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Ivonescimab Plus Chemotherapy in Non–Small Cell Lung Cancer With EGFR Variant: A Randomized Clinical Trial

Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN Randomized Clinical Trial

• Editorial
  Tirzepatide—New Evidence for the Treatment of Obesity From China
  Weiping Jia, MD, PhD; Jianzhong Xiao, MD, PhD; Juliana C.N. Chan, MBChB, MD
  JAMA
• Efficacy of Tirzepatide for Weight Loss in China: Implications for the Global Obesity Epidemic
  Frank Qian, MD, MPH; Frank B. Hu, MD, PhD
  JAMA

Efficacy of Tirzepatide for Weight Loss in China: Implications for the Global Obesity Epidemic

• Editorial
  Tirzepatide—New Evidence for the Treatment of Obesity From China
  Weiping Jia, MD, PhD; Jianzhong Xiao, MD, PhD; Juliana C.N. Chan, MBChB, MD
  JAMA

Tirzepatide—New Evidence for the Treatment of Obesity From China

• Editorial
  Efficacy of Tirzepatide for Weight Loss in China: Implications for the Global Obesity Epidemic
  Frank Qian, MD, MPH; Frank B. Hu, MD, PhD
  JAMA

Quick Uptakes

New Research Could Help Explain Anger’s Link to Heart Attacks and Strokes

To Fix Burnout, New Initiatives Go Beyond Worker Resilience and Put Onus on Health Systems

WHO: As Mpox Outbreaks Continue, Cases May Be Underestimated

Cytisinicline More Than Doubled Chances of Quitting E-Cigarettes

Poll: Health-Related Costs Top Older Adults’ Concerns

Outpatient Adverse Events More Common, Preventable Than Expected

Study: 2 APOE4 Copies May Indicate Genetic Form of Alzheimer Disease

FDA Announces Increased Oversight of Some Diagnostic Laboratory Tests

Stark Differences Exist in Health, Disability Between Males and Females

Too Few Clinicians Screen Patients for Intimate Partner Violence

Private Equity Owns 25% of Mental Health Facilities in Some States

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications

Preoperative GLP-1 Receptor Agonists and Risk of Postoperative Respiratory Complications—Reply

Updated Absolute Mortality Rates of Lupus

Long-Term Outcomes in Patients Using Protocol-Directed Active Surveillance for Prostate Cancer

Industry Payments to Physicians Endorsing Drugs and Devices on a Social Media Platform

Health and the 2024 Elections Globally

Public Health Crisis in Gaza—The Responsibility of US-Based Academic Medical Journals

• Editor's Note
  Reporting on Health and War in Medical Journals
  Gregory Curfman, MD; Kirsten Bibbins-Domingo, PhD, MD, MAS
  JAMA

The Texas Medical Board and the Futility of Medical Exceptions to Abortion Bans

The Clinic Visit

Therapies to Decrease Severe Respiratory Syncytial Virus Illness

• Audio: Treatments to Decrease Severe Respiratory Syncytial Virus (RSV) Illness

Current Comment

What Is Age-Related Macular Degeneration?

Pediatric Phoenix Sepsis Score Validation Challenges in Low-Resource Settings and in the ED

Pediatric Phoenix Sepsis Score Validation Challenges in Low-Resource Settings and in the ED

Pediatric Phoenix Sepsis Score Validation Challenges in Low-Resource Settings and in the ED—Reply

Revisiting Race and the Benefit of RAS Blockade in Heart Failure: A Meta-Analysis of Randomized Clinical Trials

Ransomware Attacks, ED Visits and Inpatient Admissions in Targeted and Nearby Hospitals

Evidence Against Use of Nitrogen for the Death Penalty

• Audio: Evidence Against Nitrogen’s Use for the Death Penalty

Chronic Pruritus: A Review

• Audio: Chronic Pruritus

Accounting for Competing Risks in Clinical Research

Mimesis: Poetry and Imitating Medicine

Needlework at the Hospital

• Editor's Note
  Mimesis: Poetry and Imitating Medicine
  Rafael Campo, MD, MA
  JAMA

