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*36 Not Available 100C>T / -1426C>T … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*38 Not Available 2587_2590delGACT Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*40 Not Available 1863_1864ins(TTT CGC CCC)2 Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*42 Not Available 3259_3260insGT Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*44 Not Available 2950G>C Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*47 Not Available 100C>T / -1426C>T … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*51 Not Available -1584C>G / -1235A>G … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*56 Not Available 3201C>T Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*57 Not Available 100C>T / 310G>T … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*62 Not Available 4044C>T Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*68A Not Available -1426C>T / -1235A>G … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*68B Not Available Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4. Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*69 Not Available 2988G>A / -1426C>T … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*92 Not Available 1995delC Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*100 Not Available -1426C>T / -1235A>G … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*101 Not Available -1426C>T / -1235A>G … show all Effect Inferred Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*1XN Not Available Normal allele duplicated. ADR Inferred Ultra-rapid drug metabolizer. Risk of toxicity, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*2XN Not Available 2850C>T / 4180G>C … show all ADR Inferred Ultra-rapid drug metabolizer. Risk of toxicity, alternative drug recommended. Details Cytochrome P450 2D6 CYP2D6*3 Not Available C allele Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*7 Not Available 2935A>C Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*8 Not Available 1758G>T Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*11 Not Available 883G>C Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*12 Not Available 124G>A Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*13 Not Available CYP2D7/2D6 hybrid gene structure Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*14A Not Available 1758G>A Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*15 Not Available 137insT, 137_138insT Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*19 Not Available 2539_2542delAACT Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*20 Not Available 1973_1974insG Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*21 Not Available 2573insC Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*31 Not Available -1770G>A / -1584C>G … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*36 Not Available 100C>T / -1426C>T … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*38 Not Available 2587_2590delGACT Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*40 Not Available 1863_1864ins(TTT CGC CCC)2 Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*42 Not Available 3259_3260insGT Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*44 Not Available 2950G>C Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*47 Not Available 100C>T / -1426C>T … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*51 Not Available -1584C>G / -1235A>G … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*56 Not Available 3201C>T Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*57 Not Available 100C>T / 310G>T … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*62 Not Available 4044C>T Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*68A Not Available -1426C>T / -1235A>G … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*68B Not Available Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4. Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*69 Not Available 2988G>A / -1426C>T … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*92 Not Available 1995delC Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*100 Not Available -1426C>T / -1235A>G … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*101 Not Available -1426C>T / -1235A>G … show all Effect Inferred Poor drug metabolizer, lower dose requirements Details Cytochrome P450 2D6 CYP2D6*3 Not Available G allele Effect Directly Studied The presence of this polymorphism in CYP2D6 results in non-functioning enzyme variant and may be associated with reduced therapeutic response when treated with codeine. Details Cytochrome P450 2D6 CYP2D6*4 Not Available 3877G>A Effect Directly Studied The presence of this polymorphism in CYP2D6 results in non-functioning enzyme variant and may be associated with reduced therapeutic response when treated with codeine. Details
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of adverse effects can be increased when Codeine is combined with 1,2-Benzodiazepine. Abametapir The serum concentration of Codeine can be increased when it is combined with Abametapir. Abatacept The metabolism of Codeine can be increased when combined with Abatacept. Abiraterone The metabolism of Codeine can be decreased when combined with Abiraterone. Acebutolol The metabolism of Codeine can be decreased when combined with Acebutolol. Acetazolamide The risk or severity of CNS depression can be increased when Codeine is combined with Acetazolamide. Acetophenazine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Codeine. Acetylcholine The risk or severity of adverse effects can be increased when Codeine is combined with Acetylcholine. Aclidinium The risk or severity of adverse effects can be increased when Aclidinium is combined with Codeine. Acyclovir The risk or severity of adverse effects can be increased when Codeine is combined with Acyclovir. Adagrasib The metabolism of Codeine can be decreased when combined with Adagrasib. Adalimumab The metabolism of Codeine can be increased when combined with Adalimumab. Adefovir dipivoxil The excretion of Adefovir dipivoxil can be decreased when combined with Codeine. Agomelatine The risk or severity of CNS depression can be increased when Codeine is combined with Agomelatine. Alfentanil The risk or severity of adverse effects can be increased when Codeine is combined with Alfentanil. Alimemazine The risk or severity of hypotension and CNS depression can be increased when Alimemazine is combined with Codeine. Alloin The therapeutic efficacy of Alloin can be decreased when used in combination with Codeine. Almotriptan The risk or severity of CNS depression can be increased when Codeine is combined with Almotriptan. Alogliptin The metabolism of Alogliptin can be decreased when combined with Codeine. Alosetron The risk or severity of CNS depression can be increased when Codeine is combined with Alosetron. Alprazolam The risk or severity of adverse effects can be increased when Codeine is combined with Alprazolam. Alverine The risk or severity of CNS depression can be increased when Codeine is combined with Alverine. Alvimopan The risk or severity of adverse effects can be increased when Codeine is combined with Alvimopan. Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Codeine. Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Codeine. Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Codeine. Aminophenazone The metabolism of Aminophenazone can be decreased when combined with Codeine. Amiodarone The metabolism of Codeine can be decreased when combined with Amiodarone. Amisulpride The risk or severity of CNS depression can be increased when Codeine is combined with Amisulpride. Amitriptyline The risk or severity of adverse effects can be increased when Amitriptyline is combined with Codeine. Amitriptylinoxide The risk or severity of CNS depression can be increased when Codeine is combined with Amitriptylinoxide. Amobarbital The risk or severity of adverse effects can be increased when Amobarbital is combined with Codeine. Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Codeine. Amphetamine Amphetamine may increase the analgesic activities of Codeine. Amprenavir The metabolism of Codeine can be decreased when combined with Amprenavir. Anakinra The metabolism of Codeine can be increased when combined with Anakinra. Anisotropine methylbromide The risk or severity of adverse effects can be increased when Anisotropine methylbromide is combined with Codeine. Antipyrine The metabolism of Antipyrine can be decreased when combined with Codeine. Apalutamide The serum concentration of Codeine can be decreased when it is combined with Apalutamide. Apomorphine The risk or severity of CNS depression can be increased when Codeine is combined with Apomorphine. Apremilast The metabolism of Codeine can be increased when combined with Apremilast. Aprepitant The metabolism of Codeine can be decreased when combined with Aprepitant. Apronalide The risk or severity of CNS depression can be increased when Codeine is combined with Apronalide. Arformoterol The metabolism of Arformoterol can be decreased when combined with Codeine. Aripiprazole The risk or severity of adverse effects can be increased when Aripiprazole is combined with Codeine. Aripiprazole lauroxil The risk or severity of CNS depression can be increased when Codeine is combined with Aripiprazole lauroxil. Artenimol The metabolism of Codeine can be decreased when combined with Artenimol. Articaine The risk or severity of CNS depression can be increased when Codeine is combined with Articaine. Asenapine The risk or severity of CNS depression can be increased when Codeine is combined with Asenapine. Astemizole The metabolism of Astemizole can be decreased when combined with Codeine. Asunaprevir The metabolism of Codeine can be decreased when combined with Asunaprevir. Atazanavir The metabolism of Codeine can be decreased when combined with Atazanavir. Atenolol The metabolism of Atenolol can be decreased when combined with Codeine. Atomoxetine The metabolism of Codeine can be decreased when combined with Atomoxetine. Atracurium The risk or severity of adverse effects can be increased when Atracurium is combined with Codeine. Atracurium besylate The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Codeine. Atropine The risk or severity of adverse effects can be increased when Atropine is combined with Codeine. Avanafil The serum concentration of Avanafil can be increased when it is combined with Codeine. Azatadine The risk or severity of adverse effects can be increased when Azatadine is combined with Codeine. Azelastine Codeine may increase the central nervous system depressant (CNS depressant) activities of Azelastine. Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Codeine. Belladonna The risk or severity of adverse effects can be increased when Belladonna is combined with Codeine. Bendroflumethiazide The therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Codeine. Benperidol The risk or severity of CNS depression can be increased when Codeine is combined with Benperidol. Benzatropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Codeine. Benzhydrocodone The risk or severity of adverse effects can be increased when Codeine is combined with Benzhydrocodone. Benzocaine The risk or severity of CNS depression can be increased when Codeine is combined with Benzocaine. Benzphetamine Benzphetamine may increase the analgesic activities of Codeine. Benzthiazide The therapeutic efficacy of Benzthiazide can be decreased when used in combination with Codeine. Benzyl alcohol The risk or severity of CNS depression can be increased when Codeine is combined with Benzyl alcohol. Bepridil The metabolism of Codeine can be decreased when combined with Bepridil. Berotralstat The metabolism of Codeine can be decreased when combined with Berotralstat. Betaxolol The metabolism of Codeine can be decreased when combined with Betaxolol. Bimekizumab The metabolism of Codeine can be increased when combined with Bimekizumab. Biperiden The risk or severity of adverse effects can be increased when Biperiden is combined with Codeine. Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Codeine. Bisoxatin The therapeutic efficacy of Bisoxatin can be decreased when used in combination with Codeine. Boceprevir The metabolism of Codeine can be decreased when combined with Boceprevir. Bortezomib The metabolism of Codeine can be decreased when combined with Bortezomib. Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Codeine. Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Codeine. Brexanolone The risk or severity of CNS depression can be increased when Codeine is combined with Brexanolone. Brexpiprazole The risk or severity of CNS depression can be increased when Codeine is combined with Brexpiprazole. Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Codeine. Brivaracetam The risk or severity of CNS depression can be increased when Codeine is combined with Brivaracetam. Bromazepam The risk or severity of adverse effects can be increased when Codeine is combined with Bromazepam. Bromocriptine The risk or severity of CNS depression can be increased when Codeine is combined with Bromocriptine. Bromotheophylline The therapeutic efficacy of Bromotheophylline can be decreased when used in combination with Codeine. Bromperidol The risk or severity of CNS depression can be increased when Codeine is combined with Bromperidol. Buclizine The risk or severity of adverse effects can be increased when Buclizine is combined with Codeine. Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Codeine. Bupivacaine The risk or severity of CNS depression can be increased when Bupivacaine is combined with Codeine. Buprenorphine Codeine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. Bupropion The metabolism of Codeine can be decreased when combined with Bupropion. Buspirone The risk or severity of CNS depression can be increased when Codeine is combined with Buspirone. Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Codeine. Butaperazine The risk or severity of hypotension and CNS depression can be increased when Butaperazine is combined with Codeine. Butobarbital The risk or severity of adverse effects can be increased when Butobarbital is combined with Codeine. Butorphanol The therapeutic efficacy of Codeine can be decreased when used in combination with Butorphanol. Butriptyline The risk or severity of CNS depression can be increased when Codeine is combined with Butriptyline. Butylscopolamine The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Codeine. Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Codeine. Calcium polycarbophil The therapeutic efficacy of Calcium polycarbophil can be decreased when used in combination with Codeine. Canakinumab The metabolism of Codeine can be increased when combined with Canakinumab. Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Codeine. Canrenoic acid The therapeutic efficacy of Canrenoic acid can be decreased when used in combination with Codeine. Captopril The excretion of Captopril can be decreased when combined with Codeine. Carbamazepine The metabolism of Codeine can be increased when combined with Carbamazepine. Carbinoxamine The risk or severity of CNS depression can be increased when Codeine is combined with Carbinoxamine. Carboxymethylcellulose The therapeutic efficacy of Carboxymethylcellulose can be decreased when used in combination with Codeine. Cariprazine The risk or severity of CNS depression can be increased when Codeine is combined with Cariprazine. Carvedilol The metabolism of Carvedilol can be decreased when combined with Codeine. Castor oil The therapeutic efficacy of Castor oil can be decreased when used in combination with Codeine. Cefazolin The excretion of Cefazolin can be decreased when combined with Codeine. Cefdinir The excretion of Cefdinir can be decreased when combined with Codeine. Cefotiam The excretion of Cefotiam can be decreased when combined with Codeine. Ceftibuten The excretion of Ceftibuten can be decreased when combined with Codeine. Ceftizoxime The excretion of Ceftizoxime can be decreased when combined with Codeine. Celecoxib The metabolism of Codeine can be decreased when combined with Celecoxib. Celiprolol The metabolism of Celiprolol can be decreased when combined with Codeine. Cenobamate The serum concentration of Codeine can be decreased when it is combined with Cenobamate. Cephalexin The excretion of Cephalexin can be decreased when combined with Codeine. Cerivastatin The metabolism of Codeine can be decreased when combined with Cerivastatin. Certolizumab pegol The metabolism of Codeine can be increased when combined with Certolizumab pegol. Cetirizine The risk or severity of CNS depression can be increased when Codeine is combined with Cetirizine. Cevimeline The metabolism of Codeine can be decreased when combined with Cevimeline. Chenodeoxycholic acid The metabolism of Codeine can be decreased when combined with Chenodeoxycholic acid. Chloral hydrate The risk or severity of CNS depression can be increased when Codeine is combined with Chloral hydrate. Chlordiazepoxide The risk or severity of adverse effects can be increased when Codeine is combined with Chlordiazepoxide. Chlormezanone The risk or severity of CNS depression can be increased when Codeine is combined with Chlormezanone. Chloroprocaine The risk or severity of CNS depression can be increased when Codeine is combined with Chloroprocaine. Chloroquine The metabolism of Codeine can be decreased when combined with Chloroquine. Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Codeine. Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Codeine. Chlorprothixene The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Codeine. Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Codeine. Cholecalciferol The metabolism of Codeine can be decreased when combined with Cholecalciferol. Choline The risk or severity of adverse effects can be increased when Choline is combined with Codeine. Choline salicylate The risk or severity of adverse effects can be increased when Codeine is combined with Choline salicylate. Ciclesonide The metabolism of Ciclesonide can be decreased when combined with Codeine. Cidofovir The excretion of Cidofovir can be decreased when combined with Codeine. Cilostazol The metabolism of Cilostazol can be decreased when combined with Codeine. Cimetidine The metabolism of Codeine can be decreased when combined with Cimetidine. Cinacalcet The metabolism of Codeine can be decreased when combined with Cinacalcet. Cinchocaine The risk or severity of CNS depression can be increased when Codeine is combined with Cinchocaine. Cinnarizine The metabolism of Cinnarizine can be decreased when combined with Codeine. Ciprofloxacin The metabolism of Codeine can be decreased when combined with Ciprofloxacin. Cisapride The metabolism of Codeine can be decreased when combined with Cisapride. Cisatracurium The risk or severity of adverse effects can be increased when Cisatracurium is combined with Codeine. Citalopram The risk or severity of serotonin syndrome can be increased when Codeine is combined with Citalopram. Clarithromycin The metabolism of Codeine can be decreased when combined with Clarithromycin. Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Codeine. Clevidipine The metabolism of Clevidipine can be decreased when combined with Codeine. Clidinium The risk or severity of adverse effects can be increased when Clidinium is combined with Codeine. Clobazam The risk or severity of respiratory depression can be increased when Clobazam is combined with Codeine. Clomipramine The metabolism of Clomipramine can be decreased when combined with Codeine. Clonazepam The risk or severity of adverse effects can be increased when Codeine is combined with Clonazepam. Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Codeine. Clopidogrel Codeine can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy. Clorazepic acid The risk or severity of adverse effects can be increased when Codeine is combined with Clorazepic acid. Clothiapine The risk or severity of CNS depression can be increased when Codeine is combined with Clothiapine. Clotiazepam The risk or severity of adverse effects can be increased when Codeine is combined with Clotiazepam. Clozapine The serum concentration of Codeine can be increased when it is combined with Clozapine. Cobicistat The metabolism of Codeine can be decreased when combined with Cobicistat. Cocaine The risk or severity of adverse effects can be increased when Cocaine is combined with Codeine. Conivaptan The metabolism of Codeine can be decreased when combined with Conivaptan. Crizotinib The metabolism of Codeine can be decreased when combined with Crizotinib. Curcumin The metabolism of Codeine can be decreased when combined with Curcumin. Cyclizine The risk or severity of CNS depression can be increased when Codeine is combined with Cyclizine. Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Codeine. Cyclopenthiazide The therapeutic efficacy of Cyclopenthiazide can be decreased when used in combination with Codeine. Cyclosporine The metabolism of Codeine can be decreased when combined with Cyclosporine. Cyclothiazide The therapeutic efficacy of Cyclothiazide can be decreased when used in combination with Codeine. Cycrimine The risk or severity of adverse effects can be increased when Cycrimine is combined with Codeine. Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Codeine. Cytarabine The risk or severity of adverse effects can be increased when Codeine is combined with Cytarabine. Dabrafenib The serum concentration of Codeine can be decreased when it is combined with Dabrafenib. Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Codeine. Danazol The metabolism of Codeine can be decreased when combined with Danazol. Dantrolene The risk or severity of CNS depression can be increased when Codeine is combined with Dantrolene. Dantron The therapeutic efficacy of Dantron can be decreased when used in combination with Codeine. Daridorexant The risk or severity of CNS depression can be increased when Codeine is combined with Daridorexant. Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Codeine. Darunavir The metabolism of Codeine can be decreased when combined with Darunavir. Dasabuvir The metabolism of Dasabuvir can be decreased when combined with Codeine. Debrisoquine The metabolism of Debrisoquine can be decreased when combined with Codeine. Decamethonium The risk or severity of CNS depression can be increased when Codeine is combined with Decamethonium. Dehydrocholic acid The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Codeine. Delavirdine The metabolism of Codeine can be decreased when combined with Delavirdine. Desflurane The risk or severity of CNS depression can be increased when Codeine is combined with Desflurane. Desipramine The risk or severity of adverse effects can be increased when Desipramine is combined with Codeine. Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Codeine. Desmopressin The risk or severity of hyponatremia can be increased when Codeine is combined with Desmopressin. Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Codeine. Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Codeine. Dexamethasone The metabolism of Codeine can be increased when combined with Dexamethasone. Dexfenfluramine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Dexfenfluramine. Dexmedetomidine The risk or severity of CNS depression can be increased when Codeine is combined with Dexmedetomidine. Dexmethylphenidate The risk or severity of CNS depression can be increased when Codeine is combined with Dexmethylphenidate. Dextroamphetamine Dextroamphetamine may increase the analgesic activities of Codeine. Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Codeine. Dextropropoxyphene The risk or severity of adverse effects can be increased when Codeine is combined with Dextropropoxyphene. Dezocine The risk or severity of adverse effects can be increased when Codeine is combined with Dezocine. Diacerein The metabolism of Codeine can be decreased when combined with Diacerein. Diamorphine The risk or severity of adverse effects can be increased when Codeine is combined with Diamorphine. Diazepam The risk or severity of adverse effects can be increased when Codeine is combined with Diazepam. Dibenzepin The risk or severity of CNS depression can be increased when Codeine is combined with Dibenzepin. Dichloralphenazone The risk or severity of CNS depression can be increased when Codeine is combined with Dichloralphenazone. Diclofenamide The therapeutic efficacy of Diclofenamide can be decreased when used in combination with Codeine. Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Codeine. Didanosine The excretion of Didanosine can be decreased when combined with Codeine. Diethylpropion Diethylpropion may increase the analgesic activities of Codeine. Difenoxin The risk or severity of CNS depression can be increased when Codeine is combined with Difenoxin. Dihydrocodeine The risk or severity of adverse effects can be increased when Codeine is combined with Dihydrocodeine. Dihydroergotamine The risk or severity of CNS depression can be increased when Codeine is combined with Dihydroergotamine. Diltiazem The metabolism of Codeine can be decreased when combined with Diltiazem. Dimenhydrinate The risk or severity of CNS depression can be increased when Codeine is combined with Dimenhydrinate. Dimethyl sulfoxide The metabolism of Codeine can be decreased when combined with Dimethyl sulfoxide. Dimetindene The risk or severity of adverse effects can be increased when Dimetindene is combined with Codeine. Dinoprostone The risk or severity of adverse effects can be increased when Dinoprostone is combined with Codeine. Diphemanil The risk or severity of adverse effects can be increased when Diphemanil is combined with Codeine. Diphenidol The risk or severity of adverse effects can be increased when Diphenidol is combined with Codeine. Diphenoxylate The risk or severity of adverse effects can be increased when Codeine is combined with Diphenoxylate. Dipotassium phosphate The therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Codeine. Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Codeine. Docusate The therapeutic efficacy of Docusate can be decreased when used in combination with Codeine. Dolasetron The risk or severity of CNS depression can be increased when Codeine is combined with Dolasetron. Domperidone The metabolism of Domperidone can be decreased when combined with Codeine. Donepezil The risk or severity of CNS depression can be increased when Codeine is combined with Donepezil. Dopamine The risk or severity of adverse effects can be increased when Codeine is combined with Dopamine. Dosulepin The risk or severity of adverse effects can be increased when Dosulepin is combined with Codeine. Doxacurium The risk or severity of adverse effects can be increased when Doxacurium is combined with Codeine. Doxazosin The risk or severity of adverse effects can be increased when Doxazosin is combined with Codeine. Doxepin The risk or severity of adverse effects can be increased when Doxepin is combined with Codeine. Doxorubicin The metabolism of Codeine can be decreased when combined with Doxorubicin. Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Codeine. Dronedarone The metabolism of Codeine can be decreased when combined with Dronedarone. Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Codeine. Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Codeine. Duloxetine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Duloxetine. Dyclonine The risk or severity of CNS depression can be increased when Codeine is combined with Dyclonine. Efavirenz The metabolism of Codeine can be decreased when combined with Efavirenz. Elagolix The metabolism of Elagolix can be decreased when combined with Codeine. Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Codeine. Eliglustat The metabolism of Codeine can be decreased when combined with Eliglustat. Eltrombopag The metabolism of Codeine can be decreased when combined with Eltrombopag. Eluxadoline The risk or severity of constipation can be increased when Codeine is combined with Eluxadoline. Elvitegravir The metabolism of Codeine can be decreased when combined with Elvitegravir. Emapalumab The metabolism of Codeine can be increased when combined with Emapalumab. Enasidenib The metabolism of Enasidenib can be decreased when combined with Codeine. Encainide The metabolism of Encainide can be decreased when combined with Codeine. Encorafenib The metabolism of Codeine can be decreased when combined with Encorafenib. Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Codeine. Entacapone The risk or severity of CNS depression can be increased when Codeine is combined with Entacapone. Enzalutamide The serum concentration of Codeine can be decreased when it is combined with Enzalutamide. Epcoritamab The serum concentration of Codeine can be increased when it is combined with Epcoritamab. Epinastine The risk or severity of CNS depression can be increased when Codeine is combined with Epinastine. Epinephrine The risk or severity of adverse effects can be increased when Codeine is combined with Epinephrine. Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Codeine. Ergoloid mesylate The risk or severity of CNS depression can be increased when Codeine is combined with Ergoloid mesylate. Ergometrine The risk or severity of CNS depression can be increased when Codeine is combined with Ergometrine. Ergotamine The metabolism of Codeine can be decreased when combined with Ergotamine. Erlotinib The metabolism of Erlotinib can be decreased when combined with Codeine. Erythromycin The serum concentration of Codeine can be increased when it is combined with Erythromycin. Escitalopram The risk or severity of serotonin syndrome can be increased when Codeine is combined with Escitalopram. Esketamine The risk or severity of adverse effects can be increased when Codeine is combined with Esketamine. Eslicarbazepine The risk or severity of CNS depression can be increased when Codeine is combined with Eslicarbazepine. Eslicarbazepine acetate The risk or severity of CNS depression can be increased when Codeine is combined with Eslicarbazepine acetate. Esmolol The metabolism of Codeine can be decreased when combined with Esmolol. Estazolam The risk or severity of adverse effects can be increased when Codeine is combined with Estazolam. Estradiol acetate The risk or severity of adverse effects can be increased when Estradiol acetate is combined with Codeine. Estradiol benzoate The risk or severity of adverse effects can be increased when Estradiol benzoate is combined with Codeine. Estradiol cypionate The risk or severity of adverse effects can be increased when Estradiol cypionate is combined with Codeine. Estradiol dienanthate The risk or severity of adverse effects can be increased when Estradiol dienanthate is combined with Codeine. Estradiol valerate The risk or severity of adverse effects can be increased when Estradiol valerate is combined with Codeine. Eszopiclone The risk or severity of CNS depression can be increased when Codeine is combined with Eszopiclone. Etacrynic acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Codeine. Etanercept The metabolism of Codeine can be increased when combined with Etanercept. Ethambutol The metabolism of Codeine can be decreased when combined with Ethambutol. Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Codeine. Ethosuximide The risk or severity of CNS depression can be increased when Codeine is combined with Ethosuximide. Ethotoin The risk or severity of CNS depression can be increased when Codeine is combined with Ethotoin. Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Codeine. Etoricoxib The metabolism of Codeine can be decreased when combined with Etoricoxib. Everolimus The metabolism of Codeine can be decreased when combined with Everolimus. Ezogabine The risk or severity of CNS depression can be increased when Codeine is combined with Ezogabine. Fedratinib The serum concentration of Codeine can be increased when it is combined with Fedratinib. Felbamate The risk or severity of CNS depression can be increased when Codeine is combined with Felbamate. Felodipine The metabolism of Codeine can be decreased when combined with Felodipine. Fenfluramine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Fenfluramine. Fenoterol The risk or severity of adverse effects can be increased when Fenoterol is combined with Codeine. Fentanyl The risk or severity of adverse effects can be increased when Codeine is combined with Fentanyl. Fesoterodine The risk or severity of adverse effects can be increased when Fesoterodine is combined with Codeine. Fexinidazole The metabolism of Fexinidazole can be decreased when combined with Codeine. Finerenone The therapeutic efficacy of Finerenone can be decreased when used in combination with Codeine. Flavoxate The risk or severity of adverse effects can be increased when Flavoxate is combined with Codeine. Flecainide The metabolism of Flecainide can be decreased when combined with Codeine. Flibanserin The risk or severity of CNS depression can be increased when Codeine is combined with Flibanserin. Fluconazole The metabolism of Codeine can be decreased when combined with Fluconazole. Flunarizine The risk or severity of CNS depression can be increased when Codeine is combined with Flunarizine. Flunitrazepam The risk or severity of adverse effects can be increased when Codeine is combined with Flunitrazepam. Fluorescein The excretion of Fluorescein can be decreased when combined with Codeine. Fluoxetine The serum concentration of Codeine can be increased when it is combined with Fluoxetine. Flupentixol The risk or severity of CNS depression can be increased when Codeine is combined with Flupentixol. Fluphenazine The risk or severity of hypotension and CNS depression can be increased when Fluphenazine is combined with Codeine. Flurazepam The risk or severity of adverse effects can be increased when Codeine is combined with Flurazepam. Fluspirilene The risk or severity of CNS depression can be increased when Codeine is combined with Fluspirilene. Fluticasone propionate The risk or severity of CNS depression can be increased when Codeine is combined with Fluticasone propionate. Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Codeine. Fluvoxamine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Fluvoxamine. Formoterol The risk or severity of adverse effects can be increased when Codeine is combined with Formoterol. Fosnetupitant The metabolism of Codeine can be decreased when combined with Fosnetupitant. Fosphenytoin The metabolism of Codeine can be increased when combined with Fosphenytoin. Fospropofol The risk or severity of CNS depression can be increased when Codeine is combined with Fospropofol. Frangula purshiana bark The therapeutic efficacy of Frangula purshiana bark can be decreased when used in combination with Codeine. Frovatriptan The risk or severity of CNS depression can be increased when Codeine is combined with Frovatriptan. Furosemide The therapeutic efficacy of Furosemide can be decreased when used in combination with Codeine. Fusidic acid The metabolism of Codeine can be decreased when combined with Fusidic acid. Gabapentin The risk or severity of CNS depression can be increased when Codeine is combined with Gabapentin. Gabapentin enacarbil The risk or severity of CNS depression can be increased when Codeine is combined with Gabapentin enacarbil. Galantamine The metabolism of Galantamine can be decreased when combined with Codeine. Gallamine triethiodide The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Codeine. gamma-Hydroxybutyric acid The risk or severity of CNS depression can be increased when Codeine is combined with gamma-Hydroxybutyric acid. Ganaxolone The risk or severity of sedation, somnolence, and CNS depression can be increased when Codeine is combined with Ganaxolone. Ganciclovir The risk or severity of adverse effects can be increased when Codeine is combined with Ganciclovir. Gefitinib The metabolism of Codeine can be decreased when combined with Gefitinib. Gepirone The risk or severity of serotonin syndrome can be increased when Gepirone is combined with Codeine. Gilteritinib The risk or severity of adverse effects can be increased when Gilteritinib is combined with Codeine. Givosiran The serum concentration of Codeine can be increased when it is combined with Givosiran. Glofitamab The serum concentration of Codeine can be increased when it is combined with Glofitamab. Gluconic Acid The therapeutic efficacy of Gluconic Acid can be decreased when used in combination with Codeine. Glutethimide The risk or severity of CNS depression can be increased when Codeine is combined with Glutethimide. Glycerin The therapeutic efficacy of Glycerin can be decreased when used in combination with Codeine. Glycerol phenylbutyrate The metabolism of Codeine can be decreased when combined with Glycerol phenylbutyrate. Glycopyrronium The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Codeine. Golimumab The metabolism of Codeine can be increased when combined with Golimumab. Granisetron The risk or severity of CNS depression can be increased when Codeine is combined with Granisetron. Grepafloxacin The excretion of Grepafloxacin can be decreased when combined with Codeine. Guanfacine The risk or severity of CNS depression can be increased when Codeine is combined with Guanfacine. Guanidine The risk or severity of adverse effects can be increased when Guanidine is combined with Codeine. Halazepam The risk or severity of adverse effects can be increased when Codeine is combined with Halazepam. Halofantrine The metabolism of Codeine can be decreased when combined with Halofantrine. Haloperidol The risk or severity of CNS depression can be increased when Haloperidol is combined with Codeine. Halothane The risk or severity of CNS depression can be increased when Codeine is combined with Halothane. Hexafluronium The risk or severity of adverse effects can be increased when Hexafluronium is combined with Codeine. Hexocyclium The risk or severity of adverse effects can be increased when Hexocyclium is combined with Codeine. Histamine The risk or severity of adverse effects can be increased when Codeine is combined with Histamine. Homatropine methylbromide The risk or severity of adverse effects can be increased when Homatropine methylbromide is combined with Codeine. Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Codeine. Hydrocodone Codeine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. Hydroflumethiazide The therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Codeine. Hydromorphone The risk or severity of adverse effects can be increased when Codeine is combined with Hydromorphone. Hydroxychloroquine The metabolism of Codeine can be decreased when combined with Hydroxychloroquine. Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Codeine. Hyoscyamine The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Codeine. Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Codeine. Idarubicin The metabolism of Idarubicin can be decreased when combined with Codeine. Iloperidone The risk or severity of CNS depression can be increased when Codeine is combined with Iloperidone. Imatinib The serum concentration of Codeine can be increased when it is combined with Imatinib. Imipramine The risk or severity of adverse effects can be increased when Imipramine is combined with Codeine. Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Codeine. Indinavir The metabolism of Codeine can be decreased when combined with Indinavir. Indomethacin The excretion of Indomethacin can be decreased when combined with Codeine. Infliximab The metabolism of Codeine can be increased when combined with Infliximab. Iofetamine I-123 Iofetamine I-123 may increase the analgesic activities of Codeine. Ipecac The metabolism of Ipecac can be decreased when combined with Codeine. Ipratropium The risk or severity of adverse effects can be increased when Ipratropium is combined with Codeine. Iptacopan The metabolism of Iptacopan can be decreased when combined with Codeine. Isavuconazole The metabolism of Codeine can be decreased when combined with Isavuconazole. Isavuconazonium The metabolism of Codeine can be decreased when combined with Isavuconazonium. Isocarboxazid The risk or severity of adverse effects can be increased when Codeine is combined with Isocarboxazid. Isoflurane The risk or severity of adverse effects can be increased when Isoflurane is combined with Codeine. Isoniazid The metabolism of Codeine can be decreased when combined with Isoniazid. Isopropamide The risk or severity of adverse effects can be increased when Isopropamide is combined with Codeine. Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Codeine. Isradipine The metabolism of Codeine can be decreased when combined with Isradipine. Istradefylline The metabolism of Istradefylline can be decreased when combined with Codeine. Itraconazole The metabolism of Codeine can be decreased when combined with Itraconazole. Ivacaftor The serum concentration of Codeine can be increased when it is combined with Ivacaftor. Ivosidenib The metabolism of Codeine can be increased when combined with Ivosidenib. Ketamine The risk or severity of CNS depression can be increased when Codeine is combined with Ketamine. Ketazolam The risk or severity of adverse effects can be increased when Codeine is combined with Ketazolam. Ketoconazole The metabolism of Codeine can be decreased when combined with Ketoconazole. Labetalol The metabolism of Codeine can be decreased when combined with Labetalol. Lactitol The therapeutic efficacy of Lactitol can be decreased when used in combination with Codeine. Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Codeine. Lamivudine The risk or severity of adverse effects can be increased when Codeine is combined with Lamivudine. Lamotrigine The risk or severity of CNS depression can be increased when Codeine is combined with Lamotrigine. Lansoprazole The metabolism of Codeine can be decreased when combined with Lansoprazole. Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Codeine. Lemborexant The risk or severity of CNS depression can be increased when Codeine is combined with Lemborexant. Levacetylmethadol The risk or severity of adverse effects can be increased when Codeine is combined with Levacetylmethadol. Levallorphan The therapeutic efficacy of Codeine can be decreased when used in combination with Levallorphan. Levetiracetam The risk or severity of CNS depression can be increased when Codeine is combined with Levetiracetam. Levobetaxolol The metabolism of Levobetaxolol can be decreased when combined with Codeine. Levobupivacaine The risk or severity of CNS depression can be increased when Codeine is combined with Levobupivacaine. Levocetirizine The risk or severity of CNS depression can be increased when Codeine is combined with Levocetirizine. Levodopa The risk or severity of CNS depression can be increased when Codeine is combined with Levodopa. Levofloxacin The excretion of Levofloxacin can be decreased when combined with Codeine. Levoketoconazole The metabolism of Codeine can be decreased when combined with Levoketoconazole. Levomilnacipran The risk or severity of serotonin syndrome can be increased when Codeine is combined with Levomilnacipran. Levorphanol The risk or severity of adverse effects can be increased when Codeine is combined with Levorphanol. Lidocaine The risk or severity of CNS depression can be increased when Lidocaine is combined with Codeine. Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Codeine. Linagliptin The metabolism of Codeine can be decreased when combined with Linagliptin. Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Codeine. Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Lisdexamfetamine. Lisuride The risk or severity of CNS depression can be increased when Codeine is combined with Lisuride. Lithium carbonate The risk or severity of CNS depression can be increased when Codeine is combined with Lithium carbonate. Lofexidine The therapeutic efficacy of Codeine can be increased when used in combination with Lofexidine. Lonafarnib The metabolism of Codeine can be decreased when combined with Lonafarnib. Lopinavir The metabolism of Codeine can be decreased when combined with Lopinavir. Lorazepam The risk or severity of adverse effects can be increased when Codeine is combined with Lorazepam. Lorcaserin The metabolism of Codeine can be decreased when combined with Lorcaserin. Lormetazepam The risk or severity of adverse effects can be increased when Codeine is combined with Lormetazepam. Lorpiprazole The metabolism of Lorpiprazole can be decreased when combined with Codeine. Loxapine The risk or severity of CNS depression can be increased when Codeine is combined with Loxapine. Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Codeine. Lumacaftor The metabolism of Codeine can be increased when combined with Lumacaftor. Lumateperone The risk or severity of CNS depression can be increased when Codeine is combined with Lumateperone. Lumefantrine The metabolism of Codeine can be decreased when combined with Lumefantrine. Lurasidone The risk or severity of CNS depression can be increased when Codeine is combined with Lurasidone. Magnesium The therapeutic efficacy of Magnesium can be decreased when used in combination with Codeine. Magnesium acetate The therapeutic efficacy of Magnesium acetate can be decreased when used in combination with Codeine. Magnesium acetate tetrahydrate The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Codeine. Magnesium carbonate The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Codeine. Magnesium cation The therapeutic efficacy of Magnesium cation can be decreased when used in combination with Codeine. Magnesium citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Codeine. Magnesium glycinate The therapeutic efficacy of Magnesium glycinate can be decreased when used in combination with Codeine. Magnesium oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Codeine. Magnesium sulfate The therapeutic efficacy of Codeine can be increased when used in combination with Magnesium sulfate. Magnesium trisilicate The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Codeine. Manidipine The metabolism of Codeine can be decreased when combined with Manidipine. Mannitol The therapeutic efficacy of Mannitol can be decreased when used in combination with Codeine. Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Codeine. Mavacamten The serum concentration of Codeine can be decreased when it is combined with Mavacamten. Mazindol The risk or severity of CNS depression can be increased when Codeine is combined with Mazindol. Mebeverine The risk or severity of adverse effects can be increased when Mebeverine is combined with Codeine. Mebutamate The risk or severity of CNS depression can be increased when Codeine is combined with Mebutamate. Mecamylamine The risk or severity of adverse effects can be increased when Mecamylamine is combined with Codeine. Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Codeine. Medifoxamine The risk or severity of CNS depression can be increased when Codeine is combined with Medifoxamine. Mefenamic acid The metabolism of Codeine can be decreased when combined with Mefenamic acid. Melatonin The risk or severity of CNS depression can be increased when Codeine is combined with Melatonin. Mepenzolate The risk or severity of adverse effects can be increased when Mepenzolate is combined with Codeine. Meperidine The risk or severity of adverse effects can be increased when Codeine is combined with Meperidine. Mephentermine Mephentermine may increase the analgesic activities of Codeine. Mephenytoin The risk or severity of CNS depression can be increased when Codeine is combined with Mephenytoin. Mepivacaine The risk or severity of CNS depression can be increased when Codeine is combined with Mepivacaine. Mesoridazine The risk or severity of hypotension and CNS depression can be increased when Mesoridazine is combined with Codeine. Metamfetamine Metamfetamine may increase the analgesic activities of Codeine. Metaxalone The risk or severity of CNS depression can be increased when Codeine is combined with Metaxalone. Metergoline The risk or severity of CNS depression can be increased when Codeine is combined with Metergoline. Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Codeine. Methantheline The risk or severity of adverse effects can be increased when Methantheline is combined with Codeine. Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Codeine. Methimazole The metabolism of Codeine can be decreased when combined with Methimazole. Methohexital The risk or severity of CNS depression can be increased when Codeine is combined with Methohexital. Methotrimeprazine Codeine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. Methoxyflurane The risk or severity of CNS depression can be increased when Codeine is combined with Methoxyflurane. Methoxyphenamine Methoxyphenamine may increase the analgesic activities of Codeine. Methscopolamine The risk or severity of adverse effects can be increased when Methscopolamine is combined with Codeine. Methscopolamine bromide The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Codeine. Methsuximide The risk or severity of CNS depression can be increased when Codeine is combined with Methsuximide. Methylcellulose The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Codeine. Methylene blue Codeine may increase the serotonergic activities of Methylene blue. Methylnaltrexone The therapeutic efficacy of Codeine can be decreased when used in combination with Methylnaltrexone. Methylphenobarbital The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Codeine. Methyprylon The risk or severity of CNS depression can be increased when Codeine is combined with Methyprylon. Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Codeine. Meticrane The therapeutic efficacy of Meticrane can be decreased when used in combination with Codeine. Metixene The risk or severity of adverse effects can be increased when Metixene is combined with Codeine. Metoclopramide The therapeutic efficacy of Metoclopramide can be decreased when used in combination with Codeine. Metocurine The risk or severity of adverse effects can be increased when Metocurine is combined with Codeine. Metocurine iodide The risk or severity of adverse effects can be increased when Metocurine iodide is combined with Codeine. Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Codeine. Metoprolol The metabolism of Codeine can be decreased when combined with Metoprolol. Metreleptin The metabolism of Codeine can be increased when combined with Metreleptin. Metyrosine Codeine may increase the sedative activities of Metyrosine. Mexiletine The metabolism of Mexiletine can be decreased when combined with Codeine. Mianserin The risk or severity of CNS depression can be increased when Codeine is combined with Mianserin. Miconazole The metabolism of Codeine can be decreased when combined with Miconazole. Midazolam The risk or severity of respiratory depression can be increased when Midazolam is combined with Codeine. Midostaurin The metabolism of Codeine can be decreased when combined with Midostaurin. Mifepristone The metabolism of Codeine can be decreased when combined with Mifepristone. Milnacipran The risk or severity of serotonin syndrome can be increased when Codeine is combined with Milnacipran. Minaprine The risk or severity of adverse effects can be increased when Codeine is combined with Minaprine. Mineral oil The therapeutic efficacy of Mineral oil can be decreased when used in combination with Codeine. Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Codeine. Mirabegron The serum concentration of Codeine can be increased when it is combined with Mirabegron. Mirtazapine Codeine may increase the serotonergic activities of Mirtazapine. Mitotane The metabolism of Codeine can be increased when combined with Mitotane. Mivacurium The risk or severity of adverse effects can be increased when Mivacurium is combined with Codeine. Moclobemide The risk or severity of adverse effects can be increased when Codeine is combined with Moclobemide. Molindone The risk or severity of CNS depression can be increased when Codeine is combined with Molindone. Monopotassium phosphate The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Codeine. Moricizine The risk or severity of hypotension and CNS depression can be increased when Moricizine is combined with Codeine. Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Codeine. Muzolimine The therapeutic efficacy of Muzolimine can be decreased when used in combination with Codeine. Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Codeine. Nadolol The metabolism of Nadolol can be decreased when combined with Codeine. Nalbuphine The therapeutic efficacy of Codeine can be decreased when used in combination with Nalbuphine. Naldemedine The therapeutic efficacy of Codeine can be decreased when used in combination with Naldemedine. Nalmefene The therapeutic efficacy of Codeine can be decreased when used in combination with Nalmefene. Naloxegol The risk or severity of adverse effects can be increased when Codeine is combined with Naloxegol. Naloxone The therapeutic efficacy of Codeine can be decreased when used in combination with Naloxone. Naltrexone The therapeutic efficacy of Codeine can be decreased when used in combination with Naltrexone. Naphazoline Naphazoline may increase the central nervous system depressant (CNS depressant) activities of Codeine. Naratriptan The risk or severity of CNS depression can be increased when Codeine is combined with Naratriptan. Nateglinide The metabolism of Nateglinide can be decreased when combined with Codeine. Nebivolol The metabolism of Nebivolol can be decreased when combined with Codeine. Nefazodone The metabolism of Codeine can be decreased when combined with Nefazodone. Nelfinavir The metabolism of Codeine can be decreased when combined with Nelfinavir. Netupitant The metabolism of Codeine can be decreased when combined with Netupitant. Nevirapine The risk or severity of adverse effects can be increased when Nevirapine is combined with Codeine. Niacin The metabolism of Codeine can be decreased when combined with Niacin. Nialamide The risk or severity of adverse effects can be increased when Codeine is combined with Nialamide. Nicardipine The risk or severity of adverse effects can be increased when Nicardipine is combined with Codeine. Nicergoline The metabolism of Nicergoline can be decreased when combined with Codeine. Nicotine The risk or severity of adverse effects can be increased when Nicotine is combined with Codeine. Nifedipine The metabolism of Nifedipine can be decreased when combined with Codeine. Nilotinib The metabolism of Codeine can be decreased when combined with Nilotinib. Nilvadipine The metabolism of Codeine can be decreased when combined with Nilvadipine. Nirogacestat The metabolism of Nirogacestat can be decreased when combined with Codeine. Nitrazepam The risk or severity of adverse effects can be increased when Codeine is combined with Nitrazepam. Nitrous oxide The risk or severity of CNS depression can be increased when Codeine is combined with Nitrous oxide. Nomifensine The risk or severity of CNS depression can be increased when Codeine is combined with Nomifensine. Norepinephrine The risk or severity of adverse effects can be increased when Codeine is combined with Norepinephrine. Normethadone The risk or severity of adverse effects can be increased when Codeine is combined with Normethadone. Nortriptyline The risk or severity of adverse effects can be increased when Nortriptyline is combined with Codeine. Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Codeine. Oliceridine The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Codeine is combined with Oliceridine. Omaveloxolone The serum concentration of Codeine can be decreased when it is combined with Omaveloxolone. Ondansetron The risk or severity of CNS depression can be increased when Codeine is combined with Ondansetron. Opium The risk or severity of adverse effects can be increased when Codeine is combined with Opium. Oritavancin The metabolism of Codeine can be decreased when combined with Oritavancin. Orphenadrine Codeine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. Osilodrostat The metabolism of Codeine can be decreased when combined with Osilodrostat. Ospemifene The metabolism of Codeine can be decreased when combined with Ospemifene. Oxamniquine The metabolism of Codeine can be decreased when combined with Oxamniquine. Oxazepam The risk or severity of adverse effects can be increased when Codeine is combined with Oxazepam. Oxcarbazepine The risk or severity of CNS depression can be increased when Codeine is combined with Oxcarbazepine. Oxitriptan The risk or severity of CNS depression can be increased when Codeine is combined with Oxitriptan. Oxprenolol The risk or severity of CNS depression can be increased when Codeine is combined with Oxprenolol. Oxybuprocaine The risk or severity of CNS depression can be increased when Codeine is combined with Oxybuprocaine. Oxybutynin The risk or severity of adverse effects can be increased when Oxybutynin is combined with Codeine. Oxycodone The risk or severity of adverse effects can be increased when Codeine is combined with Oxycodone. Oxymorphone The risk or severity of adverse effects can be increased when Codeine is combined with Oxymorphone. Oxyphencyclimine The risk or severity of adverse effects can be increased when Oxyphencyclimine is combined with Codeine. Oxyphenisatin acetate The therapeutic efficacy of Oxyphenisatin acetate can be decreased when used in combination with Codeine. Oxyphenonium The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Codeine. Pacritinib The serum concentration of Codeine can be increased when it is combined with Pacritinib. Palbociclib The risk or severity of adverse effects can be increased when Palbociclib is combined with Codeine. Paliperidone The risk or severity of CNS depression can be increased when Codeine is combined with Paliperidone. Palonosetron The risk or severity of CNS depression can be increased when Codeine is combined with Palonosetron. Pancuronium The risk or severity of adverse effects can be increased when Pancuronium is combined with Codeine. Panobinostat The metabolism of Codeine can be decreased when combined with Panobinostat. Paraldehyde Codeine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. Paramethadione The risk or severity of CNS depression can be increased when Codeine is combined with Paramethadione. Pargyline The risk or severity of adverse effects can be increased when Codeine is combined with Pargyline. Paroxetine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Paroxetine. Pazopanib The metabolism of Codeine can be decreased when combined with Pazopanib. Peginterferon alfa-2b The metabolism of Codeine can be decreased when combined with Peginterferon alfa-2b. Pegvisomant The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Codeine. Penbutolol The risk or severity of CNS depression can be increased when Codeine is combined with Penbutolol. Pentamidine The metabolism of Pentamidine can be decreased when combined with Codeine. Pentazocine The therapeutic efficacy of Codeine can be decreased when used in combination with Pentazocine. Pentobarbital The risk or severity of adverse effects can be increased when Pentobarbital is combined with Codeine. Pentolinium The risk or severity of adverse effects can be increased when Pentolinium is combined with Codeine. Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Codeine. Perazine The risk or severity of hypotension and CNS depression can be increased when Perazine is combined with Codeine. Pergolide The risk or severity of CNS depression can be increased when Codeine is combined with Pergolide. Perhexiline The metabolism of Codeine can be decreased when combined with Perhexiline. Periciazine The risk or severity of hypotension and CNS depression can be increased when Periciazine is combined with Codeine. Perphenazine The risk or severity of hypotension and CNS depression can be increased when Perphenazine is combined with Codeine. Phenacemide The risk or severity of CNS depression can be increased when Codeine is combined with Phenacemide. Phendimetrazine Phendimetrazine may increase the analgesic activities of Codeine. Phenelzine The risk or severity of adverse effects can be increased when Codeine is combined with Phenelzine. Phenformin The risk or severity of adverse effects can be increased when Codeine is combined with Phenformin. Phenolphthalein The therapeutic efficacy of Phenolphthalein can be decreased when used in combination with Codeine. Phenoxybenzamine The risk or severity of adverse effects can be increased when Phenoxybenzamine is combined with Codeine. Phensuximide The risk or severity of CNS depression can be increased when Codeine is combined with Phensuximide. Phentermine Phentermine may increase the analgesic activities of Codeine. Phenylbutyric acid The metabolism of Codeine can be decreased when combined with Phenylbutyric acid. Phenytoin The metabolism of Codeine can be increased when combined with Phenytoin. Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Codeine. Pimozide The metabolism of Pimozide can be decreased when combined with Codeine. Pindolol The risk or severity of CNS depression can be increased when Codeine is combined with Pindolol. Pipecuronium The risk or severity of adverse effects can be increased when Pipecuronium is combined with Codeine. Piperazine The metabolism of Piperazine can be decreased when combined with Codeine. Pipotiazine The risk or severity of hypotension and CNS depression can be increased when Pipotiazine is combined with Codeine. Pirenzepine The risk or severity of adverse effects can be increased when Pirenzepine is combined with Codeine. Piretanide The therapeutic efficacy of Piretanide can be decreased when used in combination with Codeine. Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Codeine. Piritramide The risk or severity of adverse effects can be increased when Codeine is combined with Piritramide. Pitolisant The serum concentration of Codeine can be decreased when it is combined with Pitolisant. Pizotifen The risk or severity of adverse effects can be increased when Pizotifen is combined with Codeine. Plantago ovata seed The therapeutic efficacy of Plantago ovata seed can be decreased when used in combination with Codeine. Plantago seed The therapeutic efficacy of Plantago seed can be decreased when used in combination with Codeine. Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Codeine. Polyethylene glycol The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Codeine. Polythiazide The therapeutic efficacy of Polythiazide can be decreased when used in combination with Codeine. Pomalidomide The risk or severity of CNS depression can be increased when Codeine is combined with Pomalidomide. Ponatinib The metabolism of Ponatinib can be decreased when combined with Codeine. Posaconazole The metabolism of Codeine can be decreased when combined with Posaconazole. Potassium The therapeutic efficacy of Potassium can be decreased when used in combination with Codeine. Potassium cation The therapeutic efficacy of Potassium cation can be decreased when used in combination with Codeine. Potassium citrate The therapeutic efficacy of Potassium citrate can be decreased when used in combination with Codeine. Potassium lactate The therapeutic efficacy of Potassium lactate can be decreased when used in combination with Codeine. Potassium sulfate The therapeutic efficacy of Potassium sulfate can be decreased when used in combination with Codeine. Practolol The metabolism of Practolol can be decreased when combined with Codeine. Pramipexole Codeine may increase the sedative activities of Pramipexole. Pramocaine The risk or severity of CNS depression can be increased when Codeine is combined with Pramocaine. Prazepam The risk or severity of adverse effects can be increased when Codeine is combined with Prazepam. Prazosin The risk or severity of adverse effects can be increased when Codeine is combined with Prazosin. Pregabalin The therapeutic efficacy of Codeine can be increased when used in combination with Pregabalin. Prilocaine The risk or severity of CNS depression can be increased when Codeine is combined with Prilocaine. Primaquine The metabolism of Codeine can be decreased when combined with Primaquine. Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Codeine. Probenecid The risk or severity of adverse effects can be increased when Probenecid is combined with Codeine. Procainamide The metabolism of Procainamide can be decreased when combined with Codeine. Procaine The risk or severity of adverse effects can be increased when Codeine is combined with Procaine. Procarbazine The risk or severity of adverse effects can be increased when Codeine is combined with Procarbazine. Prochlorperazine The risk or severity of hypotension and CNS depression can be increased when Prochlorperazine is combined with Codeine. Procyclidine The risk or severity of adverse effects can be increased when Procyclidine is combined with Codeine. Profenamine The risk or severity of adverse effects can be increased when Profenamine is combined with Codeine. Progesterone The risk or severity of adverse effects can be increased when Progesterone is combined with Codeine. Proguanil The metabolism of Codeine can be decreased when combined with Proguanil. Promazine The risk or severity of adverse effects can be increased when Promazine is combined with Codeine. Propafenone The metabolism of Codeine can be decreased when combined with Propafenone. Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Codeine. Propiomazine The risk or severity of adverse effects can be increased when Propiomazine is combined with Codeine. Propiverine The risk or severity of adverse effects can be increased when Propiverine is combined with Codeine. Propofol Codeine may increase the sedative activities of Propofol. Propranolol The metabolism of Codeine can be decreased when combined with Propranolol. Protriptyline The risk or severity of CNS depression can be increased when Codeine is combined with Protriptyline. Proxibarbal The risk or severity of CNS depression can be increased when Codeine is combined with Proxibarbal. Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Codeine. Pyrantel The risk or severity of CNS depression can be increased when Codeine is combined with Pyrantel. Quazepam The risk or severity of adverse effects can be increased when Codeine is combined with Quazepam. Quetiapine The risk or severity of adverse effects can be increased when Quetiapine is combined with Codeine. Quinethazone The therapeutic efficacy of Quinethazone can be decreased when used in combination with Codeine. Quinidine The risk or severity of adverse effects can be increased when Quinidine is combined with Codeine. Quinine The metabolism of Codeine can be decreased when combined with Quinine. Quinupramine The risk or severity of CNS depression can be increased when Codeine is combined with Quinupramine. Ramelteon The risk or severity of CNS depression can be increased when Codeine is combined with Ramelteon. Ranitidine The metabolism of Codeine can be decreased when combined with Ranitidine. Ranolazine The serum concentration of Codeine can be increased when it is combined with Ranolazine. Rapacuronium The risk or severity of adverse effects can be increased when Rapacuronium is combined with Codeine. Rasagiline The risk or severity of adverse effects can be increased when Codeine is combined with Rasagiline. Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Codeine. Remifentanil The risk or severity of adverse effects can be increased when Codeine is combined with Remifentanil. Remimazolam The risk or severity of adverse effects can be increased when Codeine is combined with Remimazolam. Remoxipride The risk or severity of CNS depression can be increased when Codeine is combined with Remoxipride. Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Codeine. Revefenacin The risk or severity of adverse effects can be increased when Revefenacin is combined with Codeine. Ribociclib The metabolism of Codeine can be decreased when combined with Ribociclib. Rifampin The metabolism of Codeine can be increased when combined with Rifampicin. Rifamycin The metabolism of Codeine can be increased when combined with Rifamycin. Rifapentine The metabolism of Codeine can be increased when combined with Rifapentine. Rilonacept The metabolism of Codeine can be increased when combined with Rilonacept. Rilpivirine The metabolism of Codeine can be decreased when combined with Rilpivirine. Riluzole The risk or severity of CNS depression can be increased when Codeine is combined with Riluzole. Rimonabant The risk or severity of adverse effects can be increased when Rimonabant is combined with Codeine. Risperidone The risk or severity of CNS depression can be increased when Codeine is combined with Risperidone. Ritlecitinib The serum concentration of Codeine can be increased when it is combined with Ritlecitinib. Ritonavir The serum concentration of Codeine can be increased when it is combined with Ritonavir. Rizatriptan The risk or severity of serotonin syndrome can be increased when Codeine is combined with Rizatriptan. Rocuronium The risk or severity of adverse effects can be increased when Rocuronium is combined with Codeine. Rolapitant The metabolism of Codeine can be decreased when combined with Rolapitant. Ropeginterferon alfa-2b The risk or severity of neuropsychiatric effects can be increased when Ropeginterferon alfa-2b is combined with Codeine. Ropinirole Codeine may increase the sedative activities of Ropinirole. Ropivacaine The risk or severity of CNS depression can be increased when Ropivacaine is combined with Codeine. Rotigotine Codeine may increase the sedative activities of Rotigotine. Rucaparib The metabolism of Codeine can be decreased when combined with Rucaparib. Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Codeine. Rupatadine The metabolism of Rupatadine can be decreased when combined with Codeine. Safinamide The risk or severity of adverse effects can be increased when Codeine is combined with Safinamide. Salmeterol The risk or severity of adverse effects can be increased when Codeine is combined with Salmeterol. Samidorphan The risk or severity of CNS depression can be increased when Codeine is combined with Samidorphan. Saquinavir The metabolism of Codeine can be decreased when combined with Saquinavir. Satralizumab The serum concentration of Codeine can be decreased when it is combined with Satralizumab. Scopolamine The risk or severity of adverse effects can be increased when Scopolamine is combined with Codeine. Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Codeine. Secukinumab The metabolism of Codeine can be increased when combined with Secukinumab. Selegiline The risk or severity of adverse effects can be increased when Codeine is combined with Selegiline. Senna leaf The therapeutic efficacy of Senna leaf can be decreased when used in combination with Codeine. Sertindole The risk or severity of CNS depression can be increased when Codeine is combined with Sertindole. Sertraline The risk or severity of serotonin syndrome can be increased when Codeine is combined with Sertraline. Sevoflurane The risk or severity of CNS depression can be increased when Codeine is combined with Sevoflurane. Sibutramine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Sibutramine. Sildenafil The metabolism of Codeine can be decreased when combined with Sildenafil. Siltuximab The metabolism of Codeine can be increased when combined with Siltuximab. Simeprevir The metabolism of Codeine can be decreased when combined with Simeprevir. Simvastatin The metabolism of Simvastatin can be decreased when combined with Codeine. Sodium ascorbate The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Codeine. Sodium fluorophosphate The therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Codeine. Sodium oxybate Codeine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. Sodium phosphate, dibasic The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Codeine. Sodium phosphate, dibasic, unspecified form The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Codeine. Sodium phosphate, monobasic The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Codeine. Sodium phosphate, monobasic, unspecified form The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Codeine. Sodium sulfate The therapeutic efficacy of Sodium sulfate can be decreased when used in combination with Codeine. Sodium tartrate The therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Codeine. Solifenacin The risk or severity of adverse effects can be increased when Solifenacin is combined with Codeine. Solriamfetol The risk or severity of CNS depression can be increased when Codeine is combined with Solriamfetol. Somatrogon The metabolism of Codeine can be increased when combined with Somatrogon. Sorbitol The therapeutic efficacy of Sorbitol can be decreased when used in combination with Codeine. Sotalol The metabolism of Sotalol can be decreased when combined with Codeine. Sotorasib The serum concentration of Codeine can be decreased when it is combined with Sotorasib. Spironolactone The risk or severity of orthostatic hypotension can be increased when Codeine is combined with Spironolactone. St. John's Wort The metabolism of Codeine can be increased when combined with St. John's Wort. Stavudine The excretion of Stavudine can be decreased when combined with Codeine. Stiripentol The metabolism of Codeine can be decreased when combined with Stiripentol. Succinylcholine The risk or severity of bradycardia can be increased when Succinylcholine is combined with Codeine. Sufentanil The risk or severity of adverse effects can be increased when Codeine is combined with Sufentanil. Sulbactam The excretion of Sulbactam can be decreased when combined with Codeine. Sulfaphenazole The metabolism of Codeine can be decreased when combined with Sulfaphenazole. Sulpiride The risk or severity of CNS depression can be increased when Codeine is combined with Sulpiride. Sulthiame The risk or severity of CNS depression can be increased when Codeine is combined with Sulthiame. Sultopride The risk or severity of CNS depression can be increased when Codeine is combined with Sultopride. Sumatriptan The risk or severity of CNS depression can be increased when Codeine is combined with Sumatriptan. Suvorexant Codeine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Codeine. Talbutal The risk or severity of adverse effects can be increased when Talbutal is combined with Codeine. Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Codeine. Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Codeine. Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Codeine. Tasimelteon The risk or severity of CNS depression can be increased when Codeine is combined with Tasimelteon. Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Codeine. Tazobactam The excretion of Tazobactam can be decreased when combined with Codeine. Tegaserod The metabolism of Codeine can be decreased when combined with Tegaserod. Telaprevir The metabolism of Codeine can be decreased when combined with Telaprevir. Telithromycin The metabolism of Codeine can be decreased when combined with Telithromycin. Telotristat ethyl The serum concentration of Codeine can be decreased when it is combined with Telotristat ethyl. Temazepam The risk or severity of adverse effects can be increased when Codeine is combined with Temazepam. Temsirolimus The metabolism of Codeine can be decreased when combined with Temsirolimus. Tenofovir alafenamide The excretion of Tenofovir alafenamide can be decreased when combined with Codeine. Tenofovir disoproxil The excretion of Tenofovir disoproxil can be decreased when combined with Codeine. Terbinafine The metabolism of Codeine can be decreased when combined with Terbinafine. Terfenadine The metabolism of Codeine can be decreased when combined with Terfenadine. Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Codeine. Tetracaine The risk or severity of CNS depression can be increased when Codeine is combined with Tetracaine. Thalidomide Codeine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. Theophylline The metabolism of Theophylline can be decreased when combined with Codeine. Thiamine The risk or severity of adverse effects can be increased when Codeine is combined with Thiamine. Thiamylal The risk or severity of CNS depression can be increased when Codeine is combined with Thiamylal. Thiethylperazine The risk or severity of hypotension and CNS depression can be increased when Thiethylperazine is combined with Codeine. Thiopental The risk or severity of adverse effects can be increased when Thiopental is combined with Codeine. Thioridazine The metabolism of Codeine can be decreased when combined with Thioridazine. Thiothixene The risk or severity of CNS depression can be increased when Codeine is combined with Thiothixene. Thonzylamine The risk or severity of adverse effects can be increased when Thonzylamine is combined with Codeine. Tiagabine The risk or severity of CNS depression can be increased when Codeine is combined with Tiagabine. Ticagrelor Codeine can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. Ticlopidine The metabolism of Codeine can be decreased when combined with Ticlopidine. Timolol The metabolism of Timolol can be decreased when combined with Codeine. Tiotropium The risk or severity of adverse effects can be increased when Tiotropium is combined with Codeine. Tipranavir The metabolism of Codeine can be decreased when combined with Tipranavir. Tizanidine The risk or severity of CNS depression can be increased when Codeine is combined with Tizanidine. Tocilizumab The metabolism of Codeine can be increased when combined with Tocilizumab. Tolcapone The risk or severity of CNS depression can be increased when Codeine is combined with Tolcapone. Tolterodine The risk or severity of adverse effects can be increased when Tolterodine is combined with Codeine. Tolvaptan The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Codeine. Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Codeine. Torasemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Codeine. Trabectedin The metabolism of Trabectedin can be decreased when combined with Codeine. Tramadol The risk or severity of serotonin syndrome can be increased when Codeine is combined with Tramadol. Tranylcypromine The risk or severity of adverse effects can be increased when Codeine is combined with Tranylcypromine. Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Codeine. Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Codeine. Triazolam The risk or severity of adverse effects can be increased when Codeine is combined with Triazolam. Trichlormethiazide The therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Codeine. Trichloroethylene The risk or severity of CNS depression can be increased when Codeine is combined with Trichloroethylene. Triclabendazole The metabolism of Codeine can be decreased when combined with Triclabendazole. Triclofos The risk or severity of CNS depression can be increased when Codeine is combined with Triclofos. Trifluoperazine The risk or severity of hypotension and CNS depression can be increased when Trifluoperazine is combined with Codeine. Triflupromazine The risk or severity of adverse effects can be increased when Triflupromazine is combined with Codeine. Trifluridine The excretion of Trifluridine can be decreased when combined with Codeine. Trihexyphenidyl The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Codeine. Trimebutine The risk or severity of adverse effects can be increased when Trimebutine is combined with Codeine. Trimethadione The risk or severity of CNS depression can be increased when Codeine is combined with Trimethadione. Trimethaphan The risk or severity of adverse effects can be increased when Trimethaphan is combined with Codeine. Trimethobenzamide The risk or severity of CNS depression can be increased when Codeine is combined with Trimethobenzamide. Trimipramine The metabolism of Trimipramine can be decreased when combined with Codeine. Tripelennamine The metabolism of Codeine can be decreased when combined with Tripelennamine. Troleandomycin The metabolism of Codeine can be decreased when combined with Troleandomycin. Tropisetron The risk or severity of CNS depression can be increased when Codeine is combined with Tropisetron. Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Codeine. Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Codeine. Tubocurarine The risk or severity of adverse effects can be increased when Tubocurarine is combined with Codeine. Tucatinib The metabolism of Tucatinib can be decreased when combined with Codeine. Umeclidinium The risk or severity of adverse effects can be increased when Umeclidinium is combined with Codeine. Urethane The risk or severity of CNS depression can be increased when Codeine is combined with Urethane. Vadadustat The serum concentration of Vadadustat can be increased when it is combined with Codeine. Valbenazine The metabolism of Valbenazine can be decreased when combined with Codeine. Valproate bismuth The risk or severity of serotonin syndrome can be increased when Codeine is combined with Valproate bismuth. Valproic acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Codeine. Vecuronium The risk or severity of adverse effects can be increased when Vecuronium is combined with Codeine. Vemurafenib The metabolism of Codeine can be decreased when combined with Vemurafenib. Venetoclax The metabolism of Codeine can be decreased when combined with Venetoclax. Venlafaxine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Venlafaxine. Verapamil The metabolism of Codeine can be decreased when combined with Verapamil. Vernakalant The metabolism of Vernakalant can be decreased when combined with Codeine. Vigabatrin The risk or severity of CNS depression can be increased when Codeine is combined with Vigabatrin. Vilazodone The metabolism of Codeine can be decreased when combined with Vilazodone. Viloxazine The metabolism of Codeine can be decreased when combined with Viloxazine. Vinblastine The metabolism of Codeine can be decreased when combined with Vinblastine. Vinorelbine The metabolism of Codeine can be decreased when combined with Vinorelbine. Voriconazole The metabolism of Codeine can be decreased when combined with Voriconazole. Vortioxetine The risk or severity of CNS depression can be increased when Codeine is combined with Vortioxetine. Yohimbine The risk or severity of CNS depression can be increased when Codeine is combined with Yohimbine. Zalcitabine The excretion of Zalcitabine can be decreased when combined with Codeine. Zaleplon The risk or severity of CNS depression can be increased when Codeine is combined with Zaleplon. Ziconotide The risk or severity of CNS depression can be increased when Codeine is combined with Ziconotide. Zidovudine The excretion of Zidovudine can be decreased when combined with Codeine. Zimelidine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Zimelidine. Ziprasidone The risk or severity of adverse effects can be increased when Codeine is combined with Ziprasidone. Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Codeine. Zolpidem Codeine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. Zonisamide The risk or severity of CNS depression can be increased when Codeine is combined with Zonisamide. Zopiclone The risk or severity of adverse effects can be increased when Codeine is combined with Zopiclone. Zotepine The risk or severity of CNS depression can be increased when Codeine is combined with Zotepine. Zuclopenthixol The risk or severity of CNS depression can be increased when Codeine is combined with Zuclopenthixol. Zuranolone The risk or severity of CNS depression can be increased when Zuranolone is combined with Codeine. - Food Interactions
- Avoid alcohol.
- Take with food. Food reduces irritation.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Codeine hydrobromide dihydrate Not Available Not Available YYPNRUMYXOJKDO-NLMNJOOOSA-N Codeine hydrochloride 406LPJ779Q 1422-07-7 NUXLENPAZQNFAM-FFHNEAJVSA-N Codeine monohydrate Q830PW7520 6059-47-8 WRRSFOZOETZUPG-FFHNEAJVSA-N Codeine phosphate 2X585M1M3T 52-28-8 WUXLCJZUUHIXFY-FFHNEAJVSA-N Codeine phosphate hemihydrate GSL05Y1MN6 41444-62-6 DKSZLDSPXIWGFO-BLOJGBSASA-N Codeine sulfate 11QV9BS0CB 6854-40-6 BOLDZXRCJAJADM-AAXBYHQXSA-N Codeine sulfate anhydrous AVW5HY4N2E 1420-53-7 BCXHDORHMMZBBZ-DORFAMGDSA-N - Product Images
- International/Other Brands
- Actacode (Sigma) / Bisoltus (Boehringer Ingelheim) / Bromophar (Qualiphar) / Bronchicum (Sanofi-Aventis) / Bronchodine (Pharmacobel) / Codant (Antigen) / Codedrill (Pierre Fabre) / Codein (Cristália) / Codeisan (Belmac) / Coderpina (Frycia Centro América) / Codicalm (Welti) / Codicept / Codinex (Pinewood) / Coducept / Cougel (Hwang's) / Coutan (Mey See) / Dinco (Center) / Farmacod (Farmacom) / Galcodine (Thornton & Ross) / Pectoral (Siphat) / Tussoret (MaxMedic)
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Codeine 15 Tablet 15 mg Oral Laboratoire Riva Inc. 1994-12-31 Not applicable Canada 
Codeine 30 Tablet 30 mg Oral Laboratoire Riva Inc. 1994-12-31 Not applicable Canada Codeine Contin 100mg Controlled Release Tab Tablet, extended release 100 mg Oral Purdue Pharma 1995-12-31 Not applicable Canada Codeine Contin 150mg Controlled Release Tab Tablet, extended release 150 mg Oral Purdue Pharma 1995-12-31 Not applicable Canada Codeine Contin 200mg Controlled Release Tab Tablet, extended release 200 mg Oral Purdue Pharma 1995-12-31 Not applicable Canada Codeine Contin 50mg Controlled Release Tab Tablet, extended release 50 mg Oral Purdue Pharma 1997-03-13 Not applicable Canada Codeine Phosphate Inj 30mg/ml Solution 30 mg / 1 mL Intramuscular; Subcutaneous Hospira Healthcare Ulc 1981-12-31 2018-09-21 Canada Codeine Phosphate Inj 60mg/ml Solution 60 mg / 1 mL Intramuscular; Subcutaneous Hospira Healthcare Ulc 1981-12-31 2018-09-21 Canada Codeine Phosphate Injection USP Liquid 30 mg / 1 mL Intramuscular; Subcutaneous Sandoz Canada Incorporated 1978-12-31 Not applicable Canada Codeine Phosphate Syrup Syrup 25 mg / 5 mL Oral Laboratoire Atlas Inc 1986-12-18 Not applicable Canada Codeine Phosphate Syrup Syrup 5 mg / mL Oral D.C. Labs Limited 1951-12-31 2005-07-19 Canada Codeine Phosphate Tab 15mg Tablet 15 mg Oral D.C. Labs Limited 1951-12-31 2003-07-11 Canada Codeine Phosphate Tab 30mg Tablet 30 mg Oral D.C. Labs Limited 1951-12-31 2003-07-11 Canada Codeine Phosphate Tab 60mg Tablet 60 mg Oral D.C. Labs Limited 1951-12-31 2003-07-11 Canada Codeine Sulfate Solution 15 mg/2.5mL Oral Precision Dose, Inc. 2013-02-25 2015-10-31 US 
