Craig Mackinlay, the Conservative MP who lost all his limbs to sepsis, will not run for his South Thanet seat in the upcoming general election.
The MP returned to the Commons on Wednesday to loud applause, hours before Rishi Sunak confirmed the polls will open on 4 July.
He said in a post on Facebook: "The snap election announcement has caused me 36 hrs of intense soul searching.
"Whilst my heart tells me to stand again, there being so much unfinished business across local regeneration and national issues which are important to me, my head knows this to be impossible at this time.
"It would be difficult to withstand the rigours of an all-out election campaign, a campaign that I'd always wish to lead from the front.
"Thereafter, upon being re-elected it would be difficult for me to sustain 70 to 80 hour working weeks which were the norm prior to my illness."
Mr Mackinlay explained that he had hoped to "phase by return to the House of Commons" as his "abilities improved" over the coming months.
"I face numerous future operations as a result of the serious sepsis that I suffered which very nearly took my life," he said.
"I have only just started the prosthetic journey and I have weekly physiotherapy and occupational therapy sessions.
"I had the most memorable appearance of my time as an MP at this week’s PMQs: it was emotional and the experience quite surreal. I shall never forget it.
"I had expected it to be the start of my return. It will, however, be remembered as my last hurrah."