20-mg tab Adult & adolescent ≥12 yr Symptomatic GERD 1 tab (20 mg) daily.
Long-term management & prevention of relapse in reflux oesophagitis 1 tab (20 mg) daily, increased to 40 mg daily if a relapse occurs.
Adult Prevention of gastroduodenal ulcers induced by nonselective NSAIDs in patients at risk w/ a need for continuous NSAID treatment 1 tab (20 mg) daily.
Patients w/ severe hepatic impairment Max: 20 mg daily.
40-mg tab Adult & adolescent ≥12 yr Reflux oesophagitis 1 tab (40 mg) daily for 4 wk, may be increased to 2 tab daily.
Adult Eradication of H. pylori in combination w/ 2 appropriate antibiotics 1 tab (40 mg) bd w/ combination of amoxicillin 1,000 mg bd & clarithromycin 500 mg bd; or w/ combination of metronidazole 400-500 mg (or tinidazole 500 mg) bd & clarithromycin 250-500 mg bd; or w/ combination of amoxicillin 1,000 mg bd & metronidazole 400-500 mg (or tinidazole 500 mg) bd.
Gastric ulcer 1 tab (40 mg) daily for 4 wk, may be increased to 2 tab daily.
Duodenal ulcer 1 tab (40 mg) daily for 2 wk, may be increased to 2 tab daily.
Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg daily & should be adapted according to clinical needs.
IV Gastric & duodenal ulcer, reflux oesophagitis 40 mg daily.
Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg daily for long-term management, titrated up or down as needed. For doses >80 mg daily, divide dose & give bd. For rapid acid control, starting dose of 2 x 80 mg w/in 1 hr.
Patient w/ severe liver impairment Max: 20 mg daily.