Summary

• Big Mouth is a hilarious and relatable animated series that explores the wild and messy world of puberty through the eyes of middle schoolers.
• The show's inclusive cast of diverse characters subverts expectations and tackles taboo topics, making it one of TV's most inclusive shows.
• The voice cast includes talented actors like Nick Kroll, John Mulaney, Jenny Slate, Maya Rudolph, and more, bringing the characters to life with their comedic flair.

With the show's return to Netflix for its penultimate season, new viewers and long-time fans alike might be wondering about the enduring (and latest) members of the Big Mouth voice cast and characters. Co-created by Nick Kroll, Adam Goldberg, Mark Levin, and Jennifer Flackett, the popular animated series centers on a group of middle schoolers and takes a look at all the highs and lows of the coming-of-age experience. Horrified, thrilled, and shocked at the changes that await them, the preteens navigate both awkward and raunchy situations, but Big Mouth makes it all as relatable as it is funny.

One of the show's defining traits is its surrealistic approach to showing just how wild and messy the teenage mind is when puberty hits. In its earliest episodes, Big Mouth centers on best friends Nick Birch (Kroll) and Andrew Glouberman (John Mulaney) navigate their first sexual experiences and other puberty-related benchmarks, they're pestered by their hormone monsters — entities that are responsible for the boys' brooding (and often ill-timed) sexual desires. Although the upcoming release of Big Mouth season 8 marks the show's final outing, the series will continue to inspire other raunchy, coming-of-age comedy series to come.

Big Mouth's Main Characters

With seven seasons under its belt, Big Mouth has evolved into an ensemble series that's one of TV's most inclusive shows. While a series that centers on hormone monsters and teens who are confronting their sexual desires for the first times seems like an unlikely venue for representation, Big Mouth has subverted expectations by tackling once-taboo topics as they relate to its diverse cast of characters. Despite the show's ensemble approach, Big Mouth definitely has a few characters who feel more central to the series' narrative than others.

Nick Kroll As Nick Birch & Maurice The Hormone Monster

Big Mouth’s lead character, Nick struggles with his self-image and sexual urges and is voiced by the show's co-creator Nick Kroll. Best known for starring in the fantasy football-themed series The League — and for his Comedy Central sketch program Kroll Show — Kroll has also lent his voice to films like Sausage Party and Sing. In Big Mouth, Kroll portrays a variety of characters, from Nick and Maurice the Hormone Monster to Coach Steve.

John Mulaney As Andrew Glouberman

Nick’s Jewish best friend, Andrew endures constant harassment from Maurice. Former Saturday Night Live writer and stand-up comic John Mulaney voices Andrew, along with the characters Babe the Blue Ox, Detective Florez, Grandpa Andrew, and Mint. Apart from his comedy projects, Mulaney is most well-known for his roles in Spider-Man: Into the Spider-Verse, Documentary Now!, and The Bear.

Jessi Klein As Jessi Glaser

Big Mouth’s main female character is smart and sassy, but insecure about her body. Jessi is voiced by Jessi Klein. Although Klein has previously developed numerous popular series for Comedy Central, she's most well-remembered for producing and writing for Inside Amy Schumer.

Jenny Slate (Seasons 1–4) & Ayo Edebiri (Season 4–Present) As Missy Foreman-Greenwald

While stand-up comedian Jenny Slate is perhaps best known for creating internet-sensation-turned-feature-film Marcel the Shell with Shoes On. The actor also voiced Missy in the first four seasons of Big Mouth, but stepped down from the role after being called out for voicing a Black character. Since the end of season 4, The Bear star Ayo Edebiri has voiced Missy. Edebiri's other writing and acting credits can be found in both TV and film, including projects like Dickinson, Bottoms, and Theater Camp.

Jason Mantzoukas as Jay Bilzerian

A bisexual teenager, Jay Bilzerian struggles with his wants and needs. The character is voiced by Jason Mantzoukas, who's appeared in just about every popular comedy series, from Brooklyn Nine-Nine and The League to The Good Place. On the big screen, the actor appears in John Wick: Chapter 3—Parabellum.

Fred Armisen as Elliot Birch

Although he's kind and well-intentioned, Nick’s father Elliot is always making things awkward, which makes Fred Armisen the perfect fit. Known for his work on Saturday Night Live and Portlandia, Armisen frequently crops up in guest spots, appearing in everything from Los Espookys to Broad City.