Codeine Sulfate Tablet 30 mg/1 Oral Glenmark Generics, Inc. USA 2006-07-01 2011-08-31 US Codeine sulfate Tablet 60 mg/1 Oral Hikma Pharmaceuticals USA Inc. 2009-07-16 Not applicable US Codeine sulfate Tablet 30 mg/1 Oral Roxane Laboratories, Inc 2009-10-01 2009-09-30 US Codeine sulfate Tablet 15 mg/1 Oral Roxane Laboratories, Inc 2009-10-01 2009-09-30 US Codeine Sulfate Solution 30 mg/5mL Oral Precision Dose, Inc. 2013-02-26 2015-10-31 US Codeine Sulfate Tablet 60 mg/1 Oral Physicians Total Care, Inc. 2009-07-15 Not applicable US Codeine sulfate Tablet 15 mg/1 Oral Hikma Pharmaceuticals USA Inc. 2009-07-16 Not applicable US Codeine sulfate Tablet 60 mg/1 Oral Roxane Laboratories, Inc 2009-10-01 2009-09-30 US Codeine Sulfate Solution 30 mg/5mL Oral TAGI Pharma, Inc. 2012-06-01 2015-10-31 US Codeine Sulfate Tablet 60 mg/1 Oral Glenmark Generics, Inc. USA 2006-07-01 2011-08-31 US Codeine sulfate Tablet 30 mg/1 Oral Hikma Pharmaceuticals USA Inc. 2009-07-16 Not applicable US Codeine sulfate Tablet 30 mg/1 Oral Roxane Laboratories, Inc 1999-10-18 2002-12-13 US Codeine sulfate Tablet 30 mg/1 Oral Roxane Laboratories, Inc 2009-07-16 2009-10-01 US Codeine Tab 15mg Tablet 15 mg Oral Rougier Pharma Division Of Ratiopharm Inc 1951-12-31 2015-10-01 Canada Codeine Tab 30mg Tablet 30 mg Oral Rougier Pharma Division Of Ratiopharm Inc 1951-12-31 1999-09-27 Canada Linctus Codeine Blanc Solution 10 mg / 5 mL Oral Laboratoire Atlas Inc 1978-12-31 Not applicable Canada - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Codeine Sulfate Tablet 30 mg/1 Oral Lannett Company, Inc. 2014-06-13 Not applicable US Codeine Sulfate Tablet 15 mg/1 Oral Lannett Company, Inc. 2014-06-13 Not applicable US Codeine Sulfate Tablet 60 mg/1 Oral Lannett Company, Inc. 2014-06-13 Not applicable US PMS-codeine Tablet 30 mg Oral Pharmascience Inc 2001-12-16 2019-04-04 Canada PMS-codeine Tablet 15 mg Oral Pharmascience Inc 2001-11-16 2019-04-04 Canada Ratio-codeine Syrup 5 mg / mL Oral TEVA Canada Limited 1977-12-31 2017-05-01 Canada Teva-codeine Tablet 15 mg Oral TEVA Canada Limited 1983-12-31 Not applicable Canada Teva-codeine Tablet 30 mg Oral TEVA Canada Limited 1983-12-31 Not applicable Canada - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image COLINCTUS 10 MIXTURE 10 mg/5 ml Elixir 10 mg/5ml Oral DRUG HOUSES OF AUSTRALIA PTE. LTD. 1989-06-22 Not applicable Singapore 
Linctus Tussis Rubra 10mg/5ml Elixir 10 mg/5ml Oral EURO ASIA MEDICO PTE. LTD. 1992-04-03 Not applicable Singapore SP-CODIN LINCTUS 9 mg/5 ml Elixir 9 mg/5ml Oral LUEN WAH MEDICAL COMPANY (SINGAPORE) PRIVATE LIMITED 1999-03-25 Not applicable Singapore - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image (extra Strength) Acetaminophen, Caffeine & 8mg Codeine Phosphate Caplets Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1998-07-22 2002-07-31 Canada 222 Tablets Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine citrate (30 mg) Tablet Oral Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc 1951-12-31 2015-08-17 Canada 282 Mep Tab Codeine phosphate (15 mg) + Acetylsalicylic acid (350 mg) + Caffeine citrate (30 mg) + Meprobamate (200 mg) Tablet Oral Merck Frosst Canada & Cie, Merck Frosst Canada & Co. 1959-12-31 1998-08-14 Canada 282 Tab Codeine phosphate (15 mg) + Acetylsalicylic acid (375 mg) + Caffeine citrate (30 mg) Tablet Oral Merck Frosst Canada & Cie, Merck Frosst Canada & Co. 1951-12-31 1998-04-21 Canada 282 Tablets Codeine phosphate (15 mg) + Acetylsalicylic acid (375 mg) + Caffeine citrate (30 mg) Tablet Oral Pendopharm Division Of Pharmascience Inc 1998-11-01 2021-05-11 Canada 292 Tab Codeine phosphate (30 mg) + Acetylsalicylic acid (375 mg) + Caffeine citrate (30 mg) Tablet Oral Merck Frosst Canada & Cie, Merck Frosst Canada & Co. 1951-12-31 1998-08-14 Canada 292 Tablets Codeine phosphate (30 mg) + Acetylsalicylic acid (375 mg) + Caffeine citrate (15 mg) Tablet Oral Pendopharm Division Of Pharmascience Inc 1998-10-01 2021-04-29 Canada A & C Tablets With Codeine 15mg Codeine phosphate (15 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral D.C. Labs Limited 1971-12-31 2003-07-11 Canada A & C Tablets With Codeine 30mg Codeine phosphate (30 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral D.C. Labs Limited 1971-12-31 2003-07-11 Canada A-FERİN 300 MG/2 MG/10 MG KAPSÜL, 1000 ADET Codeine phosphate (10 mg) + Acetaminophen (300 mg) + Chlorpheniramine maleate (2 mg) Capsule Oral HÜSNÜ ARSAN İLAÇLARI A.Ş. 2020-08-14 Not applicable Turkey 
A-FERİN 300 MG/2 MG/10 MG KAPSÜL, 20 ADET Codeine phosphate (10 mg) + Acetaminophen (300 mg) + Chlorpheniramine maleate (2 mg) Capsule Oral HÜSNÜ ARSAN İLAÇLARI A.Ş. 2020-08-14 Not applicable Turkey A-FERİN 300 MG/2 MG/10 MG KAPSÜL, 30 ADET Codeine phosphate (10 mg) + Acetaminophen (300 mg) + Chlorpheniramine maleate (2 mg) Capsule Oral HÜSNÜ ARSAN İLAÇLARI A.Ş. 1975-07-10 Not applicable Turkey A-FERİN 300 MG/2 MG/10 MG KAPSÜL, 500 ADET Codeine phosphate (10 mg) + Acetaminophen (300 mg) + Chlorpheniramine maleate (2 mg) Capsule Oral HÜSNÜ ARSAN İLAÇLARI A.Ş. 2020-08-14 Not applicable Turkey A.C. & C 8mg Tab Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral Vita Health Products Inc 1970-12-31 2019-09-23 Canada A.C. & C. 8 mg Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral Laboratoires Confab Inc Not applicable Not applicable Canada A.C. & C. 8mg Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral Westcan Pharmaceuticals Ltd. Not applicable Not applicable Canada A.C.& C Tablets Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1993-12-31 2019-06-18 Canada Ac and C Tab 1/8gr Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (30 mg) Tablet Oral Pharmascience Inc 1983-12-31 2013-09-30 Canada Ac&c Tablets Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Caffeine (15 mg) Tablet Oral Vita Health Products Inc 1987-12-31 2005-07-20 Canada Ac&c Tablets Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 2008-06-11 2019-06-18 Canada Acet 2 Codeine phosphate (15 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1994-12-31 2013-05-09 Canada Acet 3 Codeine phosphate (30 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1994-12-31 2013-05-09 Canada Acet Codeine 30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral Pharmascience Inc 1994-12-31 2018-11-13 Canada Acet Codeine 60 Codeine phosphate (60 mg) + Acetaminophen (300 mg) Tablet Oral Pharmascience Inc 1994-12-31 2018-12-31 Canada ACETAMINOFEN + CODEINA 325 MG/8MG Codeine phosphate hemihydrate (8 mg) + Acetaminophen (325 mg) Tablet Oral 2011-07-22 Not applicable Colombia 
ACETAMINOFEN 325 MG + CODEINA FOSFATO 30 MG TABLETAS Codeine phosphate (30 mg) + Acetaminophen (325 mg) Tablet Oral C.I. FARMACAPSULAS S.A.S. - PLANTA NO. 2 2011-12-07 2020-01-20 Colombia ACETAMINOFEN 325 MG + FOSFATO DE CODEINA 30 MG Codeine phosphate (30.7 mg) + Acetaminophen (325 mg) Capsule, liquid filled Oral PROCAPS S.A. 2008-12-11 Not applicable Colombia ACETAMINOFEN 325 MG/CODEINA 30 MG TABLETAS. Codeine phosphate hemihydrate (30 mg) + Acetaminophen (325 mg) Tablet Oral LABORATORIO FRANCO COLOMBIANO - LAFRANCOL S.A.S. 2015-06-02 Not applicable Colombia ACETAMINOFÉN 325MG + FOSFATO DE CODEÍNA 30 MG TABLETAS Codeine phosphate (30 mg) + Acetaminophen (325 mg) Tablet Oral SANOFI-AVENTIS DE COLOMBIA S.A. 2006-11-10 Not applicable Colombia ACETAMINOFEN/CODEINA 325 MG/8MG. Codeine phosphate (8 mg) + Acetaminophen (325 mg) Capsule, liquid filled Oral PROCAPS S.A. 2009-01-22 Not applicable Colombia Acetaminophen 300mg, Caffeine & Codeine Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Tanta Pharmaceuticals Inc Not applicable Not applicable Canada Acetaminophen 325 C & C Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine (15 mg) Tablet Oral Technilab Pharma Inc. Not applicable Not applicable Canada Acetaminophen 325 Mg Caffeine and Codeine Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine (15 mg) Tablet Oral Tanta Pharmaceuticals Inc Not applicable Not applicable Canada Acetaminophen 325 Mg With 15 Mg Caffeine and 8 Mg Codeine Phosphate Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine (15 mg) Tablet Oral Vita Health Products Inc 1987-12-31 2017-09-29 Canada Acetaminophen 500 Mg Compound Tablets With Codeine Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1984-12-31 2016-10-28 Canada Acetaminophen 500 Mg With 15 Mg Caffeine and 8 Mg Codeine Phosphate Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Vita Health Products Inc 1987-12-31 2014-07-28 Canada Acetaminophen 500mg, Caffeine and 8mg Codeine Phosphate Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Cellchem Pharmaceuticals Inc. Not applicable Not applicable Canada Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Vintage Pharmaceuticals 1988-09-30 2009-09-03 US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Vintage Pharmaceuticals 1988-09-30 2009-09-03 US ACETAMINOPHEN AND CODEINe Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Stat Rx USA 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Keltman Pharmaceuticals Inc. 2009-03-19 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Red Pharm Drug, Inc. 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Contract Pharmacy Services Pa 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Dispensing Solutions, Inc. 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aidarex Pharmaceuticals LLC 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aidarex Pharmaceuticals LLC 1988-09-30 Not applicable US 
Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A S Medication Solutions 1988-09-30 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mutual Pharmaceutical 1988-02-10 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mutual Pharmaceutical 1988-02-10 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mutual Pharmaceutical 1988-02-10 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A S Medication Solutions 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A S Medication Solutions 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A S Medication Solutions 1988-09-30 Not applicable US 
Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rxchange Co 2008-05-29 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rxchange Co 2014-11-05 Not applicable US 
Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Blenheim Pharmacal, Inc. 2013-11-11 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Liberty Pharmaceuticals, Inc. 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Liberty Pharmaceuticals, Inc. 1988-09-30 Not applicable US 
Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A S Medication Solutions 1988-09-30 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Northwind Pharmaceuticals 2014-07-18 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Directrx 2014-01-01 Not applicable US 
Acetaminophen and Codeine Codeine monohydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Remedy Repack 2013-05-23 2013-05-24 US Acetaminophen And Codeine Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Qualitest 2011-11-10 2015-10-31 US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Remedy Repack 2015-01-13 2016-01-13 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral St. Marys Medical Park Pharmacy 2016-04-01 2017-12-31 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Contract Pharmacy Services Pa 2008-05-29 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Remedy Repack 2012-03-09 2016-02-06 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Unit Dose Services 2008-05-29 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 1988-09-30 2017-02-28 US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 1988-09-30 2016-11-30 US 
Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2008-05-29 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Pd Rx Pharmaceuticals, Inc. 1988-09-30 2018-08-17 US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral H.J. Harkins Company, Inc. 1988-09-30 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral H.J. Harkins Company, Inc. 1997-05-23 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rpk Pharmaceuticals, Inc. 2008-05-29 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Proficient Rx LP 2008-05-29 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Proficient Rx LP 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Par Pharmaceutical, Inc. 1988-09-30 2022-01-31 US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Par Pharmaceutical, Inc. 1988-09-30 2022-02-28 US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Par Pharmaceutical, Inc. 1988-09-30 2022-02-28 US 
Acetaminophen and Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Direct_Rx 2019-07-03 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Direct_Rx 2019-07-12 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Direct Rx 2014-01-01 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Amneal Pharmaceuticals LLC 2008-05-29 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aphena Pharma Solutions - Tennessee, LLC 2008-05-29 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aphena Pharma Solutions - Tennessee, LLC 1988-09-30 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aphena Pharma Solutions - Tennessee, LLC 1988-09-30 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2008-05-29 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Northwind Pharmaceuticals 2016-09-29 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral RedPharm Drug, Inc. 2020-01-01 Not applicable US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PD-Rx Pharmaceuticals, Inc. 1988-09-30 2018-11-16 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2008-05-29 2019-12-31 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2008-05-29 2019-12-31 US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 1988-09-30 2017-02-28 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals, Inc. 2008-05-29 2018-12-31 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals, Inc. 2014-06-17 2020-02-11 US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals, Inc. 2014-11-13 2019-05-02 US 
Acetaminophen And Codeine Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PD-Rx Pharmaceuticals, Inc. 1988-09-30 2018-11-16 US Acetaminophen And Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PD-Rx Pharmaceuticals, Inc. 1988-09-30 2018-11-16 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2008-05-29 2019-12-31 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral NuCarePharmaceuticals, Inc. 2008-05-29 2019-12-31 US Acetaminophen and Codeine Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral PD-Rx Pharmaceuticals, Inc. 1981-08-21 2018-09-18 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PD-Rx Pharmaceuticals, Inc. 2008-05-29 2018-11-20 US Acetaminophen And Codeine Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 1988-09-30 2015-06-30 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PD-Rx Pharmaceuticals, Inc. 2008-05-29 2018-11-16 US Acetaminophen And Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 1988-09-30 2017-12-26 US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Asclemed Usa, Inc. 2008-05-29 Not applicable US Acetaminophen and Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2024-01-10 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (650 mg/1) Tablet Oral UAD LABORATORIES 2006-11-22 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rebel Distributors 2009-06-29 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rebel Distributors 2009-06-29 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Rebel Distributors 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Contract Pharmacy Services Pa 2010-02-16 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Goldline Laboratories, Inc. 1998-08-07 1998-08-08 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Physicians Total Care, Inc. 2004-10-19 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/1mL) + Acetaminophen (120 mg/1mL) Solution Oral Stat Rx USA 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Red Pharm Drug, Inc. 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Red Pharm Drug, Inc. 2010-10-07 Not applicable US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Blenheim Pharmacal, Inc. 2011-01-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Dispensing Solutions, Inc. 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rebel Distributors 2011-07-26 Not applicable US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mikart, Inc. 1986-02-25 2001-01-01 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Physicians Total Care, Inc. 1994-11-22 2012-06-30 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Physicians Total Care, Inc. 2003-09-25 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Physicians Total Care, Inc. 2009-07-08 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rebel Distributors 2011-07-26 Not applicable US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Barr Laboratories 2000-01-21 2011-12-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Barr Laboratories 1994-10-15 2012-08-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Barr Laboratories 2000-03-13 2012-08-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mikart, Inc. 1986-02-25 2013-06-23 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (650 mg/1) Tablet Oral Mikart, Inc. 1991-09-25 2013-06-23 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (650 mg/1) Tablet Oral Mikart, Inc. 1986-03-03 2013-06-23 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral A S Medication Solutions 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Aidarex Pharmaceuticals LLC 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral A S Medication Solutions 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Qualitest 1995-07-11 2015-02-22 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Directrx 2015-01-01 Not applicable US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Apotheca, Inc. 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 2010-08-29 2012-10-31 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 2010-10-07 2012-10-31 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 2010-10-07 2012-10-31 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 1990-09-30 2016-01-15 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Apotheca, Inc. 2002-05-03 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Epm Packaging Inc 2016-01-27 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral bryant ranch prepack 1981-08-21 2011-07-01 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 2005-01-10 2016-10-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Aidarex Pharmaceuticals LLC 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Remedy Repack 2013-04-08 2014-04-08 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Remedy Repack 2015-04-14 2017-03-23 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals, Inc. 2017-01-05 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Remedy Repack 2015-10-15 2017-01-24 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Actavis Pharma Company 2003-01-22 2003-01-22 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Actavis Pharma Company 2003-04-01 2009-02-28 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Actavis Pharma Company 2003-09-01 2009-02-28 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals, Inc. 2017-01-05 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Contract Pharmacy Services Pa 2017-09-28 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral NCS HealthCare of KY, LLC dba Vangard Labs 2017-01-05 2023-11-30 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Actavis Pharma Company 1990-09-30 2011-04-30 US Acetaminophen And Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mc Kesson 1988-09-30 2017-02-28 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 1990-09-30 2017-08-31 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mc Kesson Contract Packaging 1990-09-30 2017-09-30 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mesource Pharmaceuticals 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mesource Pharmaceuticals 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Sun Pharmaceutical Industries, Inc. 1978-11-16 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Sun Pharmaceutical Industries, Inc. 1980-01-23 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral PAI Holdings, LLC 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/12.5mL) + Acetaminophen (300 mg/12.5mL) Solution Oral PAI Holdings, LLC 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aidarex Pharmaceuticals LLC 2018-04-03 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Apotheca, Inc. 2010-06-08 2010-06-08 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Apotheca, Inc. 2009-03-01 2010-06-08 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals, Inc 2011-03-17 2011-05-03 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aphena Pharma Solutions - Tennessee, LLC 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Liquid Oral Mikart, LLC 1992-10-27 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Rpk Pharmaceuticals, Inc. 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral St. Mary's Medical Park Pharmacy 2018-05-08 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Contract Pharmacy Services-PA 2017-01-05 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Proficient Rx LP 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Proficient Rx LP 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aphena Pharma Solutions - Tennessee, LLC 2011-07-06 2019-02-25 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aphena Pharma Solutions - Tennessee, LLC 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aphena Pharma Solutions - Tennessee, LLC 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aurolife Pharma, LLC 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aurolife Pharma, LLC 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Aurolife Pharma, LLC 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Quality Care Products, LLC 2011-09-14 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Eywa Pharma Inc 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Eywa Pharma Inc 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Eywa Pharma Inc 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Clinical Solutions Wholesale, LLC 2019-02-27 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral ATLANTIC BIOLOGICALS COPR. 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Mylan Institutional Inc. 1996-12-23 2021-01-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2018-10-25 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Morton Grove Pharmaceuticals, Inc. 1981-07-22 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral RedPharm Drug 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Quality Care Products LLC 2011-07-06 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 107, LLC 2009-06-29 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Proficient Rx LP 1990-09-30 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Elite Laboratories, Inc. 2019-09-10 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Elite Laboratories, Inc. 2019-09-10 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Elite Laboratories, Inc. 2019-09-10 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral RedPharm Drug, Inc. 2017-01-05 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Direct_Rx 2019-07-12 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 1990-09-30 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Direct_Rx 2019-07-12 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Akorn 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Akorn 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (24 mg/10mL) + Acetaminophen (240 mg/10mL) Solution Oral Akorn 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/12.5mL) + Acetaminophen (300 mg/12.5mL) Solution Oral Akorn 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (36 mg/15mL) + Acetaminophen (360 mg/15mL) Solution Oral Akorn 1996-04-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals, Inc. 2014-10-16 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals, Inc. 2015-03-26 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral SpecGx LLC 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral SpecGx LLC 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral SpecGx LLC 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2020-03-12 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral American Health Packaging 2009-08-25 2022-02-28 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral American Health Packaging 2009-09-28 2022-02-28 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Nucare Pharmaceuticals,inc. 1981-08-21 2018-12-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2017-02-09 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Teva Pharmaceuticals USA, Inc. 1990-09-30 2022-02-28 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Teva Pharmaceuticals USA, Inc. 1990-09-30 2023-02-28 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Teva Pharmaceuticals USA, Inc. 1990-09-30 2022-02-28 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral A-S Medication Solutions 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Proficient Rx LP 2017-01-05 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2015-05-12 2018-08-23 US Acetaminophen And Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 2010-01-13 2016-06-13 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Avera McKennan Hospital 2015-11-05 2017-05-24 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral A-S Medication Solutions 1981-08-21 2017-02-28 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Cardinal Health 2011-06-10 2014-07-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2013-04-15 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Preferred Pharmaceuticals, Inc. 2011-03-01 2019-05-02 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Cardinal Health 2011-06-10 2015-12-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals, Inc. 2017-01-05 2020-04-30 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 1990-09-30 2007-07-01 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 2011-01-14 2014-08-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2015-02-10 2018-04-12 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals Inc. 2015-08-20 2020-02-11 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 1990-09-30 Not applicable US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals, Inc. 2014-02-25 2019-05-02 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PD-Rx Pharmaceuticals, Inc. 2011-07-06 2018-11-16 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral NCS HealthCare of KY, Inc dba Vangard Labs 1990-09-30 2019-05-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals, Inc. 2011-03-17 2020-02-11 US 
Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2020-06-05 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2020-09-01 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2020-09-01 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals Inc. 2020-11-03 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals Inc. 2020-11-04 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Denton Pharma, Inc. Dba Northwind Pharmaceuticals 2020-11-02 2023-12-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals Inc. 2021-01-18 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Preferred Pharmaceuticals Inc. 2021-02-05 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2021-01-14 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2021-03-18 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral American Health Packaging 2021-12-31 2024-10-31 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral American Health Packaging 2021-12-13 2024-06-30 US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Clinical Solutions Wholesale, LLC 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Coupler Enterprises Inc. 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Nucare Pharmaceuticals,inc. 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Direct_Rx 2022-08-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral St. Mary's Medical Park Pharmacy 2022-09-30 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2022-11-10 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral RedPharm Drug, Inc 1981-08-21 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral REMEDYREPACK INC. 2023-04-10 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Northwind Pharmaceuticals, LLC 2023-06-14 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Solution Oral Genus Lifesciences Inc. 2023-08-10 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Rpk Pharmaceuticals, Inc. 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral bryant ranch prepack 2019-08-02 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral medsource pharmaceuticals 2001-05-31 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Strides Pharma Science Limited 2024-05-20 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Strides Pharma Science Limited 2024-05-20 Not applicable US Acetaminophen and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Strides Pharma Science Limited 2024-05-20 Not applicable US Acetaminophen Caffeine & 8mg Cod Phos Tab Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1986-12-31 2002-07-31 Canada Acetaminophen Caffeine & 8mg Cod. Phos. Tab Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Novopharm Limited 1992-12-31 2012-12-05 Canada Acetaminophen Compound Tablets With Codeine 8mg Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral D.C. Labs Limited 1984-12-31 2005-07-19 Canada Acetaminophen Elixir With 8mg Codeine Phosphate Syrup Codeine phosphate (8 mg / 5 mL) + Acetaminophen (160 mg / 5 mL) Elixir Oral Jamp Pharma Corporation Not applicable Not applicable Canada Acetaminophen W Codeine Tab Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (30 mg) Tablet Oral Pharmascience Inc 1983-12-31 2013-09-30 Canada ACETAMINOPHEN with CODEINE Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PharmPak, Inc. 2013-12-31 Not applicable US Acetaminophen with Codeine Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Vintage Pharmaceuticals, LLC 2006-11-24 2006-11-24 US Acetaminophen With Codeine - Caplet Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral TEVA Canada Limited 1997-10-28 Not applicable Canada Acetaminophen-caffeine-codeine Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Laboratoires Confab Inc Not applicable Not applicable Canada Acetaminophen, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (150 mg/1) + Acetylsalicylic acid (180 mg/1) Capsule Oral Mikart, Inc. 1990-10-26 2008-11-19 US Acetaminophen, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (150 mg/1) + Acetylsalicylic acid (180 mg/1) Capsule Oral Mikart, Inc. 1990-10-26 2009-06-08 US Acetaminophen, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (150 mg/1) + Acetylsalicylic acid (180 mg/1) Capsule Oral Mikart, Inc. 1990-10-26 2009-06-08 US Acetaminophen, Caffeine & 8mg Codeine Phosphate Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1998-12-17 2017-09-30 Canada Acetaminophen, Caffeine & 8mg Codeine Phosphate Tablets Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Jamp Pharma Corporation 2004-06-25 Not applicable Canada Acetaminophen, Caffeine & Codeine Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1993-12-31 2019-06-18 Canada Acetaminophen, Caffeine & Codeine Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1993-12-31 2019-06-18 Canada Acetaminophen, Caffeine & Codeine Tablets Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc Not applicable Not applicable Canada Acetaminophen, Caffeine and 8 Mg Of Codeine Phosphate Tablets Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine (15 mg) Tablet Oral Cellchem Pharmaceuticals Inc. 2005-01-20 Not applicable Canada Acetaminophen, Caffeine and Codeine Phosphate Tablets Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Laboratoire Riva Inc. 1996-10-11 Not applicable Canada Acetaminophen, Caffeine, and 8mg Of Codeine Phosphate Tablets Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Cellchem Pharmaceuticals Inc. 2004-07-16 Not applicable Canada Acetaminophene Codeine Et Cafeine Caplets Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine citrate (30 mg) Tablet Oral Laboratoire Riva Inc. 1993-12-31 2019-06-17 Canada Acetaminophene Codeine Et Cafeine Fort Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine citrate (30 mg) Tablet Oral Laboratoire Riva Inc. 1993-12-31 2019-06-17 Canada Acetazone Forte C8 Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Chlorzoxazone (250 mg) Tablet Oral TEVA Canada Limited 1991-12-31 Not applicable Canada Acetylsalicylic Acid, Caffeine & 8 Mg Codeine Phosphate Tablets Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral Jamp Pharma Corporation 2004-06-25 2022-09-18 Canada Acetylsalicylic Acid, Caffeine and 8 Mg Codeine Phosphate Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral Cellchem Pharmaceuticals Inc. 1970-12-31 Not applicable Canada ACODEIN Codeine phosphate hemihydrate (30 mg) + Acetaminophen (325 mg) Tablet Oral LABORATORIO FRANCO COLOMBIANO - LAFRANCOL S.A.S. 2017-01-23 Not applicable Colombia ACTIFED COMPOUND LINCTUS Codeine phosphate (10 mg/5ml) + Pseudoephedrine hydrochloride (30 mg/5ml) + Triprolidine hydrochloride (1.25 mg/5ml) Elixir Oral GSK CONSUMER HEALTHCARE SINGAPORE PTE. LTD. 1989-05-18 Not applicable Singapore Ala-hist Ac Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (7.5 mg/5mL) Liquid Oral Poly Pharmaceuticals 2007-12-21 2018-02-01 US ALGIMIDE TABLETAS Codeine phosphate (15 mg) + Acetaminophen (325 mg) Tablet Oral 2006-11-10 2017-03-07 Colombia ALGIMIDE® NF Codeine phosphate (8 mg) + Acetaminophen (325 mg) Tablet Oral 2015-10-02 Not applicable Colombia Ambenyl Cough Syrup Codeine phosphate (10 mg / 5 mL) + Ammonium chloride (80 mg / 5 mL) + Bromodiphenhydramine hydrochloride (3.75 mg / 5 mL) + Diphenhydramine hydrochloride (8.75 mg / 5 mL) + Potassium guaiacolsulfonate (80 mg / 5 mL) Liquid Oral Parke Davis Division, Warner Lambert Canada Inc. 1979-12-31 1997-08-25 Canada Anacin With Codeine Tab Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Caffeine (32 mg) Tablet Oral Whitehall Robins Inc. 1965-12-31 2000-07-26 Canada Apo-acetaco #1 Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Apotex Corporation Not applicable Not applicable Canada APRANAX PLUS 550 MG/30 MG FILM KAPLI TABLET, 10 ADET Codeine phosphate (30 mg) + Naproxen sodium (550 mg) Tablet, coated Oral ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey APRANAX PLUS 550 MG/30 MG FILM KAPLI TABLET, 20 ADET Codeine phosphate (30 mg) + Naproxen sodium (550 mg) Tablet, coated Oral ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. 2010-11-11 Not applicable Turkey ARKODIN SIROP, 125 ML Codeine phosphate (12.5 mg/5ml) + Ephedrine hydrochloride (10 mg/5ml) Syrup Oral GÜNSA GÜNEY İLAÇ VE HAMMADDELER SAN. VE TİC. A.Ş. 1972-03-16 Not applicable Turkey ARKODIN TABLET, 15 ADET Codeine (20 mg) + Ethylmorphine (10 mg) Tablet Oral GÜNSA GÜNEY İLAÇ VE HAMMADDELER SAN. VE TİC. A.Ş. 1972-03-16 Not applicable Turkey Asa-caffeine-codeine Codeine phosphate (8 mg) + Acetylsalicylic acid (375 mg) + Caffeine (15 mg) Tablet Oral Laboratoires Confab Inc Not applicable Not applicable Canada Asa, Caffeine & 8mg Codeine Phosphate Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Caffeine (15 mg) Tablet Oral Canapharm Manufacturing Inc 2000-03-13 2006-08-25 Canada Ascomp with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Breckenridge Pharmaceutical, Inc. 2009-05-01 Not applicable US 
Ascomp with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Nexgen Pharma, Inc. 2001-11-30 Not applicable US Ascomp with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral LGM Pharma Solutions, LLC 2001-11-30 Not applicable US Atasol 15 Codeine phosphate (15 mg) + Acetaminophen (325 mg) + Caffeine citrate (30 mg) Tablet Oral Church & Dwight Canada Corp 1975-12-31 2020-02-28 Canada Atasol 30 Codeine phosphate (30 mg) + Acetaminophen (325 mg) + Caffeine citrate (30 mg) Tablet Oral Church & Dwight Canada Corp 1975-12-31 2019-04-02 Canada Atasol 8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine citrate (30 mg) Tablet Oral Church & Dwight Canada Corp 1975-12-31 2017-12-31 Canada Axacet-C1/8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral Technilab Pharma Inc. Not applicable Not applicable Canada Axisal-C1/8 Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral Technilab Pharma Inc. Not applicable Not applicable Canada AZUR COMPOSITUM SC Codeine phosphate hemihydrate (30 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany 
AZUR COMPOSITUM SC Codeine phosphate hemihydrate (30 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany Balminil Codeine + Decongestant + Expectorant Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Liquid Oral Rougier Pharma Division Of Ratiopharm Inc 2001-12-13 2015-10-01 Canada Balminil Codeine Night Time + Expectorant Codeine phosphate (3.33 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Liquid Oral Rougier Pharma Division Of Ratiopharm Inc 2003-06-03 2015-10-01 Canada BEACODYL LINCTUS Codeine phosphate (9 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Elixir Oral BEACONS PHARMACEUTICALS PTE. LTD. 1994-03-25 Not applicable Singapore BEACTAFED CO SYRUP Codeine phosphate (10 mg/5ml) + Pseudoephedrine hydrochloride (32 mg/5ml) + Triprolidine hydrochloride (1.25 mg/5ml) Syrup Oral BEACONS PHARMACEUTICALS PTE. LTD. 1989-05-30 Not applicable Singapore Benylin 2 Cold and Flu With Codeine Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc 2003-07-11 2015-08-06 Canada Benylin Codeine 3.3mg De Syr Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral Pfizer Canada Inc., Consumer Healthcare Division 1992-12-31 2003-07-11 Canada BRUFECOD Codeine phosphate hemihydrate (30 MG) + Ibuprofen (400 MG) Tablet, coated Oral Viatris Italia S.R.L. 2015-08-04 Not applicable Italy 
BUPIRIDOL Codeine phosphate hemihydrate (30 mg) + Acetaminophen (325 mg) Tablet Oral SERVICIO TECNICO GONHER FARMACEUTICA LTDA. 2017-12-29 Not applicable Colombia Butalbital, Acetaminophen and Caffeine with Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Hikma Pharmaceuticals USA Inc. 2001-03-21 2015-11-10 US Butalbital, Acetaminophen, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Dispensing Solutions, Inc. 2004-07-01 Not applicable US 
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Breckenridge Pharmaceutical, Inc. 2004-07-01 Not applicable US 
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral bryant ranch prepack 2004-07-01 Not applicable US Butalbital, Acetaminophen, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Hikma Pharmaceuticals USA Inc. 2022-05-09 Not applicable US Butalbital, Acetaminophen, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Hikma Pharmaceuticals USA Inc. 2022-05-09 Not applicable US Butalbital, Acetaminophen, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral bryant ranch prepack 2004-07-01 Not applicable US Butalbital, Acetaminophen, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Strides Pharma Inc. 2024-03-04 Not applicable US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Physicians Total Care, Inc. 2009-07-06 Not applicable US 
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral bryant ranch prepack 2003-09-18 Not applicable US 
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Vintage Pharmaceuticals, LLC 2007-01-22 2007-01-22 US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Par Pharmaceutical, Inc. 2002-04-22 2022-09-30 US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Actavis Pharma, Inc. 2003-09-18 Not applicable US 
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Actavis Pharma, Inc. 2013-07-29 Not applicable US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Nexgen Pharma, Inc. 2004-06-10 Not applicable US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Nexgen Pharma, Inc. 2004-06-10 Not applicable US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral bryant ranch prepack 2002-04-22 Not applicable US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral LGM Pharma Solutions, LLC 2004-06-10 Not applicable US Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral LGM Pharma Solutions, LLC 2004-06-10 Not applicable US Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Jerome Stevens Pharmaceuticals 2007-10-25 Not applicable US Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Physicians Total Care, Inc. 1998-06-02 Not applicable US Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral A S Medication Solutions 2006-10-26 Not applicable US Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral A-S Medication Solutions 2006-10-26 2017-08-31 US Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral bryant ranch prepack 2009-05-01 Not applicable US 
Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Amneal Pharmaceuticals of New York, LLC 2019-04-01 Not applicable US Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Actavis Pharma, Inc. 2006-10-26 Not applicable US Butalbital, Aspirin, Caffeine and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Lannett Company, Inc. 1998-08-31 Not applicable US Butalbital, Aspirin, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Endo Pharmaceuticals Inc. 2006-09-19 2006-09-19 US Butalbital, Aspirin, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Watson Laboratories, Inc. 2007-02-17 2007-02-17 US Butalbital, Aspirin, Caffeine, and Codeine Phosphate Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Mayne Pharma Inc. 2015-10-30 Not applicable US C T Acetylsalicylic Acid Codeine and Caf Tab Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Caffeine (16 mg) Tablet Oral Pharmavite Laboratories (1987) Inc. 1995-12-31 2006-07-27 Canada C-2 Buffered With Codeine Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Caffeine (15 mg) Tablet Oral Pharmascience Inc 1999-06-15 2016-10-28 Canada C2 Buffered With Codeine Tab Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Aluminum hydroxide (35 mg) + Caffeine (15 mg) + Magnesium hydroxide (70 mg) Tablet Oral Wampole Brands, A Division Of Pangeo Pharma (Canada) Inc. 1986-12-31 1999-06-15 Canada C2 Tab With Codeine Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Caffeine (15 mg) Tablet Oral Wampole Brands, A Division Of Pangeo Pharma (Canada) Inc. 1986-12-31 1996-09-09 Canada Calmylin Codeine phosphate (3.33 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Syrup Oral TEVA Canada Limited 1981-12-31 Not applicable Canada Calmylin Ace Codeine phosphate (10 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pheniramine maleate (7.5 mg / 5 mL) Syrup Oral TEVA Canada Limited 1996-12-31 Not applicable Canada Calmylin Codeine D-E Syr Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral Technilab Pharma Inc. 1993-12-31 1997-08-22 Canada Calmylin Pse With Codeine Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral TEVA Canada Limited 1996-08-30 Not applicable Canada CapCof Codeine phosphate hemihydrate (10 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) Liquid Oral Capital Pharmaceutical, LLC 2010-10-08 Not applicable US Capital and Codeine Codeine phosphate hemihydrate (12 mg/5mL) + Acetaminophen (120 mg/5mL) Suspension Oral Valeant Pharmaceuticals 2004-05-03 2016-10-31 US Carisoprodol, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (16 mg/1) + Acetylsalicylic acid (325 mg/1) + Carisoprodol (200 mg/1) Tablet Oral Actavis Totowa LLC 1999-06-01 2008-08-20 US Carisoprodol, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (16 mg/1) + Acetylsalicylic acid (325 mg/1) + Carisoprodol (200 mg/1) Tablet Oral Ingenus Pharmaceuticals Nj, Llc 2017-09-11 2017-09-11 US Carisoprodol, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (16 mg/1) + Acetylsalicylic acid (325 mg/1) + Carisoprodol (200 mg/1) Tablet Oral Eon Labs, Inc. 1996-04-16 2019-09-30 US Carisoprodol, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (16 mg/1) + Acetylsalicylic acid (325 mg/1) + Carisoprodol (200 mg/1) Tablet Oral Rising Pharmaceuticals, Inc. 2018-03-12 2020-01-31 US Carisoprodol, Aspirin and Codeine Phosphate Codeine phosphate hemihydrate (16 mg/1) + Acetylsalicylic acid (325 mg/1) + Carisoprodol (200 mg/1) Tablet Oral Ingenus Pharmaceuticals, LLC 2019-01-21 2022-07-31 US CATALAC MAX® Codeine phosphate (30 mg) + Acetaminophen (325 mg) Tablet Oral QUIBI S.A. EN REESTRUCTURACION 2023-04-18 Not applicable Colombia Cheracol Cough Syrup Codeine phosphate (10 mg / 5 mL) + Ammonium chloride (91 mg / 5 mL) + Ethanol (3 % / 5 mL) + Guaifenesin (100 mg / 5 mL) Syrup Oral Shire Pharma Canada Ulc 1992-12-31 2003-07-18 Canada Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Rebel Distributors 1996-09-01 Not applicable US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Dispensing Solutions, Inc. 1996-09-01 Not applicable US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral A S Medication Solutions 1996-09-01 2013-06-07 US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral A S Medication Solutions 1996-09-01 2013-06-07 US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral bryant ranch prepack 1996-09-01 2013-05-01 US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Rpk Pharmaceuticals, Inc. 1996-09-01 Not applicable US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral REMEDYREPACK INC. 2019-02-04 Not applicable US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral A-S Medication Solutions 1996-09-01 Not applicable US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Par Pharmaceutical 1996-09-01 2020-03-31 US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral A-S Medication Solutions 1996-09-01 2018-05-18 US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral REMEDYREPACK INC. 2016-11-02 2018-06-27 US Cheratussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Preferred Pharmaceuticals, Inc 1996-09-01 2019-07-23 US Cheratussin DAC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Par Pharmaceutical 1997-01-01 2017-09-30 US CHLORSEDYL LINCTUS Codeine phosphate (9 mg/5ml) + Chlorpheniramine maleate (4 mg/5ml) + Ephedrine hydrochloride (7.2 mg/5ml) Elixir Oral BEACONS PHARMACEUTICALS PTE. LTD. 1989-05-22 Not applicable Singapore CO EFFERALGAN Codeine (30 MG) + Acetaminophen (500 MG) Tablet, effervescent Oral Upsa Sas 2014-07-08 2021-05-27 Italy CO EFFERALGAN Codeine (30 MG) + Acetaminophen (500 MG) Tablet, effervescent Oral Upsa Sas 2014-07-08 Not applicable Italy CO EFFERALGAN Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Upsa Sas 2014-07-08 Not applicable Italy CO EFFERALGAN Codeine phosphate hemihydrate (30 MG) + Acetaminophen (500 MG) Tablet, effervescent Oral Pharmacy Value S.R.L. 2014-07-08 2023-01-31 Italy CO EFFERALGAN Codeine phosphate hemihydrate (30 MG) + Acetaminophen (500 MG) Tablet, effervescent Oral Programmi Sanitari Integrati S.R.L. 2014-07-08 2024-04-02 Italy Coactifed Codeine phosphate (10 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) + Triprolidine hydrochloride (2 mg / 5 mL) Syrup Oral Glaxosmithkline Inc 1960-12-31 2018-05-28 Canada Coactifed Codeine phosphate (20 mg) + Pseudoephedrine hydrochloride (60 mg) + Triprolidine hydrochloride (4 mg) Tablet Oral Glaxosmithkline Inc 1963-12-31 2015-03-03 Canada Coactifed Codeine phosphate (10 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) + Triprolidine hydrochloride (2 mg / 5 mL) Syrup Oral Glaxosmithkline Inc 1963-12-31 2014-11-24 Canada Cocet Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (650 mg/1) Tablet Oral Poly Pharmaceuticals 2009-07-01 2012-05-01 US Cocet Plus Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (650 mg/1) Tablet Oral Poly Pharmaceuticals 2010-06-29 2012-05-21 US CODALGEN® Codeine phosphate (8 mg) + Acetaminophen (325 mg) Tablet Oral 2018-05-28 Not applicable Colombia CODALGEN® F Codeine phosphate (30 mg) + Acetaminophen (325 mg) Tablet Oral 2018-06-08 Not applicable Colombia CODAMOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, effervescent Oral Abiogen Pharma S.P.A. 2014-07-08 Not applicable Italy CODAMOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Abiogen Pharma S.P.A. 2014-07-08 Not applicable Italy Codar AR Codeine phosphate hemihydrate (8 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) Liquid Oral Respa Pharmaceuticals 2011-06-20 Not applicable US Codar D Codeine phosphate hemihydrate (8 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Respa Pharmaceuticals 2011-07-13 Not applicable US Codar GF Codeine phosphate hemihydrate (8 mg/5mL) + Guaifenesin (200 mg/5mL) Liquid Oral Respa Pharmaceuticals 2011-06-21 Not applicable US CODASEL TABLET, 20 ADET Codeine phosphate (10 mg) + Acetaminophen (400 mg) Tablet Oral AKDENİZ İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 2017-02-02 Turkey CODEFEN 50/50 MG EFERVESAN TABLET, 20 ADET Codeine phosphate (50 mg) + Diclofenac sodium (50 mg) Tablet, effervescent NEUTEC İLAÇ SAN. TİC. A.Ş. 2012-03-14 Not applicable Turkey CODEFEN 50/50 MG EFERVESAN TABLET, 30 ADET Codeine phosphate (50 mg) + Diclofenac sodium (50 mg) Tablet, effervescent NEUTEC İLAÇ SAN. TİC. A.Ş. 2012-03-14 Not applicable Turkey CODEFEN® Codeine phosphate (30 mg) + Acetaminophen (325 mg) Tablet, coated Oral EUROFARMA COLOMBIA S.A.S. 2019-08-13 Not applicable Colombia Codeine and Chlorpheniramine Maleate ER Codeine phosphate hemihydrate (54.3 mg/1) + Chlorpheniramine maleate (8 mg/1) Tablet, extended release Oral Nexgen Pharma, Inc. 2015-09-01 Not applicable US Codeine Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Leading Pharma, Llc 2019-12-19 Not applicable US Codeine Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Preferred Pharmaceuticals Inc. 2021-06-14 Not applicable US Codeine Phosphate and Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Atlantic Biologicals Corp. 2018-09-24 Not applicable US Codeine Phosphate and Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Noble Pharmaceuticals, Llc 2017-01-17 Not applicable US Codeine Phosphate and Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Bishop Pharma, LLC 2018-11-28 Not applicable US Codeine Phosphate and Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral BioRamo, LLC 2017-01-17 Not applicable US Codeine Phosphate and Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Virtus Pharmaceuticals LLC 2017-10-23 2020-10-31 US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Quality Care Products, LLC 2019-04-05 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Atlantic Biologicals Corp. 2014-04-01 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Method Pharmaceuticals, LLC 2014-04-01 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Nucare Pharmaceuticals,inc. 2014-04-01 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Preferred Pharmaceuticals Inc. 2018-08-07 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Westminster Pharmaceuticals, LLC 2020-07-15 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Nucare Pharmaceuticals,inc. 2020-07-15 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Atlantic Biologicals Corp. 2020-07-15 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Proficient Rx LP 2020-07-15 Not applicable US Codeine-guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Direct Rx 2022-03-07 Not applicable US Codeine-Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral A-S Medication Solutions 2020-07-15 Not applicable US Codeprex Pennkinetic Codeine (20 mg/5mL) + Chlorpheniramine (4 mg/5mL) Suspension, extended release Oral UCB Manufacturing Inc 2004-06-21 2004-06-22 US Codipront Capsule Codeine phosphate hemihydrate (30 mg) + Phenyltoloxamine (10 mg) Capsule, extended release Oral RX PHARMA PTE. LTD. 2007-07-30 Not applicable Singapore Coditussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (200 mg/5mL) Syrup Oral Glendale Inc 2016-05-01 Not applicable US Coditussin DAC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (200 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Syrup Oral Glendale Inc 2016-05-01 Not applicable US Codrix Codeine phosphate hemihydrate (15 mg/1) + Acetaminophen (500 mg/1) Tablet Oral Andrx Laboratories, Inc. 2007-09-18 Not applicable US Codrix Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (500 mg/1) Tablet Oral Andrx Laboratories, Inc. 2008-04-25 Not applicable US Codrix Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (500 mg/1) Tablet Oral Andrx Laboratories, Inc. 2008-05-16 Not applicable US COPHADYL COUGH LINCTUS Codeine phosphate (9 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Elixir Oral ICM PHARMA PTE. LTD. 1996-12-14 Not applicable Singapore COPHADYL-E COUGH LINCTUS Codeine phosphate (9 mg/5ml) + Ephedrine hydrochloride (6 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Elixir Oral ICM PHARMA PTE. LTD. 1996-12-28 Not applicable Singapore Coryphen 325 Codeine 30 Tab Codeine phosphate (30 mg) + Acetylsalicylic acid (325 mg) Tablet Oral Rougier Pharma Division Of Ratiopharm Inc 1979-12-31 1999-09-27 Canada Coryphen 650 Codeine 30 Tab Codeine phosphate (30 mg) + Acetylsalicylic acid (650 mg) Tablet Oral Rougier Pharma Division Of Ratiopharm Inc 1979-12-31 1999-09-27 Canada Cotabs Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine citrate (30 mg) Tablet Oral Pharmavite Laboratories (1987) Inc. 1961-12-31 2000-08-18 Canada Cotrifed Codeine phosphate (10 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) + Triprolidine hydrochloride (2 mg / 5 mL) Liquid Oral Technilab Pharma Inc. 1989-12-31 1997-08-22 Canada Cough and Allergy Syrup With Codeine Codeine phosphate (3.3 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Syrup Oral Laboratoire Riva Inc. 2019-10-08 Not applicable Canada Cough Syr W Codeine Diphenhyd HCl & Ammon Cl Codeine phosphate (3.3 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Syrup Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1989-12-31 1997-08-08 Canada Cough Syr W.cod. Pseudoephed.hcl Guaifenesin Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1994-12-31 2002-07-31 Canada Cough Syrup Codeine phosphate (3.33 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Syrup Oral TEVA Canada Limited 1986-12-31 Not applicable Canada Cough Syrup With Codeine Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral Cellchem Pharmaceuticals Inc. Not applicable Not applicable Canada Cough Syrup With Codeine Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral Jamp Pharma Corporation 2005-12-05 Not applicable Canada Cough Syrup With Codeine Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) Syrup Oral TEVA Canada Limited 1995-12-31 Not applicable Canada COUGHLAX FORTE SYRUP Codeine phosphate (10 mg/5ml) + Ammonium chloride (62.5 mg/5ml) + Chlorpheniramine maleate (5 mg/5ml) + Ephedrine hydrochloride (5 mg/5ml) Syrup Oral BEACONS PHARMACEUTICALS PTE. LTD. 1989-05-06 Not applicable Singapore Covan Syrup Codeine phosphate (10 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) + Triprolidine hydrochloride (2 mg / 5 mL) Syrup Oral Pharmascience Inc 2000-12-11 Not applicable Canada Damylin Avec Codeine Sirop Codeine phosphate (3.3 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Syrup Oral Laboratoire Atlas Inc Not applicable Not applicable Canada Damylin With Codeine Syrup Codeine phosphate (3.3 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Syrup Oral Laboratoire Riva Inc 2002-09-13 Not applicable Canada DEPHEDRIN ŞURUP, 150 ML Codeine phosphate hemihydrate (15 mg/15ml) + Chlorpheniramine maleate (2 mg/15ml) + Ephedrine hydrochloride (15 mg/15ml) + Guaifenesin (100 mg/15ml) Syrup BİOFARMA İLAÇ SAN. VE TİC. A.Ş. 1968-05-24 Not applicable Turkey Dex-Tuss Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (300 mg/5mL) Liquid Oral Cypress Pharmaceuticals, Inc. 2011-07-28 2014-01-06 US Dexphen w/ Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Dexchlorpheniramine maleate (1 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) Liquid Oral Breckenridge Pharmaceutical, Inc. 2010-10-10 2010-10-10 US DHASEDYL SYRUP Codeine phosphate (9 mg/5ml) + Ephedrine hydrochloride (6 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Syrup Oral DRUG HOUSES OF AUSTRALIA PTE. LTD. 1992-04-13 Not applicable Singapore DIFAST FTABLETAS Codeine phosphate hemihydrate (40.72 mg) + Ibuprofen (200 mg) Tablet, coated Oral LABORATORIOS SIEGFRIED S.A.S. 2006-11-10 Not applicable Colombia Dimetane Expectorant C Codeine phosphate (2 mg / mL) + Brompheniramine maleate (0.4 mg / mL) + Guaifenesin (20 mg / mL) + Phenylephrine hydrochloride (1 mg / mL) Syrup Oral Foundation Consumer Brands, Llc 2001-09-28 2021-12-31 Canada Dimetane Expectorant-C Syr Codeine phosphate (10 mg / 5 mL) + Brompheniramine maleate (2 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Phenylephrine hydrochloride (5 mg / 5 mL) + Phenylpropanolamine hydrochloride (5 mg / 5 mL) Syrup Oral Whitehall Robins Inc. 1993-12-31 2001-04-10 Canada Dimetapp-C Codeine phosphate (2 mg / mL) + Brompheniramine maleate (0.4 mg / mL) + Phenylephrine hydrochloride (1 mg / mL) Syrup Oral Foundation Consumer Brands, Llc 2001-09-05 2021-12-31 Canada Dimetapp-C Syr Codeine phosphate (10 mg / 5 mL) + Brompheniramine maleate (2 mg / 5 mL) + Phenylephrine hydrochloride (5 mg / 5 mL) + Phenylpropanolamine hydrochloride (5 mg / 5 mL) Syrup Oral Whitehall Robins Inc. 1993-12-31 2001-04-10 Canada DOLADAMON P DRAJE, 20 ADET Codeine phosphate hemihydrate (15 mg) + Acetaminophen (300 mg) Tablet, coated Oral MENARİNİ SAĞLIK VE İLAÇ SAN. VE TİC. A.