The cast of Frasier: Where are they now?

Kelsey Grammer (Frasier)

Kelsey Grammer got his start in theater before taking on the role of Frasier in Cheers. He moved into a leading man role with this spin-off — winning four Primetime Emmys, two Golden Globes, and a SAG award in the process.

He went on to have a journeyman's career, snagging a Tony nomination for his work in La Cage aux Folles and honing his voice acting credentials in Anastasia (1997), Toy Story 2 (1999), and in The Simpsons as Sideshow Bob, winning another Emmy for the latter. The actor later waded into action star territory with roles in The Expendables 3 (2014), Transformers: Age of Extinction (2014), and X-Men: The Last Stand (2006). You might have also spotted him on episodes of 30 Rock, Modern Family, and other comedy darlings.

"My initial feelings were that Frasier should die with Cheers," Grammer told ABC's Chris Connelly on the set of EW's 2013 Reunions issue. "I said, 'Okay, he's not married and he doesn't really see his child' and, of course, I forgot to mention that I didn't want any animals on the show, but one oversight." Ultimately, though, he was satisfied with the outcome. "I'm going to go out on a limb: It was a pretty perfect show."

Grammer has been married four times, including to reality TV star Camille Grammer, with whom he shares one daughter, actress Spencer Grammer (Rick and Morty). He married his current wife, Kayte Walsh, in 2011. She's a mother to three of his seven children.

David Hyde Pierce (Niles)

David Hyde Pierce had his breakout role in the early '90s political comedy The Powers That Be. His intense resemblance to Grammer prompted Frasier producers to craft the role of the doc's brother specifically for him.

While he's still best known for his four-time Emmy winning role as Frasier's younger brother Niles, Pierce has enjoyed a varied career with appearances on Nixon (1995), Wet Hot American Summer (2001), Down with Love (2003), and the thriller The Perfect Host (2010). He also played the voice of Slim in 1998's A Bug's Life, Abe Sapien in 2004's Hellboy, and won a Tony in 2007 for his leading role in Curtains.

Much of Frasier's magic came from the realistic family dynamic between Pierce and Grammer. "I watched a lot of Cheers preparing to do it," Pierce recalled to EW. "I know with my own family, that the things that make people really seem like family and siblings is they have physical mannerisms."

Pierce has been in a relationship with Brian Hargrove since the '80s. They married in 2008. He will not be returning for the revival, having said a number of years ago that he doesn't see a reason to repeat his performance of Niles.

Peri Gilpin (Roz)

Peri Gilpin took over the role of Frasier's wise-cracking cohost after Lisa Kudrow, who would go on to fame and fortune in Friends, was fired for a lack of chemistry with the cast. Gilpin had actually appeared in an episode of Cheers' final season as a journalist who interviews Woody Boyd (Woody Harrelson).

She's since starred in ABC Family's teen drama Make It or Break It, lent her voice to the films like The Jungle Book: Mowgli's Story (1998) and Final Fantasy: The Spirits Within (2001), and has appeared on episodes of Why Women Kill, Broad City, Scorpion, and Kevin Can F**k Himself.

"It was not just life transforming, it was tons of fun," Gilpin told EW of her tenure on the show. "They wrote a real three-dimensional person and [she] is the kind of person you always have at work, the person with the smart-ass comments."

Gilpin has been married to painter Christian Vincent since 1999. They had twins via surrogate in 2004. She made a guest appearance on the Frasier revival.

Jane Leeves (Daphne)

Jane Leeves appeared in To Live and Die in L.A. (1985) before rising to prominence with a recurring role on Murphy Brown and as the pious Marla on Seinfeld. She was suggested for the role of Daphne by NBC executives, and Grammer cast her after just one read-through. Leeves has also appeared in Miracle on 34th Street (1994), James and the Giant Peach (1996) Music of the Heart (1999). She continued her television career with roles on Fox's The Resident and TV Land's Hot in Cleveland.

Much of Daphne's arc concerns her initially unrequited (but then very much requited) romance with Niles. It was an idea Leeves hatched herself early on. "Jane Leeves, in the first photo shoot we did, after she said, 'I always thought it would be nice if Daphne had a thing for Niles,' [and] we started sort of hanging over each other," Pierce told EW.

"There is just something about Niles and David that is adorable," she recalled.

Leeves is married to Marshall Coben, an executive at CBS Paramount Television, with whom she has two children. She and Peri Gilpin have maintained a close friendship and live near one another.

