Animated anthology featuring four rotating cartoon segments: 1) The Mini-Monsters: Normal human twin siblings Sherman and Melissa find themselves in for a surprise when they are sent to summer camp for one year. 2) Street Frogs: Depicting the typical teen-aged hijinks of a gang of street-smart frogs named Big Max, Spider, Moose The Loose, "Honey Love" Loretta , and Dr. Slick. 3) Karate Kat: In a world inhabited by anthropomorphic cats, a private investigator catuses his karate to fight crime in his town which is usually in the form of gang leader Big Papa and his two lackeys named Boom-Boom Burmese and Sumo Sai. 4) TigerSharks: A group of powered-up human/sea animal hybrids consisting of Mako, Walro, Dolph, Octavia, Lorca, Bronc, Angel, and Gupp become involved in underwater adventures that has them facing off against villains like T-Ray and Captain Bizzarly.

Despite the show title, the segments have no history in newspaper comic strips.