AI in Medicine

How Artificial Intelligence Will Enhance Imaging Access and Analysis

• Audio: AI in Radiology: Enhancing Analysis, Education, and Access

Monoclonal Antibody Authorized to Protect At-Risk People From COVID-19

Microneedle Vaccine Patches Generated Immune Response in Children

Federal Trade Commission Bans Noncompete Clauses

Blood Pressure Drugs Linked to More Fractures, Falls in VA Nursing Homes

New Drug for UTIs Gets the Greenlight

Progress in Heart Failure Deaths Reversed Over Past Decade

HHS Commits Millions to Improving Maternal, Infant Health

Lower Dose of Mpox Vaccine Was Safe, Effective

Monoclonal Antibody Protected Majority of Children From Malaria

Hypertension and Kidney Function After Living Kidney Donation

• Audio Author Interview: Outcomes After Living Kidney Donation

• Editorial
  Prospectively Examining Outcomes After Living Kidney Donation: Informing the Altruist
  Elizabeth C. Lorenz, MD; Wolfgang C. Winkelmayer, MD, MPH, ScD
  JAMA
  • Audio Author Interview: Outcomes After Living Kidney Donation

Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis

• Audio Author Interview: Outcomes After Living Kidney Donation

• Editorial
  Expanding the Overton Window in Deceased Kidney Donor Eligibility—Enough to Make a Difference?
  Xingxing S. Cheng, MD, MS; Colin R. Lenihan, MB BCh BAO, PhD
  JAMA
  • Audio Author Interview: Outcomes After Living Kidney Donation

Health and the 2024 US Election

Shingles Vaccination in Medicare Part D After Inflation Reduction Act Elimination of Cost Sharing

Heard but Excluded: A Language Manifesto

The Other Side of the Curtain

Prospectively Examining Outcomes After Living Kidney Donation: Informing the Altruist

• Audio Author Interview: Outcomes After Living Kidney Donation

Expanding the Overton Window in Deceased Kidney Donor Eligibility—Enough to Make a Difference?

• Audio Author Interview: Outcomes After Living Kidney Donation

Congress, the Doctor

Social Isolation and Loneliness in Older Adults

• Editor's Note
  Illness, Isolation, and the Poetry of Illumination
  Rafael Campo, MD, MA
  JAMA

Phoenix Criteria for Pediatric Sepsis and Septic Shock

Phoenix Criteria for Pediatric Sepsis and Septic Shock—Reply

Krill Oil for Knee Osteoarthritis: A Randomized Clinical Trial

Dispensing of Glucagon-Like Peptide-1 Receptor Agonists to Adolescents and Young Adults, 2020-2023

Advancing Access to Cell and Gene Therapies in Medicaid

Chronic Chagas Disease in the US

A Good Prognosis

Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke

Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke—Reply

US Public Health Preparedness and Response to Highly Pathogenic Avian Influenza A(H5N1) Viruses

Survival Benefit Associated With Participation in Clinical Trials of Anticancer Drugs: A Systematic Review and Meta-analysis

• Editorial
  Study Participants, Future Patients, and Outcomes That Matter in Cancer Clinical Trials
  Brooke E. Wilson, MBBS; Elizabeth A. Eisenhauer, MD; Christopher M. Booth, MD
  JAMA

Federal Trade Commission Actions on Prescription Drugs, 2000-2022

• Audio: The Federal Trade Commission’s Role in the Oversight of Drug Companies

• Editorial
  Federal Trade Commission Oversight of the Pharmaceutical Industry
  Amy Kapczynski, JD
  JAMA

Are Patients With Cancer Best Managed in a Clinical Trial?

