- Roy Scheider
- Dr. Heywood Floyd
- John Lithgow
- Dr. Walter Curnow
- Dame Helen Mirren
- Tanya Kirbuk
- Bob Balaban
- Dr. R. Chandra
- Keir Dullea
- Dave Bowman
- Madolyn Smith Osborne
- Caroline Floyd
- Dana Elcar
- Dimitri Moisevitch
- Taliesin Jaffe
- Christopher Floyd
- James McEachin
- Victor Milson
- Mary Jo Deschanel
- Betty Fernandez, Bowman's Wife
- Elya Baskin
- Maxim Brajlovsky
- Saveliy Kramarov
- Dr. Vladimir Rudenko
- Oleg Rudnik
- Dr. Vasili Orlov
- Natasha Schneider
- Irina Yakunina
- Vladimir Skomarovsky
- Yuri Svetlanov
- Peter Hyams
- Cinematographer, Director, Producer, Screenwriter
- Arthur C. Clarke
- Writer
- Neil A. Machlis
- Associate Producer
- Jonathan A. Zimbert
- Associate Producer
- David Shire
- Original Music
- Mia Goldman
- Film Editing
- James Mitchell
- Film Editing
