Born 1959 in Palermo (Italy), Giovanni Pitruzzella graduated in law from the Università degli Studi di Palermo (University of Palermo, Italy) in 1982. It was at that university that his activities as a researcher led him to teach constitutional law there from 1983 to 1986. He then lectured in constitutional law at the Università degli Studi di Cagliari (University of Cagliari, Italy), where he gave a course on public law from 1986 to 1997, and, subsequently, at the Università degli Studi di Palermo (University of Palermo, Italy). From 2014 to 2017, he taught in the field of constitutional and competition law at the Libera Università Internazionale degli Studi Sociali Guido Carli (Free International University of Social Studies Guido Carli, Italy). He is an author of several reference works on public law, constitutional law, administrative law and competition law.

During his career, Mr Pitruzzella also performed a number of duties for public institutions. From 1993 to 1996, he was a legal adviser to the Italian Government, then President of the Commission for application of the special status of the Region of Sicily from 1998 to 2002.

Appointed as a member of the Commissione di garanzia del diritto di sciopero nei servizi pubblici essenziali (Commission for proper exercise of the right to strike in essential public services, Italy) in 2006, he was President of that commission from 2009 to 2011. Alongside those duties, he was a legal adviser to the Italian Ministry of Health from 2008 to 2011. Between 2011 and 2018, he was President of the Autorità garante della concorrenza e del mercato italiana (Italian Competition Authority).

In April 2013, Mr Pitruzzella was appointed as a member of the Commission for institutional reforms in the economic and social field. In June of that same year, he was invited to join the Commission for constitutional reforms as an expert.

Advocate General at the Court of Justice from 8 October 2018 to 14 November 2023.