John Mahoney (Martin)

John Mahoney segued into acting later in life, having edited medical journals before making waves in theater, winning a Tony in 1986 for his performance in The House of Blue Leaves, and pivoting to film with roles in Moonstruck (1987), Say Anything (1989), and Barton Fink (1991). Like his costar Peri Gilpin, he also appeared in a one-off episode of Cheers, but his proper breakout came through playing Martin on Frasier. Mahoney was the first choice for the role based on creator Peter Casey's father, so much so that no audition was necessary.

For Mahoney, his decision to join the series was just as obvious. "The [pilot] script was so brilliant [that] I'd be an idiot to turn it down," he recalled to EW. "Plus, to work with Kelsey meant a great deal to me… I don't think anything I've ever done in my life I'm more proud of than Frasier."

Following Frasier, he continued to act while reuniting with costars Kelsey Grammer and David Hyde Pierce on an episode of The Simpsons and appearing in the 2010 film Flipped.

Mahoney died in 2018 at the age of 77 due to complications from throat cancer.

Jean Smart (Lana)

Veteran actor Jean Smart had a recurring role as Lana, Frasier's former school crush with whom he kindles a romance. The part earned her two Emmys for Outstanding Guest Star in a Comedy Series. Smart's career has spanned over 40 years, starting with her big break in the '80s sitcom Designing Women before enjoying turns in Sweet Home Alabama (2002), 24, Garden State (2004), and winning another Emmy for Samantha Who.

In recent years, Smart's had an HBO-boosted renaissance, appearing in Watchmen and Mare of Eastown while winning awards (two Primetime Emmys, a Golden Globe, and two SAG awards, to be exact) for her raucous role in Hacks. You may have also spotted her in films like The Accountant (2016), Superintelligence (2020), and Babylon (2022).

In a 2023 interview with Vanity Fair, Smart called Lana "one of my favorite roles ever… I read it and I said, 'Oh dear god, where do I sign?' You know, it was just one of the funniest things I had ever read. Truly one of the best sitcoms ever, ever, ever."

Smart continued: "She had anger issues, but she could just be really sweet and charming and funny and kind of sexy and then she would just go off on people, from zero to 60. And it was a lot of fun."

Smart met her husband, Richard Gilliland, on the set of Designing Women. They were married from 1987 until his death in 2021 at age 71 due to a brief illness. They had two sons together.

Bebe Neuwirth (Lilith)

Bebe Neuwirth began her career on Broadway before starring in 80 episodes of Cheers as Frasier's paramour and the mother of his son, Freddy — a role that earned her two Primetime Emmy awards.

She made her film debut in Say Anything (1989) alongside her future Frasier costar John Mahoney. Though Neuwirth only appeared in 12 episodes of Frasier, her indelible presence permeates the series. She continued her career by starring in Madam Secretary, acting in The Good Wife and The Flight Attendant, and in films like Jumanji (1995), The Faculty (1998), Summer of Sam (1999), How to Lose a Guy in 10 Days (2003), and Tick Tick Boom (2021).

Neuwirth was married to Paul Dorman from 1984 to 1991. She later married Chris Calkins in 2009. She appears on the revival in an episode centered around Freddy's birthday.

Dan Butler (Bulldog)

Theater actor Dan Butler appeared in Hannibal Lecter flicks Manhunter (1986) and The Silence of the Lambs (1991) before being cast as irascible sports broadcaster Bob "Bulldog" Briscoe in all but one season of Frasier. He also played Art in Rosanne and landed roles in films like Captain Ron (1992), Enemy of the State (1998), Crazy Stupid Love (2011), and most recently in the controversial biopic Blonde (2022).

Butler is married to producer Richard Waterhouse. He does not appear in the Frasier revival.

Edward Hibbert (Gil)

Edward Hibbert began his career as an actor in the U.K., before coming to the U.S. The effeminate restaurant critic Gil Chesterton was his breakout role, leading to parts in The Paper (1994), The First Wives Club (1996), Uptown Girls (2003), The Prestige (2006), Mary Poppins Returns (2018), and voicing Zazu in The Lion King III (1998) and The Lion King 1½ (2004). He's since appeared on the shows Grace and Frankie and Blue Bloods. Hibbert is also a literary agent, representing the authors Chuck Palahniuk and Ed Sikov, among others.

In a 2019 interview, Hibbert remarked that, "I've never known anything which is as brilliantly funny [as Frasier]." He does not appear in the revival.