Ş. 1996-11-12 Not applicable Turkey EFEKO ŞURUP, 100 ML Codeine phosphate (15 mg/5ml) + Ephedrine hydrochloride (15 mg/5ml) Syrup Oral HÜSNÜ ARSAN İLAÇLARI A.Ş. 2020-08-14 2018-08-17 Turkey Empracet-30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral Glaxosmithkline Inc 1986-12-31 2002-05-28 Canada Empracet-60 Codeine phosphate (60 mg) + Acetaminophen (300 mg) Tablet Oral Glaxosmithkline Inc 1986-12-31 2002-05-28 Canada EndaCof C Codeine phosphate hemihydrate (10 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) Liquid Oral Larken Laboratories, Inc. 2009-05-25 2015-11-10 US EndaCof DC Codeine phosphate hemihydrate (10 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Larken Laboratories, Inc. 2010-10-19 2013-02-28 US Endal CD Codeine phosphate hemihydrate (7.5 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) Liquid Oral Tiber Laboratories, LLC 2011-03-28 2013-04-30 US Exdol 15tab Codeine phosphate (15 mg) + Acetaminophen (300 mg) + Caffeine citrate (30 mg) Tablet Oral Merck Frosst Canada & Cie, Merck Frosst Canada & Co. 1977-12-31 1998-04-21 Canada Exdol 30tab Codeine phosphate (30 mg) + Acetaminophen (300 mg) + Caffeine citrate (30 mg) Tablet Oral Merck Frosst Canada & Cie, Merck Frosst Canada & Co. 1977-12-31 1998-04-21 Canada Exdol 8 Tab Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine citrate (30 mg) Tablet Oral Merck Frosst Canada & Cie, Merck Frosst Canada & Co. 1977-12-31 1998-04-21 Canada Exdol-15 Codeine phosphate (15 mg) + Acetaminophen (300 mg) + Caffeine citrate (30 mg) Tablet Oral Pharmascience Inc 1998-09-01 2016-07-14 Canada Exdol-30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) + Caffeine citrate (30 mg) Tablet Oral Pharmascience Inc 1998-09-01 2016-07-14 Canada Exdol-8 Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine citrate (30 mg) Tablet Oral Pharmascience Inc 1998-08-01 2016-07-14 Canada FEDAC COMPOUND LINCTUS Codeine phosphate (10 mg/5ml) + Pseudoephedrine hydrochloride (30 mg/5ml) + Triprolidine hydrochloride (1.25 mg/5ml) Elixir Oral DRUG HOUSES OF AUSTRALIA PTE. LTD. 1989-01-06 Not applicable Singapore FENOKODIN 20 MG / 10 MG TABLET, 20 ADET Codeine (20 mg) + Ethylmorphine (10 mg) Tablet Oral ADEKA İLAÇ SAN. VE TİC. A.Ş. 1965-12-07 Not applicable Turkey FENOKODIN ÖKSÜRÜK ŞURUBU, 150 ML Codeine phosphate (2 mg/mL) + Ephedrine hydrochloride (1 mg/mL) + Sodium citrate (20 mg/ml) + Thiocolchicoside (20 mg/ml) Syrup Oral ADEKA İLAÇ SAN. VE TİC. A.Ş. 1966-09-30 Not applicable Turkey Fioricet with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Physicians Total Care, Inc. 1994-05-24 2011-06-30 US Fioricet with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Actavis Pharma Company 1992-07-30 2013-07-26 US Fioricet with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Actavis Pharma, Inc. 2013-07-29 Not applicable US Fiorinal with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Physicians Total Care, Inc. 1990-10-26 2011-06-30 US Fiorinal with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Actavis Pharma, Inc. 1990-10-26 2020-03-31 US Fiorinal with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetylsalicylic acid (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Allergan, Inc. 1990-10-26 2022-04-30 US Fiorinal-C 1/2 Codeine phosphate (30 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral Aralez Pharmaceuticals Canada Inc 1970-12-31 Not applicable Canada Fiorinal-C 1/4 Codeine phosphate (15 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral Aralez Pharmaceuticals Canada Inc 1970-12-31 Not applicable Canada FULPEN 400 MG/ 50 MG/ 9,5 MG TABLET, 20 ADET Codeine phosphate (9.5 mg) + Acetylsalicylic acid (400 mg) + Caffeine (50 mg) Tablet Oral ADEKA İLAÇ SAN. VE TİC. A.Ş. 1983-12-21 Not applicable Turkey G Tussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral The Generic Pharmaceutical Company 2016-12-01 Not applicable US Ganituss Nr Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Cypress Pharmaceuticals, Inc. 1995-12-01 2011-08-26 US GELONIDA SCHMERZTABLETTEN Codeine phosphate hemihydrate (30 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany GERALGINE PLUS 300 MG/30 MG TABLET, 20 ADET Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral BİOFARMA İLAÇ SAN. VE TİC. A.Ş. 2017-03-16 Not applicable Turkey GERALGINE-K 500 MG/30 MG/10 MG TABLET, 20 ADET Codeine phosphate (10 mg) + Acetaminophen (500 mg) + Caffeine (30 mg) Tablet Oral BİOFARMA İLAÇ SAN. VE TİC. A.Ş. 2016-04-04 Not applicable Turkey Guaiatussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral A-S Medication Solutions 2010-09-08 Not applicable US Guaiatussin AC Sugar Free Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Akorn Operating Company LLC 2010-09-08 Not applicable US Guaiatussin AC Sugar Free Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Preferred Pharmaceuticals, Inc. 2010-09-08 Not applicable US Guaiatussin AC Sugar Free Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Cardinal Health 107, LLC 2010-09-08 Not applicable US Guaifen/ac Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Direct_Rx 2023-01-13 Not applicable US Guaifenesin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Syrup Oral Rising Pharmaceuticals 2015-03-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Physicians Total Care, Inc. 2004-10-05 2011-02-28 US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Apotheca, Inc. 2011-01-28 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Dispensing Solutions, Inc. 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral A S Medication Solutions 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Directrx 2015-01-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Pharmaceutical Associates, Inc. 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Pharmaceutical Associates, Inc. 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral A-S Medication Solutions 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Nucare Pharmaceuticals,inc. 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral REMEDYREPACK INC. 2019-11-19 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Proficient Rx LP 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Preferred Pharmaceuticals Inc. 2020-02-07 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Lake Erie Medical DBA Quality Care Products LLC 2006-10-01 2019-10-11 US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Cardinal Health 2006-10-01 2016-10-31 US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Rpk Pharmaceuticals, Inc. 2006-10-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (20 mg/10mL) + Guaifenesin (200 mg/10mL) Solution Oral Pharmaceutical Associates, Inc. 2006-10-01 Not applicable US GUAIFENESIN and CODEINE PHOSPHATE Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral QUAGEN PHARMACEUTICALS LLC 2022-05-23 Not applicable US GUAIFENESIN and CODEINE PHOSPHATE Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral QUAGEN PHARMACEUTICALS LLC 2022-05-23 Not applicable US GUAIFENESIN and CODEINE PHOSPHATE Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Nucare Pharmaceuticals,inc. 2022-05-23 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Preferred Pharmaceuticals Inc. 2023-02-01 Not applicable US Guaifenesin and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Solution Oral Cardinal Health 107, LLC 2023-06-27 Not applicable US Guaifenesin and Codeine Phosphate SF Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Physicians Total Care, Inc. 2011-04-26 Not applicable US Guaifenesin DAC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Rising Pharmaceuticals 2016-02-01 Not applicable US Histex Ac Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (10 mg/5mL) + Triprolidine hydrochloride monohydrate (2.5 mg/5mL) Syrup Oral Allegis Pharmaceuticals, LLC 2015-08-12 Not applicable US Iophen C NR Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Qualitest 1997-05-01 2017-12-31 US KÜRAMOL TABLET, 20 ADET Codeine phosphate (10 mg) + Acetaminophen (500 mg) + Caffeine (30 mg) Tablet Oral SANTA FARMA İLAÇ SAN. A.Ş. 1990-11-20 Not applicable Turkey LERTUS® FORTE 50 MG COMPRIMIDOSRECUBIERTOS Codeine phosphate hemihydrate (50 mg) + Diclofenac sodium (50 mg) Tablet, film coated Oral ADIUM SAS 2006-11-10 2021-10-01 Colombia Lortuss EX Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (22.5 mg/5mL) Solution Oral Poly Pharmaceuticals 2009-11-20 2014-04-10 US Lortuss EX Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Sallus Laboratories, Llc 2014-06-01 2019-12-31 US LUDICODINE SURUP, 180 G Codeine phosphate (8.33 mg/5ml) + Ephedrine hydrochloride (8.33 mg/5ml) Syrup Oral LİBA LABORATUARLARI A.Ş. 1980-09-22 Not applicable Turkey LUDICODINE TABLET, 15 ADET Codeine (20 mg) + Ethylmorphine (10 mg) Tablet Oral LİBA LABORATUARLARI A.Ş. 1984-09-19 Not applicable Turkey M-clear Wc Codeine phosphate hemihydrate (6.33 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral R.A. McNeil Company 2008-10-30 Not applicable US M-end Max D Codeine phosphate hemihydrate (6 mg/5mL) + Dexbrompheniramine maleate (0.667 mg/5mL) + Pseudoephedrine hydrochloride (20 mg/5mL) Liquid Oral R.A. McNeil Company 2011-10-13 2017-02-28 US M-end PE Codeine phosphate hemihydrate (6.33 mg/5mL) + Brompheniramine maleate (1.33 mg/5mL) + Phenylephrine hydrochloride (3.33 mg/5mL) Liquid Oral R.A. McNeil Company 2008-11-11 Not applicable US M-end Wc Codeine phosphate hemihydrate (6.33 mg/5mL) + Brompheniramine maleate (1.33 mg/5mL) + Pseudoephedrine hydrochloride (10 mg/5mL) Liquid Oral R.A. McNeil Company 2008-09-30 2015-04-30 US Mar-cof BP Codeine phosphate hemihydrate (7.5 mg/5mL) + Brompheniramine maleate (2 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Syrup Oral Marnel Pharmaceuticals, Llc 2009-10-01 Not applicable US MAR-COF CG Expectorant Codeine phosphate hemihydrate (7.5 mg/5mL) + Guaifenesin (225 mg/5mL) Syrup Oral Marnel Pharmaceuticals, Llc 2008-12-01 Not applicable US Maxi-Tuss AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Mcr American Pharmaceuticals, Inc. 2020-08-01 Not applicable US Maxi-Tuss CD Codeine phosphate hemihydrate (10 mg/5mL) + Chlorpheniramine maleate (4 mg/5mL) + Phenylephrine hydrochloride (10 mg/5mL) Liquid Oral Mcr American Pharmaceuticals, Inc. 2018-04-01 Not applicable US Mersyndol With Codeine Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Doxylamine succinate (5 mg) Tablet Oral Sanofi Aventis 1982-12-31 Not applicable Canada Mesehist WC Codeine phosphate hemihydrate (6.33 mg/5mL) + Brompheniramine maleate (1.33 mg/5mL) + Pseudoephedrine hydrochloride (10 mg/5mL) Liquid Oral Trigen Laboratories, Inc. 2011-02-15 2013-11-30 US Methoxacet-C 1/8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral TEVA Canada Limited 1998-05-19 2018-11-12 Canada Methoxisal-C 1/2 Codeine phosphate (32.4 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral TEVA Canada Limited 1998-05-19 2018-11-15 Canada Methoxisal-C 1/4 Codeine phosphate (16.2 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral TEVA Canada Limited 1998-05-19 2018-11-12 Canada Methoxisal-C 1/8 Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral TEVA Canada Limited 1998-05-19 2019-03-29 Canada Muscle & Back Pain Relief - 8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral Vita Health Products Inc 2000-07-24 2019-09-23 Canada Muscle & Back Pain Relief-8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral Pharmascience Inc 2002-03-22 2016-10-28 Canada Muscle and Back Pain Relief - 8 Tablets Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral Cellchem Pharmaceuticals Inc. 2009-11-04 Not applicable Canada Muscle and Back Pain Relief Caplets Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral Jamp Pharma Corporation Not applicable Not applicable Canada Muscle and Back Pain Relief-8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral TEVA Canada Limited 2004-09-13 2021-08-12 Canada Nasotuss Codeine phosphate hemihydrate (10 mg/5mL) + Chlorcyclizine hydrochloride (25 mg/5mL) + Phenylephrine hydrochloride (10 mg/5mL) Liquid Oral Hawthorn Pharmaceuticals, Inc. 2010-11-08 2012-12-09 US Neo AC Codeine phosphate hemihydrate (10 mg/5mL) + Mepyramine maleate (15 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Syrup Oral Laser Pharmaceuticals Llc 2009-09-22 2017-07-03 US Ninjacof-XG Codeine phosphate hemihydrate (8 mg/5mL) + Guaifenesin (200 mg/5mL) Liquid Oral Centurion Labs 2014-11-20 Not applicable US NODOL_SIMPLE TABLETAS Codeine phosphate hemihydrate (8 mg) + Acetaminophen (325 mg) Tablet Oral NUTRI MACK S.A.S. 2012-06-04 2022-08-25 Colombia NODOL® FORTE TABLETAS Codeine phosphate hemihydrate (30 mg) + Acetaminophen (325 mg) Tablet Oral NUTRI MACK S.A.S. 2012-06-15 Not applicable Colombia Notuss PE Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (10 mg/5mL) Liquid Oral Sj Pharmaceuticals, Llc 2009-07-16 2011-06-09 US Novahistex C Codeine phosphate (15 mg / 5 mL) + Phenylephrine hydrochloride (20 mg / 5 mL) Syrup Oral Aventis Pharma Ltd. 1994-12-31 2001-07-20 Canada Novo Ac and C 8mg Tab Codeine phosphate (8 mg) + Acetylsalicylic acid (400 mg) + Caffeine (15 mg) Tablet Oral Novopharm Limited 1978-12-31 2015-10-26 Canada Novo-gesic C15 Codeine phosphate (15 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Novopharm Limited 1986-12-31 2003-02-10 Canada Novo-gesic C30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Novopharm Limited 1986-12-31 2003-02-10 Canada Novo-gesic-C8 Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Novopharm Limited 1985-12-31 2015-10-26 Canada Nu-acetaco #1 Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Nu Pharm Inc Not applicable Not applicable Canada NUROFEN PLUS TABLET, 12 ADET Codeine phosphate (12.8 mg) + Ibuprofen (200 mg) Tablet Oral RECKİTT BENCKİSER TEMİZLİK MALZEMELERİ SAN. TİC. A.Ş. 2008-02-07 Not applicable Turkey OPTIPYRIN Codeine phosphate hemihydrate (60 mg) + Acetaminophen (1000 mg) Suppository Rectal 2006-04-01 Not applicable Germany OPTIPYRIN Codeine phosphate hemihydrate (60 mg) + Acetaminophen (1000 mg) Suppository Rectal 2006-04-01 Not applicable Germany Oradrine Tablets Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine (32.4 mg) + Diphenylpyraline hydrochloride (2 mg) + Phenylpropanolamine hydrochloride (25 mg) Tablet Oral Pharmavite Laboratories (1987) Inc. 1989-12-31 2001-03-30 Canada PACOFEN S TABLET 20 TABLET Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (30 mg) Tablet Oral MENARİNİ SAĞLIK VE İLAÇ SAN. VE TİC. A.Ş. 1994-12-15 Not applicable Turkey PACOFEN TABLET 20 TABLET Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (30 mg) Tablet Oral MENARİNİ SAĞLIK VE İLAÇ SAN. VE TİC. A.Ş. 1988-02-03 Not applicable Turkey PACOFEN TABLETS Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (30 mg) Tablet Oral TEVA PHARMACEUTICAL INVESTMENTS SINGAPORE PTE. LTD. 1991-07-05 Not applicable Singapore PADEINA Codeine phosphate (30 mg) + Acetaminophen (500 mg) Granule, effervescent Oral So.Se.Pharm S.R.L. Societa' Di Servizio Per L'industria Farmaceutica Ed Affini 2018-02-22 Not applicable Italy PADEINA Codeine phosphate (30 mg) + Acetaminophen (500 mg) Tablet, effervescent Oral So.Se.Pharm S.R.L. Societa' Di Servizio Per L'industria Farmaceutica Ed Affini 2018-02-22 Not applicable Italy Painex Tab 0.25gr Codeine phosphate (15 mg / tab) + Acetylsalicylic acid (375 mg / tab) + Caffeine citrate (30 mg / tab) Tablet Oral Icn Pharmaceuticals 1974-12-31 1998-08-13 Canada Painex Tab 0.5gr Codeine phosphate (30 mg / tab) + Acetylsalicylic acid (375 mg / tab) + Caffeine citrate (30 mg / tab) Tablet Oral Icn Pharmaceuticals 1974-12-31 1998-08-13 Canada PANACO TABLETS Codeine phosphate (9 mg) + Acetaminophen (500 mg) Tablet Oral BEACONS PHARMACEUTICALS PTE. LTD. 1991-02-19 Not applicable Singapore PANADEINE TABLET Codeine phosphate (8 mg) + Acetaminophen (500 mg) Tablet Oral SANOFI-AVENTIS SINGAPORE PTE. LTD. 1991-01-29 Not applicable Singapore PARACETAMOL 325 MG + CODEINA 30 MG Codeine phosphate (30 mg) + Acetaminophen (325 mg) Tablet, coated Oral 2019-05-29 Not applicable Colombia PARACETAMOL AL COMP Codeine (30 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany PARACETAMOL AL COMP Codeine (30 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany PARACETAMOL CODEINE TABLETS Codeine phosphate (8 mg) + Acetaminophen (500 mg) Tablet Oral SUNWARD PHARMACEUTICAL PRIVATE LIMITED 1991-02-07 Not applicable Singapore PARACETAMOL COMP STADA Codeine (30 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany PARACETAMOL COMP STADA Codeine (30 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany PARACETAMOLO E CODEINA ALTER Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Laboratori Alter S.R.L. 2014-07-08 Not applicable Italy PARACETAMOLO E CODEINA DOC GENERICI Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Doc Generici Srl 2014-10-15 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy PARACETAMOLO E CODEINA TEVA Codeine (30 MG) + Acetaminophen (500 MG) Tablet, coated Oral Teva B.V. 2019-07-17 Not applicable Italy Parafon Forte C8 W Codeine Tab Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Chlorzoxazone (250 mg) Tablet Oral Mcneil Pharmaceutical, Division Of Ortho Mcneil Inc. 1985-12-31 1999-11-09 Canada PARAKODIN TABLET, 20 ADET Codeine (10 mg) + Acetaminophen (500 mg) Tablet Oral ATABAY KİMYA SAN. VE TİC. A.Ş. 2010-02-15 Not applicable Turkey PARALGIN TABLET Codeine phosphate hemihydrate (8 mg) + Acetaminophen (500 mg) Tablet Oral APEX PHARMA MARKETING PTE. LTD. 1996-06-01 Not applicable Singapore Pentuss Srs Codeine (2 mg / mL) + Chlorpheniramine maleate (.8 mg / mL) Syrup Oral Rhone Poulenc Rorer 1984-12-31 1999-08-12 Canada Phenaphen No 2 Cap Codeine phosphate (16.2 mg / cap) + Acetylsalicylic acid (325 mg / cap) + Phenobarbital (16.2 mg / cap) Capsule Oral Ayerst Laboratories 1993-12-31 1999-08-12 Canada Phenaphen No 3 Cap Codeine phosphate (32.4 mg / cap) + Acetylsalicylic acid (325 mg / cap) + Phenobarbital (16.2 mg / cap) Capsule Oral Ayerst Laboratories 1992-12-31 1996-09-10 Canada Phenaphen No 4 Cap Codeine phosphate (64.8 mg) + Acetylsalicylic acid (325 mg) + Phenobarbital (16.2 mg) Capsule Oral Ayerst Laboratories 1992-12-31 1999-08-12 Canada Phenaphen No.2 Cap Codeine phosphate (16.2 mg / cap) + Acetylsalicylic acid (325 mg / cap) + Phenobarbital (16.2 mg / cap) Capsule Oral Wyeth Ayerst Canada Inc. 1999-04-12 2001-08-30 Canada Phenaphen No.3 Cap Codeine phosphate (32.4 mg / cap) + Acetylsalicylic acid (325 mg / cap) + Phenobarbital (16.2 mg / cap) Capsule Oral Wyeth Ayerst Canada Inc. 1995-12-31 2004-07-27 Canada Phenaphen No.4 Cap Codeine phosphate (64.8 mg / cap) + Acetylsalicylic acid (325 mg / cap) + Phenobarbital (16.2 mg / cap) Capsule Oral Wyeth Ayerst Canada Inc. 1998-08-03 2002-05-17 Canada Phenergan Expectorant With Codeine Liq Codeine phosphate (10 mg / 5 mL) + Potassium guaiacolsulfonate (40 mg / 5 mL) + Promethazine hydrochloride (5.65 mg / 5 mL) Liquid Oral Rhone Poulenc Rorer 1993-12-31 1997-08-13 Canada Phenergan Expectorant With Codeine Liquid Codeine phosphate (10 mg / 5 mL) + Potassium guaiacolsulfonate (40 mg / 5 mL) + Promethazine hydrochloride (5.65 mg / 5 mL) Liquid Oral Columbia Laboratories 1996-12-31 2006-07-11 Canada Phenergan Vc Expectorant W Codeine Liq Codeine phosphate (10 mg / 5 mL) + Phenylephrine hydrochloride (5 mg / 5 mL) + Potassium guaiacolsulfonate (44 mg / 5 mL) + Promethazine hydrochloride (5 mg / 5 mL) Liquid Oral Rhone Poulenc Rorer 1994-12-31 1997-08-13 Canada PHENEXPECT CD SYRUP Codeine phosphate (5.7 mg/5ml) + Ammonium chloride (135 mg/5ml) + Diphenhydramine hydrochloride (12.5 mg/5ml) Syrup Oral DRUG HOUSES OF AUSTRALIA PTE. LTD. 1991-03-12 Not applicable Singapore Phenylhistine DH Codeine phosphate hemihydrate (10 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Qualitest 1996-10-01 2018-04-30 US PHL-acet-codeine 30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral Pharmel Inc 2004-07-22 2004-07-22 Canada PHL-acet-codeine 60 Codeine phosphate (60 mg) + Acetaminophen (300 mg) Tablet Oral Pharmel Inc 2004-07-22 2004-07-22 Canada Phrenilin Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (325 mg/1) + Butalbital (50 mg/1) + Caffeine (40 mg/1) Capsule Oral Valeant Pharmaceuticals North America 2005-09-05 2007-09-30 US Pluratuss Codeine phosphate hemihydrate (10 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Phenylephrine hydrochloride (7.5 mg/5mL) Liquid Oral Creekwood Pharmaceuticals, Inc. 2010-01-06 2011-03-31 US PMS-acetaminophen With Codeine Elixir Codeine phosphate (8 mg / 5 mL) + Acetaminophen (160 mg / 5 mL) Elixir Oral Pharmascience Inc 1991-12-31 Not applicable Canada PMS-pharnal-C 1/4 Capsules Codeine phosphate (15 mg / cap) + Acetylsalicylic acid (330 mg / cap) + Butalbital (50 mg / cap) + Caffeine (40 mg / cap) Capsule Oral Pharmascience Inc Not applicable Not applicable Canada PMS-pharnal-C1/2 Capsules Codeine phosphate (30 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral Pharmascience Inc Not applicable Not applicable Canada Poly Hist NC Codeine phosphate hemihydrate (10 mg/1mL) + Pseudoephedrine hydrochloride (15 mg/1mL) + Triprolidine hydrochloride monohydrate (1.25 mg/1mL) Liquid Oral Poly Pharmaceuticals 2010-01-01 2018-02-01 US Poly-tussin Codeine phosphate hemihydrate (10 mg/5mL) + Chlorcyclizine hydrochloride (9.375 mg/5mL) Liquid Oral Poly Pharmaceuticals 2012-09-18 2014-09-30 US Poly-Tussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Phenylephrine hydrochloride (7.5 mg/5mL) Liquid Oral Poly Pharmaceuticals 2007-12-21 2014-04-10 US Poly-Tussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Phenylephrine hydrochloride (10 mg/5mL) Liquid Oral Poly Pharmaceuticals, Inc. 2014-06-02 Not applicable US Poly-tussin D Codeine phosphate hemihydrate (10 mg/5mL) + Chlorcyclizine hydrochloride (9.375 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Poly Pharmaceuticals 2012-09-18 2018-02-01 US Pracet 30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral Laboratoire Riva Inc Not applicable Not applicable Canada Pro-clear Ac Codeine phosphate hemihydrate (9 mg/5mL) + Mepyramine maleate (8.33 mg/5mL) Syrup Oral Pro-Pharma LLC 2008-09-08 Not applicable US Pro-red Ac Codeine phosphate hemihydrate (9 mg/5mL) + Dexchlorpheniramine maleate (1 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) Syrup Oral Pro-Pharma, LLC 2013-09-30 Not applicable US Pro-red Ac Codeine phosphate hemihydrate (9 mg/5mL) + Mepyramine maleate (8.33 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) Syrup Oral Pro-Pharma, LLC 2008-09-08 2014-11-30 US Procet-30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral Pro Doc Limitee 2009-02-24 2019-11-01 Canada PROCODIN SYRUP Codeine phosphate (9 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Syrup Oral DRUG HOUSES OF AUSTRALIA PTE. LTD. 1990-03-28 Not applicable Singapore PROMEDYL-B LINCTUS Codeine phosphate (9 mg/5ml) + Ephedrine hydrochloride (7.2 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Elixir Oral BEACONS PHARMACEUTICALS PTE. LTD. 1989-05-22 Not applicable Singapore PROMELIX SYRUP Codeine phosphate (9 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Syrup Oral SUNWARD PHARMACEUTICAL PRIVATE LIMITED 1991-08-07 Not applicable Singapore Prometh with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Rebel Distributors 1984-10-31 Not applicable US Prometh with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Remedy Repack 2013-07-08 2013-07-09 US Prometh with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Actavis Pharma Company 1990-09-30 2015-06-30 US Prometh with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral bryant ranch prepack 1990-09-30 2012-06-01 US Promethazine HCl and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral ANI Pharmaceuticals, Inc. 2009-01-26 2009-01-26 US Promethazine HCl, Phenylephrine HCl and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral ANI Pharmaceuticals, Inc. 2008-11-26 2009-02-19 US Promethazine HCl, Phenylephrine HCl, Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Amneal Pharmaceuticals LLC 2013-11-01 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Pharmaceutical Associates, Inc. 1988-12-22 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Atlantic Biologicals Corps. 1997-08-26 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Remedy Repack 2013-06-04 2013-06-05 US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Apotheca, Inc. 1997-08-26 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Sun Pharmaceutical Industries Limited 2010-03-17 2017-04-28 US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Apotheca, Inc. 2010-03-17 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral A-S Medication Solutions 2010-03-17 2016-11-30 US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Nostrum Laboratories, Inc. 2010-03-17 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Proficient Rx LP 2010-03-17 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Akorn 1997-08-26 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Tris Pharma Inc 2018-03-12 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Amneal Pharmaceuticals LLC 2013-03-15 2019-02-05 US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Preferred Pharmaceuticals, Inc. 2014-07-22 2019-02-26 US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Atlantic Biologicals Corp. 2018-03-12 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral QUAGEN PHARMACEUTICALS LLC 2020-10-08 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Atlantic Biologicals Corp. 2020-10-08 Not applicable US Promethazine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral bryant ranch prepack 2018-03-12 Not applicable US Promethazine Hydrochloride Phenylephrine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral bryant ranch prepack 1990-09-30 2009-07-01 US Promethazine Hydrochloride, Phenylephrine Hydrochloride and Codeine Phosphate Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Akorn 2015-06-16 Not applicable US Promethazine VC With Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.5 mg/5mL) Syrup Oral Dispensing Solutions, Inc. 2006-12-07 Not applicable US Promethazine VC With Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Physicians Total Care, Inc. 1999-03-01 Not applicable US Promethazine VC With Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral A S Medication Solutions 2006-12-07 Not applicable US Promethazine Vc With Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Actavis Pharma Company 1990-09-30 2010-09-30 US Promethazine VC with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral A-S Medication Solutions 2006-12-07 2017-09-30 US Promethazine VC with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Par Pharmaceutical 2006-12-07 2019-07-31 US Promethazine VC with Codeine Oral Solution Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral PAI Holdings, LLC 2021-03-18 Not applicable US Promethazine Vc With Codine Codeine phosphate hemihydrate (10 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Vintage Pharmaceuticals, LLC 2007-11-14 2007-11-14 US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Physicians Total Care, Inc. 2001-02-13 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Rebel Distributors 2006-01-31 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral A S Medication Solutions 2006-01-31 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Aidarex Pharmaceuticals LLC 2006-01-31 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Atlantic Biologicals Corps. 2006-01-31 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Unit Dose Services 2006-01-31 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Lohxa 1984-12-17 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Rpk Pharmaceuticals, Inc. 2006-01-31 Not applicable US Promethazine With Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral H.J. Harkins Company,Inc. 2015-12-08 Not applicable US Promethazine With Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Syrup Oral Vintage Pharmaceuticals, LLC 2007-11-14 2007-11-14 US Promethazine With Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Liquid Oral Apotheca, Inc. 2010-01-01 2010-03-09 US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral A-S Medication Solutions 1984-12-17 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Preferred Pharmaceuticals, Inc 2012-02-14 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Atlantic Biologicals Corp. 2019-09-10 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Par Pharmaceutical 2006-01-31 2021-05-31 US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Proficient Rx LP 2006-01-31 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Morton Grove Pharmaceuticals, Inc. 1984-12-17 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Nucare Pharmaceuticals,inc. 2006-01-31 2019-12-31 US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Nucare Pharmaceuticals,inc. 2006-01-31 2019-12-31 US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral A-S Medication Solutions 2006-01-31 2018-02-27 US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC 2012-03-21 2019-10-11 US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral PAI Holdings, LLC 2020-09-18 Not applicable US Promethazine with Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral RedPharm Drug, Inc. 2021-01-01 Not applicable US Promethazine/Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Promethazine hydrochloride (6.25 mg/5mL) Solution Oral Direct_Rx 2023-06-02 Not applicable US Pronal - C1/2 Capsules Codeine phosphate (30 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral Pro Doc Limitee 2009-06-25 2013-01-18 Canada Pronal C1/4 Capsules Codeine phosphate (15 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral Pro Doc Limitee 2009-06-25 2013-01-18 Canada Pseudodine C Codeine phosphate hemihydrate (10 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) + Triprolidine hydrochloride monohydrate (1.25 mg/5mL) Syrup Oral Wockhardt USA, Inc. 2008-11-28 Not applicable US PYCDOL 325/8 MG Codeine phosphate (8 mg) + Acetaminophen (325 mg) Capsule, liquid filled Oral PROCAPS S.A. 2017-03-31 Not applicable Colombia PYCDOL® 325/30 Codeine (30 mg) + Acetaminophen (325 mg) Capsule, liquid filled Oral PROCAPS S.A. 2017-07-31 Not applicable Colombia RelCof-C Codeine phosphate hemihydrate (6.3 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Burel Pharmaceuticals, Llc 2009-09-02 2017-12-31 US Resyl mit Codein - Tropfen Codeine phosphate hemihydrate (10 mg) + Guaifenesin (100 mg) Solution / drops Oral Stada Arzneimittel Gmb H 1972-05-12 Not applicable Austria 