Maya Rudolph as Connie the Hormone Monstress

Throughout Big Mouth, Connie the Hormone Monstress shows up when big events happen in the lives of the series' young women characters. She’s voiced by former SNL cast member Maya Rudolph, who also made a big splash in the Oscar-nominated Bridesmaids. On Big Mouth, Rudolph also voices Diane Birch, the Ghost of Elizabeth Taylor, and the Ghost of Whitney Houston.

Jordan Peele as the Ghost of Duke Ellington

Simply known as “Duke,” this Big Mouth character is trapped between heaven and hell, and remains at his location of death: Nick’s home. After becoming a household name thanks to his sketch series Key & Peele, the actor-turned-filmmaker cemented his place as horror's go-to director with films like Get Out, Us, and Nope.

Big Mouth's Supporting Cast

An ensemble cast is often only as good as its supporting characters. After all, some solid sidekicks and B-plots are what elevate a series from being main character-focused to something broader and more far-reaching. When it comes to stand-out supporting characters, Big Mouth has them in spades, partially because of series stellar supporting voice cast, which features big-name actors, comedians, and other personalities. Some of the series most memorable supporting players include:

• Andrew Rannells as Matthew MacDell.
• Paula Pell as Barbara Glouberman — Andrew's mother.
• Richard Kind as Marty Glouberman — Andrew's overbearing father.
• Seth Morris as Greg Glaser — Jessi Glaser's always-stoned father.
• Jessica Chaffin as Shannon Glaser, Jessi's mother.
• June Diane Raphael as the popular student Devin LeSeven.
• Jak Knight as popular student DeVon Furtive-Oldman.
• Gina Rodriguez as Gina Alvarez, a member of the soccer team who goes through puberty early on.
• Neil Casey as a student named Lars as well as Detective Dumont.
• Joe Wengert as Caleb Linden, a student who's potentially on the autism spectrum; Stan the Hormore Monster; and various other recurring Big Mouth characters.
• Fran Gilesspie as the student Samira.
• Jon Daly as Judd Birch, Nick's dark-yet-caring older brother.
• Kat Dennings (seasons 1–4) & Chloe Fineman (season 5–present) as Leah Birch, Nick's older sister.
• Chelsea Peretti as Monica Foreman-Greenwald — Missy's mother — as well as the sentient cell phone, Cellsea.
• Heather Lawless as Jenna "Jay's Mom" Bilzerian.
• Mark Duplass as Val Bilzerian — Jay's bully of an older brother.
• Paul Scheer as Kurt Bilzerian, another of Jay's bullying older brothers.
• Nathan Fillion as himself (a.k.a. Missy's celebrity crush).
• Rob Huebel as a teacher, Mr. Terry Lizer.
• David Thewlis as Lionel St. Swithens — a Shame Wizard and the Hormone Monsters' mortal enemy who haunts the kids, stoking their deepest shame.
• John Gemberling as Tyler Pico, Nick's immature hormone monster.
• Gil Ozeri as Wiggles, Missy's stuffed toy; Brad the couch cushion; and Gil, a Hormone Monster.

