- Helen Hunt
- Dr. JoAnne 'Jo' Thornton-Harding
- Bill Paxton
- William Harding
- Cary Elwes
- Dr. Jonas Miller
- Jami Gertz
- Dr. Melissa Reeves
- Lois Smith
- Meg Greene
- Alan Ruck
- Robert 'Rabbit' Nurick
- Philip Seymour Hoffman
- Dustin Davis
- Jeremy Davies
- Laurence
- Todd Field
- Tim 'Beltzer' Lewis
- Zach Grenier
- Eddie
- Nicholas Sadler
- Kubrick
- Abraham Benrubi
- Bubba
- Jake Busey
- Mobile Lab Technician
- Scott Thomson
- Jason 'Preacher' Rowe
- Erik LaRay Harvey
- Eric
- Jan de Bont
- Director
- Michael Crichton
- Producer, Writer
- Anne-Marie Martin
- Writer
- Laurie MacDonald
- Executive Producer
- Gerald R. Molen
- Executive Producer
- Walter F. Parkes
- Executive Producer
- Steven Spielberg
- Executive Producer
- Kathleen Kennedy
- Producer
- Ian Bryce
- Producer
- Tori Amos
- Original Music
- Michael Anthony
- Original Music
- Ritchie Blackmore
- Original Music
- Sammy Hagar
- Original Music
- Mark Mancina
- Original Music
- Alex Van Halen
- Original Music
- Jack N. Green
- Cinematographer
- Michael Kahn
- Film Editing
- Risa Bramon Garcia
- Casting
- Joseph C. Nemec III
- Production Design
- Ronald R. Reiss
- Set Decoration
- Ellen Mirojnick
- Costume Design
