Filmography
| Year | Title | Role |
| 2024 | Deadpool & Wolverine (2024) | Wade Wilson/Deadpool |
| 2024 | IF (2024) | Actor, Producer |
| 2022 | The Adam Project (2022) | Big Adam |
| 2022 | Spirited (2022) | Clint Briggs |
| 2021 | Free Guy (2021) | Guy |
| 2021 | The Hitman's Wife's Bodyguard (2021) | Michael Bryce |
| 2021 | Red Notice (2021) | Nolan Booth |
| 2020 | The Croods: A New Age The IMAX 2D Experience (2020) | Guy |
| 2019 | Pokémon Detective Pikachu | Detective Pikachu |
| 2019 | Great Bear Rainforest: Land of the Spirit Bear | Narrator |
| 2018 | Deadpool 2 | Wade Wilson/Deadpool |
| 2018 | Once Upon a Deadpool | Wade Wilson/Deadpool |
| 2017 | Life (2017) | Rory Adams |
| 2017 | The Hitman's Bodyguard | Michael Bryce |
| 2016 | Deadpool (2016) | Wade/Deadpool |
| 2016 | Criminal (2016) | Bill Pope |
| 2016 | Huntwatch | Narrator |
| 2015 | Woman in Gold | Randy Schoenberg |
| 2015 | Self/less | Young Damian/Edward |
| 2015 | Mississippi Grind | Curtis |
| 2014 | The Captive | Matthew |
| 2014 | The Voices | Jerry Hickfang/Mr. Whiskers/Bosco/Deer/Bunny/Monkey |
| 2013 | The Croods | Guy |
| 2013 | R.I.P.D. | Nick Walker |
| 2013 | Turbo (2013) | Turbo |
| 2012 | Safe House | Matt Weston |
| 2011 | Green Lantern | Hal Jordan/Green Lantern |
| 2011 | The Change-Up | Mitch Planko |
| 2011 | The Whale (2011) | Executive Producer, Narrator |
| 2010 | Buried | Paul Conroy |
| 2009 | The Proposal (2009) | Andrew Paxton |
| 2009 | X-Men Origins: Wolverine | Wade Wilson/Deadpool |
| 2009 | Adventureland | Mike Connell |
| 2009 | Paper Man | Captain Excellent |
| 2008 | Definitely, Maybe | Will Hayes |
| 2008 | Fireflies in the Garden | Michael |
| 2007 | Smokin' Aces | Richard Messner |
| 2007 | The Nines | Gary/Gavin/Gabriel |
| 2005 | The Amityville Horror (2005) | George Lutz |
| 2005 | Just Friends | Chris Brander |
| 2005 | School of Life (2005) | Mr. D |
| 2005 | Waiting ... | Monty |
| 2004 | Harold & Kumar Go to White Castle | Male Nurse |
| 2004 | Blade: Trinity | Hannibal King |
| 2003 | Foolproof | Kevin |
| 2002 | National Lampoon's Van Wilder - Sneak Preview | Van Wilder |
| 2001 | Finder's Fee | Quigley |
| 2001 | Buying the Cow | Mike Hanson |
| 2000 | We All Fall Down | Red Shoes |
| 1999 | Coming Soon | Henry Lipschitz |
| 1999 | Dick | Chip |
| 1995 | Serving in Silence: The Margarethe Cammermeyer Story | Andy |