• Kristen Bell as Pam, a pillow Jay has a sexual relationship with.
• Jack McBrayer & Craig Robinson as Nick's pubic hairs.
• Rosa Salazar as seventh-grade teacher Miss Benitez.
• Michaela Watkins as Dina Reznick — the Cantor of the Temple Beth Amphetamine.
• Zach Woods as the student Daniel and also a sock.
• Natasha Lyonne as Suzette, a motel pillow.
• Alia Shawkat as Roland, a friend of Nick's from New York.
• Kristen Wiig as Jessi's vulva.
• Andy Daly as Dr. Wendy Engle — Nick's doctor.
• Harvey Fierstein as Jerome, an older gay man.
• Jean Smart as Kitty Bouchet the Depression Kitty — an anthropomorphic purple cat employed in the Department of Puberty's Depression Ward.
• Bobby Cannavale as Gavin Reeves, an intense Hormone Monster.
• Zachary Quinto as Aiden, Matthew's ex-boyfriend.
• Ali Wong as new student Ali.
• Julie Klausner as Cherry Marashina, Andrew's cousin.
• Judd Hirsch as Lewis Glouberman, Andrew's late grandfather.
• David Cross as Skip Glouberman, Marty's brother and Andrew's uncle.
• Thandiwe Newton as Mona, Missy's British accented hormone monstress.
• Maria Bamford as Tito Taylor Thomas the Anxiety Mosquito.
• John Oliver as Harry, a camp counselor.
• Seth Rogen as Seth Goldberg, a Canadian camper.
• Somali Rose as Missy's overalls.
• Zach Galifianakis as the Gratitoad, a talking toad that expresses gratitude.
• Josie Totah as camper Natalie el-Khoury.
• Lena Waithe as Missy's cousin Lena.
• Quinta Brunson as Missy's cousin Quinta.
• Sterling K. Brown as Michael Angelo, Jessi's ex-boyfriend from New York.
• Brandon Kyle Goodman as Walter Las Palmas, Nick's Lovebug turned hate-worm.
• Keke Palmer as Rochelle Hillhurst, Missy's lovebug who was a hate-worm.
• Pamela Adlon as Sonya Poinsetta, Jessi's lovebug.
• Kristen Schaal as Bernadette "Bernie" Sanders.
• Jemaine Clement as Simon Sex, a sensitive, shroom-taking Hormone Monster.
• Brian Tyree Henry as Missy's crush Elijah.
• Chris O'Dowd as Flanny O'Lympic, Andrew's Irish accented lovebug that debuted in Human Resources.
• Peter Capaldi as Seamus MacGregor, Nick's long-lost Scottish grandfather.
• Cole Escola as Montel, Maury's and Connie's biological non-binary child.
• Megan Thee Stallion as Megan — a Hormone Monstress modeled after the rapper.
• Zazie Beetz as Dani, Megan's client.
• Stephanie Beatriz as high school student Lulu.
• Patrick Page as Dread, the evolution of Tito.

Big Mouth's Guest Stars

In addition to its top-notch main and supporting casts, Big Mouth boasts tons of memorable guest stars. Although they may have only appeared in an episode or two, these delightful cameos underscore just how beloved the coming-of-age comedy is with viewers and actors alike. While Big Mouth season 7 features Lin-Manuel Miranda and other notable contributors, the series as a whole boasts some impressive A-listers, including:

• Jess Harnell as Dwayne Johnson, a fictionalized version of the wrestler-turned-actor.
• Mae Whitman as Tallulah Levine, a friend of Leah's who crushes on Nick.
• Jon Hamm as a plate of Scallops.
• Martin Short as Gordie, the main character of the Canadian Netflix hit, Gordie's Journey.
• Carol Kane as the Menopause Banshee, a banshee that represents female menopause.
• Wanda Sykes as the ghost of Harriet Tubman.
• Rob Riggle as Col. Adderall, the personification of the ADHD medication.
• Antoni Porowski, Tan France, Karamo Brown, Bobby Berk, and Jonathan Van Ness from Queer Eye as themselves.
• Retta as Daisy Ellington, Duke Ellington's mother.
• Paul Giamatti as Andrew's feces.
• Maya Erskine and Anna Konkle as Misha and Izzy, two seventh-graders Nick and Andrew hook up with — in a cheeky reference to the actors' own coming-of-age series PEN15.
• Aidy Bryant as Emmy Fairfax, a Lovebug.
• Kumail Nanjiani as himself.
• Adam Scott as teacher Dylan Keating.
• Hugh Jackman as a fictitious version of himself.
• Annaleigh Ashford as The Rice Purity Test, an anthropomorphic quiz.
• Amber Ruffin as Amber, Elijah's aunt.
• Ira Glass as himself.
• Jeff Goldblum as the Apple Brooch.
• Steve-O as himself.
• Tyler The Creator as Jesus.
• Juliet Mills as Rita St. Swithens, the Grand Dame of Humiliation and Lionel's mother.
• Adam Levine, Ed Helms, and Matt Rogers as members of the boy band, Bros 4 Life.
• Lupita Nyong’o as Asha, a Kenyan Shame Wizard.
• Padma Lakshmi as Priya, Marissa's mother.
• Maitreyi Ramakrishnan as a student named Marissa.
• Billy Porter as Ocean, a high school student.
• Rosie Perez as Petra the Ambition Gremlin.
• Randall Park as Peter "Pete" Doheny, a Logic Rock that represents logic within humans.
• Lin-Manuel Miranda as a singing pubic hair.
• Don Cheadle as himself.