Federal Trade Commission Oversight of the Pharmaceutical Industry

Study Participants, Future Patients, and Outcomes That Matter in Cancer Clinical Trials

Maintenance of Certification’s Value to Patients and Physicians

Maintenance of Certification’s Value to Patients and Physicians—Reply

Pamrevlumab for Idiopathic Pulmonary Fibrosis: The ZEPHYRUS-1 Randomized Clinical Trial

• Editorial
  When the Third Time Is Not the Charm—Trial Outcomes in Idiopathic Pulmonary Fibrosis
  Ana C. Zamora, MD; Victor E. Ortega, MD, PhD; Eva M. Carmona, MD, PhD
  JAMA

Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial

• Editorial
  β-Blockers in Chronic Obstructive Pulmonary Disease—Walking the Tightrope
  MeiLan K. Han, MD; Mark T. Dransfield, MD
  JAMA

Caring for the Critically Ill Patient

Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial

When the Third Time Is Not the Charm—Trial Outcomes in Idiopathic Pulmonary Fibrosis

β-Blockers in Chronic Obstructive Pulmonary Disease—Walking the Tightrope

Combined Vaccines Against COVID-19, Flu, and Other Respiratory Illnesses Could Soon Be Available

• Audio: May 2024 Medical News Summary

Antipsychotics for Dementia Tied to More Serious Harms Than Expected

WHO Updates Terminology for Pathogens That Spread Through the Air

Pregnancy Complications Tied to Higher Risk of Death Decades Later

Urine-Based Test Could Help Identify Aggressive Prostate Cancer

New HHS Rule Strengthens Privacy Around US Reproductive Care

Changes to Medicare, Medicaid Coverage Could Cause Thousands of Deaths

CMS Finalizes Staffing Minimum Requirements for Nursing Homes

Autoantibody Profile Emerged Years Before Multiple Sclerosis Diagnosis

Patients Treated by Female Physicians Had Better Mortality Rates

Sex Differences in Primary Care–Based Chronic Kidney Disease Management

I Kept Crying

Communicating Medicine

“Inoculation” to Resist Misinformation

The Challenge of the Computer

Poison Ivy, Poison Oak, and Poison Sumac

Error in the Exclusion of Participants From Analysis in the ACTIV-6 Platform Randomized Clinical Trial

AI in Medicine

AI-Generated Clinical Summaries

AI in Medicine

AI-Generated Clinical Summaries—Reply

Errors in Results From Erroneous Exclusion of Participants in Analysis

Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024

Fosamax Fractures—Justice Has Not Been Served

Blood Testing for Phosphatidylethanol

Poetry and the Meaning of Care

Even Joy

• Editor's Note
  Poetry and the Meaning of Care
  Rafael Campo, MD, MA
  JAMA

An Adaptive Behavioral Intervention for Weight Loss Management: A Randomized Clinical Trial

• Editorial
  Lifestyle Interventions for Obesity in the Era of GLP-1 Receptor Agonists
  Jamy D. Ard, MD; Kristina H. Lewis, MD; Justin B. Moore, PhD
  JAMA

Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial

• Audio: Financial Incentives for Weight Loss in Men With Obesity

• Editorial
  Lifestyle Interventions for Obesity in the Era of GLP-1 Receptor Agonists
  Jamy D. Ard, MD; Kristina H. Lewis, MD; Justin B. Moore, PhD
  JAMA

Lifestyle Interventions for Obesity in the Era of GLP-1 Receptor Agonists

Prognostic Value of Cardiovascular Biomarkers in the Population

• Editorial
  Can Cardiovascular Risk Assessment Be Improved in the 21st Century?
  Thomas A. Gaziano, MD, MSc; J. Michael Gaziano, MD, MPH
  JAMA

The State of State Biomarker Testing Insurance Coverage Laws

Can Cardiovascular Risk Assessment Be Improved in the 21st Century?