Robafen AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Syrup Oral Major 2002-10-11 2014-03-31 US Robafen AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Syrup Oral Major Pharmaceuticals 2017-12-14 2020-10-31 US Robaxacet-8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral Glaxosmithkline Consumer Healthcare Ulc 1992-12-31 Not applicable Canada Robaxisal C 1/2 Codeine phosphate (32.4 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral Glaxosmithkline Consumer Healthcare Ulc 1992-12-31 Not applicable Canada Robaxisal C 1/4 Codeine phosphate (16.2 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral Glaxosmithkline Consumer Healthcare Ulc 1992-12-31 Not applicable Canada Robaxisal C-1/8 Tablets Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral Wyeth Ltd. 1992-12-31 2012-08-02 Canada Robitussin Ac Codeine phosphate (10 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pheniramine maleate (7.5 mg / 5 mL) Syrup Oral Glaxosmithkline Consumer Healthcare Ulc 1993-12-31 2023-09-14 Canada Robitussin Syrup With Codeine Codeine phosphate (3.3 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pheniramine maleate (7.5 mg / 5 mL) Syrup Oral Wyeth Ltd. 1993-12-31 2004-08-04 Canada Rounox Avec Codeine 15tab Codeine phosphate (15 mg / tab) + Acetaminophen (325 mg / tab) Tablet Oral Rougier Pharma Division Of Ratiopharm Inc 1979-12-31 1999-09-27 Canada Rounox Codeine 30 Tab Codeine phosphate (30 mg / tab) + Acetaminophen (325 mg / tab) Tablet Oral Rougier Pharma Division Of Ratiopharm Inc 1980-12-31 1999-09-27 Canada Rounox Codeine 60 Tab Codeine phosphate (60 mg / tab) + Acetaminophen (325 mg / tab) Tablet Oral Rougier Pharma Division Of Ratiopharm Inc 1980-12-31 1999-09-27 Canada Routec and Codeine 30 - Tab Codeine phosphate (30 mg / tab) + Acetaminophen (325 mg / tab) Tablet Oral Rougier Pharma Division Of Ratiopharm Inc 1997-08-20 1999-09-27 Canada Rydex Codeine phosphate hemihydrate (6.33 mg/5mL) + Brompheniramine maleate (1.33 mg/5mL) + Pseudoephedrine hydrochloride (10 mg/5mL) Liquid Oral Centurion Labs 2010-05-14 Not applicable US Sinutab With Codeine Tablets Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Chlorpheniramine maleate (2 mg) + Pseudoephedrine hydrochloride (30 mg) Tablet Oral Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc 1991-12-31 2015-08-06 Canada Soma Codeine phosphate hemihydrate (16 mg/1) + Acetylsalicylic acid (325 mg/1) + Carisoprodol (200 mg/1) Tablet Oral Meda Pharmaceuticals Ltd 1960-10-05 2002-03-31 US SP-CODRINE SYRUP Codeine phosphate (9 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Syrup Oral SPECTRUM HEALTH PROMOTION PTE LTD 1998-04-05 Not applicable Singapore SP-COSEDYL SYRUP Codeine phosphate (9 mg/5ml) + Ephedrine hydrochloride (7.2 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Syrup Oral LUEN WAH MEDICAL COMPANY (SINGAPORE) PRIVATE LIMITED 1999-11-01 Not applicable Singapore Spasmhalt-8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Methocarbamol (400 mg) Tablet Oral Pendopharm Division Of Pharmascience Inc 1998-11-25 2022-07-18 Canada Spasmhalt-asa-8 Codeine phosphate (8 mg) + Acetylsalicylic acid (325 mg) + Methocarbamol (400 mg) Tablet Oral Pendopharm Division Of Pharmascience Inc 1998-11-25 2013-08-15 Canada Statuss Green Codeine phosphate hemihydrate (9 mg/5mL) + Chlorcyclizine hydrochloride (12.5 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Magna Pharmaceuticals 2011-12-20 2013-08-05 US SUNSEDYL COUGH LINCTUS Codeine phosphate (9 mg/5ml) + Ephedrine hydrochloride (7.2 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Elixir Oral SUNWARD PHARMACEUTICAL PRIVATE LIMITED 1989-06-26 Not applicable Singapore SUNSEDYL FORTE COUGH LINCTUS Codeine phosphate (10.0 mg/5ml) + Ephedrine hydrochloride (7.2 mg/5ml) + Promethazine hydrochloride (3.6 mg/5ml) Elixir Oral SUNWARD PHARMACEUTICAL PRIVATE LIMITED 1994-06-21 Not applicable Singapore Suppress Cough Syr W.cod.diphen.hcl Amm.chl. Codeine phosphate (3.3 mg / 5 mL) + Ammonium chloride (125 mg / 5 mL) + Diphenhydramine hydrochloride (12.5 mg / 5 mL) Syrup Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1996-12-31 2002-07-31 Canada TACHIDOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, effervescent Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 Not applicable Italy TACHIDOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 Not applicable Italy TACHIDOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 Not applicable Italy TACHIDOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 Not applicable Italy TACHIDOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 Not applicable Italy TACHIDOL Codeine (30 MG) + Acetaminophen (500 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 Not applicable Italy TACHIDOL Codeine (30 MG) + Acetaminophen (500 MG) Granule Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 Not applicable Italy TACHIDOL Codeine (7.5 MG/5ML) + Acetaminophen (125 MG/5ML) Syrup Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 2021-07-02 Italy TACHIDOL Codeine (7.5 MG) + Acetaminophen (125 MG) Granule, effervescent Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2014-07-08 2021-07-02 Italy TACHIDOLENE Codeine phosphate (30 MG) + Acetaminophen (1000 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2017-03-07 2023-02-23 Italy TACHIDOLENE Codeine phosphate (30 MG) + Acetaminophen (1000 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2017-03-07 2023-02-23 Italy TACHIDOLENE Codeine phosphate (30 MG) + Acetaminophen (1000 MG) Tablet, film coated Oral Aziende Chimiche Riunite Angelini Francesco Acraf Spa 2018-10-16 2023-02-23 Italy TALVOSILEN 500/20MG Codeine phosphate hemihydrate (20 mg) + Acetaminophen (500 mg) Tablet Oral 2006-07-01 Not applicable Germany TALVOSILEN FORT 500/30 Codeine phosphate hemihydrate (30 mg) + Acetaminophen (500 mg) Capsule Oral 2006-07-01 Not applicable Germany TALVOSILEN FORT 500/30 Codeine phosphate hemihydrate (30 mg) + Acetaminophen (500 mg) Capsule Oral 2006-07-01 Not applicable Germany TALVOSILEN FORTE 1000/60 Codeine phosphate hemihydrate (60 mg) + Acetaminophen (1000 mg) Suppository Rectal 2006-04-01 Not applicable Germany TALVOSILEN FORTE 1000/60 Codeine phosphate hemihydrate (60 mg) + Acetaminophen (1000 mg) Suppository Rectal 2006-04-01 Not applicable Germany Tamicode Tablets Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Viva Pharmaceutical Inc. Not applicable Not applicable Canada Terpin Hydrate Codeine Elx CF Codeine (.23 %) + Terpin hydrate (1.83 %) Elixir Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1965-12-31 1997-08-08 Canada Teva-cotridin Codeine phosphate (10 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) + Triprolidine hydrochloride (2 mg / 5 mL) Syrup Oral TEVA Canada Limited 1996-07-30 Not applicable Canada Teva-cotridin Expectorant Codeine phosphate (10 mg / 5 mL) + Guaifenesin (100 mg / 5 mL) + Pseudoephedrine hydrochloride (30 mg / 5 mL) + Triprolidine hydrochloride (2 mg / 5 mL) Syrup Oral TEVA Canada Limited 1994-12-31 Not applicable Canada Teva-emtec-30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral TEVA Canada Limited 1984-12-31 Not applicable Canada Teva-lenoltec No. 1 Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral TEVA Canada Limited 1986-12-31 Not applicable Canada Teva-lenoltec No. 2 Codeine phosphate (15 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral TEVA Canada Limited 1986-12-31 Not applicable Canada Teva-lenoltec No. 3 Codeine phosphate (30 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral TEVA Canada Limited 1985-12-31 Not applicable Canada Teva-lenoltec No. 4 Codeine phosphate (60 mg) + Acetaminophen (300 mg) Tablet Oral TEVA Canada Limited 1986-12-31 Not applicable Canada Teva-tecnal C 1/2 Codeine phosphate (30 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral TEVA Canada Limited 1984-12-31 Not applicable Canada Teva-tecnal C 1/4 Codeine phosphate (15 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral TEVA Canada Limited 1984-12-31 Not applicable Canada TITRETTA ZAEPFCHEN 1000/60 Codeine phosphate hemihydrate (60 mg) + Acetaminophen (1000 mg) Suppository Rectal 2006-04-01 Not applicable Germany TITRETTA ZAEPFCHEN 1000/60 Codeine phosphate hemihydrate (60 mg) + Acetaminophen (1000 mg) Suppository Rectal 2006-04-01 Not applicable Germany Triacin-C Codeine phosphate hemihydrate (10 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) + Triprolidine hydrochloride monohydrate (1.25 mg/5mL) Syrup Oral STI Pharma 2013-01-01 Not applicable US Triacin-C Codeine phosphate hemihydrate (10 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) + Triprolidine hydrochloride monohydrate (1.25 mg/5mL) Syrup Oral Actavis Pharma Company 1990-09-30 2007-04-30 US Trianal C½ Codeine phosphate (30 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral Laboratoire Riva Inc. 1998-03-09 Not applicable Canada Trianal C¼ Codeine phosphate (15 mg) + Acetylsalicylic acid (330 mg) + Butalbital (50 mg) + Caffeine (40 mg) Capsule Oral Laboratoire Riva Inc. 2006-12-22 Not applicable Canada Triatec-30 Codeine phosphate (30 mg) + Acetaminophen (300 mg) Tablet Oral Laboratoire Riva Inc. 1989-12-31 Not applicable Canada Triatec-8 Codeine phosphate (8 mg) + Acetaminophen (325 mg) + Caffeine (15 mg) Tablet Oral Laboratoire Riva Inc 1991-12-31 Not applicable Canada Triatec-8 Fort Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Laboratoire Riva Inc. 1992-12-31 Not applicable Canada Tricode AR Codeine phosphate hemihydrate (8 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Respa Pharmaceuticals 2011-06-20 Not applicable US Tricode GF Codeine phosphate hemihydrate (8 mg/5mL) + Guaifenesin (200 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Respa Pharmaceuticals 2011-06-20 Not applicable US TRIFEN 100 ML SUS. Codeine phosphate (7.5 mg/5ml) + Guaifenesin (100 mg/5ml) + Pseudoephedrine (20 mg/5ml) + Triprolidine hydrochloride (1.25 mg/5ml) Syrup Oral İLAÇSAN İLAÇ SAN. TİC. LTD. ŞTİ. 1995-01-10 Not applicable Turkey Tusnel C Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Llorens Pharmaceutical International Division 1995-01-01 Not applicable US Tussaminic C Forte Syrup Codeine phosphate (15 mg / 5 mL) + Mepyramine maleate (12.5 mg / 5 mL) + Pheniramine maleate (12.5 mg / 5 mL) + Phenylpropanolamine hydrochloride (25 mg / 5 mL) Syrup Oral Novartis 1992-12-31 2001-04-06 Canada Tussaminic C Pediatric Syrup Codeine phosphate (5 mg / 5 mL) + Mepyramine maleate (6.25 mg / 5 mL) + Pheniramine maleate (6.25 mg / 5 mL) + Phenylpropanolamine hydrochloride (12.5 mg / 5 mL) Syrup Oral Novartis 1993-12-31 2000-07-19 Canada TUSSORET TAG/NACHT KAPSELN Codeine phosphate hemihydrate (30 mg) + Amlodipine besylate (50 mg) Capsule Oral 2006-04-01 Not applicable Germany TUSSORET TAG/NACHT KAPSELN Codeine phosphate hemihydrate (30 mg) + Amlodipine besylate (50 mg) Capsule Oral 2006-04-01 Not applicable Germany Tuxarin Codeine phosphate hemihydrate (54.3 mg/1) + Chlorpheniramine maleate (8 mg/1) Tablet, extended release Oral Mainpointe Pharmaceuticals 2018-10-15 Not applicable US Tuzistra XR Codeine phosphate (14.7 mg/5mL) + Chlorpheniramine maleate (2.8 mg/5mL) Suspension, extended release Oral Vernalis Therapeutics, Inc. 2015-05-31 2019-05-31 US Tuzistra XR Codeine phosphate (14.7 mg/5mL) + Chlorpheniramine maleate (2.8 mg/5mL) Suspension, extended release Oral Aytu BioPharma, Inc. 2015-05-31 Not applicable US Tylenol No 1 Tab Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Mcneil Pharmaceutical, Division Of Ortho Mcneil Inc. 1978-12-31 1996-09-09 Canada Tylenol No.1 Caplets Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc 1971-12-31 2016-09-29 Canada Tylenol No.1 Forte Caplets Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc 1996-08-28 2015-08-06 Canada Tylenol No1 Forte Tablets With Codeine Codeine phosphate (8 mg) + Acetaminophen (500 mg) + Caffeine (15 mg) Tablet Oral Mcneil Pharmaceutical, Division Of Ortho Mcneil Inc. 1985-12-31 1996-09-09 Canada Tylenol W Codeine No2 Tab Codeine phosphate (15 mg / tab) + Acetaminophen (300 mg / tab) + Caffeine (15 mg / tab) Tablet Oral Mcneil Pharmaceutical, Division Of Ortho Mcneil Inc. 1978-12-31 1996-09-09 Canada Tylenol W Codeine No3 Tab Codeine phosphate (30 mg / tab) + Acetaminophen (300 mg / tab) + Caffeine (15 mg / tab) Tablet Oral Mcneil Pharmaceutical, Division Of Ortho Mcneil Inc. 1978-12-31 1996-09-09 Canada Tylenol W Codeine No4 Tab Codeine phosphate (60 mg / tab) + Acetaminophen (300 mg / tab) Tablet Oral Mcneil Pharmaceutical, Division Of Ortho Mcneil Inc. 1978-12-31 1996-09-09 Canada TYLENOL with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Physicians Total Care, Inc. 2003-10-29 2011-06-30 US TYLENOL with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral McNeil Pharmaceuticals 1977-08-17 2012-03-01 US TYLENOL with Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral McNeil Pharmaceuticals 1977-08-17 2012-03-01 US TYLENOL with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A S Medication Solutions 1986-10-10 Not applicable US TYLENOL with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 1982-01-01 2011-10-31 US TYLENOL with Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Cardinal Health 1982-01-01 2012-02-29 US TYLENOL with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral PD-Rx Pharmaceuticals, Inc. 1977-08-17 2018-08-01 US TYLENOL with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral A-S Medication Solutions 1977-08-17 Not applicable US TYLENOL with Codeine Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Janssen Pharmaceuticals, Inc. 1977-08-17 2021-01-11 US TYLENOL with Codeine Codeine phosphate hemihydrate (60 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Janssen Pharmaceuticals, Inc. 1977-08-17 2021-01-11 US Tylenol With Codeine Elixir Codeine phosphate (8 mg / 5 mL) + Acetaminophen (160 mg / 5 mL) Elixir Oral Mcneil Pharmaceutical, Division Of Ortho Mcneil Inc. 1986-12-31 1996-09-09 Canada Tylenol With Codeine Elixir Codeine phosphate (8 mg / 5 mL) + Acetaminophen (160 mg / 5 mL) Elixir Oral Janssen Pharmaceuticals 1986-12-31 2013-07-02 Canada Tylenol With Codeine No. 2 - Tab Codeine phosphate (15 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Janssen Pharmaceuticals 1964-12-31 2020-09-25 Canada Tylenol With Codeine No. 3 - Tab Codeine phosphate (30 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Janssen Pharmaceuticals 1964-12-31 2020-09-25 Canada Tylenol With Codeine No. 4 Codeine phosphate (60 mg) + Acetaminophen (300 mg) Tablet Oral Janssen Pharmaceuticals 1978-12-31 2020-09-25 Canada UNIDRYL CD EXPECTORANT Codeine phosphate (5 mg/5ml) + Ammonium chloride (135 mg/5ml) + Diphenhydramine hydrochloride (14 mg/5ml) Syrup Oral EURO ASIA MEDICO PTE. LTD. 1989-05-22 Not applicable Singapore UNISEDYL FORTE LINCTUS Codeine phosphate (10 mg/5ml) + Ephedrine hydrochloride (8 mg/5ml) + Promethazine hydrochloride (4 mg/5ml) Elixir Oral EURO ASIA MEDICO PTE. LTD. 1989-05-22 Not applicable Singapore VERMIDON-K TABLET, 20 ADET Codeine phosphate (10 mg) + Acetaminophen (500 mg) + Caffeine (30 mg) Tablet Oral SANDOZ İLAÇ SAN. VE TİC. A.Ş. 2005-06-17 Not applicable Turkey Virtussin A/C Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Unit Dose Services 2015-07-07 Not applicable US Virtussin A/C Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Proficient Rx LP 2015-07-07 Not applicable US Virtussin A/C Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral A-S Medication Solutions 2015-07-07 2019-09-30 US Virtussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Virtus Pharmaceuticals 2015-07-07 2023-03-31 US Virtussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Preferreed Pharmaceuticals Inc. 2014-10-06 2017-12-27 US Virtussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Virtus Pharmaceuticals LLC 2014-04-09 2015-07-10 US Virtussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral A-S Medication Solutions 2015-07-07 Not applicable US Virtussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral bryant ranch prepack 2015-07-07 Not applicable US Virtussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral bryant ranch prepack 2015-07-07 Not applicable US Virtussin Ac W/alc Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Liquid Oral Virtus Pharmaceuticals LLC 2019-11-04 2022-11-30 US Virtussin DAC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Virtus Pharmaceuticals 2014-11-21 2016-03-24 US Virtussin Dac Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Virtus Pharmaceuticals 2019-01-31 2022-11-30 US Wampole-acetaminophen/codeine/caffeine Codeine phosphate (8 mg) + Acetaminophen (300 mg) + Caffeine (15 mg) Tablet Oral Jamp Pharma Corporation 2016-12-23 Not applicable Canada WINADEINE F®-TABLETAS Codeine phosphate (30 mg) + Acetaminophen (325 mg) Tablet Oral SANOFI - AVENTIS DE COLOMBIA S.A. 2006-11-10 2018-01-22 Colombia WINADEINE® SUSPENSIÓN Codeine phosphate (0.6 g) + Acetaminophen (6.5 g) Suspension Oral SANOFI - AVENTIS DE COLOMBIA S.A. 2021-08-05 Not applicable Colombia WINADEINE® TABLETAS Codeine phosphate (8 mg) + Acetaminophen (325 mg) Tablet Oral SANOFI - AVENTIS DE COLOMBIA S.A. 2006-11-10 Not applicable Colombia Z-tuss Ac Codeine phosphate hemihydrate (9 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) Liquid Oral Magna Pharmaceuticals, Inc. 2011-01-11 2020-12-31 US Z-tuss E Codeine phosphate hemihydrate (9 mg/5mL) + Guaifenesin (200 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Magna Pharmaceuticals 2011-10-12 2013-10-25 US ZEUSEFF Codeine phosphate (30 MG) + Acetaminophen (500 MG) Tablet Oral Omikron Italia s.r.l. 2014-10-06 Not applicable Italy Zodryl AC 25 Codeine phosphate hemihydrate (3 mg/3mL) + Chlorpheniramine maleate (0.999 mg/3mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl AC 30 Codeine phosphate hemihydrate (3.5 mg/3.5mL) + Chlorpheniramine maleate (1.001 mg/3.5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl AC 35 Codeine phosphate hemihydrate (4 mg/4mL) + Chlorpheniramine maleate (1 mg/4mL) Suspension Oral CodaDose, Inc. 2040-01-01 Not applicable US Zodryl AC 40 Codeine phosphate hemihydrate (4.5 mg/4.5mL) + Chlorpheniramine maleate (0.999 mg/4.5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl AC 50 Codeine phosphate hemihydrate (5 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl AC 60 Codeine phosphate hemihydrate (7.5 mg/7.5mL) + Chlorpheniramine maleate (1.995 mg/7.5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl AC 80 Codeine phosphate hemihydrate (10 mg/10mL) + Chlorpheniramine maleate (2 mg/10mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl DAC 25 Codeine phosphate hemihydrate (3 mg/3mL) + Chlorpheniramine maleate (0.999 mg/3mL) + Pseudoephedrine hydrochloride (15 mg/3mL) Suspension Oral CodaDose Inc. 2040-01-01 Not applicable US Zodryl DAC 30 Codeine phosphate hemihydrate (3.5 mg/3.5mL) + Chlorpheniramine maleate (1.001 mg/3.5mL) + Pseudoephedrine hydrochloride (15.001 mg/3.5mL) Suspension Oral CodaDose Inc. 2040-01-01 Not applicable US Zodryl DAC 35 Codeine phosphate hemihydrate (4 mg/4mL) + Chlorpheniramine maleate (1 mg/4mL) + Pseudoephedrine hydrochloride (15 mg/4mL) Suspension Oral CodaDose Inc. 2040-01-01 Not applicable US Zodryl DAC 40 Codeine phosphate hemihydrate (4.5 mg/4.5mL) + Chlorpheniramine maleate (0.999 mg/4.5mL) + Pseudoephedrine hydrochloride (14.999 mg/4.5mL) Suspension Oral CodaDose Inc. 2040-01-01 Not applicable US Zodryl DAC 50 Codeine phosphate hemihydrate (5 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Suspension Oral CodaDose Inc. 2040-01-01 Not applicable US Zodryl DAC 60 Codeine phosphate hemihydrate (7.5 mg/7.5mL) + Chlorpheniramine maleate (1.995 mg/7.5mL) + Pseudoephedrine hydrochloride (30 mg/7.5mL) Suspension Oral CodaDose Inc. 2040-01-01 Not applicable US Zodryl DAC 80 Codeine phosphate hemihydrate (10 mg/10mL) + Chlorpheniramine maleate (2 mg/10mL) + Pseudoephedrine hydrochloride (30 mg/10mL) Suspension Oral CodaDose Inc. 2040-01-01 Not applicable US Zodryl DEC 25 Codeine phosphate hemihydrate (3 mg/3mL) + Guaifenesin (60 mg/3mL) + Pseudoephedrine hydrochloride (15 mg/3mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl DEC 30 Codeine phosphate hemihydrate (3.5 mg/3.5mL) + Guaifenesin (70 mg/3.5mL) + Pseudoephedrine hydrochloride (15.001 mg/3.5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl DEC 35 Codeine phosphate hemihydrate (4 mg/4mL) + Guaifenesin (80 mg/4mL) + Pseudoephedrine hydrochloride (15 mg/4mL) Suspension Oral CodaDose, Inc. 2040-01-01 Not applicable US Zodryl DEC 40 Codeine phosphate hemihydrate (4.5 mg/4.5mL) + Guaifenesin (90 mg/4.5mL) + Pseudoephedrine hydrochloride (14.998 mg/4.5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl DEC 50 Codeine phosphate hemihydrate (5 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl DEC 60 Codeine phosphate hemihydrate (7.5 mg/7.5mL) + Guaifenesin (150 mg/7.5mL) + Pseudoephedrine hydrochloride (30 mg/7.5mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US Zodryl DEC 80 Codeine phosphate hemihydrate (10 mg/10mL) + Guaifenesin (200 mg/10mL) + Pseudoephedrine (30 mg/10mL) Suspension Oral CodaDose, Inc. 2009-08-24 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Airacof Codeine phosphate hemihydrate (7.5 mg/5mL) + Diphenhydramine hydrochloride (12.5 mg/5mL) + Phenylephrine hydrochloride (7.5 mg/5mL) Liquid Oral Centurion Labs 2010-01-08 2016-05-02 US Chlorpheniramine and Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) Liquid Oral Breckenridge Pharmaceutical, Inc. 2009-10-01 2011-02-28 US Codeine Phosphate and Pseudoephedrine Hydrochloride Codeine phosphate hemihydrate (10 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Syrup Oral Breckenridge Pharmaceutical, Inc. 2009-12-01 2011-11-30 US Codeine Phosphate Guaifenesin Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (200 mg/5mL) Liquid Oral Kylemore Pharmaceuticals, LLC 2010-01-01 2012-11-30 US Codeine Sulfate Codeine sulfate (60 mg/1) Tablet Oral Glenmark Generics, Inc. USA 2006-07-01 2011-08-31 US Codeine Sulfate Codeine sulfate (30 mg/1) Tablet Oral Glenmark Generics, Inc. USA 2006-07-01 2011-08-31 US Dexphen w/ Codeine Codeine phosphate hemihydrate (10 mg/5mL) + Dexchlorpheniramine maleate (1 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) Liquid Oral Breckenridge Pharmaceutical, Inc. 2010-10-10 2010-10-10 US EndaCof-C Codeine phosphate hemihydrate (10 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) Liquid Oral Larken Laboratories, Inc. 2009-05-25 2012-01-31 US Endal CD Codeine phosphate hemihydrate (7.5 mg/5mL) + Diphenhydramine hydrochloride (10 mg/5mL) + Phenylephrine hydrochloride (7.5 mg/5mL) Syrup Oral Tiber Laboratories 2009-12-09 2009-12-31 US ExeClear C Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (2 mg/5mL) Liquid Oral Larken Laboratories, Inc. 2008-10-17 2015-11-10 US Guaifenesin AC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) Syrup Oral Rising Pharmaceuticals 2015-03-01 Not applicable US Guaifenesin DAC Codeine phosphate hemihydrate (10 mg/5mL) + Guaifenesin (100 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Rising Pharmaceuticals 2016-02-01 Not applicable US Lexuss 210 Codeine phosphate hemihydrate (10 mg/5mL) + Chlorpheniramine maleate (2 mg/5mL) Liquid Oral Centurion Labs 2009-04-15 2009-09-01 US Notuss-NX Codeine phosphate hemihydrate (10 mg/5mL) + Chlorcyclizine hydrochloride (9.375 mg/5mL) Liquid Oral Sj Pharmaceuticals, Llc 2010-11-03 2012-08-18 US Notuss-NXD Codeine phosphate hemihydrate (10 mg/5mL) + Chlorcyclizine hydrochloride (9.375 mg/5mL) + Pseudoephedrine hydrochloride (30 mg/5mL) Liquid Oral Sj Pharmaceuticals, Llc 2010-11-03 2012-08-18 US Poly-Tussin AC Codeine phosphate hemihydrate (10 mg/5mL) + Brompheniramine maleate (4 mg/5mL) + Phenylephrine hydrochloride (10 mg/5mL) Liquid Oral Poly Pharmaceuticals, Inc. 2014-06-02 Not applicable US Theracodeine-300 Codeine phosphate hemihydrate (30 mg/1) + Acetaminophen (300 mg/1) + gamma-Aminobutyric acid (100 mg/1) Kit Oral Physician Therapeutics Llc 2011-02-15 Not applicable US Tl-hist CD Codeine phosphate hemihydrate (10 mg/1mL) + Brompheniramine maleate (4 mg/1mL) + Phenylephrine hydrochloride (7.5 mg/1mL) Liquid Oral Trigen Laboratories, Inc. 2010-01-01 2012-07-31 US Tl-hist Cm Codeine phosphate hemihydrate (10 mg/1mL) + Chlorpheniramine maleate (2 mg/1mL) Liquid Oral Trigen Laboratories, Inc. 2010-01-01 2011-11-30 US Zotex-C Codeine phosphate hemihydrate (10 mg/5mL) + Mepyramine maleate (5 mg/5mL) + Phenylephrine hydrochloride (5 mg/5mL) Syrup Oral Vertical Pharmaceuticals, Inc. 2008-10-10 2010-10-31 US
Categories
- ATC Codes
- N02AA79 — Codeine, combinations with psycholepticsR05DA04 — Codeine
- R05DA — Opium alkaloids and derivatives
- R05D — COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
- R05 — COUGH AND COLD PREPARATIONS
- R — RESPIRATORY SYSTEM
- N02AJ — Opioids in combination with non-opioid analgesics
- N02A — OPIOIDS
- N02 — ANALGESICS
- N — NERVOUS SYSTEM
- N02AJ — Opioids in combination with non-opioid analgesics
- N02A — OPIOIDS
- N02 — ANALGESICS
- N — NERVOUS SYSTEM
- Drug Categories
- Alkaloids
- Analgesics
- Antitussive Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Cough and Cold Preparations
- Cytochrome P-450 CYP2D6 Substrates
- Cytochrome P-450 CYP3A Substrates
- Cytochrome P-450 CYP3A4 Substrates
- Cytochrome P-450 Substrates
- Heterocyclic Compounds, Fused-Ring
- Morphinans
- Morphine Derivatives
- Narcotics
- Natural Opium Alkaloids
- Nervous System
- OAT1/SLC22A6 inhibitors
- OCT1 inhibitors
- OCT1 substrates
- Opiate Agonists
- Opiate Alkaloids
- Opioid Agonist
- Opioids
- Opium Alkaloids and Derivatives
- Phenanthrenes
- Respiratory System Agents
- Sensory System Agents
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- UGT2B7 substrates
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
- Kingdom
- Organic compounds
- Super Class
- Alkaloids and derivatives
- Class
- Morphinans
- Sub Class
- Not Available
- Direct Parent
- Morphinans
- Alternative Parents
- Phenanthrenes and derivatives / Tetralins / Coumarans / Anisoles / Aralkylamines / Alkyl aryl ethers / Piperidines / Trialkylamines / Secondary alcohols / Oxacyclic compounds show 3 more
- Substituents
- Alcohol / Alkyl aryl ether / Amine / Anisole / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Coumaran / Ether show 15 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- morphinane alkaloid, organic heteropentacyclic compound (CHEBI:16714) / Isoquinoline alkaloids (C06174)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- UX6OWY2V7J
- CAS number
- 76-57-3
- InChI Key
- OROGSEYTTFOCAN-DNJOTXNNSA-N
- InChI
- InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
- IUPAC Name
- (1S,5R,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraen-14-ol
- SMILES
- [H][C@]12C=C[C@H](O)[C@@H]3OC4=C5C(C[C@H]1N(C)CC[C@@]235)=CC=C4OC
References
- Synthesis Reference
Nagaraj R. Ayyangar, Anil R. Choudhary, Uttam R. Kalkote, Vasant K. Sharma, "Process for the preparation of codeine from morphine." U.S. Patent US4764615, issued May, 1912.
