- Tom Hanks
- Sam Baldwin
- Meg Ryan
- Annie Reed
- Bill Pullman
- Walter
- Ross Malinger
- Jonah Baldwin
- Rosie O'Donnell
- Becky
- Rob Reiner
- Jay
- Gaby Hoffmann
- Jessica
- Victor Garber
- Greg
- Rita Wilson
- Suzy
- Barbara Garrick
- Victoria
- Carey Lowell
- Maggie Abbott Baldwin
- Calvin Trillin
- Uncle Milton
- Dana Ivey
- Claire Bennett
- David Hyde Pierce
- Dennis Reed
- Nora Ephron
- Director, Screenwriter
- David S. Ward
- Screenwriter
- Jeff Arch
- Screenwriter
- Patrick Crowley
- Executive Producer
- Lynda Obst
- Executive Producer
- Gary Foster
- Producer
- Marc Shaiman
- Original Music
- Sven Nykvist
- Cinematographer
- Robert M. Reitano
- Film Editing
- Juliet Taylor
- Casting
- Jeffrey Townsend
- Production Design
- Clay A. Griffith
- Set Decoration