Apixaban to Prevent Recurrence After Cryptogenic Stroke

Apixaban to Prevent Recurrence After Cryptogenic Stroke

Apixaban to Prevent Recurrence After Cryptogenic Stroke

Apixaban to Prevent Recurrence After Cryptogenic Stroke—Reply

Cardiovascular Burden of the V142I Transthyretin Variant

• Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

• Editorial
  Heart Failure in African American Individuals, Version 2.0
  Clyde W. Yancy, MD, MSc
  JAMA
  • Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant
• Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger
  Mathew S. Maurer, MD; Edward J. Miller, MD, PhD; Frederick L. Ruberg, MD
  JAMA
  • Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger

• Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

• Editorial
  Heart Failure in African American Individuals, Version 2.0
  Clyde W. Yancy, MD, MSc
  JAMA
  • Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

Heart Failure in African American Individuals, Version 2.0

• Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

• Editorial
  Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger
  Mathew S. Maurer, MD; Edward J. Miller, MD, PhD; Frederick L. Ruberg, MD
  JAMA
  • Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

College Athlete Deaths by Suicide Have Doubled, and Researchers Want to Know Why

• Audio: May 2024 Medical News Summary

National Academies Report: COVID-19 Vaccines Don’t Cause Many Potential Harms

Two-Thirds of Unhoused People Have Mental Health Disorders

Clinicians Underprescribe Newer Antibiotics for Drug-Resistant Disease

Five-in-One Meningitis Vaccine Rolls Out

Permanent Procedures to Prevent Pregnancy in US Jumped After Dobbs

Deprescribing Program Tied to Reductions in PPI Use in US

Exercise Might Lower Heart Disease Risk in Part By Decreasing Stress in the Brain

Study: Stigma in Medical Records Tied to Diagnostic Errors

Imaging Approach Tracked Subtle Changes Linked With Mild Brain Injury

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial

• Editorial
  PhALLCON Soars to New Heights—Faster, Stronger, but Better?
  Rebecca P. Bystrom, MD; Daniel J. DeAngelo, MD, PhD; Jacqueline S. Garcia, MD
  JAMA

Causal Inference About the Effects of Interventions From Observational Studies in Medical Journals

• Editor's Note
  What Does the Proposed Causal Inference Framework for Observational Studies Mean for JAMA and the JAMA Network Journals?
  Annette Flanagin, RN, MA; Roger J. Lewis, MD, PhD; Christopher C. Muth, MD; Gregory Curfman, MD
  JAMA

The Best Versions of Ourselves

PhALLCON Soars to New Heights—Faster, Stronger, but Better?

Service Animals in Health Care Settings

• Audio: Service Animals in Health Care Settings

What Does the Proposed Causal Inference Framework for Observational Studies Mean for JAMA and the JAMA Network Journals?

The “Day of Rest” and Human Efficiency

Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults, 2011-2020

Safeguarding Research Using Federal Health Insurance Data

A 3-Year-Old With Gingival Hemorrhage and Musculoskeletal Pain

Bird Flu Outbreak in Dairy Cows Is Widespread, Raising Public Health Concerns

• Audio: May 2024 Medical News Summary

Thomas, Unsainted

Denosumab-Associated Severe Hypocalcemia in Dialysis-Dependent Patients

Denosumab-Associated Severe Hypocalcemia in Dialysis-Dependent Patients—Reply

Associations of Internal Medicine Residency Milestone Ratings and Certification Examination Scores With Patient Outcomes

Substances in Counterfeit Prescription Pills Seized by Law Enforcement, 2017-2022

Conveying Risks of Harm in Alzheimer Disease by Amyloid Lowering

Fritz Kahn and the Centenary of The Doctor of the Future

A Review of Thyroid Cancer

A Review of Thyroid Cancer

A Review of Thyroid Cancer—Reply

Despite New Recommendations, the Debate Over Mammography Guidelines Continues

• Audio: USPSTF Recommendation: Screening for Breast Cancer

• Editorial
  Toward More Equitable Breast Cancer Outcomes
  Joann G. Elmore, MD, MPH; Christoph I. Lee, MD, MS
  JAMA
  • Audio: USPSTF Recommendation: Screening for Breast Cancer
• USPSTF Breast Cancer Screening Guidelines Do Not Go Far Enough
  Wendie A. Berg, MD, PhD
  JAMA Oncol