US4764615- General References
- Schroeder K, Fahey T: Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD001831. [Article]
- Vree TB, van Dongen RT, Koopman-Kimenai PM: Codeine analgesia is due to codeine-6-glucuronide, not morphine. Int J Clin Pract. 2000 Jul-Aug;54(6):395-8. [Article]
- Srinivasan V, Wielbo D, Tebbett IR: Analgesic effects of codeine-6-glucuronide after intravenous administration. Eur J Pain. 1997;1(3):185-90. [Article]
- Bhandari M, Bhandari A, Bhandari A: Recent updates on codeine. Pharm Methods. 2011 Jan;2(1):3-8. doi: 10.4103/2229-4708.81082. [Article]
- Chen ZR, Somogyi AA, Reynolds G, Bochner F: Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers. Br J Clin Pharmacol. 1991 Apr;31(4):381-90. [Article]
- Takahama K, Wakuda I, Fukushima H, Isohama Y, Kai H, Miyata T: Differential effect of codeine on coughs caused by mechanical stimulation of two different sites in the airway of guinea pigs. Eur J Pharmacol. 1997 Jun 18;329(1):93-7. [Article]
- Straube C, Derry S, Jackson KC, Wiffen PJ, Bell RF, Strassels S, Straube S: Codeine, alone and with paracetamol (acetaminophen), for cancer pain. Cochrane Database Syst Rev. 2014 Sep 19;(9):CD006601. doi: 10.1002/14651858.CD006601.pub4. [Article]
- Boom M, Niesters M, Sarton E, Aarts L, Smith TW, Dahan A: Non-analgesic effects of opioids: opioid-induced respiratory depression. Curr Pharm Des. 2012;18(37):5994-6004. doi: 10.2174/138161212803582469. [Article]
- Prommer E: Role of codeine in palliative care. J Opioid Manag. 2011 Sep-Oct;7(5):401-6. [Article]
- Lotsch J: Opioid metabolites. J Pain Symptom Manage. 2005 May;29(5 Suppl):S10-24. doi: 10.1016/j.jpainsymman.2005.01.004. [Article]
- Al-Hasani R, Bruchas MR: Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology. 2011 Dec;115(6):1363-81. doi: 10.1097/ALN.0b013e318238bba6. [Article]
- Pan HL, Wu ZZ, Zhou HY, Chen SR, Zhang HM, Li DP: Modulation of pain transmission by G-protein-coupled receptors. Pharmacol Ther. 2008 Jan;117(1):141-61. doi: 10.1016/j.pharmthera.2007.09.003. Epub 2007 Sep 22. [Article]
- Codeine phosphate tablets, 30mg [Link]
- DailyMed: Codeine and promethazine syrup [Link]
- Codittusin, DailyMed [Link]
- FDA Approved Drug Products: CODEINE SULFATE tablets, for oral use CII (Jan 2024) [Link]
- FDA Approved Drug Products: Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Capsules for oral use, CIII (Jan 2024) [Link]
- EPAR, Codeine [File]
- Codeine, MedSafe NZ document [File]
- External Links
- Human Metabolome Database
- HMDB0004995
- KEGG Drug
- D03580
- KEGG Compound
- C06174
- PubChem Compound
- 5284371
- PubChem Substance
- 46507764
- ChemSpider
- 4447447
- BindingDB
- 50105098
- 1545976
- ChEBI
- 16714
- ChEMBL
- CHEMBL485
- ZINC
- ZINC000003806721
- Therapeutic Targets Database
- DAP000213
- PharmGKB
- PA449088
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Codeine
- FDA label
- Download (138 KB)
- MSDS
- Download (52.5 KB)
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Roxane laboratories inc
- Packagers
- Actavis Group
- Aidarex Pharmacuticals LLC
- Amarin Pharmaceuticals
- Amerisource Health Services Corp.
- Amneal Pharmaceuticals
- Apotheca Inc.
- A-S Medication Solutions LLC
- Athlon Pharmaceuticals Inc.
- Barr Pharmaceuticals
- BASF Corp.
- Blansett Pharmacal Co. Inc.
- Blenheim Pharmacal
- Breckenridge Pharmaceuticals
- Bryant Ranch Prepack
- C.O. Truxton Inc.
- Cardinal Health
- Carlisle Laboratories Inc.
- Centurion Labs
- Century Pharmaceuticals Inc.
- Cerovene Inc.
- Comprehensive Consultant Services Inc.
- Corepharma LLC
- Coupler Enterprises Inc.
- D.M. Graham Laboratories Inc.
- DAVA Pharmaceuticals
- Direct Dispensing Inc.
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- Duramed
- Eon Labs
- Glenmark Generics Ltd.
- Golden State Medical Supply Inc.
- Great Southern Laboratories
- H and H Laboratories
- H.J. Harkins Co. Inc.
- Heartland Repack Services LLC
- Hi Tech Pharmacal Co. Inc.
- Hospira Inc.
- Innoviant Pharmacy Inc.
- Ivax Pharmaceuticals
- Janssen-Ortho Inc.
- Jerome Stevens Pharmaceuticals Inc.
- Kaiser Foundation Hospital
- Keltman Pharmaceuticals Inc.
- Lake Erie Medical and Surgical Supply
- Lannett Co. Inc.
- Lehigh Valley Technologies Inc.
- Liberty Pharmaceuticals
- Major Pharmaceuticals
- Mallinckrodt Inc.
- Mckesson Corp.
- MCR American Pharmaceuticals Inc.
- Medvantx Inc.
- Mikart Inc.
- Murfreesboro Pharmaceutical Nursing Supply
- Mutual Pharmaceutical Co.
- Nexgen Pharma Inc.
- Novartis AG
- Nucare Pharmaceuticals Inc.
- Ortho-McNeil-Janssen Pharmaceuticals Inc.
- Palmetto Pharmaceuticals Inc.
- Patient First Corp.
- PCA LLC
- PD-Rx Pharmaceuticals Inc.
- Pharmaceutical Association
- Pharmedix
- Pharmpak Inc.
- Physicians Total Care Inc.
- Poly Pharmaceuticals Inc.
- Preferred Pharmaceuticals Inc.
- Prepackage Specialists
- Prepak Systems Inc.
- Qualitest
- Ranbaxy Laboratories
- Rebel Distributors Corp.
- Redpharm Drug
- Remedy Repack
- Roxane Labs
- Sandhills Packaging Inc.
- SJ Pharmaceuticals LLC
- Southwood Pharmaceuticals
- St Mary's Medical Park Pharmacy
- Stanley Pharmaceuticals Ltd.
- Stat Rx Usa
- Talbert Medical Management Corp.
- Teva Pharmaceutical Industries Ltd.
- TG United Inc.
- UDL Laboratories
- United Research Laboratories Inc.
- Va Cmop Dallas
- Valeant Ltd.
- Vascondor Inc.
- Veratex Corp.
- Vintage Pharmaceuticals Inc.
- Watson Pharmaceuticals
- West-Ward Pharmaceuticals
- Wockhardt Ltd.
- Dosage Forms
Form Route Strength Tablet Oral Solution Oral Tablet, coated Oral Syrup Oral 10 mg/5ml Syrup Oral Solution Oral 24 mg/mL Capsule Oral Elixir Oral 4 mg/5ml Tablet, effervescent Oral Tablet, effervescent Solution Oral 16 MG/ML Tablet, extended release Oral Tablet, extended release Oral 100 mg Tablet, extended release Oral 150 mg Tablet, extended release Oral 200 mg Tablet, extended release Oral 50 mg Tablet Oral Solution Intramuscular; Subcutaneous 30 mg / 1 mL Solution Intramuscular; Subcutaneous 60 mg / 1 mL Liquid Intramuscular; Subcutaneous 30 mg / 1 mL Syrup Oral 25 mg / 5 mL Syrup Oral 5 mg / mL Tablet Oral 15 mg Tablet Oral 60 mg Solution Oral 15 mg/2.5mL Solution Oral 30 mg/5mL Tablet Oral 15 mg/1 Tablet Oral 30 mg/1 Tablet Oral 60 mg/1 Solution Oral 1 MG Tablet Oral 50 mg/1 Suspension, extended release Oral Capsule Oral 30 mg/1 Capsule, extended release Oral Capsule, extended release Oral 30 mg Elixir Oral 10 mg/5ml Elixir Oral 9 mg/5ml Syrup Syrup Oral 9 mg/5ml Solution / drops Oral Suppository Rectal 180 mg Suppository Rectal 360 mg Tablet, film coated Oral Solution Oral 10 mg / 5 mL Suppository Rectal Tablet Oral 9 mg Tablet Oral 8 mg Granule, effervescent Oral Liquid Oral 10 mg / mL Tablet Oral 30 mg Syrup Oral Capsule, liquid filled Oral Liquid Oral Elixir Oral 9 mg/5ml Elixir Oral 10.0 mg/5ml Granule Oral Elixir Oral Kit Oral Solution Oral 22.1 mg/g Solution Oral 2.5 mg/mL Syrup Oral 135 mg/5ml Elixir Oral 10 mg/5ml Suspension Oral - Prices
Unit description Cost Unit Codeine phosphate powder 8.25USD g Codeine Phosphate 30 mg/ml 1.31USD ml Codeine sulfate 60 mg tablet 0.86USD tablet Codeine sulfate 30 mg tablet 0.76USD tablet Codeine ph 30 mg/ml syringe 0.54USD ml Codeine ph 15 mg/ml syringe 0.49USD ml Codeine sulfate 15 mg tablet 0.43USD tablet Ratio-Codeine 30 mg Tablet 0.09USD tablet Ratio-Codeine 15 mg Tablet 0.07USD tablet Ratio-Codeine 5 mg/ml Syrup 0.03USD ml DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US8062667 No 2011-11-22 2029-03-29 US US8790700 No 2014-07-29 2027-03-15 US US9066942 No 2015-06-30 2032-01-03 US US6383471 No 2002-05-07 2019-04-06 US US6248363 No 2001-06-19 2019-11-23 US US9107921 No 2015-08-18 2032-01-03 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 154-156 MSDS boiling point (°C) 250 http://www.chm.bris.ac.uk/webprojects2002/winder/information.htm water solubility soluble in water http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con126132.pdf logP 1.39 https://www.agilent.com/cs/library/applications/5990-9625EN.pdf logS -1.52 ADMET & DMPK 1(4) (2013) 48-62; doi: 10.5599/admet.1.4.24 pKa 8.2 http://www.inchem.org/documents/pims/pharm/codeine.htm - Predicted Properties
Property Value Source Water Solubility 0.577 mg/mL ALOGPS logP 1.2 ALOGPS logP 1.34 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) 13.78 Chemaxon pKa (Strongest Basic) 9.19 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 41.93 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 84.6 m3·mol-1 Chemaxon Polarizability 31.95 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9966 Blood Brain Barrier + 0.9979 Caco-2 permeable + 0.8867 P-glycoprotein substrate Substrate 0.8631 P-glycoprotein inhibitor I Inhibitor 0.5435 P-glycoprotein inhibitor II Non-inhibitor 0.8724 Renal organic cation transporter Inhibitor 0.638 CYP450 2C9 substrate Non-substrate 0.7698 CYP450 2D6 substrate Substrate 0.9274 CYP450 3A4 substrate Substrate 0.7796 CYP450 1A2 substrate Non-inhibitor 0.6494 CYP450 2C9 inhibitor Non-inhibitor 0.8866 CYP450 2D6 inhibitor Inhibitor 0.6978 CYP450 2C19 inhibitor Non-inhibitor 0.8256 CYP450 3A4 inhibitor Non-inhibitor 0.8899 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.747 Ames test Non AMES toxic 0.9133 Carcinogenicity Non-carcinogens 0.9567 Biodegradation Not ready biodegradable 0.9935 Rat acute toxicity 2.8450 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8556 hERG inhibition (predictor II) Non-inhibitor 0.8615
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 174.847793 predictedDarkChem Lite v0.1.0 [M-H]- 175.160093 predictedDarkChem Lite v0.1.0 [M-H]- 174.739793 predictedDarkChem Lite v0.1.0 [M-H]- 174.61856 predictedDeepCCS 1.0 (2019) [M+H]+ 174.899893 predictedDarkChem Lite v0.1.0 [M+H]+ 175.225793 predictedDarkChem Lite v0.1.0 [M+H]+ 175.147793 predictedDarkChem Lite v0.1.0 [M+H]+ 177.01411 predictedDeepCCS 1.0 (2019) [M+Na]+ 174.999293 predictedDarkChem Lite v0.1.0 [M+Na]+ 175.306393 predictedDarkChem Lite v0.1.0 [M+Na]+ 175.051793 predictedDarkChem Lite v0.1.0 [M+Na]+ 184.3921 predictedDeepCCS 1.0 (2019)
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- AgonistRegulator
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone...
- Gene Name
- OPRM1
- Uniprot ID
- P35372
- Uniprot Name
- Mu-type opioid receptor
- Molecular Weight
- 44778.855 Da
References
- Takahama K, Shirasaki T: Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs. Cough. 2007 Jul 9;3:8. [Article]
- Raffa RB: A novel approach to the pharmacology of analgesics. Am J Med. 1996 Jul 31;101(1A):40S-46S. doi: 10.1016/s0002-9343(96)00137-4. [Article]
- Codeine FDA label [File]
- EPAR, Codeine [File]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- Curator comments
- This target action is based on in vitro data.
- General Function
- Opioid receptor activity
- Specific Function
- G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synt...
- Gene Name
- OPRK1
- Uniprot ID
- P41145
- Uniprot Name
- Kappa-type opioid receptor
- Molecular Weight
- 42644.665 Da
References
- Mignat C, Wille U, Ziegler A: Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes. Life Sci. 1995;56(10):793-9. [Article]
- Schmidt H, Vormfelde Sv, Klinder K, Gundert-Remy U, Gleiter CH, Skopp G, Aderjan R, Fuhr U: Affinities of dihydrocodeine and its metabolites to opioid receptors. Pharmacol Toxicol. 2002 Aug;91(2):57-63. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Opioid receptor activity
- Specific Function
- G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine n...
- Gene Name
- OPRD1
- Uniprot ID
- P41143
- Uniprot Name
- Delta-type opioid receptor
- Molecular Weight
- 40368.235 Da
References
- Mignat C, Wille U, Ziegler A: Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes. Life Sci. 1995;56(10):793-9. [Article]
- Schmidt H, Vormfelde Sv, Klinder K, Gundert-Remy U, Gleiter CH, Skopp G, Aderjan R, Fuhr U: Affinities of dihydrocodeine and its metabolites to opioid receptors. Pharmacol Toxicol. 2002 Aug;91(2):57-63. [Article]
- ChemBL resource, opioid receptors [Link]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
- Gene Name
- CYP2D6
- Uniprot ID
- P10635
- Uniprot Name
- Cytochrome P450 2D6
- Molecular Weight
- 55768.94 Da
References
- Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48(11):689-723. doi: 10.2165/11318030-000000000-00000. [Article]
- Yue QY, Sawe J: Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. Eur J Clin Pharmacol. 1997;52(1):41-7. [Article]
- Flockhart Table of Drug Interactions [Link]
- Codeine FDA label [File]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE: Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. doi: 10.1124/dmd.104.000794. Epub 2004 Aug 10. [Article]
- Yue QY, Sawe J: Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. Eur J Clin Pharmacol. 1997;52(1):41-7. [Article]
- Codeine FDA label [File]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Glucuronosyltransferase activity
- Specific Function
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol su...
- Gene Name
- UGT2B7
- Uniprot ID
- P16662
- Uniprot Name
- UDP-glucuronosyltransferase 2B7
- Molecular Weight
- 60694.12 Da
References
- Coffman BL, Rios GR, King CD, Tephly TR: Human UGT2B7 catalyzes morphine glucuronidation. Drug Metab Dispos. 1997 Jan;25(1):1-4. [Article]
- Raungrut P, Uchaipichat V, Elliot DJ, Janchawee B, Somogyi AA, Miners JO: In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans. J Pharmacol Exp Ther. 2010 Aug;334(2):609-18. doi: 10.1124/jpet.110.167916. Epub 2010 May 18. [Article]
- Codeine FDA label [File]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Glucuronosyltransferase activity
- Specific Function
- UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as...
- Gene Name
- UGT2B4
- Uniprot ID
- P06133
- Uniprot Name
- UDP-glucuronosyltransferase 2B4
- Molecular Weight
- 60512.035 Da
References
- Raungrut P, Uchaipichat V, Elliot DJ, Janchawee B, Somogyi AA, Miners JO: In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans. J Pharmacol Exp Ther. 2010 Aug;334(2):609-18. doi: 10.1124/jpet.110.167916. Epub 2010 May 18. [Article]
- Gelston EA, Coller JK, Lopatko OV, James HM, Schmidt H, White JM, Somogyi AA: Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects. Br J Clin Pharmacol. 2012 May;73(5):786-94. doi: 10.1111/j.1365-2125.2011.04145.x. [Article]
- Codeine FDA label [File]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- SubstrateInhibitor
- General Function
- Secondary active organic cation transmembrane transporter activity
- Specific Function
- Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnico...
- Gene Name
- SLC22A1
- Uniprot ID
- O15245
- Uniprot Name
- Solute carrier family 22 member 1
- Molecular Weight
- 61153.345 Da
References
- Tzvetkov MV, dos Santos Pereira JN, Meineke I, Saadatmand AR, Stingl JC, Brockmoller J: Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration. Biochem Pharmacol. 2013 Sep 1;86(5):666-78. doi: 10.1016/j.bcp.2013.06.019. Epub 2013 Jul 5. [Article]
- Dujic T, Zhou K, Donnelly LA, Tavendale R, Palmer CN, Pearson ER: Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Diabetes. 2015 May;64(5):1786-93. doi: 10.2337/db14-1388. Epub 2014 Dec 15. [Article]
- Venkatasubramanian R, Fukuda T, Niu J, Mizuno T, Chidambaran V, Vinks AA, Sadhasivam S: ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children. Pharmacogenomics. 2014 Jul;15(10):1297-309. doi: 10.2217/pgs.14.99. [Article]
Drug created at June 13, 2005 13:24 / Updated at May 28, 2024 16:46