Even though BMD has not put out a notice with compatibility issues using DRS16 on macOS Catalina
Most audio software companies have requested customer's to hold off upgrading to Catalina, until such time they test their software for compliance for the notarisation process that apple has implemented in Catalina 10.15.
https://developer.apple.com/news/?id=09032019aEven though this has been relaxed by apple until 2020, the software developers are moving cautiously and have advised their customer to stay away from upgrading until the companies test their software.
So, if you are not a user, switching to other audio apps for audio post production or not a heavy third party plugin user on DRS 16, then you are good to upgrade to Catalina for DRS 16.
As Robert mentioned, I too have been running DRS 16 since the beta of macOS Catalina and never had any issues as such.
So you are good to go.